Gene n1193 (Tetrahymena)
n1193
Species: Tetrahymena
Alias: 1193, n1193, 3678.m00027
External Links:
Annotation:
Group:
Other
Family:
Ciliate-E4
Sequence
Protein domains of n1193.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | n1193.AA | Ciliate-A5 | 131-476 | 20 | 3.5e-36 | 122.91 | In-house | 44-275 (275) | Show / Hide |
Range on Protein: 131-476
Range on HMM: 44-275/275
Sequence Identity: 20% (74 aa)
QHQNLIQLIKYFDYNYNSMCTSFHRLITVTEYLSRDLSTELFFRKLLI-EKTTSSATPKNGESTTKSNQMQVSLSSKSQRSLSANSVAVQNQSQVKNNSN
||.|...||.. .. .. |..| ... ..|| . .| .|. || . .
QHPNIVKLIDFHTHKKEEFCSQFYKVNCYYEYHDNNLEQEMQMRKQCQKD--------------------------------------------------
MLHSKRLSEIQRKSVLIVTKVFSTHENDNIIEDQGEDEGNFYEKRGAIAKQIKNRSHFQFNASDNAYRFQEKEFTYILKSLISGLCYLQMQNRTHQCLRS
...| | ||...||| ..||| | | .|
------------------------------------------------------------------IFYNEQELWYIMDCLISVCMYLQQNNICHGDIRP
SSIFIARDGTIKLTDPHLFN--QSSLY---TYIYKGQLEHIVTFNYSQKFSGAYLSPLLVSNVEYS----VVKPEHNEYKSDVFTLAVIMLEIAYLNKL-
..|.. || .||.| .| . ..| ||. ..|. | | . ||||.. . . . ||||.||||||.| .|.|| . . .
QNICLTQDGQVKLMD---MNESKDFFYQINWSSYKQYQHHMSTEN------KQYLSPMQWYQMMHRDEQNIQRPEHNWYKSDVFCLGMICLEMCTMRDCT
DNYFDYTEYCLVDVEGLQILAENLKDIYSQSIISLLLQMLDENEDIRPDFVSLAQKL
.| ||. ... . .| . ... ||.. |....||| .| ||||. ..| |
QFYYDYETFQIQNNQLIKQLIQMKEKKYSEQFINFIKQMLQFEENKRPDFHQIYQYL
|
|||||||||
| Kinase | n1193.AA | Ciliate-E4 | 297-344 | 35 | 1.2e-09 | 28.81 | In-house | 103-150 (150) | Show / Hide |
Range on Protein: 297-344 Range on HMM: 103-150/150 Sequence Identity: 35% (17 aa) RFQEKEFTYILKSLISGLCYLQMQNRTHQCLRSSSIFIARDGTIKLTD .| | | |. ..|... ||| | ||. |. | ||. .|. | HFDESEIWQIAFCCINAMYYLQQVNITHGDLKPSNIFFDQYFMVKIAD |
|||||||||
| Kinase | n1193.AA | Ciliate-E4 | 131-176 | 32 | 1.5e-08 | 25.14 | In-house | 54-99 (150) | Show / Hide |
Range on Protein: 131-176 Range on HMM: 54-99/150 Sequence Identity: 32% (15 aa) QHQNLIQLIKYFDYNYNSMCTSFHRLITVTEYLSRDLSTELFFRKL .| |.|.. || |.|. ||. . ||| .|| ... .|. NHENIIMVYEYFHKKEDQFCSSIYRLYWFMEYLQKDLQQHIKQHKQ |
|||||||||
| Kinase | n1193.AA | FRAY | 306-344 | 38 | 6e-06 | 14.06 | In-house | 112-150 (277) | Show / Hide |
Range on Protein: 306-344 Range on HMM: 112-150/277 Sequence Identity: 38% (15 aa) ILKSLISGLCYLQMQNRTHQCLRSSSIFIARDGTIKLTD |||.. ||||. . | . . | |. |||| . | ILKEVLKGLCYFHKNGQIHRDIKAGNILIGEDGTIQIAD |
|||||||||
| Kinase | n1193.AA | TKL-ciliate1 | 441-476 | 22 | 3.1e-05 | 13.88 | In-house | 244-279 (279) | Show / Hide |
Range on Protein: 441-476 Range on HMM: 244-279/279 Sequence Identity: 22% (8 aa) ENLKDIYSQSIISLLLQMLDENEDIRPDFVSLAQKL . . ...|... |. ....| ||.| . | | QFIHFDCPQNFHNLMMRCWCQNPNKRPNFNEIIQIL |
|||||||||
| Kinase | n1193.AA | S_TKc | 153-479 | 8 | 5.5e-05 | -103.84 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 153-479
Range on HMM: 1-231/231
Sequence Identity: 8% (30 aa)
FHRLITVTE------YLSRDLS-TELFFRKLLIEKTTSSATPKNGESTTKSNQMQVSLSSKSQRSLSANSVAVQNQSQVKNNSNMLHSKRLSEIQRKSVL
.. | .. . |. |. . ... | . ....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------------------------------------------------------EHIR
IVTKVFSTHENDNIIEDQGEDEGNFYEKRGAIAKQIKNR---SHFQFNASDNA----YRFQEKEFTYILKSLISGLCYLQMQNRTHQCLRSSSIFIARDG
.. . .||. . . .. . . . |.. . . ..| | . .... ....| |. .. | | . |.. .
