Gene n131 (Tetrahymena)
n131
Species: Tetrahymena
Alias: 131, n131, 3829.m01194
External Links:
Annotation:
Sequence
Protein domains of n131.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| PI3Kc | n131.AA | PI3Kc | 588-839 | 27 | 4.8e-83 | 283.13 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 588-839
Range on HMM: 1-336/336
Sequence Identity: 27% (93 aa)
PFIIKGGDDLRQELLIMQLIQKFHEIFKQG----GVPLYLRPYEIIVASESSGFIEFLPNTLSIDALKKKY-----------------------------
..| |.||||||. ..||... . | .. ...|..||| .|. .. .|.||. ||. .. ..|||
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM
--------------------------------PKFTNLYEFYRRTFNDY---FEEAQKNFIESLAGYSLICYLLQIKDRHNGNILID-NQGHIIHIDFGF
|. ||.. ...| |. . ||..||. |.|||. ..|.|.|.||||.||..| . ||..|||||.
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH
TLSIAPGGIKF-----ETAHFKLTNEYVALMG--GRNSDQFGYYKSLLVRAFIEIKKHVNTICNLVQIMCDQSNLPCFDEF--DMIQFRGRFKEN-FTDK
.. .|. ..| |.. |.|| ..| .|| | .|..|||.... .||. ..|| |.| ||...| . ...||.. . | .. | || .. .|.
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDE
EFIDYVDE-----LIKGSCDKWSTNQYDKFQLMQNG
| . |.. ||. |.. | | |. |......
EAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
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| PI3_PI4_kinase | n131.AA | PI3_PI4_kinase | 586-790 | 22 | 1.2e-43 | 156.1 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 586-790
Range on HMM: 1-300/300
Sequence Identity: 22% (67 aa)
LRPFIIKGGDDLR--QELLIMQLI-----------------------QKFHEIFKQGGVPLY----LRPYEIIVASESSGFIEFLPNTLSIDALKKKY--
||| ||||||| |. ..||.| . .. . |. |. . ..|| .| .. .|.||..||..... . ..|
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV
---PKF------------------------------------TNLYEFYRRTFNDY---FEEAQKNFIESLAGYSLICYLLQIKDRHNGNILI---DNQG
|. ||.. .... | . || .||..|.||.. . |.|.. ||||.||.. . .|
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG
HIIHIDFGFTLS--IAPGGIKFETAHFKLTN------EYVALMGG----RNSDQFGYYKSLLVRAFIEIKKHVNTICNLV-------QIMCDQSNLPCFD
|..|||||. . ....|.|. |..| ..| .||| .| .| .......|. . .| | . || ..| . . . .
HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS
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| Kinase | n131.AA | ATR | 662-780 | 22 | 1.2e-09 | 28.61 | In-house | 148-267 (267) | Show / Hide |
Range on Protein: 662-780 Range on HMM: 148-267/267 Sequence Identity: 22% (28 aa) EFYRRTFNDYFE--EAQKNFIESLAGYSLICYLLQIKDRHNGNILIDN-QGHIIHIDFGFTLSIAPGGIKFETAHFKLTNEYVALMGGRNSDQFGYYKSL ... |.| | . ...|.. | | .... |.. . ||| ||||| | ..|.|. |. |.|| | || .. | .. DWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTY--GLFRRA LVRAFIEIKKHVNTICNLVQIM .. ...| . | ... CEVIMMCMRDHRDDIMSVWDCF |
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| Kinase | n131.AA | FRAP | 678-717 | 46 | 2.2e-07 | 23.35 | In-house | 139-179 (251) | Show / Hide |
Range on Protein: 678-717 Range on HMM: 139-179/251 Sequence Identity: 46% (19 aa) NFIESLAGYSLICYLLQIKDRHNGNILIDNQ-GHIIHIDFG |. ||| |.. |.| . ||| ||... . | |.||||| NYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFG |
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| Kinase | n131.AA | PIKK | 674-718 | 45 | 4e-06 | 18.57 | In-house | 184-229 (290) | Show / Hide |
Range on Protein: 674-718 Range on HMM: 184-229/290 Sequence Identity: 45% (21 aa) EAQKNFIESLAGYSLICYLLQIKDRHNGNILIDNQ-GHIIHIDFGF |. .|.. |.| . | | . ||| ||.|| | | |.|||||. ERRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGC |
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| Kinase | n131.AA | ATM | 682-745 | 38 | 1.4e-05 | 13.31 | In-house | 143-207 (304) | Show / Hide |
Range on Protein: 682-745 Range on HMM: 143-207/304 Sequence Identity: 38% (25 aa) SLAGYSLICYLLQIKDRHNGNILIDNQG-HIIHIDFGFTLSIAPGGIKFETAHFKLTNEYVALMG | | |.. |.| . ||| |||| | ..||| | || |.|| . | || SVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMG |
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| Kinase | n131.AA | PIKK | 588-654 | 29 | 0.000263 | 12.01 | In-house | 32-102 (290) | Show / Hide |
Range on Protein: 588-654 Range on HMM: 32-102/290 Sequence Identity: 29% (21 aa) PFIIKGGDDLRQELLIMQLIQKFHEIFKQG----GVPLYLRPYEIIVASESSGFIEFLPNTLSIDALKKKY |. ||..||||. .|||.| .. . | .| | .| | .| || ..|.... .. |.. PYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYKQW |
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| Kinase | n131.AA | DNAPK | 588-616 | 48 | 0.0055 | 6.49 | In-house | 34-62 (301) | Show / Hide |
Range on Protein: 588-616 Range on HMM: 34-62/301 Sequence Identity: 48% (14 aa) PFIIKGGDDLRQELLIMQLIQKFHEIFKQ ||..||. |||| | || | || . PFCYKGIEDLRQDQRIEQLFQVMNNIFEY |
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| Kinase | n131.AA | ATM | 590-608 | 47 | 0.010371 | 4.03 | In-house | 3-21 (304) | Show / Hide |
Range on Protein: 590-608 Range on HMM: 3-21/304 Sequence Identity: 47% (9 aa) IIKGGDDLRQELLIMQLIQ ..|| |||||. . | | LVKGRDDLRQDAVMQQVFQ |
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| Kinase | n131.AA | FRAP | 589-606 | 50 | 0.020271 | 4.88 | In-house | 4-21 (251) | Show / Hide |
Range on Protein: 589-606 Range on HMM: 4-21/251 Sequence Identity: 50% (9 aa) FIIKGGDDLRQELLIMQL |..|| .|.|| .||| FLLKGHEDIRQDERVMQL |
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| Kinase | n131.AA | DNAPK | 684-718 | 41 | 0.052858 | 2.86 | In-house | 192-230 (301) | Show / Hide |
Range on Protein: 684-718 Range on HMM: 192-230/301 Sequence Identity: 41% (16 aa) AGYSLICY---LLQIKDRHNGNILID-NQGHIIHIDFGF . | .|| | | ||| | .. | || ||||. RNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGH |
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