n545

Species: Tetrahymena
Alias: n545, 3698.m01713, 545
External Links:
Annotation:

Classification

Group: Atypical
Family: PI3K
Subfamily: PI4K

Sequence

Name Sequence Type Origin Length Description Download
n545.AA Protein None 864 None Fasta, JSON
n545.NA RNA None 2598 None Fasta, JSON

Protein domain

Protein domains of n545.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PI3Kc n545.AA PI3Kc 599-861 24 1.9e-64 221.37 SMART 1-336 (336) Show / Hide
Range on Protein: 599-861
Range on HMM: 1-336/336
Sequence Identity: 24% (85 aa)

HMIVKTGDNIKQEQFAVQLIYQFDQIFKME----ELDLKLTPYEIVSLGPQSGILEMVKNSITLDGLLK-------QIHSYKEIK---------------
..|.|.||   |.... |.. ... | . .     .||...|| ....||..|..|.|.|. ||  ..|       .. .|....               
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

------------------------------------DLRHFFQLYYGSQ---FKKAQYNFCSSLAAYSLVCYFLQIKDRHNGNILLH-KNGHIIHIDFGF
                                    .|...|. ....    . .|. ||..|.|.|. |.| |.|.||||.||.|. |.||..|||||.
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH

FLSNAPGKGLSI----EQNVPFKLLSDYISILG--GIESDMFQTFRRLFFQGFQAACKHQDKILILVKMLYSGHGLTL-PCFEKGEQCILDLEQRFNPPN
.....|.| .      |  |||.| .|.. . |  |..|..|. ||..  ....|. ||...|. |. |. ..    . ||. ..|  |  |.|||.. .
IFGHGPKKPGFKHHHRER-VPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDP---IMPCWRMMEKDIKYLRQRFRLDH

ISNDGELSMHCNM-----LINQSLDNWRARWYDKWQYFCQG
  .| | . .        ||. |.. |  | |. .... |.
-LSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY

PI3_PI4_kinase n545.AA PI3_PI4_kinase 597-797 18 9e-43 153.21 Pfam 1-291 (300) Show / Hide
Range on Protein: 597-797
Range on HMM: 1-291/300
Sequence Identity: 18% (54 aa)

LVHMIVKTGDNIK--QEQFAVQLI-----------------------YQFDQIFKMEELDLK----LTPYEIVSLGPQSGILEMVKNSITLDGLLKQIHS
 ...|.| ||     |..  .|.|                         .. . | . .|..    ..|| ....||..|..|.|.|. |......  . 
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

YKEIKD--------------------------------------LRHFFQLYYGSQ---FKKAQYNFCSSLAAYSLVCYFLQIKDRHNGNILL---HKNG
 ...|.                                      |...|  ....    . .|  ||..|.| .. | | |.. ||||.||..   ...|
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG

HIIHIDFGFFLSNAPGKGLSIEQNVPFKLLS------DYISILGG----IESDMFQTFRRLFFQGFQAACKHQDKILILV-------KMLY
|..|||||... .. .|..     |||...       .... .||     .| ....||.. .. ..|  .|.. ...|         ...
HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMV

Kinase n545.AA ATR 689-796 26 2e-13 41.71 In-house 163-267 (267) Show / Hide
Range on Protein: 689-796
Range on HMM: 163-267/267
Sequence Identity: 26% (29 aa)

AQYNFCSSLAAYSLVCYFLQIKDRHNGNILLHK-NGHIIHIDFGFFLSNAPGKGLSIEQNVPFKLLSDYISILGGIESDMFQTFRRLFFQGFQAACKHQD
.. |.| | |....| | . . |||  |||. | || ..|.|.      . |. . .   |||.|    .  .| ....    |||      .   .|.|
SRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIF--NSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGL--FRRACEVIMMCMRDHRD

KILILVKML
 |. ...  
DIMSVWDCF

Kinase n545.AA FRAP 692-731 48 5.6e-08 25.55 In-house 139-179 (251) Show / Hide
Range on Protein: 692-731
Range on HMM: 139-179/251
Sequence Identity: 48% (20 aa)

NFCSSLAAYSLVCYFLQIKDRHNGNILLHKN-GHIIHIDFG
|.  |||  |.. | | . |||  ||.| .  | |.|||||
NYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFG

Kinase n545.AA PIKK 692-732 42 2e-06 19.45 In-house 188-229 (290) Show / Hide
Range on Protein: 692-732
Range on HMM: 188-229/290
Sequence Identity: 42% (18 aa)

NFCSSLAAYSLVCYFLQIKDRHNGNILLHK-NGHIIHIDFGF
|...|.|  . | | | . |||  ||.. . .| |.|||||.
NYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGC

Kinase n545.AA PIKK 631-672 28 1.7e-05 16.38 In-house 68-109 (290) Show / Hide
Range on Protein: 631-672
Range on HMM: 68-109/290
Sequence Identity: 28% (12 aa)

DLKLTPYEIVSLGPQSGILEMVKNSITLDGLLKQIHSYKEIK
.| .. | .. .....|..| | |. || ...||  . |.|.
HLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYKQWCQKKHIR

Kinase n545.AA ATM 696-761 37 8.3e-05 10.84 In-house 143-207 (304) Show / Hide
Range on Protein: 696-761
Range on HMM: 143-207/304
Sequence Identity: 37% (25 aa)

SLAAYSLVCYFLQIKDRHNGNILL-HKNGHIIHIDFGFFLSNAPGKGLSIEQNVPFKLLSDYISILG
| |  |.| | | . |||  |||.  .   ..||| |       || |     |||.|  | .  .|
SVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQ--GKILPTPETVPFRLTRDIVDGMG

Kinase n545.AA ATR 632-680 32 0.004905 5.7 In-house 70-116 (267) Show / Hide
Range on Protein: 632-680
Range on HMM: 70-116/267
Sequence Identity: 32% (16 aa)

LKLTPYEIVSLGPQSGILEMVKNSITLDGLLKQIHSYKEIKDLRHFFQL
...  | .. |  |..|.| | | .||  .|...  .|| |    | ||
YHMRTYAVIPLNDQCCIIEWVNNTATLRPILDKL--WKEKKQYMQFYQL