Gene n210 (Tetrahymena)

n210

Species: Tetrahymena
Alias: 3814.m00884, 210, n210
External Links:
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
n210.AA Protein None 532 None Fasta, JSON
n210.NA RNA None 1599 None Fasta, JSON
n210.kin_dom Protein Kinase Domain None 253 None Fasta, JSON

Protein domain

Protein domains of n210.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase n210.AA Ciliate-E2 73-281 19 1.6e-22 74.14 In-house 84-361 (365) Show / Hide 
Range on Protein: 73-281
Range on HMM: 84-361/365
Sequence Identity: 19% (57 aa)

NILQRVVHPNVVQFEEHFN--SSHVFFMQMEYCPN-NLRQLLKEK------------SLSQQEQFHYAMQVIR---------------GVQAIHSVN-HS
|||... |||.... |.|   . . ... ||||   .|....|..            ... .|  ..  |...               ... .|| |   
NILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNII

HKELKTQNILVNQQGNLVIGDFGLDREDDIFYQKCQS------------------------QDDLVNSQRW---YVAPEIQMGQP---GILQN-INQPAD
|  .| .|||.     . | |||| .. |...|...                         |....|.. .   |.|||| .|..    ..|.  .  .|
HRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCD

IWSLGIIILEIFGLKYVSNFQSIEQLQLTLDLLYNQDFSFINF------------------IDKFLTDIIKQ----LLNSEPSKRPI-IDDVKK
|||||.|. |    |.             ..   .....| ..                  ...   |.||.    .|. .|.||.  ......
IWSLGVILYEMLFGKPPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase n210.AA CMGC 74-222 19 3.1e-19 59.01 In-house 74-329 (513) Show / Hide 
Range on Protein: 74-222
Range on HMM: 74-329/513
Sequence Identity: 19% (49 aa)

ILQRVV-----------------HPNVVQFEEHFNSSH-----------------VFFMQMEYCPNNLRQLLKEKS----------LSQQE---------
||...                  |.|.|.  ..| ...                  ... .||....| |..|...          ||. .         
ILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRP

---QFHYA------MQVIRGVQ--AIHSVN--HSHKELKTQNILVNQQ--------------------GNLVIGDFGLDREDDIFYQKCQSQ--------
     ..        |..||.    .|| .    |  || .|||.|..                    |.| |.|||| |  ..   ....|        
PHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNV

---------DDLVNSQRWYVAPEIQMGQP-----GILQNINQPADIWSLGIIILEIF
              . ||| |||| .| .      . .. ..| |.||.| |. |..
NKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMY
S_TKc n210.AA S_TKc 26-292 20 3.8e-18 67.52 SMART 1-231 (231) Show / Hide 
Range on Protein: 26-292
Range on HMM: 1-231/231
Sequence Identity: 20% (58 aa)

FTISGQI-------VAKMKDINRVIIATKDSRQVAFKVRHFQSKLQLKEYQDQANILQRVVHPNVVQFEEHFNSSHVFFMQMEYCPN---NLRQLLKEKS
..|  .|       | | ....       . |.|| |. .       .  .   .||..  |||.|.. ..| . . ..| ||||..   .|....|.. 
YEILRKIGKGAFGKVYKCRHKK-------TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

-------LSQQEQFHYAMQVIRGVQAIHSVNHSHKELKTQNILVNQQGNLVIGDFGLDREDDIFYQKCQSQDDLVNSQRWYVAPEIQMGQPGILQNINQ-
       ..  .  .|. |...... .|| .  |  || .|||...  .. |.|||| |.           . .. . .||.|||.           .  
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGT-PWYMAPEVL--------GYGKC

PADIWSLGIIILEIFGLKYVSNFQSIEQLQLTLDLLYNQDFSFINFIDKFLTDIIKQLLNSEPSKRPIIDDVKKMIQKEIDVRFV
..|.||.|.|. | .  .         |.|......           .. . |.|...|. .|.||| . .. .. ..     ..
KCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase n210.AA CDK 73-165 27 1.6e-17 52.44 In-house 60-159 (284) Show / Hide 
Range on Protein: 73-165
Range on HMM: 60-159/284
Sequence Identity: 27% (30 aa)