REIQILKK-HHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--
TIKLTDPHLFNQSSLYTYIYKGQLEHIVTFNYSQKFSGAYLSPLLVSNVEYSVVKPEHNEYKSDVFTLAVIMLEIAY----LNKLDNYFDYTEYCLVDVE
.||..| | . .. ... . |..| .. .. |.|. . .|. | .. ... . ..
HIKICD---FGLARQL---------------TTFCGTPWYMAPEVL----------GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG----
GLQILAENLKDIYSQSIISLLLQMLDENEDIRPDFVSLAQ------KLGIF
|.. .... ..|. . . || . | . |
-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
|||||||||
| Kinase | n1193.AA | PAKB | 297-344 | 31 | 0.00011 | 13.19 | In-house | 91-138 (252) | Show / Hide |
Range on Protein: 297-344 Range on HMM: 91-138/252 Sequence Identity: 31% (15 aa) RFQEKEFTYILKSLISGLCYLQMQNRTHQCLRSSSIFIARDGTIKLTD | .| .. .. | || | | .| || ..||..||.| RMNEEQIATVCRQVLQALAYLHAQGVIHRDIKSDSILLTHDGRVKLSD |
|||||||||
| Kinase | n1193.AA | SAK | 298-344 | 29 | 0.000345 | 9.86 | In-house | 97-143 (254) | Show / Hide |
Range on Protein: 298-344 Range on HMM: 97-143/254 Sequence Identity: 29% (14 aa) FQEKEFTYILKSLISGLCYLQMQNRTHQCLRSSSIFIARDGTIKLTD | |.| ... .. |. || . | | | | ..|| .|. | FTEEEARHFMHQIVIGMLYLHSHGIMHRDLTLSNILLTRDMHCKIAD |
|||||||||
| Kinase | n1193.AA | Ciliate-C6 | 436-476 | 39 | 0.000506 | 10.15 | In-house | 266-306 (306) | Show / Hide |
Range on Protein: 436-476 Range on HMM: 266-306/306 Sequence Identity: 39% (16 aa) LQILAENLKDIYSQSIISLLLQMLDENEDIRPDFVSLAQKL . |. .. ||| . || | .|| | | ||| | | IRIMKNMCKDISYKEIIKLVSKMLETNPDHRPDMSILIQTI |
|||||||||
| Kinase | n1193.AA | STE20 | 296-344 | 28 | 0.000825 | 10.15 | In-house | 112-160 (288) | Show / Hide |
Range on Protein: 296-344 Range on HMM: 112-160/288 Sequence Identity: 28% (14 aa) YRFQEKEFTYILKSLISGLCYLQMQNRTHQCLRSSSIFIARDGTIKLTD ....|.. ||.. . || || ... | . . | . || .||.| HPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLAD |
|||||||||
| Kinase | n1193.AA | MKC | 290-344 | 40 | 0.000967 | 10.28 | In-house | 91-145 (260) | Show / Hide |
Range on Protein: 290-344 Range on HMM: 91-145/260 Sequence Identity: 40% (22 aa) NASDNAYRFQEKEFTYILKSLISGLCYLQMQNRTHQCLRSSSIFIARDGTIKLTD .|| |.. |.|. |. | . || || .| | | |. | . || ||| | EASQNSHKFCESCIAYVCKEMLQGLMYLHEHNIVHRDLKSANIMMNTDGEIKLID |
|||||||||
| Kinase | n1193.AA | HH498 | 449-476 | 21 | 0.000977 | 7.28 | In-house | 257-284 (284) | Show / Hide |
Range on Protein: 449-476 Range on HMM: 257-284/284 Sequence Identity: 21% (6 aa) QSIISLLLQMLDENEDIRPDFVSLAQKL .....|. .. . . . ||||. .| HHWSNLIQMCWHPCPENRPDFDQIVTIL |
|||||||||
| MORN | n1193.AA | MORN | 2363-2385 | 43 | 3e-06 | 27.23 | Pfam | 1-23 (23) | Show / Hide |
Range on Protein: 2363-2385 Range on HMM: 1-23/23 Sequence Identity: 43% (10 aa) FQGEWQNGHMNGYGVLYYPSQNK ..|||.|| |.|.||...|. .. YEGEWKNGKMHGHGVYTWPDGDR |
|||||||||
| MORN | n1193.AA | MORN | 2340-2362 | 47 | 0.000272 | 20.34 | Pfam | 1-23 (23) | Show / Hide |
Range on Protein: 2340-2362 Range on HMM: 1-23/23 Sequence Identity: 47% (11 aa) YEGEKMNGVRHGRGKFFYGDGGS |||| ||..||.|.. . ||. YEGEWKNGKMHGHGVYTWPDGDR |
|||||||||
| MORN | n1193.AA | MORN | 2361-2382 | 36 | 0.000319 | 20.54 | SMART | 1-22 (22) | Show / Hide |
Range on Protein: 2361-2382 Range on HMM: 1-22/22 Sequence Identity: 36% (8 aa) GSFQGEWQNGHMNGYGVLYYPS .|||.||.. |.||..... DRYEGEWHNGKRHGHGVYWWAN |
|||||||||
| MORN | n1193.AA | MORN | 2385-2406 | 36 | 0.000845 | 17.37 | SMART | 1-22 (22) | Show / Hide |
Range on Protein: 2385-2406 Range on HMM: 1-22/22 Sequence Identity: 36% (8 aa) KAYEGEWDDDKFNGKGIMYNER ||||| ..|. |.|... DRYEGEWHNGKRHGHGVYWWAN |
|||||||||
| MORN | n1193.AA | MORN | 2387-2403 | 47 | 0.001768 | 17.39 | Pfam | 1-17 (23) | Show / Hide |
Range on Protein: 2387-2403 Range on HMM: 1-17/23 Sequence Identity: 47% (8 aa) YEGEWDDDKFNGKGIMY ||||| ..|..|.|... YEGEWKNGKMHGHGVYT |
|||||||||
| MORN | n1193.AA | MORN | 2338-2359 | 45 | 0.003011 | 13.24 | SMART | 1-22 (22) | Show / Hide |
Range on Protein: 2338-2359 Range on HMM: 1-22/22 Sequence Identity: 45% (10 aa) SYYEGEKMNGVRHGRGKFFYGD . |||| || |||.|.. . . DRYEGEWHNGKRHGHGVYWWAN |
|||||||||
| MORN | n1193.AA | MORN | 2429-2451 | 34 | 8e-06 | 25.99 | Pfam | 1-23 (23) | Show / Hide |
Range on Protein: 2429-2451 Range on HMM: 1-23/23 Sequence Identity: 34% (8 aa) YEGDFKDDFKNGVGTLYLSNGER |||..|.....| |... ..| | YEGEWKNGKMHGHGVYTWPDGDR |
|||||||||
| MORN | n1193.AA | MORN | 2452-2474 | 39 | 3.8e-05 | 23.45 | Pfam | 1-23 (23) | Show / Hide |
Range on Protein: 2452-2474 Range on HMM: 1-23/23 Sequence Identity: 39% (9 aa) YIGRFKNDMVHGRGTFYKSDGSF | | .||.. ||.|... .||. YEGEWKNGKMHGHGVYTWPDGDR |
|||||||||
| MORN | n1193.AA | MORN | 2450-2471 | 31 | 6.4e-05 | 23.6 | SMART | 1-22 (22) | Show / Hide |
Range on Protein: 2450-2471 Range on HMM: 1-22/22 Sequence Identity: 31% (7 aa) ERYIGRFKNDMVHGRGTFYKSD ||.| ..|.. ||.|... .. DRYEGEWHNGKRHGHGVYWWAN |
|||||||||
| MORN | n1193.AA | MORN | 2427-2448 | 27 | 0.000888 | 17.21 | SMART | 1-22 (22) | Show / Hide |
Range on Protein: 2427-2448 Range on HMM: 1-22/22 Sequence Identity: 27% (6 aa) VKYEGDFKDDFKNGVGTLYLSN .|||..... . | |... .| DRYEGEWHNGKRHGHGVYWWAN |
|||||||||