Gene n1172 (Tetrahymena)

n1172

Species: Tetrahymena
Alias: n.9801, n1172, 1172
External Links:
Annotation:

Classification

Group: CAMK
Family: CDPK

Sequence

Name Sequence Type Origin Length Description Download
n1172.AA Protein None 2845 None Fasta, JSON
n1172.NA RNA None 5073 None Fasta, JSON
n1172.kin_dom Protein Kinase Domain None 255 None Fasta, JSON

Protein domain

Protein domains of n1172.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase n1172.AA Ciliate-E2a 1840-2097 44 1.3e-166 494.42 In-house 1-275 (275) Show / Hide 
Range on Protein: 1840-2097
Range on HMM: 1-275/275
Sequence Identity: 44% (124 aa)

YDILNKKLGEGFFGSVEVVQLKGTKQNRAMKKVDKHMLDSKMQREEFIQEIDILKTLDHPNILKIYEFYEDNRYLYIITELCNGRELFDVIVEDDTCFTE
|... ||.|.|.||||...|.|.|....||||..|.| ..|...|.|..||.|...||||||.|.||.|||....|...|.|.|.||.| |......|.|
YKFI-KKIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEE

-QQTMKIMQQSLS-ALQYAHSKCYAHRDIKPENIMID------IETQKIKIIDWGTSTSF--N-GEKIKQLVGSAYYIAPEILKRKG------YDEKVDI
 |. ..|||| |. .|.| |.... |||.|||||...      |....|||||.|..| .  . .....| .|...|.|||.|. |       ||.|.|.
IQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDM

WSLGIVFYLLITGTTPYNAETTTEIFEEIKKYKLSFEDPL-WEKFSTECKDLLSKMLNPQPNKRISAQQALKHPWF
||.|..||.|..|..|....|..||....||.|..|..|  |||.| |||||..|||...|.|||.|||||.||||
WSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase n1172.AA CDPK 1842-2097 48 1.6e-136 421.1 In-house 2-271 (271) Show / Hide 
Range on Protein: 1842-2097
Range on HMM: 2-271/271
Sequence Identity: 48% (133 aa)

ILNKKLGEGFFGSVEVVQLK-GTKQNR-AMKKVDKHMLDSKMQREEFIQEIDILKTLDHPNILKIYEFYEDNRYLYIITE--LCNGRELFDVIVEDDTCF
...|.||.| ||.|  |..| .|.| | ||| . |  .  | | . |..||.|||.||||||.||||||.|... ||..|  .| | ||||.|.|    |
KIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGH-F

TEQQTMKIMQQSLSALQYAHSKCYAHRDIKPENIMIDIETQ------KIKIIDWGTSTSFNG------EKIKQLVGSAYYIAPEILKRKGYDEKVDIWSL
||... .||.| |||..|.||.   |||.|||||. |.          ||.||||||. |..      .|..| .|  ||||||.|..| |.||.||||.
TEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVLQKK-YNEKCDIWSC

GIVFYLLITGTTPYNAETTTEIFEEIKKYKLSFEDPLWEKFSTECKDLLSKMLNPQPNKRISAQQALKHPWF
|.. | |. |. | ....  ||.| .|| | |||.| |.. | |.||| .|||.. |.||.||||||.||||
GVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase n1172.AA CAMK 1846-2097 26 1.3e-102 331.47 In-house 1-425 (425) Show / Hide 
Range on Protein: 1846-2097
Range on HMM: 1-425/425
Sequence Identity: 26% (112 aa)

KLGEGFFGSVEVVQLKGTK------------QNRAMKKVDKHMLDSKM-------------------------QREEFIQEIDILKT-------LDHPNI
.||.| || |  .. | |.            |  |.| .||  |..|.                          |... .||.|.|.       ||||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LKIYEFYEDNRY-------------------LYIIT---ELCNGREL----FDVIVED--------------DTCFTEQQTMKIMQQSLSALQYAHSKCY
.|.||.|||..|                   .|...   |.| | ||    || |||               . .|||... ....| .||..| ||.  
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