NILQRVVHPNVVQFEEHFNSS-----------HVFFMQMEYCPNNLRQLLKEKSLSQQEQFHYAMQVIRGVQAIHSVNHSHKELKTQNILVNQQGN----
..|.   |||.|.  . . ..           . ..| .||..  | ....          .| .| .||.  .|| .  |  ||.||||.| .|.    
SLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCG

-LVIGDFGL
 | |.||||
RLKIADFGL
Kinase n210.AA CAMK 73-217 17 1.6e-17 52.33 In-house 83-323 (425) Show / Hide 
Range on Protein: 73-217
Range on HMM: 83-323/425
Sequence Identity: 17% (42 aa)

NILQRVV-------HPNVVQFEEHFNSSHV-------------------FFMQM---EYCPNN------LRQLLKEKS---------------LSQQEQF
.|....        |||.... |.. ..|.                   ..| |   |||..       .  . . ..               .. .|  
EIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREAR

HYAMQVIRGVQAIHSVNHSHKELKTQNILVNQQ-----------------GNLVIGDFGLDREDDI-----FYQKCQSQDDLVNSQRW------------
.|  |.. .|. .|| |  |  ||  |||...                  .|. | |||. .. |      . .....   . ..| |            
RYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQ-WTTPTEGQKMKTF

-----YVA-PEIQMGQP---------GILQNINQPADIWSLGII
     |.| ||.  |..         .  . .....|.||.|.|
CGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVI
Kinase n210.AA ULK 73-165 26 2.4e-16 54.53 In-house 62-184 (324) Show / Hide 
Range on Protein: 73-165
Range on HMM: 62-184/324
Sequence Identity: 26% (32 aa)

NILQRVV---HPN--VVQFEEHFNSSHV--FFMQMEYCPN-NLRQLLKEK----------SLSQQEQFHYAMQVIRGVQAIHSVNHSHKELKTQNILVNQ
.|..      |||  .|.. . |..|.   ... ||||.  .|.|..|..           ||.||  .. .| . | ...|. |  |  .| ||||.. 
QIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHN

QGNLV------------IGDFGL
                 |.|||.
GQPKTDSKKVHPNGVLKIADFGF
Kinase n210.AA Pkinase 72-165 30 3.4e-16 58.34 Pfam 51-158 (293) Show / Hide 
Range on Protein: 72-165
Range on HMM: 51-158/293
Sequence Identity: 30% (33 aa)

ANILQRVVHPNVVQFEEHFNSSHVFFMQMEYCPN-----NLRQLLK---EKSL--SQQEQFHYAMQVIRGVQAIHSVNHSHKELKTQNILVNQQGNL---
. |..|. |||.|.. . | ..    | ||||..      |  ...   ....  | .|  .|. |..||.. .|| .  |  || .|||....|..   
IQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDAC

-VIGDFGL
  |.||||
VKICDFGL
Kinase n210.AA ULK 74-165 25 3.9e-16 52.88 In-house 63-188 (329) Show / Hide 
Range on Protein: 74-165
Range on HMM: 63-188/329
Sequence Identity: 25% (32 aa)

ILQRVV--------HPNVVQFEEHFNSSHV--FFMQMEYCPN-NLRQLLKEK-----------SLSQQEQFHYAMQVIRGVQAIHSVNHSHKELKTQNIL
|...          |||.|.. . |..|.   ... ||||.  .|.|..|..            ||.||  .. .| . | ...|. |  |  .| ||||
IMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNIL

VNQQGNLV------------IGDFGL
..                  |.|||.
IHNGQPKTDSKKVHPNGVLKIADFGF
Kinase n210.AA Ciliate-E2-Unclassified 47-281 17 8.5e-16 51.3 In-house 22-348 (352) Show / Hide 
Range on Protein: 47-281
Range on HMM: 22-348/352
Sequence Identity: 17% (60 aa)

KDSRQV-----AFKVRHFQSKLQ------------LKEYQ-DQAN--------ILQRVVHPNVVQFEEHFNSSHVFFMQMEYCPN-NLRQLLKE------
|.  |.     . |.... .|..            ... . .. .        ||.   ||..| ....|..   ... ||||.. .|.| .|.      
KQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQ

------------KSLSQQEQF-----HYAMQVIRGVQAIHSVNHS-HKELKTQNILVNQQG---NLVIGDFGLDR---EDDIFYQKC------QSQDDLV
            | .. |.       .|. |.. | . .|. |.  |  .| .|||....|   .. | |||. .   ... .. .       . .... 
KGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMM

NSQ---RWYV----APEIQMGQPGILQNINQP----ADIWSLGIIILE-IFGLKYVSNFQSIEQLQ------------LTLDLLYNQDFSFINFID----
...     |     |||. .|     || ...    .||||||.|. | .||    .  ..... |              ..  ......| .|      
WTFCGTPNYMPQYTAPEVLQG-----QNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIP

--------KFLTDIIKQLLNSEPSKRPIIDDVKK
         |..|.....|.  |.||. ......
KHWSPEAKDFINDLLQKMLKKNPNKRITFEQILN
Kinase n210.AA Ciliate-A2 65-284 22 1.9e-15 50.33 In-house 42-272 (272) Show / Hide 
Range on Protein: 65-284
Range on HMM: 42-272/272
Sequence Identity: 22% (54 aa)

LKEYQDQANILQRVVHPNVVQFEEHFNSSHVFFMQMEYC-PNNLRQLLK-----EKSLSQQEQFHYAMQVIRGVQAIHSVNHSHKELKTQNILVNQQGN-
|.| ...| .|. . |||.|. .. |      | |||.|   .| .  .     .|.....   |.| |.. ... .|. |  . .|. .||| .|... 
LQECKHEAQFLKNCNHPNIVKYHDEFQIGFYYFIQMEKCPECSLQDWIDKFQNQQKFIPDHQFVHFACQILDAIEYLHNKNYVLRDLSLRNILIDQDNQI

LVIGDFGLDREDDIFYQKCQSQDDLVNSQRWYVAPEI-QM---------GQPGILQNINQPADIWSLGIIILEIFGLKYVSNFQSIEQLQLT-LDLLYNQ
..  |||| .. .   .  . ..  ...   |  ||. ..         ... | |. .  .||| .||  . . |...      .. ..||     .. 
IKLCDFGLAKKYQPEINSQMFYTSCPKGVFFYYPPECHFQCFEMNGEQNKKQQIKQTFM--GDIWAFGICLYQLGGADQ------QHCYKLTQCNQKKWW

DFSFINFIDKFLTDIIKQLLNSEPSKRP-IIDDVKKMIQ
 ..  .. |. . .||.|.||..| ||| .|.  .. ..
QYQDYPNLDEKCNQIIQQILNCDPKKRPSSIQQIRHHWH
Kinase n210.AA TKL 80-283 18 5.5e-15 50.41 In-house 84-364 (364) Show / Hide 
Range on Protein: 80-283
Range on HMM: 84-364/364
Sequence Identity: 18% (52 aa)

HPNVVQFEEHFNSSHV-------------FFMQMEYCPNNL-RQLLKEKSLSQQEQFHYAMQVIRGVQAIHS--------VNHSHKELKTQNILVNQQGN
|||.|||    ...               ... |||||.   . .|       .  .. |... ||..  ||         .  |  ||..||||.. ..
HPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWT

--------------LVIGDFGLDR-EDDIFYQKCQS-----------QDDLVNSQR---WYVAPEIQMGQPGILQ-----------NINQPADIWSLGII
              . |.|||| |  .  . .....           ..   ..|.    . |||. .||.   .             .. .|..| ||.
NVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIV

ILEIFG--LKY--VSNFQSI------EQLQLTLDLLYNQDFSFI----------NFIDKFLTDIIKQLLNSEPSKRPIIDDVKKMI
. ||.   . |    ... |      | . .  |  .      |          . ... . .....  ...|.|||  ....| .
LWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase n210.AA GCN2 70-165 31 8.6e-15 47.84 In-house 252-354 (511) Show / Hide 
Range on Protein: 70-165
Range on HMM: 252-354/511
Sequence Identity: 31% (32 aa)

