n518

Species: Tetrahymena
Alias: n518, 3700.m01693, 518
External Links:
Annotation:

Classification

Group: Other
Family: Ciliate-B1

Sequence

Name Sequence Type Origin Length Description Download
n518.AA Protein None 580 None Fasta, JSON
n518.NA RNA None 1746 None Fasta, JSON
n518.kin_dom Protein Kinase Domain None 258 None Fasta, JSON

Protein domain

Protein domains of n518.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase n518.AA Ciliate-B1 114-389 43 3e-145 488.82 In-house 1-290 (290) Show / Hide
Range on Protein: 114-389
Range on HMM: 1-290/290
Sequence Identity: 43% (126 aa)

LQLENVIGKGAVSEVFLGN-QQNSYLQREYEVCLKIKSVQDNDEKQGKLNHNVLRILDCLDFKANENKISCQSSRVNPANTYNNLIDYIQEKYIITEYCN
 |..||||.||.|.||.|. .||...|.|..|....|..||||..|.|.....|.|..||..|.|.||||||||...........|...|..|||.|||.
YQQNNVIGQGAISQVFYGQFCQNQQCQQEVAVKKITKQTQDNDKQQNKYYQQELEIIQCLIKKMNNNKISCQSSPCDHICNIYDVIQCQQQYYIIMEYCE

KSSLYDYLTDKGFSLQLTEVLDTSMQIAQGLKFLHDQKIMHRDLKPENIFVHEVN--------QDKYLFKIGDFGIGKQFQEEGIEQSFVGTINYMSPEV
...||.|............|||...|||.|...||..||.|||||||||..|..|        |..|.|||.||||.|..||. ..||.|||||||.||.
QGDLYNYIYNCHQNFTHDIVLDFCIQIAKGIQYLHKHKICHRDLKPENILIHKKNVPIYYNKQQNHYIFKITDFGISKMQQEY-MMQSCVGTINYMAPEI

IN-RQQYSNQIDYWSLGCIIYEIYKGYQMFR--GYTEKEVEEKIKNFRS---QQHFVFSLNISLEN-IIHKCLVSSNQGGYQNIDQIINDIQ
.| .|||....|.||.|||.|||....|.|.  |.|..||...|.||     | ||   .. . .. |. .|| . ..   . |||||... 
LNFNQQYDKKVDIWSFGCIMYEIITNEQLFCSLGNTQQEVANQIRNFQCCDYQCHFQNNIYQEIQQLIQKYCL-QPDPENRITIDQIIDRLM

Kinase n518.AA Pkinase 205-335 36 2.1e-43 154.58 Pfam 76-214 (293) Show / Hide
Range on Protein: 205-335
Range on HMM: 76-214/293
Sequence Identity: 36% (52 aa)

YIITEYCNKS----SLYDYLT-DKGFSL--QLTEVLDTSMQIAQGLKFLHDQKIMHRDLKPENIFVHEVNQDKYLFKIGDFGIGKQ--FQEEGIEQSFVG
|...|||..     .|.||.. ... ..  .  |. .   ||..||...|...|.|||||||||.... .. .  .||.|||. ||      .  ..|.|
YMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCG

TINYMSPEVIN-RQQYSNQIDYWSLGCIIYEIYKGYQMFRG
|..||.||||. .| |.  .| ||.|||.|| . |.  |.|
TPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPG

Kinase n518.AA S_TKc 114-385 23 2.2e-38 134.76 SMART 1-231 (231) Show / Hide
Range on Protein: 114-385
Range on HMM: 1-231/231
Sequence Identity: 23% (68 aa)

LQLENVIGKGAVSEVFLGNQQNSYLQREYEVCLKIKSVQDNDEKQGKLNHNVLRILDCLDFKANENKISCQSSRVNPANTYNNLIDYIQEKYIITEYCNK
 .. ..||||| ..|...   .       .| .|| .             ...| ...|     .| . .  . ..            .. |...|||. 
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQD------------DHLYMVMEYCDG

--SSLYDYLTDKGFS-----LQLTEVLDTSMQIAQGLKFLHDQKIMHRDLKPENIFVHEVNQDKYLFKIGDFGIGKQFQEEGIEQSFVGTINYMSPEVIN
   .|.||. ..|       .   ..     ||...|...|...|.|||||||||.. |        ||.|||. .|.       .|.|| .||.|||. 
DLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMAPEVL-

