Gene n73 (Tetrahymena)

n73

Species: Tetrahymena
Alias: 41.m00302, 73, n73
External Links:
Annotation:

Classification

Group: Atypical
Family: PI3K
Subfamily: PI4K

Sequence

Name Sequence Type Origin Length Description Download
n73.AA Protein None 894 None Fasta, JSON
n73.NA RNA None 2685 None Fasta, JSON

Protein domain

Protein domains of n73.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PI3Kc n73.AA PI3Kc 619-891 24 1.8e-72 248.03 SMART 1-336 (336) Show / Hide 
Range on Protein: 619-891
Range on HMM: 1-336/336
Sequence Identity: 24% (85 aa)

HFIVKTGDNLKQEQFAQQLIYQFDQIFKDS----ELNLILRPYEIISLGPNCGIIEVVKNSVTFDSLIQKLNTQQK------------------------
..|.|.|| | |.....|.. ... | .       ..| .||| .|..||.||.||.|.|..|. ..  |.....|                        
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

------------------------------GMN----LQEFFKSYYGSG---LYKAQKNFCSSLAAYSLVCYFLQIKDRHNGNILLH-KDGYICHIDFGF
                              ...    |...|......     ..|..||..|.|.|. |.| |.|.||||.||.|. |.| . |||||.
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH

LLSNAPGNNLIQKNNQRQGVGFELNVPFKLLTDYINVLG--GVNSDLFKQFRQLFHKGFMAARKNQDKILILVKMFYSSHGASL-PCFEKGEEAIKALEE
.....|.. ...             |||.| .|...| |  |..|..|..||.. .....|.||....|. |. |. .   ... ||. ..|..|| |..
IFGHGPKKPGFKHH-H------RERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVY---DPIMPCWRMMEKDIKYLRQ

RFNPKNIKLENEYFVH-TN----QLIDQSLDNWKSRWYDKWQYFCQG
||.. . . ..| . . ..    .||  |.. | .| |. .... |.
RFRLDH-LSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
PI3_PI4_kinase n73.AA PI3_PI4_kinase 617-836 18 3.3e-34 124.76 Pfam 1-300 (300) Show / Hide 
Range on Protein: 617-836
Range on HMM: 1-300/300
Sequence Identity: 18% (58 aa)

LVHFIVKTGDNLK--QEQFAQQLI-----------------------YQFDQIFKDSELNLI----LRPYEIISLGPNCGIIEVVKNSVTFDSLIQKL--
 ..||.| || |   |..   |.|                         .. . |   . .     ..|| .|..||.||.||.|.|..||. .. .   
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

-------------------------------------NTQQKGMNLQEFFKSYYGS-GLYK-AQKNFCSSLAAYSLVCYFLQIKDRHNGNILL---HKDG
                                     . ..|.  .|.| |...   . .  | .||..|.| .. | | |.. ||||.||..   ...|
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG

YICHIDFGFLLSNAPGNNLIQKNNQRQGVGFELNVPFKLLT------DYINVLGG----VNSDLFKQFRQLFHKGFMAARKNQDKILILV-------KMF
 . |||||. . .. .. ..              |||...       ......||     .|  .  ||.. .. . | |.... ...|         ..
HLFHIDFGHCFPHWKMKHFHKP----------ERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECM

YSSHGASLPC
. .   ... 
VHDGLPMWRS
Kinase n73.AA ATR 707-826 24 4.8e-10 29.99 In-house 161-267 (267) Show / Hide 
Range on Protein: 707-826
Range on HMM: 161-267/267
Sequence Identity: 24% (30 aa)

YKAQKNFCSSLAAYSLVCYFLQIKDRHNGNILLHK-DGYICHIDFGFLLSNAPGNNLIQKNNQRQGVGFELNVPFKLLTDYINVLGGVNSDLFKQFRQLF
| ...|.| | |....| | . . |||  |||. |  | . |.|.  .             |. . .     |||.|    .. .| . ..    ||.  
YSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIF------------NSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGL--FRRAC

HKGFMAARKNQDKILILVKMF
    |  |...| |. ... |
EVIMMCMRDHRDDIMSVWDCF
Kinase n73.AA FRAP 712-751 48 5.1e-07 21.98 In-house 139-179 (251) Show / Hide 
Range on Protein: 712-751
Range on HMM: 139-179/251
Sequence Identity: 48% (20 aa)

NFCSSLAAYSLVCYFLQIKDRHNGNILLHKD-GYICHIDFG
|.  |||  |.. | | . |||  ||.| .  | | |||||
NYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFG
Kinase n73.AA PIKK 707-753 37 9e-06 17.49 In-house 183-230 (290) Show / Hide 
Range on Protein: 707-753
Range on HMM: 183-230/290
Sequence Identity: 37% (18 aa)

YKAQKNFCSSLAAYSLVCYFLQIKDRHNGNILLHKD-GYICHIDFGFL
. . .|...|.|  . | | | . |||  ||.. .. | | |||||..
WERRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCC
Kinase n73.AA PIKK 651-701 29 0.004028 7.65 In-house 68-118 (290) Show / Hide 
Range on Protein: 651-701
Range on HMM: 68-118/290
Sequence Identity: 29% (15 aa)

NLILRPYEIISLGPNCGIIEVVKNSVTFDSLIQKLNTQQKGMNLQEFFKSY
.| .| | .| ....||.|| | |.||   .. ..  . ..   || . .|
HLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYKQWCQKKHIRHEQEAQMNY
Kinase n73.AA ATR 654-685 40 0.022633 3.4 In-house 72-103 (267) Show / Hide 
Range on Protein: 654-685
Range on HMM: 72-103/267
Sequence Identity: 40% (13 aa)

LRPYEIISLGPNCGIIEVVKNSVTFDSLIQKL
.| | .| |  .|.||| | | .|  ....||
MRTYAVIPLNDQCCIIEWVNNTATLRPILDKL