DQANILQRVVHPNVVQFEEH----FNSSHVFFMQMEYCP-NNLRQLLKEKSLSQQEQ--FHYAMQVIRGVQAIHSVNHSHKELKTQNILVNQQGNLVIGD
.|  ... . |.|.| .. .    . ..|. . |||||.  .|||.... .. ....  . |. |.. |.. ||| . .|. || .||.. ..||  |||
QQQDKMCQNQHKNKVHYKCMNCKKPKEVHYLYIQMEYCEGKTLRQYIDNHGWCMDHDELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGD

FGL
|||
FGL
TyrKc n210.AA TyrKc 33-283 19 5.8e-09 -77.75 SMART 1-280 (280) Show / Hide 
Range on Protein: 33-283
Range on HMM: 1-280/280
Sequence Identity: 19% (57 aa)

VAKMKDINR-----VIIATKDSRQVAFKVRHFQSKLQLKEYQDQANILQRV--VHPNVVQF----EEH---FNSSHVFFMQMEYCPN-NLRQLLKEKS--
. . | . .     |  .| . .||| |. .  .   ...  . |.|. ..   |||.|..     ..   | ...  .. |||.|. .|.. |...   
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LSQQEQFHYAMQVIRGVQAIHSVNHSHKELKTQNILVNQQGNLVIGDFGLDREDDIF--------YQKCQS--QDDLVNSQRWYVAPEIQMGQPGILQNI
|. ..  ... |. .| . .|| |  |  | . |.||. ..   |.|||| |. .          | . ..  . . .   ||. |||       |  ..
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APEC------INYGK

-NQPADIWSLGIIILEIFGLKYVSNFQS----IEQLQLTLDLLYNQDFSFINF--------IDKFLTDIIKQLLNSEPSKRPIIDDVKKMI
 .   |.|| |. . ||| .            ..  ..  ..                     . . .|.||  . .|..||   .... .
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase n210.AA Pkinase 187-283 18 2e-06 24.16 Pfam 175-293 (293) Show / Hide 
Range on Protein: 187-283
Range on HMM: 175-293/293
Sequence Identity: 18% (24 aa)

RWYVAPEIQMGQPGIL--QNINQPADIWSLGIIILEIFGLKYVSNFQSI------EQLQLTLDLLYNQDFSFINFID--------------------KFL
.||.|||.      |.  | . ...|.||.|.|. | .  .    |..       .|.|.    .. .  . .   .                    . .
PWYMAPEV------IRGGQYYGPKVDMWSCGCILYEMLCGR--PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEEC

TDIIKQLLNSEPSKRPIIDDVKKM--I
 |.|| .|.  |.||| ......   .
KDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase n210.AA GCN2 189-222 37 0.000394 9.88 In-house 419-447 (511) Show / Hide 
Range on Protein: 189-222
Range on HMM: 419-447/511
Sequence Identity: 37% (13 aa)

YVAPEIQMGQPGILQNINQPADIWSL-GIIILEIF
|..||.|          || .|..|| |||..|..
YMCPEQQ------KSHYNQKVDMYSLGGIIFFEMW
Kinase n210.AA ULK 189-273 25 0.000445 10.23 In-house 217-317 (329) Show / Hide 
Range on Protein: 189-273
Range on HMM: 217-317/329
Sequence Identity: 25% (26 aa)

YVAPEIQMGQPGILQNIN-QPADIWSLGIIILEIFGLKYV--SNFQSIEQLQLTLDLLYN------------QDFS---FINFIDKFLTDIIKQLLNSEP
| ||.| .|| |  .. .   .||||||.|. |.   |.   ..  . ..||   .|. |             .|     .. | . . |.|...|  ..
YMAPQILQGQ-GEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDE

SKR
..|
KDR
Kinase n210.AA ULK 189-273 25 0.001182 8.91 In-house 213-312 (324) Show / Hide 
Range on Protein: 189-273
Range on HMM: 213-312/324
Sequence Identity: 25% (26 aa)

YVAPEIQMGQPGILQNIN-QPADIWSLGIIILEIFGLKYV---SNFQSIE----QL------QLTLDLLYNQDFS---FINFIDKFLTDIIKQLLNSEPS
| ||.|..|| |  .. .   .||||||.|. |.   ||    . |.. .    .|      |...    . .|     .. | . . |.|...|  ...
YMAPQILQGQ-GEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEK

KR
.|
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