AHRDIKPENIMIDIET----------------QKIKIIDWGTSTSFN-------------------------GEKIKQLVGSAYYIA-PEILKR------
.|||.|||||..|                    .|||||.| .. |.                         |.| |  .|. .|.| ||.|..      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------KGYDEKVDIWSLGIVFYLLITGTTPYNAE-------------TTTEIFEEIKKYKLSFEDPLWEK--------------------FSTECKD
        ..|..|.|.||.|.. | . .|. |....             .  |.|| |.| | .|..| . .                    .|.||||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LLSKMLNPQPNKRISAQQALKHPWF
|..|||.. |.||....|.|.|||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase n1172.AA CAMK1 1842-2097 39 2.5e-102 298.29 In-house 2-276 (276) Show / Hide 
Range on Protein: 1842-2097
Range on HMM: 2-276/276
Sequence Identity: 39% (109 aa)

ILNKKLGEGFFGSVEVVQLKGT---KQNRAMKKVD-KHMLDSKMQ--REEFIQEIDILKT---LDHPNILKIYEFYEDNRYLYIITELCNGRELFDVIVE
.. |..|.| |. |  .. | |   ... |.|  | | ... | .  .| . .||.|.|.   .||||| |.||.||.....|...||..| |||| |||
EFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIVE

DDTCFTEQQTMKIMQQSLSALQYAHSKCYAHRDIKPENIM-IDI-ETQKIK--IIDWGTSTSFN-GE-KIKQLVGSAYYIAPEILKR---KGYDEKVDIW
 . ..||..  .||.| |||..| |||  .|||.||||.   |. |  |||  |.| | |. |. .| . |. .|. .|.|||.|..   |.|| ..|.|
KG-NYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMW

SLGIVFYLLITGTTPYNAET-TTEIFEEIKKYKLSFEDPLWEKFSTE-CKDLLSKMLNPQPNKRISAQQALKHPWF
| |...| | .|  | ..|.   |.|| |||... |  | | . | .  ||....||.. |.||....|.|.|||.
SIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase n1172.AA Ciliate-E2 1841-2097 29 8e-99 334.61 In-house 1-365 (365) Show / Hide 
Range on Protein: 1841-2097
Range on HMM: 1-365/365
Sequence Identity: 29% (110 aa)

DILNKKLGEGFFGSVEVVQLKGTKQNRAMK-------------KVDKHMLDSKMQR----EEFIQEIDILK----------------TLDHPNILKIYEF
 ...||.|.| ||||  .. . .... |.|             ||.. .   |...    |.. |||.|..                .|.||||.|.||.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YE--DNRYLYIITELCNGRELFDVIVEDDTC----------FTEQQTMKIMQQSLS---------------ALQYAHSKC-YAHRDIKPENIMIDIETQK
..  |. ..|...|.|.| .||| | . ...          |||..  .||.| |.               ||.| |||    |||||||||..      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

IKIIDWGTSTSFNGEKIKQL---------------------------------VGSAYYIAPEILKRKG---------YDEKVDIWSLGIVFYLLITGTT
|||||.|.|. .. . ....                                 .|...| |||||..|.         ||.|.||||||...| ...| .
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PYNAETTTEIFEEIKKYKLSFEDPL--------------WEKFSTECKDLLSK----MLNPQPNKRIS-AQQALKHPWF
|.        ...||. |..|  |               |.| | |||||..|    ||. .|.|||. ..|.|.||||
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase n1172.AA S_TKc 1841-2097 32 1.8e-94 321.05 SMART 1-231 (231) Show / Hide 
Range on Protein: 1841-2097
Range on HMM: 1-231/231
Sequence Identity: 32% (89 aa)

DILNKKLGEGFFGSVEVVQLKGTKQNRAMKKVDKHMLDSKMQREEFIQEIDILKTLDHPNILKIYEFYEDNRYLYIITELCNG--RELFDVIVEDDT---
  . .|.|.| ||.|  .. |.|..  |.|...          | ...||.|||  .|||| |.|....|  .||...|.|.|   .|||.|..  .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

--CFTEQQTMKIMQQSLSALQYAHSKCYAHRDIKPENIMIDIETQKIKIIDWGTSTSFNGEKIKQLVGSAYYIAPEILKRKGYDE-KVDIWSLGIVFYLL
   |.| .. ..|.| ..||.| ||.   |||.|||||..|     |||.| | .. .     . ..|. .|.|||.|   ||.  |.|.||.|...| .
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