RQQYSN-QIDYWSLGCIIYEIYKGYQMFRGYTEKEVEEKIKNFRSQQHFVFSLNISLENIIHKCLV------SSNQGGYQ-----NIDQII
  .|.   .| ||.|||.|| . ||  |.  ..... .||.              .. ..| |||.       .     |     .... .
--GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase n518.AA Ciliate-E2 114-371 17 4.9e-37 124.68 In-house 1-346 (365) Show / Hide
Range on Protein: 114-371
Range on HMM: 1-346/365
Sequence Identity: 17% (67 aa)

LQLENVIGKGAVSEVFLG----NQQNSYLQREYEVC--------------LKIKSVQDNDEKQGKLNHNVLRILDCLDFKANENKISCQSSRVNPANTYN
  . ..||.|. . |...    .|... .....                   .|... |. .| |   ...| ..| .                    | 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-F--------------------YK

-----------------NLIDYIQ--EK---YIITEYCNKSSLYDYLTDKGFS----------LQLTEVLDTSMQIAQ---------------GLKFLHD
                 ..... |   .   |...|||.  .|.||. ..  .          . . |... . ||.|               .|..|| 
KINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHS

QK-IMHRDLKPENIFVHEVNQDKYLFKIGDFGIGKQFQEEGIEQS--------------------------------FVGTINYMSPEVINRQQ------
.. |.|||.|||||..          || |||. |..... ....                                ..|| .||.||..|...      
KNNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQK

---YSNQIDYWSLGCIIYEIYKGYQMFRGYTEKEVEEKIKNFRSQQHFVF--------------SLNISLE--NIIHK----CLV
   |. ..|.||||.|.||   |.  |        ...||.   .  . .               ...|.|  ..| |    .|.
QKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQ

Kinase n518.AA ULK 197-326 30 2.5e-36 124.36 In-house 83-249 (329) Show / Hide
Range on Protein: 197-326
Range on HMM: 83-249/329
Sequence Identity: 30% (51 aa)

LIDYIQEK-----YIITEYCNKSSLYDYLTDKG---------FSLQLTEVLDTSMQIAQGLKFLHDQKIMHRDLKPENIFVHE---------VNQDKYLF
|.|. ...     |||.||||   | .|.  ..           |   |..   .||..|.|.||...|.|||.||.|| .|.         |.. .. .
LYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVL

KIGDFGIGKQFQEE----GIEQSFV------GTINYMSPEVIN----RQQYSNQ-IDYWSLGCIIYEI
||.||| .|.....     .....|      ||  ||.|....    ...|..   | ||||||.||.
KIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEM

Kinase n518.AA Ciliate-E2-Unclassified 116-371 20 4.2e-35 119.22 In-house 3-334 (352) Show / Hide
Range on Protein: 116-371
Range on HMM: 3-334/352
Sequence Identity: 20% (73 aa)

LENVIGKGAVSEVFLGNQQNSYLQ---------REYEVCLK------------IKSVQ-DNDEKQGKLNHNVLRILDCLDFKANENKISCQSSRVNPANT
.  .||.|. ..|..  . . ...         ..| ....            ... . ....|                   . |||  |. . .|   
IIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRK-------------------Y-NKIMQQILLNHPHPF

YNNLIDYIQEK---YIITEYCNKSSLYDYLTDKGF----------------SLQLTEVL-----DTSMQIAQGLKFLHDQK-IMHRDLKPENIFVHEVNQ
  ..... | |   ||..|||.  .| .|......                 ..  ...     .   || |||..|| .. | |||.|||||.... ..
IVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK

DKYLFKIGDFGIGKQFQE----------------EGIEQSFVGTINYM----SPEVINRQQYSNQ----IDYWSLGCIIYEIYKGYQMFRGYTEKE----
 .|  || |||| |. |.                . . ..|.||.|||    .|||. .|.|...    .|.||||.|.||.  ||  | ......    
-NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQL

------------VEEKIKNFRSQ----------QHFVFSLNISLENIIHKCLV
            ....||.   |          .|  ..    ......|.|.
ITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLK

Kinase n518.AA NEK 205-326 38 6e-35 120.69 In-house 82-217 (286) Show / Hide
Range on Protein: 205-326
Range on HMM: 82-217/286
Sequence Identity: 38% (52 aa)

YIITEYCN-KSSLYDY---LTDK---GFSLQLTEVLDTSMQIAQGLKFLHDQ-----KIMHRDLKPENIFVHEVNQDKYLFKIGDFGIGKQFQEEGIEQS
.|. |||. .  ||.    .  .   |  ..  ...|   |.. .||..||.     ||.|||.|| |||    | |  . ||||||| |... .   ..
CIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAY

--FVGTINYMSPEVINRQQYSNQIDYWSLGCIIYEI
  .|||  ||||||.. . |.|  | |||||..||.
TTQVGTPYYMSPEVCQNKPYNNKSDIWSLGCVLYEM

Kinase n518.AA CAMK 196-324 20 3.8e-34 106.89 In-house 102-325 (425) Show / Hide
Range on Protein: 196-324
Range on HMM: 102-325/425
Sequence Identity: 20% (47 aa)

NLIDYIQ----------------------EKYIIT---EYCNKS----SLYDYLTDKGF--------------SLQLTEVLDTSMQIAQGLKFLHDQKIM
.|.....                      . |...   |||        |.||....|                ..  |.     ||.......|...|.
KLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIV

HRDLKPENIFVHEVNQDK-------------YLFKIGDFGIGKQFQEEGIEQ------------------------SFVGTINYMS-PEVINRQQ-----
||||||||| . . | |.             .  || |||  ..|..   .                          |.||  ||. |||.|...     
HRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQ

---------YSNQIDYWSLGCIIY
         |. ..| ||.|.| |
NATDEEKPYYGPKCDMWSCGVILY

Kinase n518.AA ULK 197-368 26 4.4e-34 118.35 In-house 80-295 (324) Show / Hide
Range on Protein: 197-368
Range on HMM: 80-295/324
Sequence Identity: 26% (59 aa)

LIDYIQEK-----YIITEYCNKSSLYDYLTDKG--------FSLQLTEVLDTSMQIAQGLKFLHDQKIMHRDLKPENIFVHE---------VNQDKYLFK
|.|. ...     |||.||||   | .|.  ..          |   |..   .||..|.|.||...|.|||.||.|| .|.         |.. .. .|
LYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLK

IGDFGIGKQFQEEG----IEQSFV------GTINYMSPEVIN----RQQYSNQ-IDYWSLGCIIYEIYKGY-----QMFRGYTEKEVEEKIKN------F
|.||| .|......    . |..|      ||  ||.|....    ...|..   | ||||||.||.  |.     . |. . .. ... |.|      .
IADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLY-IQKLINNGKEQQIY

RSQQHFVFSLNISLENIIHK
  .| . | ...  ...| .
IKNQPIQFPKPP-KDPKISP

Kinase n518.AA CAMK-Unique 205-346 25 8.8e-34 108.75 In-house 111-314 (363) Show / Hide
Range on Protein: 205-346
Range on HMM: 111-314/363
Sequence Identity: 25% (51 aa)

YIITEYCNKSSLYDYLTD-----------------KGFSLQLTE----VLDTSMQIAQGLKFLHDQKIMHRDLKPENIFVHEVNQD------------KY
||..|||..  |.|.. .                 |    ...|    ..  . .... ....|.|.| |||||.||| | .  .|             .
YIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNW

LFKIGDFGIGKQFQEEGIEQ---SFVGTINYMSP--------------EVINRQQYSNQI----DYWSLGCIIYEIYKGYQMFRGYTEK--------EVE
  |. |||. .....   .    ...||. ||.|              ||||.| |. |     | |||| | |.   |.  | . .|.        | .
HIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKEIF

EKIK
|.|.
ECIC

Kinase n518.AA TKL 205-327 24 2.4e-33 117.09 In-house 114-283 (364) Show / Hide
Range on Protein: 205-327
Range on HMM: 114-283/364
Sequence Identity: 24% (43 aa)

YIITEYCNKSSLYDYLTDKGFSLQLTEVLDTSMQIAQGLKFLHDQK--------IMHRDLKPENIFVHEVNQ----------DKYLFKIGDFGIGKQFQE
.|..||| . ||..||.       .   .. ...||.|. .|| ..        | |||||..||.|.| ..          . .  ||.|||. . ...
CIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQ

EG--------------------IEQSFVGTINYMSPEVINRQ----------------QYSNQIDYWSLGCIIYEIY
.|                       . .||...|.|||.. |                .|| ..| .| | ...||.
SGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEIL

Kinase n518.AA STE 205-325 28 1.5e-31 108.68 In-house 113-260 (359) Show / Hide
Range on Protein: 205-325
Range on HMM: 113-260/359
Sequence Identity: 28% (45 aa)

YIITEYCNKSSLYDYLT---DKGFSLQ----------LTEVLDTSMQIAQG-LKFLHDQKIMHRDLKPENIFVHEVNQDKYLFKIGDFGIGKQFQEEGIE
.|. ||..  || | .     .|..|.           ...     || .| |..||...|.|||.|| ||..          |. |||. .|..... .
WICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDFGVCGQLTDSMAN

Q-----------------SFVGTINYMSPEVINR------QQYSNQIDYWSLGCIIYE
.                 .||||  .|.||||..      ..|. . | ||||| | |
IQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIE

Kinase n518.AA Pkinase_Tyr 205-327 29 1.3e-13 46.75 Pfam 83-208 (270) Show / Hide
Range on Protein: 205-327
Range on HMM: 83-208/270
Sequence Identity: 29% (39 aa)

YIITEYCNKSSLYDYLTDK---GFSLQLTEVLDTSMQIAQGLKFLHDQKIMHRDLKPENIFVHEVNQDKYLFKIGDFGIGKQFQEEGIEQSFVGT-----
||..||. . .|.||| ..   . .| . . |. ..|||.|. .|..... ||||   |. |.|    .   ||.|||  .  ....   . ...     
YIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE----NNVVKICDFGLARDIYNDDYY-YRKRGGGKLP

INYMSPEVINRQQYSNQIDYWSLGCIIYEIY
|  |.||.||   .. . | || |  ..||.
IKWMAPECINYGKFTTKSDVWSFGVLMWEIF

Kinase n518.AA TyrKc 114-388 21 6.5e-11 -46.19 SMART 1-280 (280) Show / Hide
Range on Protein: 114-388
Range on HMM: 1-280/280
Sequence Identity: 21% (67 aa)

LQLENVIGKGAVSEVFLGNQQNSYLQREYEVCLKIKSVQDNDEKQ---------GKL--NH-NVLRIL-DCLDFKANENKISCQSSRVNPANTYNNLIDY
..|. ..| ||  ||..|           . .  .|.....  ..          ||  .| |..|..  |.. . |                      |
ITLGKKLGEGAFGEVYKGTWK--------IQVA-VKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--------------------FMY

IQEKYIITEYCNKSSLYDYLTDKGFSLQLTEVLDTSMQIAQGLKFLHDQKIMHRDLKPENIFVHEVNQDKYLFKIGDFGIGKQFQEE------GIEQSF-
|.  .|..||. . .| ||| ...  |.. . |. . |||.|  .||.... ||||   |. |.| .      ||.|||  .   ..      .   .  
IEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKK

---VGT----INYMSPEVINRQQYSNQIDYWSLGCIIYEIY-KGYQMFRG-----YTEKEVEEKIKNFRSQQHFVF-------SLNISLENIIHKCLVS-
    |     |  |.||.||   .. . | || |  ..||.  | |   |      . .|| |..|. .                   . .|. .|    
EHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHED

SNQGGYQNIDQIINDI
 ..    .  .|. ..
PEDR--PTFSEIHECF

Kinase n518.AA CAMK 119-131 30 0.042742 1.74 In-house 1-13 (425) Show / Hide
Range on Protein: 119-131
Range on HMM: 1-13/425
Sequence Identity: 30% (4 aa)

VIGKGAVSEVFLG
..|.|. ..|.|.
TLGRGSFGKVKLC

Kinase n518.AA TKL 120-157 23 0.172881 1.14 In-house 1-42 (364) Show / Hide
Range on Protein: 120-157
Range on HMM: 1-42/364
Sequence Identity: 23% (10 aa)

IGKGAVSEVFLGNQQNSYLQRE-----YEVCLKIKSVQDNDEK
||.|. .||. |. ..    ..     ..|  |. .....||.
IGSGGFGEVYKGKWRGWGG-KCPSDTGKDVAVKKFKSHNDDEF

Kinase n518.AA ULK 114-135 28 0.249347 0.55 In-house 1-25 (324) Show / Hide
Range on Protein: 114-135
Range on HMM: 1-25/324
Sequence Identity: 28% (7 aa)

LQLENVIGKGAVS-EVFLG--NQQN
 .| ...|||.    |. |  ...|
YCLNHCLGKGSFGVKVYKGRNKKTN

Kinase n518.AA ULK 114-135 25 0.322214 0.11 In-house 1-24 (329) Show / Hide
Range on Protein: 114-135
Range on HMM: 1-24/329
Sequence Identity: 25% (6 aa)

LQLENVIGKGAVSEVFLG--NQQN
 .| ...|||.   |. |  ....
YCLNHCLGKGSFGKVYKGRNKKTK

Kinase n518.AA Pkinase 114-158 15 4.385331 1.38 Pfam 1-41 (293) Show / Hide
Range on Protein: 114-158
Range on HMM: 1-41/293
Sequence Identity: 15% (7 aa)

LQLENVIGKGAVSEVFLGNQQNSYLQREYEVCLKIKSVQDNDEKQ
.... .||.|. ..|...  ...      .|..|| .........
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKRHEKSWK