Gene n1203 (Tetrahymena)
n1203
Species: Tetrahymena
Alias: 566.m00005, 1203, n1203, 566.m00006, 566.m00007
External Links:
Annotation:
Group:
Other
Family:
Ciliate-C7
Sequence
Protein domains of n1203.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | n1203.AA | Ciliate-C7 | 78-240 | 78 | 5.8e-120 | 386.12 | In-house | 1-164 (164) | Show / Hide |
Range on Protein: 78-240 Range on HMM: 1-164/164 Sequence Identity: 78% (128 aa) FRFLGQGGQGLVLLVKDSKTNIRYAIKGVQIRDPFGNFYEDVNNQVKQEVEILKKCRDSPYVVSLLDQFEGEQFSYLVLTECQ-GTLTQILERNQNKRLN ||||||| |||||| ||.|||.||||||||.||. ||...|.||||.||..|||.|.||||||.||.||||.||.||||.||| |||.||.||||||||| FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN EMSAIKYANDIAQGIYYIHSQNCLVNDLKMDNILIDYNGNAVVSDFGLADNQISKSGYSTNQYM |.||||||.|||||.|||||.||.|||||||||||||||||||.|||||||.. ||.|..|||| EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKSKYQINQYM |
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| Pkinase | n1203.AA | Pkinase | 75-236 | 27 | 3.3e-27 | 97.28 | Pfam | 1-170 (293) | Show / Hide |
Range on Protein: 75-236 Range on HMM: 1-170/293 Sequence Identity: 27% (48 aa) YSDFRFLGQGGQGLVLLVKDSKTNIRYAIKGVQIRDPFGNF-YEDVNNQVKQEVEILKKCRDSPYVVSLLDQFEGEQFSYLVLTECQG-----TLTQILE | | .|.|. | | . .. .|....|.| . |. .. ..... .|..|.|.. ..|..| |.| || .. |.|. |.| | ... YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL---SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS RNQNKRL--NEMSAIKYANDIAQGIYYIHSQNCLVNDLKMDNILIDYNGNA----VVSDFGLADN--QISKSGYST . ..... | ...|. |..|..|.||.... ||| .||||| ||. ..||||| ..| ..| TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTT |
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| Kinase | n1203.AA | Ciliate-E2-Unclassified | 75-252 | 21 | 6e-27 | 90.53 | In-house | 1-239 (352) | Show / Hide |
Range on Protein: 75-252
Range on HMM: 1-239/352
Sequence Identity: 21% (52 aa)
YSDFRFLGQGGQGLVLLVKDSKTNIRYAIKGVQIRDPFG-NFYEDVNNQVKQEVEILKKCR------------------DSPYVVSLLDQFEGEQFSYLV
| . .||||.| | .....|.. ||.| . . .. .. . ..| ..... ..|..| ....|. .| |.|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV
LTEC-QGTLTQILE---------------RNQNKRLNEMSAI-----KYANDIAQGIYYIHSQN-CLVNDLKMDNILIDYNG---NAVVSDFGLA-----
. | .|.| |... ..|.|.. | |. .|. | ||. |.|..| .. |.| .|||.| || . ..|||..
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ
---------------DNQISKSGYSTNQYMGNFLYQAPECYD
..|.... |..|| . |.|||...
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMP-Q-YTAPEVLQ
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| Kinase | n1203.AA | Ciliate-E1 | 81-251 | 19 | 1.4e-24 | 77.11 | In-house | 1-182 (202) | Show / Hide |
Range on Protein: 81-251 Range on HMM: 1-182/202 Sequence Identity: 19% (36 aa) LGQGGQGLVLLVKDSKTN-IRYAIKGVQIRDPFGNFYEDVNNQVKQEVE-ILKKCRDSPYVVSLLDQFEGEQ--FSYLVLTECQGTLTQILE-------- .|.|....|. | ..| . .|.| ..... |. .. ......| |.| . |.. ..|... .| ........|. .|.. |. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCF---NYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYW ---RNQNKRLNEMSAIKYANDIAQGIYYIHSQNCLVNDLKMDNILIDYNGNAVVSDFGLADNQISKSGYSTNQYMGNFLYQAPECY ..... ... .. . .. .|. ..|..| . |.|..||||. .|| | .|||......... ..... |. ||.| QQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQY |
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| Kinase | n1203.AA | CAMK | 80-249 | 18 | 2e-24 | 75.02 | In-house | 1-290 (425) | Show / Hide |
Range on Protein: 80-249 Range on HMM: 1-290/425 Sequence Identity: 18% (54 aa) FLGQGGQGLVLLVKDSKTN------------IRYAIKGVQ-----------------IRDPFGNF-----YEDVNNQVKQEVEILKKCR------DSPYV ||.|. | | |... .|. ..||| . |.. . . .|..|.||.||.. | | . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VSLLDQFEG-------------------EQFSYLVL---TECQGT------LTQILERNQN------------KRLNEMSAIKYANDIAQGIYYIHSQNC ..|.. .| ... |.|. |.| . | |. .. .|..| | .| |.... |.||.| IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI LVNDLKMDNILIDYN-----------------GNAVVSDFGLADNQISKSGYS----------------------TNQYMGNFLYQA-PE ||| .|||.|.| .| ..|||.| ...... . . | | | || VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPE |
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| Kinase | n1203.AA | CAMKL | 75-225 | 25 | 2.2e-24 | 74.62 | In-house | 1-176 (297) | Show / Hide |
Range on Protein: 75-225 Range on HMM: 1-176/297 Sequence Identity: 25% (46 aa) YSDFRFLGQGGQGLVLLVKD-SKTNIRYAIKGVQIR----DPFGNFY------EDVNNQVKQEVEILKKCR--DSPYVVSLLDQFEGEQF------SYLV | . ||.|. | | | .. . |....||| . .. ||. . |.. ...|..|.|. . | ...|.. .| ... ||| YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV LTECQGT---LTQILERNQNKR--LNEMSAIKYANDIAQGIYYIHSQNCLVNDLKMDNILIDYNG--NAVVSDFGLA . |.| | . .... ..| . | | .| | ...|.||.. |.| .|||.|.|| |. ..|||.. MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFS |
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| Kinase | n1203.AA | Ciliate-E2 | 75-249 | 18 | 9.7e-22 | 71.39 | In-house | 1-257 (365) | Show / Hide |
Range on Protein: 75-249 Range on HMM: 1-257/365 Sequence Identity: 18% (50 aa) YSDFRFLGQGGQGLVLLVKDSKTNIRYAIK---GVQIRDP-----FGNFYEDVNNQVKQEVEILKK----CR------------------DSPYVVSLLD | . .|||..| | ..|. |.. ..||| | ... . ... .... |...|..|. .| ..|... . . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE QFE--GEQFSYLVLTECQG-TLTQILERN----------QNKRLNEMSAIKYANDIAQ---------------GIYYIHSQN-CLVNDLKMDNILIDYNG |. .. |||. ||| .| .... | . |...| .... |.| .. |.||.| .. |.| .|||. CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---- NAVVSDFGLADNQISKSGYST------------------------------NQYMGNFLYQAPE ..||||. .. .. . | |.. |. |.||| -IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPE |
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| Kinase | n1203.AA | ULK | 75-225 | 25 | 7.4e-20 | 66.07 | In-house | 1-189 (329) | Show / Hide |
Range on Protein: 75-225 Range on HMM: 1-189/329 Sequence Identity: 25% (48 aa) YSDFRFLGQGGQGLVLLVKDSKT----NIRYAIKGVQIR--DPFGNFY--EDVNNQVKQEVEILKKCRD---SPY----VVSLLDQFEGEQF--SYLVLT |. . ||.| | | .. || |. .|.| ... . . | . . ...|.|..|.|| . ... .| |.| || .. |... YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME ECQG-TLTQILERNQN--------KRLNEMSAIKYANDIAQGIYYIHSQNCLVNDLKMDNILIDYNGNAV------------VSDFGLA |.| .| |....|.. |||.|. ||.. .|..| ..|..|. |.| .||||. . ..|||.| YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA |
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| Kinase | n1203.AA | STE | 75-249 | 18 | 2.1e-19 | 65.23 | In-house | 1-232 (359) | Show / Hide |