ITGTTPYNAETTTEIFEEIKKYKLSFEDPLWEKFSTECKDLLSKMLNPQPNKRISAQQALK-------HPWF
..| .|.   .  ..|. |.              | |.||...|.|.  |.||..| .||.       ||||
LCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase n1172.AA Pkinase 1842-2097 32 4.1e-89 307.14 Pfam 2-293 (293) Show / Hide 
Range on Protein: 1842-2097
Range on HMM: 2-293/293
Sequence Identity: 32% (95 aa)

ILNKKLGEGFFGSVEVVQLKGTKQNRAMKKVDKHMLDSKMQREEFI-QEIDILKTLDHPNILKIYEFYEDNRYLYIITELCNGR----ELFDVIV-EDDT
 . .|.|.| ||.|   . ||| .  |.|...|.  .|..... .  .|| |.| |.||||...|...||....|...|.|.|     .|||.|  ....
HIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHG

CF--TEQQTMKIMQQSLSALQYAHSKCYAHRDIKPENIMIDIETQKI----KIIDWGTST---SFNGEKIKQLVGSAYYIAPEILK-RKGYDEKVDIWSL
||  .|..  ..| | |..|.| ||.   |||.|||||.|| ..  |    ||.|.| .      |..  . ..|. .|.|||... ...|. |||.||.
CFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GIVFYLLITGTTPYNAE------TTTEIFEEIKKYKLSFEDPLWEKFS-----------------TECKDLLSKMLNPQPNKRISAQQALKHPWF
|...| ...| .|.  .      .  .....|.. .|.|. | |   |                  ||||.....|.. |.||..|.|.|.||||
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase n1172.AA CAMK-Unique 1842-2097 26 3.2e-85 281.25 In-house 2-363 (363) Show / Hide 
Range on Protein: 1842-2097
Range on HMM: 2-363/363
Sequence Identity: 26% (95 aa)

ILNKKLGEGFFGSVEVVQLKGTKQNRAMKKVDKHMLDSKMQRE-----------------EFIQEIDILKTLDHPNILKIYEF----YEDNR--------
.... .|.| || |  .. . |.  .|.|.| |    .| | .                 ..  |..|.|..|||||.|.|..    ..| .        
KMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLII

-------YLYIITELCNGRELFDVIVED-------------------DTCFTE--QQTMKIMQQSLSALQYAHSKCYAHRDIKPENIMIDIE--------
       |.||..|.|.|..|||.|..                     . |.|   .|  |||. |||. |.||.   |||.|.||||.  .        
KTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHR

-------TQKIKIIDWGTSTSFNGEKIK----QLVGSAYYIAP--------------EILKRKGYDEKV----DIWSLGIVFYLLITGTTPYNAETTT--
         .||..|.| .. .|. |        .|. .|.||              |.... .||...    |||||| . |....| .| ..|.    
DFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRD

------EIFEEIKKYKL-SFEDPLWEK---FSTECKDLLSKMLNPQPNKRISAQQALKHPWF
      |||| |.| .. .|. . |.     | | ||.. . ..  |..|.|| ..|.|.|.
YENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase n1172.AA CAMKL 1840-2097 33 1e-82 263.78 In-house 1-297 (297) Show / Hide 
Range on Protein: 1840-2097
Range on HMM: 1-297/297
Sequence Identity: 33% (102 aa)

YDILNKKLGEGFFGSVEVVQL-KGTKQNRAMKKVDKHMLDSKMQREEFIQ----------------EIDILKTLD---HPNILKIYEFYEDNRY------
|.|.   ||.| || |   .  . |..  |.| .||    .|.. .....                || |.| |.   |||| |.|| .|. ..      
YRIGK-TLGKGSFGKVKLATHIRTTGEKVAIKIIDK----KKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKK

LYIITELCNGRE--LFDVIVED-DTC--FTEQQTMKIMQQSLSALQYAHSKCYAHRDIKPENIMIDIETQ-KIKIIDWGTSTSFN------GEKIKQLVG
.|...|.| | |  ||| ||.  .    ..| .. .. .| .||..| ||.. .|||||||||..|     .||||| | |. .       |.| |   |
IYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCG

SAYYIAPEILKR--KGYD-EKVDIWSLGIVFYLLITGTTPYNAETT------TEIFEEIKKYKLSFEDPLWEKFSTECKDLLSKMLNPQPNKRISAQQAL
|  | ||||...  | ||  ||||||.|.. | ...|. | ...|           .. |. .. ...| | . | .|.||..|||.. |.||....| .
SPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIM

KHPWF
.|||.
NHPWM
Kinase n1172.AA Ciliate-E2-Unclassified 1842-2097 27 2.3e-82 279.92 In-house 2-352 (352) Show / Hide 
Range on Protein: 1842-2097
Range on HMM: 2-352/352
Sequence Identity: 27% (98 aa)

ILNKKLGEGFFGSVEVVQLKGTKQNRAMKKVDKHMLDS-KMQRE--EFIQEIDILKTLD-----------------HPNILKIYEFYE--DNRYLYIITE
...|..|.| ||.|  .| | .||  |||   |.. .. | ...  |...|..... .                  ||.......||.  |  ..||..|
KIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVME

LCNGRELFDVIVEDDT----------------CFTEQQTM-----KIMQQSLSALQYAHSKC-YAHRDIKPENIMIDIETQ--KIKIIDWGTST---SFN
.|.| .|.. | .  .                .|||||.      ... | |..|.| |.|    |||||||||..| . .  .|||||.| |    ..|
YCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNN

GEK--------------IKQLVGSAYYI----APEILKRKGYD----EKVDIWSLGIVFYLLITGTTPYNAETTTE----------------IFEEIKKY
...              ... .|. .|.    |||.|....||    .|.||||||...| ...|. |..... ..                ....||. 
NCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQK

KLSFEDPLW----EKFSTECKDLLS----KMLNPQPNKRISAQQALKHPWF
...|    |     . | |.||...    |||. .|||||...|.|.||||
NIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase n1172.AA RSK 1844-2097 31 5.1e-73 248.9 In-house 1-278 (278) Show / Hide 
Range on Protein: 1844-2097
Range on HMM: 1-278/278
Sequence Identity: 31% (89 aa)

NKKLGEGFFGSVEVVQLK---GTKQNRAMKKVDKHMLDSKMQ-REEFIQEIDILKTLD-HPNILKIYEFYEDNRYLYIITELCNGRELFDVIVEDDT--C
 | ||.| .|.| ... .    |.|  ||| ..|.... .    .   .|..||..   ||.| . .. .... .||.|.|.|.| |||. . .  .  |
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FTEQQTMKIMQQSLSALQYAHSKCYAHRDIKPENIMIDIETQK---IKIIDWGTSTSF---NGEKIKQLVGSAYYIAPEILK----RKGYDEKVDIWSLG
|.|     .| .  .|... |..   |||.|||||. | |.     ||..| | .  |   .... .  .... |.|||.||    ..|.|. .|.||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

IVFYLLITGTTPYNA---ETTTEIFEEIKKYKLSFEDPLWEKFSTECKDLLSKMLNPQPNKRIS-----AQQALKHPWF
.. | . || .|. .   ..  ||.. |.| |.|.. | |.. |.|.|||..|||   |.||..     |.. ..||||
VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase n1172.AA ULK 1842-2097 30 1.1e-69 237.88 In-house 2-324 (324) Show / Hide 
Range on Protein: 1842-2097
Range on HMM: 2-324/324
Sequence Identity: 30% (98 aa)

ILNKKLGEGFFGSVEVVQL--KGT---KQNRAMKKVDKH-MLDSKMQRE------EFIQEIDILKTLD---HPN--ILKIYEFYEDN--RYLYIITELCN
.||..||.| || | | .   | |   .|  | |..||  | ..| ..|       ...|| |.|.|.   |||  | | |...|.    ..|||.|.||
CLNHCLGKGSFG-VKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GRELFDVIVEDDTC--------FTEQQTMKIMQQSLSALQYAHSKCYAHRDIKPENIMIDIETQK-----------IKIIDWGTSTSFNG-----EKIKQ
|  |.. | .. ..        ..||.. ....| ...... |.. . ||||||.||.|   ..|           .|| | | . ...       ....
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

LV------GSAYYIAPEILK----RKGYD-EKVDIWSLGIVFYLLITGTTP---YNAETTT----EIFEE-------IKKYKLSFEDP-LWEKFSTECKD
.|      |. .| ||.||.    .| |.  |.||||||..|| ...| .|   . ....     .  .        ||. .. | .|    |.| ||||
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LLSKMLNPQPNKRISAQQALKHPWF
|...||  ....||| .. ..||||
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase n1172.AA Pkinase_Tyr 1842-1966 29 1.9e-15 52.95 Pfam 2-137 (270) Show / Hide 
Range on Protein: 1842-1966
Range on HMM: 2-137/270
Sequence Identity: 29% (41 aa)

ILNKKLGEGFFGSVEVVQLK----GTKQNRAMKKVDKHMLDSKMQ--REEFIQEIDILKTL-DHPNILKIYEFYE-DNRY--LYIITELCNGRELFDVIV
...|||||| ||.|    .|    .||.  | |.. |.   .. |  ||.|..|. |.|.| .||||.. |     . .   .||..|.. .  | |   
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

ED---DTCFTEQQTMKIMQQSLSALQYAHSKCYAHRDI
.    .  .| ..  .. .|  ....| .|| . |||.
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase n1172.AA TyrKc 1841-2097 21 1e-14 15.07 SMART 1-280 (280) Show / Hide 
Range on Protein: 1841-2097
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

DILNKKLGEGFFGSVEVVQLKGTKQNRAMKKVDKHMLDSKMQREEFIQEIDILKTL--DHPNILKIYEFYEDN-------RYLYIITELCNGRELFDVI-
  |.||||||.|| |   ..|   .. | |.. ..       ||.|..|. |.. |  .||||...|    .          |.|..|.. .  | | . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

VEDDTCFTEQQTMKIMQQSLSALQYAHSKCYAHRDIKPENIMIDIETQKIKIIDWGTSTSFNGE-------KIKQL----VGS----AYYIAPEILKRKG
   .. .. ..  ... |  .  .| |||.. |||.   |.... .   .|| | | |     .       . .       |         ||| .. . 
KHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YDEKVDIWSLGIVFYLLIT-GTTPYNA-----ETTTEIFEEIKKY-KLSFEDPLWEK-----FSTECKDLLSKMLNPQPNKRISAQQALKHPWF
. .| |.|| |.. . . | | .||        . .|..| .|.   .   .           ..|  .. ..  . .|..| . ..   |  |
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase n1172.AA Pkinase_Tyr 2007-2053 30 0.143438 5.94 Pfam 182-231 (270) Show / Hide 
Range on Protein: 2007-2053
Range on HMM: 182-231/270
Sequence Identity: 30% (15 aa)

APEILKRKGYDEKVDIWSLGIVFYLLIT-GTTP-YNAETTTEIFEEI-KK
||| .. . . .| |.|| |.. . ..| | .| |   . .|..| | ..
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYED
Efhand n1172.AA efhand 2126-2154 34 1.5e-05 24.7 Pfam 1-29 (29) Show / Hide 
Range on Protein: 2126-2154
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

ELSDLFIHLDTNKDGKLSKEEIFNGYKNL
|| ..| ..|...||....||  ...|.|
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh n1172.AA EFh 2126-2154 31 9.3e-05 23.06 SMART 1-29 (29) Show / Hide 
Range on Protein: 2126-2154
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

ELSDLFIHLDTNKDGKLSKEEIFNGYKNL
|. ..| ..|...||....||   . |.|
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand n1172.AA efhand 2163-2191 31 5e-06 26.44 Pfam 1-29 (29) Show / Hide 
Range on Protein: 2163-2191
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

ISEKIFSEVDVDNNGSIDYNEFLACTMQK
  ...|.|.|.|..| ||..||... ...
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh n1172.AA EFh 2163-2191 27 4.2e-05 24.2 SMART 1-29 (29) Show / Hide 
Range on Protein: 2163-2191
Range on HMM: 1-29/29
Sequence Identity: 27% (8 aa)

ISEKIFSEVDVDNNGSIDYNEFLACTMQK
  ...|...|.|..| ||..||... . .
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand n1172.AA efhand 2199-2227 34 1e-05 25.33 Pfam 1-29 (29) Show / Hide 
Range on Protein: 2199-2227
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

TLKRAFDLFDIDGDKQITAKEIKSVLQDN
 ||..|..|| ||| .|. .| ...... 
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh n1172.AA EFh 2199-2227 34 5.6e-05 23.79 SMART 1-29 (29) Show / Hide 
Range on Protein: 2199-2227
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

TLKRAFDLFDIDGDKQITAKEIKSVLQDN
 .|..|..|| ||| .|. .| | ...  
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
EFh n1172.AA EFh 2235-2263 44 1.7e-09 38.83 SMART 1-29 (29) Show / Hide 
Range on Protein: 2235-2263
Range on HMM: 1-29/29
Sequence Identity: 44% (13 aa)

IWEQIIQEVDKDGNGVIDFNEFQQMMDSI
 ........||||.| |||.||..|| |.
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand n1172.AA efhand 2235-2263 44 6.5e-09 37.03 Pfam 1-29 (29) Show / Hide 
Range on Protein: 2235-2263
Range on HMM: 1-29/29
Sequence Identity: 44% (13 aa)

IWEQIIQEVDKDGNGVIDFNEFQQMMDSI
 ......|.||||.| |||.||..|| ..
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
Tubulin n1172.AA Tubulin 2353-2614 17 6.4e-37 118.05 Pfam 6-223 (223) Show / Hide 
Range on Protein: 2353-2614
Range on HMM: 6-223/223
Sequence Identity: 17% (51 aa)

NIGQCGNQIGLQLID------------------------YFESTSHNYEDTYLKNSDQNT-FHSIHIDTEPKIIKP-LIENRKKYYN-IDPKNVLFFQHG
..|||||.|| ....                        .|.           |.....    .| |.|.|. ..  .  . |.  . ....|.   . |
GVGQCGNNIGNHMWEQLCQEHCINPDGGNNDYQDDNINVFFYEV---------KTNHGIYGPRFIAINTDPQHLNEMIKAPNKR--WIFIGNNFTRGKEG

RGNNWSLGYMDEQKLQNQVKKNNKPLTFNKFTESQPYQLSQNTASLNNNSDLLQIGLKGNNQEIIPSQQMLKENTQILENLIDIMRKEIEKIDYCMGIHM
 ||||. ||.                                                                 .. .  ....||..|| |.. .. .
AGNNWEVGYYTH-------------------------------------------------------------GKEAADESMEEIRKQVEKCDGFDMFFI

ISSLGGGTGSGLGSRLIEEFRDLFSDIQIINTVVFPH--KSGETTLQHYNCALSLAHLQKYSDCIIYFQNDKVNSYLNLARSSSVE-KAIDL
....|||||||... ..|  .... .. ... |.||    ..| ... || .|.| .|....||.| ..||| . ..   .. ...  | . 
THGMGGGTGSGAAPVIAEMAKEMYPGALTVAFVTFPFPNIFSEGVVRMYNAILGLHELIEHCDCVIVIDNDKLYDIC--NNQLDIQNPAFKH
Tubulin n1172.AA Tubulin 2418-2633 15 8e-07 -13.54 SMART 1-232 (232) Show / Hide 
Range on Protein: 2418-2633
Range on HMM: 1-232/232
Sequence Identity: 15% (38 aa)

NVLFFQHG-RGNNWSLGYMDE----QKLQNQVKKNNKPLTFNKFTESQPYQLSQNTASLNNNSDLLQIGLKGNNQE---IIPSQQMLKENTQ-----ILE
.  .|  | .| .    .| |    . ...  .                      .   |  . .|.   | ...|   |    .  .         . .
KIKVFGVGDGGGCNAVNHMIEPGPREGIDGG-QG------------------EVEFICANTDAQALHPESKAPGKEGKKIQIGNNWTRGHGAGANPEVGR

NLID-IMRKEIE--KIDYC-----MGIHMISSLGGGTGSGLGSRLIEEFRD--LFSDI---QIINTVVFPHKSGETTLQHYNCALSLAHLQKYSDCIIYF
  ..   . ||.   .. |      ..    ..|||||.|... . |  ||   . .     ..  |..| .| |.  . ||  .....|....||.| .
EAAEEQSMDEIRFEALEGCDCHHLDMVFITHGMGGGTGTGAAPVIAEIARDVKEMGILTTALKVGVVTKP-FSFEGVVRMYNAEEGIHELREHVDCLIVI

QNDKVNSYL--NLARSSSV------EKAIDLTNINQYIA---SNLFNLLKLND
 |||  . .  ....  .       .     ...|. .|   .   .|.    
PNDKLYDICDRKNTM-NKGAKNKMIPMQPAFKMANDVLAQAVQGITDLITFPG