AqueK048

Species: A.queenslandica
Alias: AqueK048
External Links:
Annotation:

Classification

Group: Atypical
Family: PIKK
Subfamily: TRRAP

Sequence

Name Sequence Type Origin Length Description Download
AqueK048.AA Protein None 2638 None Fasta, JSON

Protein domain

Protein domains of AqueK048.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FAT AqueK048.AA FAT 1557-1900 17 8.4e-66 220.56 Pfam 1-408 (408) Show / Hide
Range on Protein: 1557-1900
Range on HMM: 1-408/408
Sequence Identity: 17% (75 aa)

PFLVLENAWRVQDWSA--MREASTQAE------------PICSESYSARLNLLRGFLAL--CYPDEQRLNAVEKLVEAASIQSVKQWRR-LPHIVSNSHI
  | .| |||...|    |.|   .                ..  .. . .. ...|.|  .. ... .  ...... |   ..  |.. ||. ..|.|.
APLAAEAAWRLGQWDETYMDEYISVMKKLLGEDQLTFIDEDSPDEPTWDRSFFQAILCLYKHHNQFDTY-EAHRYIDKARQLLDTEWTACLPGESYNRHY

PLLQLSQQIIELQEATQIHSGLQSG-------SLSRQSFLNEVKTIFKTWKNRLPNH-FDDLSYWSDIFLWREQHFRSIIKAYDGTSHGEQSNQAMLAVH
|...  |...||.|. |..|.. ..       |...|  .      ..||..|||.   .... |..|. ||  .|  | ..|        ....... |
PVMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHM------RQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQRYM-------NSFCYRGPH

HLAGGITQFSSIARKQKLITVSLDSLSRIHN------------IPSVPV------------VDLFQKIRQQVKCYLMTA-STMEPSEIQEAF----DFIE
 ..  . .|....||. .  .. ..|....             .|.. .            .. ||..|....|..     .   .||. .     . |.
EDMWMWIKFANLCRKHGRMQLCEKTLKMLYTYDPSEEDWHPRAPPQWTYAYLKYMWATGQQQEAFQHLREFTSCHMQHDLGVHNNNEIN-GLTYNLEVIN

STNLKYFSKEMVS-EFLALKGTFLIQY----------GKSEEANKCFSAAVQLHDGLYK-AWALWGDFLDQLFAVDK-------------NITLAVSALT
.|||.||....   .. ...| ....           ....|...|...|..... .|| ||. |. . ...|  ..             .|...| |..
NTNLEYFYTKLLAMRCYHKQGMWQWKLYEEQYMNWNQEQKDEILQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQPQREEQNYTHMIIQHVVPAVK

CFLHACRHQSEPKSRKYLARTIW
||.|....... .||....| .|
CFFHSIALSQGSNSRQDTLRLLW

Kinase AqueK048.AA PIKK 2279-2555 23 1.8e-66 227.15 In-house 1-290 (290) Show / Hide
Range on Protein: 2279-2555
Range on HMM: 1-290/290
Sequence Identity: 23% (70 aa)

IARFMPRVEIVQKHNTTVRRLYIQGDNGKIYPYLV--LNDVQASKNRREERVLQLFRLLNYSLKKEKETCKRHLQFSVPKVVALSPQMRLLEDDVSILSL
..|||.|...|..|..  ...|| | .||.||||.  . |      |...||.|||.|.|  | |..|. ||||......|...|....|.|.  . ..|
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDL-----RQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTL

SDIFKQYCNSQNQDWDILITL---------------YYERLAALQTRGEKINLTTIKNMFSQIQMAHAPTSIIRDWAEKSCASLTDFWTLRKQITRQLAL
 .| ||.|   .   .. ..                || .... | .. .    . |      ||   | .. ..|.. .. . ...|..|.  ||..|.
KEIYKQWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAV

VGLAEFVFHLSRLDLEMFQISRSSGCLTQTFYKFEINNEGA-LDANRAVPFRLTPNIQSFLSPIGISGPLYMSMVAVARVLVQPQYSIESILLAL
.. .... .| .. .|...| ...| .    . . ..  .  |.... ||||||.|.  ...|.|..|... ....|.... |.. .. ... ..
MCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF

Kinase AqueK048.AA TRRAP 2279-2324 76 2.1e-27 94.51 In-house 1-46 (46) Show / Hide
Range on Protein: 2279-2324
Range on HMM: 1-46/46
Sequence Identity: 76% (35 aa)

IARFMPRVEIVQKHNTTVRRLYIQGDNGKIYPYLVLNDVQASKNRR
||||||||||||||||  ||||| | |||||||||.||. .   ||
IARFMPRVEIVQKHNTAARRLYIRGHNGKIYPYLVMNDICKINARR

Kinase AqueK048.AA PI3Kc 2316-2620 16 7.5e-10 -7.09 SMART 1-336 (336) Show / Hide
Range on Protein: 2316-2620
Range on HMM: 1-336/336
Sequence Identity: 16% (58 aa)

DVQASKN----RREERVLQLFRLLNYSLKKEKETCKRHLQFSVPKVVALSPQMRLLEDDVSILSLSDIFKQYCNSQNQDWDILITLYYERLAA-------
 |.  |.    |...|..|.||| |  ..|.||...|.|..  .|.....|.....|.  .  .|  | | |.  .... |. .  .  .| .       
AVIF-KCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDML-VPEIQKNM

------------LQTRGEKINLTTIKNMFSQIQMAHAPTSIIRDWAEKSCASL-TDFWTLRKQITRQLALVGLAEFVF-----HLSRLDLEM--------
               . .. .. ..| .. .. . . |  ...||  . . .   |.|. |.. ||..|    . ...     |.. . | |        
YMMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPP--VLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHI

-FQISRSSGCLTQTFYKFEINNEGALDANRAVPFRLTPNIQSFLS----PIGISGPLYMSMVAVARVLVQPQYSIESILLALFRDEF-IAWSKR-KQEEA
 |    ..|..  .|  .          . .||||||....   .    | |  |  .. .. . |.. ... .| ... .. .|.  . |..  |  . 
DFGHIFGHGPKKPGFKHH-H--------RERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKY

EGHFVSLADVSSEMVTPFVNDAVDITLTRLFNLADFETGKSQVSTLISA
...   | ..| | ..... .  .. | .  | . . . . .  ..  .
LRQRFRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY

Kinase AqueK048.AA FATC 2613-2638 42 3.9e-08 29.08 Pfam 8-33 (33) Show / Hide
Range on Protein: 2613-2638
Range on HMM: 8-33/33
Sequence Identity: 42% (11 aa)

QVSTLISAASNLDNICRMDPAWNPWL
||. ||. |.. .|.|.|.. | ||.
QVDRLIQEATDPENLCQMYIGWCPWW

Kinase AqueK048.AA PI3_PI4_kinase 2323-2386 15 1.3e-07 29.87 Pfam 13-101 (300) Show / Hide
Range on Protein: 2323-2386
Range on HMM: 13-101/300
Sequence Identity: 15% (14 aa)

R--REERVLQLF-----------------------RLLNYSLKKEKETCKRHLQFSVPKVVALSPQMRLLEDDVSILSLSDIFKQYCNS
|  ...|..|..                       || |  .||......|..|.  .......|.....|.  . .... | . |...
RCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMVK

Kinase AqueK048.AA PI3_PI4_kinase 2507-2565 16 0.001505 14.82 Pfam 223-300 (300) Show / Hide
Range on Protein: 2507-2565
Range on HMM: 223-300/300
Sequence Identity: 16% (13 aa)

RAVPFRLTP------NIQSFL------SPIGISGPLYMSMVAVARVLVQPQYSIESIL-------LALFRDEFIAWSK
..||||.|.      .... .       |.|  | .  ... . |.| ... .. . |       .....|. . |..
ERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS