n858

Species: Tetrahymena
Alias: 858, 175.m00071, n858
External Links:
Annotation:

Classification

Group: Atypical
Family: PI3K
Subfamily: PI4K

Sequence

Name Sequence Type Origin Length Description Download
n858.AA Protein None 1249 None Fasta, JSON
n858.NA RNA None 3750 None Fasta, JSON

Protein domain

Protein domains of n858.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PI3K_rbd n858.AA PI3K_rbd 147-244 13 0.000165 10.01 SMART 1-116 (116) Show / Hide
Range on Protein: 147-244
Range on HMM: 1-116/116
Sequence Identity: 13% (16 aa)

QEEKMIKDDK-PIKYEK---RIEIE---------AGLVTGADEVIKNILREIFKQ---AKVKLEPNNPDH--QFILQIKGFREYLTGNYPMLSYDRVRIN
 ..|.....   .. .|   ....|          ..    ..... .. ..|..   .. .. .| |    ..||.. |..|||....|  ... .|  
MSRKCPEHIWMKTINNKIIIVVHWEKRVCNWQQTKTMDCNPNCTPDSVMHQFFCKMMMNHSMHDQNDPTDECDYILKVCGRDEYLHPDHPLGQFEYIRNC

LRGHEHLDVRLTEIPI
.   .  .. | | . 
IMWGRCPHFVLMECCK

PI3K_rbd n858.AA PI3K_rbd 174-226 17 0.000194 19.05 Pfam 40-97 (115) Show / Hide
Range on Protein: 174-226
Range on HMM: 40-97/115
Sequence Identity: 17% (10 aa)

ADEVIKNILREIFKQ---AKVKLEPNNPDH--QFILQIKGFREYLTGNYPMLSYDRVR
.... . .. ..|.     . .. .| .    ...|.. |..|||.|..|  ... .|
PNDTPFQVMHQAFCKMAMKHSVHDQNDVQNPGDYVLKVCGRDEYLHGDHPLCQFEYIR

PI3K_C2 n858.AA PI3K_C2 550-635 25 7.9e-15 55.62 Pfam 11-115 (168) Show / Hide
Range on Protein: 550-635
Range on HMM: 11-115/168
Sequence Identity: 25% (27 aa)

LF--HGSNCL-RTV-ETKKQPFC----KSIRFNEWVTFDNLKISQIPLEARICMNIILHSDDQNEH---------QIIGSTSFSLFDQ-DDKYRQGLNAL
..  || ..|   |  |.  ||.    .....|||.||........|..||.|  |  ...   .          . || ....|||. ..  |.|  .|
VYDGHGGKPLCKPVQSTSYKPFNNHFFPRWNWNEWITFPQIQYCDLPRDARLCITIWEIYCKKKSESNMNEQNKKCPIGWCNLPLFDHEKCMLRCGMHKL

NV-WP
.. ||
HMTWP

PI3K_C2 n858.AA PI3K_C2 497-618 19 6.1e-05 20.08 SMART 1-133 (133) Show / Hide
Range on Protein: 497-618
Range on HMM: 1-133/133
Sequence Identity: 19% (28 aa)

LKLCKIRKEKLLKDAQMDTSITNHGIDGVAFMGGLEKKFGLNCTP-Y-----LVSLKVMLFHG--SNCLRTVETKK----QPFCKS-----IRFNEWVTF
.| |.... .. . .     ||...|...           ||. . |      . . . |.||   . . .| |..    ..| ..     ...|||.||
VKICSLWCCNRPFVFL-PHEITIYCIHDIM----------LNWSQDYESSCVDLYVECQLYHGMGKQFCCPVRTSYHQYVKHFFNRTFHLFWKWNEWLTF

DNLKISQIPLEARICMNIILHSD-DQNEHQII----GSTSFSLF
........| .||.|  |  ..| .  .  ..    |.. |..|
FPIQYCDLPRMARLCITIWDVYDDSKKSEPFFSRCVGWSNFDWF

PI3Ka n858.AA PI3Ka 713-902 25 2.3e-33 118.09 SMART 1-232 (232) Show / Hide
Range on Protein: 713-902
Range on HMM: 1-232/232
Sequence Identity: 25% (61 aa)

NWNSTP--KTDDLARLQQLLSIDPLRRLSEQSEEDKHVLMICRNHYK-TLTHTL------QIFLFAIDWLDPEQVKEAILMLKQW--TLLSPEDALPLLD
. .. |    ..  .|..... .|.  |   .||.|  .   |..|  .    |       ... ...| ....||.|. ...||  ....||||| |||
DYDLKPRWNEEERDQLEDIMKYPPTYEL---TEEEKDLIWKFRHYYLTNHPKALPSMCFPKFLR-CVNWSWADEVKQAYQLMHQWWWPPIDPEDALELLD

ANMAN---ESVRLYAVERVSTFSDDEIALYMLELTQSILYE--------------------------SKHFSPLVDMLLERSLQNPFVVGHELFWQLKSQ
.. ..   . || |||..   .||||. .| | | | . ||                          . | |||...||.|.|.||  .|| ..|.||| 
PKFPDYNCPHVRQYAVQCLEQMSDDELLHYLLQLVQALKYENFDHIKHHFCEFDQDQSMSMTKEEDGPYHDSPLCRFLLQRALCNP-RIGHFFYWYLKSE

L------HIKAFYERYFLIIEQMLMLC-GSFRNELVV
.      | . ...|. .. |...  | |    .|  
MYDHCQLHDPHYCQRFGMLLEMYCRGCCGHHMRHLFK

PI3Ka n858.AA PI3Ka 766-902 33 2e-30 106.23 Pfam 58-211 (211) Show / Hide
Range on Protein: 766-902
Range on HMM: 58-211/211
Sequence Identity: 33% (52 aa)

FLF-AIDWLDPEQVKEAILMLKQ--WTLLSPEDALPLLDANMAN--ESVRLYAVERVST-FSDDEIALYMLELTQSILYE----SKHFSPLVDMLLERSL
||   . | |..||..|.  ..   |. ..|.||| |||.| ..  ..|| |||..  . .||||. .|.| |.| . ||      | |.|.  ||.|..
FLQLCVKWHDYDQVAQAYQLMDCRVWPPIDPCDALELLDCNFPDNCPMVRQYAVKCLESYMSDDELLCYLLQLVQALKYENFDEPFHDSYLSRFLLWRAW

QNPFVVGHELFWQLKSQL------HIKAF-YERYFLIIEQMLMLCGSFRNELVV
||. . || .|| .|| .      |.|..  .|. .. |...  ||  . .|  
QNRQRIGHFFFWYMKSEMYKDDEGHDKDYICQRFGVLLESYCRECGTHMQHLNK

PI3Kc n858.AA PI3Kc 987-1248 34 1.9e-106 360.84 SMART 1-336 (336) Show / Hide
Range on Protein: 987-1248
Range on HMM: 1-336/336
Sequence Identity: 34% (117 aa)

NILFKCGDDIRQDQLTLQLLKIMDKIWLDA----GHDFRMKPYKVITTDDQVGMIEIVNNSETTAKIHSKY-----------------------------
 ..|||||| |||....|....|.|||       . |..|.|||.| | .. |||| |.|.|| ..|..||                             
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

--------------------------GGVLGAFRNNTIWQYLKDKNMDP-HSFEIATDNFLRSCAGYCVATYILGIGDRHADNIMLS-QTGHLFHIDFGH
                          .|....|  ... ....... || ...  | ||| |||||||..|||||||||| |||||  .|||.|||||||
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH

FLGNFKTKFGIK---RERAPFVLTKEMAFVMG--GKDGNLFRKFEEYCTQAYNLVRKSGNFIINIFLLMLEAGM-PELQSP-QDIEYLRNQLSIN-LTEQ
..|....|.|.|   |||.||.||..|  |||  ||.  .| .| ..| .||...||. | |.|.| .|. ... |....   ||.|||...  . |...
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDE

EATNKFKK-----EITDSLNSLFRRIDNFFHGLRRR
||...|..      | .|..|.. |. ..|| ..  
EAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY

PI3_PI4_kinase n858.AA PI3_PI4_kinase 985-1199 30 7.7e-84 289.63 Pfam 1-300 (300) Show / Hide
Range on Protein: 985-1199
Range on HMM: 1-300/300
Sequence Identity: 30% (91 aa)

NINILFKCGDDIR--QDQLTLQLL-----------------------KIMDKIWLDAGHDFR----MKPYKVITTDDQVGMIEIVNNSETTAKIHSKYGG
.. ..||.||| |  ||....|..                       ..|.|.|   | |.|    | ||..| | .. |||| |.|..| ..|...|. 
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

VLG-AFRN----------------------------------NTIWQYLKDKNMDP-HSFEIATDNFLRSCAGYCVATYILGIGDRHADNIML---SQTG
 .. ...|                                  . . |.....| |.   .  | ||| |||||.||..||||.||||.||||.     ||
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG

HLFHIDFGHFLGNFKTKFGIKRERAPFVLTK------EMAFVMGG----KDGNLFRKFEEYCTQAYNLVRKSGNFIINIF-------LLMLEAGMPELQS
|||||||||.....|.|...|.|| ||..|.      .|  .|||    ..   . .|..|| .||...|. .|...| .       ..|...|.|.. |
HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS





Kinase n858.AA ATR 1074-1189 31 2.9e-16 51.5 In-house 155-267 (267) Show / Hide
Range on Protein: 1074-1189
Range on HMM: 155-267/267
Sequence Identity: 31% (37 aa)

MDPHSFEIATDNFLRSCAGYCVATYILGIGDRHADNIMLSQ-TGHLFHIDFGHFLGNFKTKFGIKRERAPFVLTKEMAFVMGG-KDGNLFRKFEEYCTQA
.|| ..  . .|..|| | .|.  ||.|.||||.|||.. . .| . |.|.    .  .. | .  |  || ||. | | ||  |   |||.    |   
PDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQ-FEV-PEIVPFRLTHNMVFGMGPMKTYGLFRRA---CEVI

YNLVRKSGNFIINIFLLM
  ..|.  . |. ..   
MMCMRDHRDDIMSVWDCF

Kinase n858.AA PIKK 1082-1154 43 1.2e-13 46.39 In-house 185-257 (290) Show / Hide
Range on Protein: 1082-1154
Range on HMM: 185-257/290
Sequence Identity: 43% (32 aa)

ATDNFLRSCAGYCVATYILGIGDRHADNIML-SQTGHLFHIDFGHFLGNFKTKFGIKRERAPFVLTKEMAFVMG
.. |..|| |  |.. ||||.|||| .|||. .||| . |||||.  .  .. .    |  || ||. | . ||
RRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVP-EKVPFRLTRNMVNAMG

Kinase n858.AA FRAP 1085-1124 58 1.1e-11 39.31 In-house 139-179 (251) Show / Hide
Range on Protein: 1085-1124
Range on HMM: 139-179/251
Sequence Identity: 58% (24 aa)

NFLRSCAGYCVATYILGIGDRHADNIMLS-QTGHLFHIDFG
|. || |   .| ||||.||||  ||||  .|| . |||||
NYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFG

Kinase n858.AA ATM 1088-1124 50 1.1e-07 20.21 In-house 142-179 (304) Show / Hide
Range on Protein: 1088-1124
Range on HMM: 142-179/304
Sequence Identity: 50% (19 aa)

RSCAGYCVATYILGIGDRHADNIMLS-QTGHLFHIDFG
|| |   .  ||||.||||  ||..  |   | ||| |
RSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG

Kinase n858.AA DNAPK 1086-1128 47 1.8e-07 23.04 In-house 190-233 (301) Show / Hide
Range on Protein: 1086-1128
Range on HMM: 190-233/301
Sequence Identity: 47% (21 aa)

FLRSCAGYCVATYILGIGDRHADNIMLS-QTGHLFHIDFGHFLG
| |. |  |.  .|||||||| .| |    .|    |||||  |
FIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFG

Kinase n858.AA SMG1 1083-1123 42 7e-06 15.2 In-house 187-228 (242) Show / Hide
Range on Protein: 1083-1123
Range on HMM: 187-228/242
Sequence Identity: 42% (18 aa)

TDNFLRSCAGYCVATYILGIGDRHADNIMLS-QTGHLFHIDF
|  . || |   .  ||.|.|||| ||...   ||   |||.
TQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDY

Kinase n858.AA PIKK 989-1009 47 0.001062 9.78 In-house 34-54 (290) Show / Hide
Range on Protein: 989-1009
Range on HMM: 34-54/290
Sequence Identity: 47% (10 aa)

LFKCGDDIRQDQLTLQLLKIM
|.|...|.|||| ..||. .|
LCKGHEDLRQDQRVMQLFQLM