Range on Protein: 75-249 Range on HMM: 1-232/359 Sequence Identity: 18% (44 aa) YSDFRFLGQGGQGLVLLVKDSK---------------TNIRYAIKGVQIRDP-----------FGNFYEDVNNQVKQEVEILKKCRD-SPYVVSLLDQFE . . ...|.|. | | . .. | |. ..||| . ... | .. .|...|..|.|||.. .|..| .. .. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF GE-------QFSYLVLTECQ-GTLTQILE------RNQN------KRLNEMSAIKYANDIAQG-IYYIHSQNCLVNDLKMDNILIDYNGNAVVSDFGLAD | . .... . |.|..|.. ...| .|..| .... .| .| ||.||.. |.| .|||. . .|||.. KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG NQIS---------------KSGYSTNQYMGNFLYQAPE . .. .. .| | . ||| QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE |
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| Kinase | n1203.AA | ULK | 75-225 | 26 | 4.8e-18 | 60.66 | In-house | 1-185 (324) | Show / Hide |
Range on Protein: 75-225 Range on HMM: 1-185/324 Sequence Identity: 26% (49 aa) YSDFRFLGQGGQG-LVLLVKDSKT---NIRYAIKGVQIR--DPFGNFY--EDVNNQVKQEVEILKKCR--DSPY--VVSLLDQFEGE--QFSYLVLTECQ |. . ||.| | | .. || | .|.| ... . | . . .. |.|..|.|| .|. .| |.| || . |... |. YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN G-TLTQILERNQN-------KRLNEMSAIKYANDIAQGIYYIHSQNCLVNDLKMDNILIDYNGNAV------------VSDFGLA | .| |....|.. |||.|. ||.. .|..| ..|..|. |.| .|||| . ..|||.| GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA |
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| Kinase | n1203.AA | S_TKc | 75-301 | 22 | 1.4e-16 | 62.29 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 75-301
Range on HMM: 1-231/231
Sequence Identity: 22% (58 aa)
YSDFRFLGQGGQGLVLLVKDSKTNIRYAIKGVQIRDPFGNFYEDVNNQVKQEVEILKKCRDSPYVVSLLDQFEGEQFSYLVLTECQG---TLTQILERNQ
| | .|.|. | | .... ||. ..||| . .....|..|||| . |..| |.| |. .. |.|. | | .| .......
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG
NKR----LNEMSAIKYANDIAQGIYYIHSQNCLVNDLKMDNILIDYNGNAVVSDFGLADNQISKSGYSTNQYMGNFLYQAPECYDPADL-----------
.. ..| | .|. |.... |.||.. . ||| .|||.| . ..||||| . . | | ||| . .
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCI
-----FGKVYYDEYLKL------GVTLKYIIEGLTNFIPKNRMPIKEALI-----ILKGII
|. .. ... .| .|... .. |..|. . ||| . .
LYEMLCGYPPFP-QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | n1203.AA | Ciliate-A2 | 159-251 | 31 | 6.4e-15 | 48.48 | In-house | 80-179 (272) | Show / Hide |
Range on Protein: 159-251 Range on HMM: 80-179/272 Sequence Identity: 31% (31 aa) C-QGTLTQILE--RNQNKRLNEMSAIKYANDIAQGIYYIHSQNCLVNDLKMDNILIDYNGN-AVVSDFGLA---DNQISKSGYSTNQYMGNFLYQAPECY | .. | . . || | .... ....|. | ..| |.|..| . ||. ||||| ... .. ||||| ...|. . ..|.. | |.| |||. CPECSLQDWIDKFQNQQKFIPDHQFVHFACQILDAIEYLHNKNYVLRDLSLRNILIDQDNQIIKLCDFGLAKKYQPEINSQMFYTSCPKGVFFYYPPECH |
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| Kinase | n1203.AA | TyrKc | 75-310 | 17 | 2.1e-07 | -102.77 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 75-310 Range on HMM: 1-280/280 Sequence Identity: 17% (53 aa) YSDFRFLGQGGQGLVLLVKDSKTNIRYAIKGVQIRDPFGNFYEDVNNQVKQEVEILKKC-RDSPYVVSLLDQFEGEQ------FSYLVLTE--CQGTLTQ . . || | | | . . . | |.| .. .| .|..| . | .| |. .. .....| . | | . ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD ILERNQNKRLNEMSAIKYANDIAQGIYYIHSQNCLVNDLKMDNILIDYNGNAVVSDFGLADNQISK------SGYSTNQY--MGNFL----YQAPECYDP | ....| |. .... .||.| |.||.|| || |.|.. |. . .|||||. . .. . | . . |... |||| YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-- ADL--------------------FGKVYYDEY----LKLGVTLKYIIEGLTNFIPKN-------RMPIKEALIILKGIIS-------FEFQLDEM . .|. | . .. ..|. .| .|.| ..| . |... |. ... NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | n1203.AA | Ciliate-A2 | 82-133 | 32 | 1e-06 | 19.19 | In-house | 1-55 (272) | Show / Hide |
Range on Protein: 82-133 Range on HMM: 1-55/272 Sequence Identity: 32% (18 aa) GQGGQGLVLLVKD--SKTNIRYAIKGVQIRDPFGN-FYEDVNNQVKQEVEILKKC |||. |.|..|.. . | |||| . | |... . . | | ..||.| GQGCFGCVIFVEHMDNHNNEKYAIKIQSIIDGIDQKISQQKLQECKHEAQFLKNC |
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