Gene n1167 (Tetrahymena)

n1167

Species: Tetrahymena
Alias: n1167, 1167, n.15452
External Links:
Annotation:

Classification

Group: Other
Family: Ciliate-C6

Sequence

Name Sequence Type Origin Length Description Download
n1167.AA Protein None 622 None Fasta, JSON
n1167.NA RNA None 1524 None Fasta, JSON
n1167.kin_dom Protein Kinase Domain None 218 None Fasta, JSON

Protein domain

Protein domains of n1167.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase n1167.AA Ciliate-C6 221-464 66 9.40000000001e-175 586.85 In-house 1-274 (306) Show / Hide 
Range on Protein: 221-464
Range on HMM: 1-274/306
Sequence Identity: 66% (183 aa)

LNYRDSIGCGSFGQVYKVKNKYKQIIKNPDILQNMPDYYACKQIHISQDG--ENQSQQIFHEIEVLEKLKKYEYVIKLQNYIIE-ERSAYLVLDLAESTL
.|||||.|.||||||||.|||.||||||.||||.|||||||||||..|..  |||..||||||||||||||||.|||.|||.|| .|..|.|||||||||
INYRDSLGSGSFGQVYKCKNKHKQIIKNMDILQQMPDYYACKQIHMTQQMSFENQMSQIFHEIEVLEKLKKYENVIKMQNYFIEPNRQTYIVLDLAESTL

QDKINEKQAN----LLKIQISFKKIEKKSEKFDESEIVKFLSQI----------EGIAHRDIKPSNILIKDD--NFYLSDFGCAEILFESQEARNN-LVM
||.|..||||     .|..|.......|.|.|||.|||.|..||          ..|||||||||||||.||  |.||||||||. ||.|...||| ..|
QDCIQMKQANVNNFYFKQEINIFSFNYKYEHFDENEIVQFCKQIGKTLADIYNECNIAHRDIKPSNILIMDDENNYYLSDFGCAQQLFQSEFTRNNDIHM

GTLKWMSPELKEMKK----------NQVVDYFKSDIFSLGMLLLYMLTLSDISSVNSDEFTKNQKIRIMKNYCK
||||||||||.||||          ||..||||.|||||||.|||||||||||.||.|||.||||||||||.||
GTLKWMSPELREMKKQYNQHQDDNSNQQIDYFKCDIFSLGMILLYMLTLSDISQVNCDEFMKNQKIRIMKNMCK
Kinase n1167.AA Ciliate-C6 465-612 69 6.1e-105 354.94 In-house 145-306 (306) Show / Hide 
Range on Protein: 465-612
Range on HMM: 145-306/306
Sequence Identity: 69% (113 aa)

GKTLAIIYVEERIAHRDIKPSNILIIDN--NYYLSDFGCAENLFDSEGAKYN-LVMGTLKWMSPELKEKKK----------IEAIDYFKSDIFSLGMVLL
|||||.||.|..|||||||||||||.|.  ||||||||||..||.||... | ..|||||||||||.|.||           ..|||||.|||||||.||
GKTLADIYNECNIAHRDIKPSNILIMDDENNYYLSDFGCAQQLFQSEFTRNNDIHMGTLKWMSPELREMKKQYNQHQDDNSNQQIDYFKCDIFSLGMILL

YMLTLSDISAVNSDEFSKNQKLRIMRNSCKYVS-KEIILLVSKMLETNPDFRPDAPILIQAI
||||||||| ||.|||.||||.|||.|.||..| ||||.|||||||||||.|||..||||.|
YMLTLSDISQVNCDEFMKNQKIRIMKNMCKDISYKEIIKLVSKMLETNPDHRPDMSILIQTI
Kinase n1167.AA Pkinase 221-438 23 7.3e-29 103.13 Pfam 1-207 (293) Show / Hide 
Range on Protein: 221-438
Range on HMM: 1-207/293
Sequence Identity: 23% (56 aa)

LNYRDSIGCGSFGQVYKVKNKYKQIIKNPDILQNMPDYYACKQIHISQDGENQSQQIFH--EIEVLEKLKKYEYVIKLQNYIIEERSAYLVLDLAES---
.     || ||||.||| ..|  ..             .|.|.|  . . ... |. ..  ||... .| . .....|  .  .... |.|....|    
YHIGRKIGSGSFGCVYKCHHKGTGK------------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY

--TLQDKINEKQANLLKIQISFKKIEKKSEKF--DESEIVKFLSQI---------EGIAHRDIKPSNILIK-DDNF----YLSDFGCAEIL-FESQEARN
   | | |                  ... .|  .| |. ... ||         .|| |||.||.||||. ...      ..|||.|. .   ...  .
VMDLFDYIST----------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MT

NLVMGTLKWMSPELKEMKKN-QVVDYFKSDIFSLGMLLLYMLT
 .. ||. .|.||.     . .  .  |.|..|.| .| .||.
TFC-GTPWYMAPEV----IRGGQYYGPKVDMWSCGCILYEMLC
Kinase n1167.AA STE 221-438 23 3.2e-23 78.9 In-house 1-263 (359) Show / Hide 
Range on Protein: 221-438
Range on HMM: 1-263/359
Sequence Identity: 23% (63 aa)

LNYRDSIGCGSFGQVYKVKNKYKQIIKNPDILQ----NMPDYYACKQIHISQDG---------------ENQSQQIFHEIEVLEKLKK-YEYVIKLQNYI
.   . || |.||.||| .|. . .|  .   .    .. ...| ||......                ... ||| .||... |...  ....|   . 
WEGIEKIGKGAFGTVYKAMNHKNCNIH-KTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

IEER-------SAYLVLDLAE-STLQDKINEKQANLLKIQISFKKIEKKSEKFDESEIVKFLSQ-IEG---------IAHRDIKPSNILIKDDNFYLSDF
. |        . .... . .  .| | |..|   .   .....   . . .|.||.| ... | ..|         | ||||||.|||.      |.||
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQ---H-QHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDF

GCAEILFES--------------QEA-RNNLVMGTLKWMSPELKEMKKNQ-VVDY-FKSDIFSLGMLLLYMLT
|.. .| .|                . ..| . ||  ||.||  .  ..  . .| .|.|| ||| ... |.|
GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMAT
Kinase n1167.AA ULK 219-438 22 8.3e-22 74.19 In-house 1-247 (324) Show / Hide 
Range on Protein: 219-438
Range on HMM: 1-247/324
Sequence Identity: 22% (62 aa)

YELNYRDSIGCGSFG-QVYKVKNKYKQIIKNPDILQNMPDYYACKQIHISQDGENQSQ--------QIFHEIEVLEKLK--KYEY--VIKLQNYIIEE--
|.|| .  .| |||| .||| .|| ..             |.|||.| ...  .....        ..  ||... |||  | ..  ..||  .  .   
YCLNHC--LGKGSFGVKVYKGRNKKTNT---------QNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNH

RSAYLVLDLAES-TLQDKINEKQA---NLLKIQISFKKIEKKSEKFDESEIVKFLSQIE---------GIAHRDIKPSNILIKDDNFY------------
   |..... .  .|.. |....      .           .  .. |.|...|. ||          .| ||||||.||||.... .            
NNIYIIMEYCNGGDLEQYIKKNKKLPET-E-----------EKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVL

-LSDFGCAEILFE-SQEARNN-------LVMGTLKWMSPELKEMK-KNQVVDYFKSDIFSLGMLLLYMLT
 ..||| | .... ..|.  .       .. ||   |.|.. . . ...  . .|.||.|||... .||.
KIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLY
Kinase n1167.AA Ciliate-E2 221-438 20 5.5e-21 68.76 In-house 1-291 (365) Show / Hide 
Range on Protein: 221-438
Range on HMM: 1-291/365
Sequence Identity: 20% (62 aa)

LNYRDSIGCGSFG-----QVYKVKNKYKQIIKNPDILQNMP---DYYACKQIHISQDGENQSQQIFHEIEVLEKLK---------------KYEYVIKLQ
 .    || |.||     .|.||....  .|.. ...   .   .... |.. . .  .|| .||. || .. ...               .  ..||. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY

NYII--EERSAYLVLDLAES-TLQDKINEKQANLLKIQISFKKIEKKSEKFDESEIVKFLSQIE------------------------G-IAHRDIKPSN
 . .   . . |||.....  .|.| |.... . ....      . . ..|.| || ..  ||                         . | ||||||.|
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIE-----K-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPEN

ILIKDDNFYLSDFGCAEILFESQEARN------------------------------NLVMGTLKWMSPELKEMKK-----NQVVDYFKSDIFSLGMLLL
||.      ..||| . .. .... |                               | . ||.  |.||  ..||     .|    .|.||.|||..| 
ILF----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILY

YMLT
.||.
EMLF
Kinase n1167.AA ULK 219-438 22 7.7e-21 69.54 In-house 1-251 (329) Show / Hide 
Range on Protein: 219-438
Range on HMM: 1-251/329
Sequence Identity: 22% (61 aa)

YELNYRDSIGCGSFGQVYKVKNKYKQIIKNPDILQNMPDYYACKQIH---ISQDGEN-----QSQQIFHEIEVLEKLK-------KYEYVIKLQNYIIEE
|.|| .  .| ||||.||    | . .... |  .|   ..|||.|    ..|.  .     . |..  ||... |||       . ....||  .  . 
YCLNHC--LGKGSFGKVY----KGRNKKTK-D-YVN--EKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETS

--RSAYLVLDLAES-TLQDKINEKQA----NLLKIQISFKKIEKKSEKFDESEIVKFLSQIE---------GIAHRDIKPSNILIKDDNFY---------
     |..... .  .|.. |....       .           .  .. |.|...|. ||          .| ||||||.||||.... .         
NHNNIYIIMEYCNGGDLEQYIKKNKKLPEDT-E-----------EKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPN

----LSDFGCAEILFES--QEARNNLVM------GTLKWMSPELKEMK-KNQVVDYFKSDIFSLGMLLLYMLT
    ..||| |  . ..  ... .          ||   |.|.. . . ...  . .|.||.|||... .||.
GVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLY
Kinase n1167.AA CAMK 226-438 18 3.3e-19 57.86 In-house 1-329 (425) Show / Hide 
Range on Protein: 226-438
Range on HMM: 1-329/425
Sequence Identity: 18% (62 aa)

SIGCGSFGQVYKVKNK-YKQIIKNPDILQNMPDYYACKQIHIS----------------QDGENQS----------QQIFHEIEVLEKLKK------YEY
 .| ||||.|.....|  .. ..   |. | .  .|.| |  .                .. ....          .....|||.. ||..       . 
TLGRGSFGKVKLCIHKNTTGKERVHHIYTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN

VIKLQNYIIE-------------------ERSAYLVL---DLAEST-----LQDKINEK--------QANLLKIQISFKKIEKKSEKFDESEIVKFLSQI
.|||  ..                     ..  |.|.   ....       | |.| |.        |            |  .. .|.|.|  ..  ||
IIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQ----------FDIV-ERGRFTEREARRYFRQI

---------EGIAHRDIKPSNILIKDDNF---------------Y---LSDFGCAEILFESQEARNN----------------------LVMGTLKWMS-
          .|.|||.|| |||. |.|                .   ..||| | ....... ...                       . ||.  |. 
CSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAA

PELKEMKK--------NQVVDY--FKSDIFSLGMLLLYMLT
||. . |.        ..  .|  .|.|. |.| .|  ||.
PEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLC
Kinase n1167.AA S_TKc 221-612 16 6.8e-18 66.69 SMART 1-231 (231) Show / Hide 
Range on Protein: 221-612
Range on HMM: 1-231/231
Sequence Identity: 16% (67 aa)

LNYRDSIGCGSFGQVYKVKNKYKQIIKNPDILQNMPDYYACKQIHISQDGENQSQQIFHEIEVLEKLKKYEYVIKLQNYIIEERSAYLVLDLAES---TL
    . || |.||.|||...|                ..|.|.|.         ..|  ||..|.|  . ....||  .. .  . |.|.....    .|
YEILRKIGKGAFGKVYKCRHKK------------TGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDL

QDKINEKQANLLKIQISFKKIEKKSEKFDESEIVKFLSQI---------EGIAHRDIKPSNILIKDDNFYLSDFGCAEILFESQEARNNLVMGTLKWMSP
 | | ... . |.             .|.| .. ... ||          || |||.||.|||. . .  ..||| | .|        . . ||. .|.|
FDYIKKRGRHGLR------------FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL--------TTFCGTPWYMAP

ELKEMKKNQVVDYFKSDIFSLGMLLLYMLT----LSDISSVNSDEFTKNQKIRIMKNYCKGKTLAIIYVEERIAHRDIKPSNILIIDNNYYLSDFGCAEN
|.         ...|.|. |.| .|  ||.     .             |  ...|. .                                         
EVL------GYGKCKCDWWSCGCILYEMLCGYPPFP-------------QMQMMFKKIG-----------------------------------------

LFDSEGAKYNLVMGTLKWMSPELKEKKKIEAIDYFKSDIFSLGMVLLYMLTLSDISAVNSDEFSKNQKLRIMRNSCKYVSKEIILLVSKMLETNPDFRPD
                                                                               |.| . ...|.|. .|. || 
-------------------------------------------------------------------------------SPEAKDFIRKCLQKDPEKRPT

APILIQ---------AI
|  . |          .
A-EALQDEWDIKCHPWF
Kinase n1167.AA STE 474-605 22 3.8e-17 57.19 In-house 170-348 (359) Show / Hide 
Range on Protein: 474-605
Range on HMM: 170-348/359
Sequence Identity: 22% (42 aa)

EERIAHRDIKPSNILIIDNNYYLSDFGCAENLFDS--------------EGA-KYNLVMGTLKWMSPELKEKKKIE-AIDY-FKSDIFSLGMVL------
. .| ||||||.|||.      |.|||.. .| ||               .. | | . ||  ||.||  .. .     .| .|.|| ||| ..      
SHHIIHRDIKPANILL----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATG

-LYMLTLSDISAVNSDEFSK-------------NQKLRIMRNSC---------------KYVSKEIILLVSKMLETNPDFRPDA
   . .... .|     |..             ..  ..  . .               . .|.| .  ..| |. .|. ||.|
KPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTA
Kinase n1167.AA Ciliate-E2 450-605 22 4.3e-17 55.19 In-house 142-356 (365) Show / Hide 
Range on Protein: 450-605
Range on HMM: 142-356/365
Sequence Identity: 22% (51 aa)

FTKNQKIRIMKNYCKGKT-----------LAIIYVEER--IAHRDIKPSNILIIDNNYYLSDFGCAE---------------NLFDSEG-----------
|| .. ..|||  ..|             ||. |  ..  | ||||||.|||.      ..||| .                ...   .           
FTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD

-----AKYNLVMGTLKWMSPELKEKKK-----IEAIDYFKSDIFSLGMVLLYMLTL-SDISAVNSDEFSKNQKLRIMRN--------------SCKYVSK
       .| . ||.  |.||  ..||      .    .|.||.|||..| .||.           .  |..|...  .              | |..|.
QIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQ

EIILLVSK----MLETNPDFRPD-A
| . | .|    ||. .|. |.. .
ECKDLIKKFGKRMLQKDPEKRITGW
Kinase n1167.AA Pkinase 474-612 19 4.9e-16 57.78 Pfam 126-293 (293) Show / Hide 
Range on Protein: 474-612
Range on HMM: 126-293/293
Sequence Identity: 19% (35 aa)

EERIAHRDIKPSNILII-DNNY----YLSDFGCAENLFDSEGAKYNLVMGTLKWMSPELKEKKKIE-AIDY-FKSDIFSLGMVLLYMLT----LSDI---
...| |||.||.||||  ...      ..|||.|. .    .  .. . ||. .|.||.     |  . .|  |.|..|.| .| .||.     ..    
SMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV-----IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWH

-SAVNSDEFSKNQKLRIMRNSCKYVS--------------------KEIILLVSKMLETNPDFRPDAPILIQA--I
 . .. ..  .. . .. . .. . .                    .| . .....|. .|  || |. . |   .
DN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase n1167.AA ULK 473-555 26 7.4e-16 51.92 In-house 147-251 (329) Show / Hide 
Range on Protein: 473-555
Range on HMM: 147-251/329
Sequence Identity: 26% (28 aa)

VEERIAHRDIKPSNILIIDNNYY-------------LSDFGCAENLFDS--EGAKYNLVM------GTLKWMSPELKEKK-KIEAIDYFKSDIFSLGMVL
....| ||||||.|||| ... .             ..||| |  . ..  | . .          ||   |.|.. ... . .  . .|.||.|||...
HKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIF

LYMLT
 .||.
YEMLY
Kinase n1167.AA C8 360-433 34 1.8e-15 50.27 In-house 144-226 (226) Show / Hide 
Range on Protein: 360-433
Range on HMM: 144-226/226
Sequence Identity: 34% (29 aa)

IAHRDIKPSNILIKDDNFYL-----SDFGCAEILFESQEARNNLVM---GTLKWMSPELKEMKKNQVVDY-FKSDIFSLGMLL
| ||||||.|.|.. |. |.     .||| |  . ....      |   ||.... ||  . ..||. .|  .||.||.|..|
IMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase n1167.AA Ciliate-E2-Unclassified 468-555 25 4.8e-15 48.64 In-house 154-265 (352) Show / Hide 
Range on Protein: 468-555
Range on HMM: 154-265/352
Sequence Identity: 25% (28 aa)

LAI-IYVEE-RIAHRDIKPSNILIIDN----NYYLSDFGCAENLFDSEGAK--------------YNLVMGTLKWM----SPELKEKKKIEAIDYFKSDI
...  . ..  | ||||||.|||. .|    .  ..||| . .. .... .              .. ..||.  |    .||. .... .    .|.||
QGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDI

FSLGMVLLYMLT
.|||..| .||.
WSLGVILYEMLF
Kinase n1167.AA C8 477-550 37 1.5e-14 47.0 In-house 144-226 (226) Show / Hide 
Range on Protein: 477-550
Range on HMM: 144-226/226
Sequence Identity: 37% (31 aa)

IAHRDIKPSNIL-IIDNNYY----LSDFGCAENLFDSEGAKYNLVM---GTLKWMSPELKEKKKIEAIDY-FKSDIFSLGMVL
| ||||||.|.|   |.||     |.||| |  . ...   .   |   ||.... ||  .|.. .  .|  .||.||.|.||
IMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase n1167.AA TKL 359-433 21 2.1e-14 48.28 In-house 160-279 (364) Show / Hide 
Range on Protein: 359-433
Range on HMM: 160-279/364
Sequence Identity: 21% (26 aa)

GIAHRDIKPSNILIKDDN---------------FYLSDFGCAEILFES------------------QEARNNLVMGTLKWMSPEL--KEMKKNQVV----
.|.|||.|..|||.....                 ..||| .  ...|                  .. ... . ||. ||.||.  ..|. .. |    
PIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDE

-----DYF-KSDIFSLGMLL
     .|. |.|..| |..|
FCKGFEYSEKCDVYSFGIVL
Kinase n1167.AA TKL 477-612 18 2.3e-14 48.16 In-house 161-364 (364) Show / Hide 
Range on Protein: 477-612
Range on HMM: 161-364/364
Sequence Identity: 18% (37 aa)

IAHRDIKPSNILIIDNN---------------YYLSDFGCAENLFDSEGAKYNL------------------VMGTLKWMSPEL---------K---EKK
|.|||.|..|||. .|.                 ..||| . ... |.. . .                   . ||. ||.||.         |   .. 
IIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDE-

KIEAIDYF-KSDIFSLGMVLLYMLTLSDISAVNS-----------DEFSKNQ--KLRIMRN----------SCKYVSKEIILLVSKMLETNPDFRPDAPI
...  .|. |.|..| |.||  .||     . .            ..|...   .||  .            |... .... |  .  ...|. || .  
FCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQE

LIQAI
... .
ILKRL
Kinase n1167.AA ULK 473-555 25 1.5e-13 44.52 In-house 143-247 (324) Show / Hide 
Range on Protein: 473-555
Range on HMM: 143-247/324
Sequence Identity: 25% (27 aa)

VEERIAHRDIKPSNILIIDNNYY-------------LSDFGCAENLFD-SEGAKYN-------LVMGTLKWMSPELKEKK-KIEAIDYFKSDIFSLGMVL
... | ||||||.|||| ... .             ..||| |  ... .. .  .       .. ||   |.|.. ... . .  . .|.||.|||...
HKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIF

LYMLT
 .||.
YEMLY
Kinase n1167.AA CAMK 477-555 26 1.5e-13 39.29 In-house 200-329 (425) Show / Hide 
Range on Protein: 477-555
Range on HMM: 200-329/425
Sequence Identity: 26% (34 aa)

IAHRDIKPSNILIIDN------------------NYYLSDFGCAENLFDSE----------------------GAKYNLVMGTLKWMS-PELKEKKK---
|.|||.|| |||. ||                  |  ..||| |  ....|                      | |.. . ||.  |. ||. ..|.   
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----IEAIDY--FKSDIFSLGMVLLYMLT
      | ..|  .|.|. |.| .|  ||.
MQNATDEEKPYYGPKCDMWSCGVILYIMLC
Kinase n1167.AA Ciliate-C8 477-550 28 2e-13 44.79 In-house 140-238 (238) Show / Hide 
Range on Protein: 477-550
Range on HMM: 140-238/238
Sequence Identity: 28% (28 aa)

IAHRDIKPSNILIIDNNYY-----LSD------FGCAENLFDSEG--------AKYNL----VMGTLKWMSPELKEK-KKIEAIDYF-KSDIFSLGMVL
| ||||||.|.| .... |     |.|      || |  | ...          ..      ..|.. .. ||. .| ..|.   .  |||..|.| ||
IMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase n1167.AA Ciliate-E2-Unclassified 219-438 19 1.1e-12 40.3 In-house 1-265 (352) Show / Hide 
Range on Protein: 219-438
Range on HMM: 1-265/352
Sequence Identity: 19% (56 aa)

YELNYRDSIGCGSFGQVYKV---KNKYKQIIKNPDILQNMPDYYACKQIHISQDGENQSQQIFHEIEVLEKLKKYEYVI-----------------KLQN
|....   || |.||.|||.   |.|.....|           |..|.....|   .....|  |.. ....||   .                  ..  
YKIIKQ--IGQGGFGKVYKCQHKKQKQYYAMK-----------YMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKM

YIIEERS--AYLVLDLAES-TLQDKINE------KQANLLKIQISFK---KIEKKSEKFDESEIV-----KFLSQ----I-----EG-IAHRDIKPSNIL
. ...     |.|....|  .|.. |..      |          ..   .  |....|.| ...     ... |    .     .. | ||||||.|||
FYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQK----------GNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENIL

IKDD----NFYLSDFGCAEILFES--------------QEARNNLVMGTLKWM----SPELKEMKKNQ---VVDYFKSDIFSLGMLLLYMLT
....    .  ..||| .  . ..              .. . . ..||.  |    .||. . ...        .|.||.|||..| .||.
FDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA---YKCDIWSLGVILYEMLF
Kinase n1167.AA Ciliate-C8 360-433 27 2.7e-12 40.65 In-house 158-256 (238) Show / Hide 
Range on Protein: 360-433
Range on HMM: 158-256/238
Sequence Identity: 27% (27 aa)

IAHRDIKPSNILIKDDNFY-----LSD------FGCAEILFESQE--------ARNNL----VMGTLKWMSPELKEM-KKNQVVDYF-KSDIFSLGMLL
| ||||||.|.|  .|. |     |.|      || |  |  ...                 ..|.. .. ||. .  ...|   .  |||..|.| .|
IMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase n1167.AA TyrKc 221-612 10 5e-09 -76.74 SMART 1-280 (280) Show / Hide 
Range on Protein: 221-612
Range on HMM: 1-280/280
Sequence Identity: 10% (48 aa)

LNYRDSIGCGSFGQVYKVKNKYKQIIKNPDILQNMPDYYACKQIHISQDGENQSQQIFHEIEVLEKL-KKYEYVIKLQNYIIEE-------RSAYLVLDL
.   . .|.| ||.||| . |                  | | .. .       . . .|.... || .. . ...|  .....          ..|. .
ITLGKKLGEGAFGEVYKGTWK---------------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEY

AE-----STLQDKINEKQANLLKIQISFKKIEKKSEKFDESEIVKFLSQIEGIAHRDIKPSNILIKDDNFYLSDFGCAEILFESQEARNNLVMGTLKWMS
..     . |... ..                                                                                    
MPHGDLKDYLRKHRPK------------------------------------------------------------------------------------

PELKEMKKNQVVDYFKSDIFSLGMLLLYMLTLSD----ISSVNSDEFTKNQKIRIMKNYCKGKTLAIIYVEERIAHRDIKPSNILIIDNN-YYLSDFGCA
                   ...  || ...  ..    ..|                               .. |||.   |.|. .|.    |||| .
-------------------LCMKDLLSFCWQIACGMEYLHSK------------------------------NCIHRDLAARNCLVGENHTVKISDFGLS

ENLFDS-----EGAKYN-----LVM--GTLKWMSPELKEKKKIEAIDYF----KSDIFSLGMVL--LYMLTLSDISA-----VNSDEFSKNQKLRIMRNS
 .. |      ..  |             ..||.|        |.|.|     |||..| | ..  .. .  .  .      .. .|  .. | . ..  
RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP--------ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQ

CKY--------VSKEIILLVSKMLETNPDFRPDAPILIQAI
 ..         ..|.  . ..  . .|. ||    ... .
PPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase n1167.AA TKL 227-239 69 0.021161 4.47 In-house 1-13 (364) Show / Hide 
Range on Protein: 227-239
Range on HMM: 1-13/364
Sequence Identity: 69% (9 aa)

IGCGSFGQVYKVK
|| |.||.||| |
IGSGGFGEVYKGK
Kinase n1167.AA CAMK 582-605 37 0.023871 2.57 In-house 393-416 (425) Show / Hide 
Range on Protein: 582-605
Range on HMM: 393-416/425
Sequence Identity: 37% (9 aa)

YVSKEIILLVSKMLETNPDFRPDA
.||.| . |..|||...|. |. .
FVSQECKDLIRKMLQVDPEKRMTI