Gene ATM (S.moellendorffii)

ATM

Species: S.moellendorffii
Alias: ATM
External Links:
Annotation:

Classification

Group: Atypical
Family: PIKK
Subfamily: ATM

Sequence

Name Sequence Type Origin Length Description Download
ATM.AA Protein None 734 None Fasta, JSON
ATM.NA RNA None 2205 None Fasta, JSON

Protein domain

Protein domains of ATM.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ATM.AA ATM 411-667 57 1.2e-124 400.39 In-house 1-259 (304) Show / Hide 
Range on Protein: 411-667
Range on HMM: 1-259/304
Sequence Identity: 57% (151 aa)

RQLAKSGGDDLRQDAVMEQLFGLVNTLLKDHSETRIRCLQIRTYKVVPFTPSAGALEWVNGTIPLGQYLLGSSKVPGAHTRYSVADWTFAECREHIVKES
||| | | ||||||||| | | . ||||.   ||| | | | ||||||    .| |||  |||| ...|   .   ||| ||   |.    |   ..   
RQLVK-GRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTIPIDKFLINNED--GAHKRYRPNDFSAFQCQKKMMEVQ

NKS-----AAFQTVCKNFRPVFRYFFRENFSRAADWFEKRLNYTRSVAASSMVGYVVGLGDRHSMNILIDQANADVVHIDLGVAFDQGLMLKTPETIPFR
 ||       |  ||.|| ||||||  | |   | |||||| |||||| ||.|||..||||||  ||||    |..|||||||||.|| .| ||||.|||
KKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFR

LTRDVIDGMGVTGVEGVFRRCCEATLSVLRANKEALLTIIEVFIHDPLYRWALSPLKALQRQ
||||..||||.|||||||||||| |. |.|  .| ||||.|| . |||. | . |||||  |
LTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKALYLQ
Kinase ATM.AA PIKK 380-648 35 2.6e-101 342.86 In-house 1-290 (290) Show / Hide 
Range on Protein: 380-648
Range on HMM: 1-290/290
Sequence Identity: 35% (103 aa)

YFDGFEGSITVMRGVNVPKVVLCRGSDGQKYRQLAKSGGDDLRQDAVMEQLFGLVNTLLKDHSETRIRCLQIRTYKVVPFTPSAGALEWVNGTIPLGQYL
.  ..  ..|||     ||  . ||.||  |..| | |..|||||....|||.|.||.|   .|.. | |.||||.|.| ..  | .|||... .|.  .
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCK-GHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIY

LGSSKVPGAHTRYSVAD----------------WTFAECREHI----VKESNKSAAFQTVCKN-FRPVFRYFFRENFSRAADWFEKRLNYTRSVAASSMV
    .  ..  .. . .                 .. . . ..       ..| ..|  .. | ....|...| . |. ...|.|.| |||||.| ..||
KQWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMV

GYVVGLGDRHSMNILIDQANADVVHIDLGVAFD-QGLMLKTPETIPFRLTRDVIDGMGVTGVEGVFRRCCEATLSVLRANKEALLTIIEVF
||. ||||||  ||.||. ....||||.|..|  ..  |..||..||||||. ...||..|||||||||||... ..| ..| |.|. |||
GYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase ATM.AA PI3Kc 411-717 25 4.4e-71 243.39 SMART 1-336 (336) Show / Hide 
Range on Protein: 411-717
Range on HMM: 1-336/336
Sequence Identity: 25% (90 aa)

RQLAKSGGDDLRQDAVMEQLFGLVNTLLKDHSETRIRCLQIRTYKVVPFTPSAGALEWVNGTIPLGQYLL----------------------GSSKVPGA
. . | .|||||||. | |.|.|.|....  .|.| | |..|.||..|  |  | .|||. . .| | .                       . .. . .
AVIFK-CGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQ-K-N

HTRYSVADWTFAECREHIVKES-----NKSAAFQTVCKNFRPVFRYFFRENFSRA-ADWFEKRLNYTRSVAASSMVGYVVGLGDRHSMNILIDQANADVV
  .|   .|   .|  ..  .      ..  .. ..|... ||.. .|.|.|  .  ||.| | |.|||.|. .||.|. |.||||. ||..|  .  ..
--MY-MMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCF

HIDLGVAFDQGLMLKTP-----ETIPFRLTRDVIDGMG----VTGVEGVFRRCCEATLSVLRANKEALLTIIEVFIHDPL-YRWALSPLKALQRQEYADV
|||.| .|..| .. ..     |. |||||.| ...||    ..|..| ||.||. .. ..| .........|....||.   |  .  |... .. .  
HIDFGHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM-EKDIKYLRQRFR

EDPDKVEGNKDATRALMRVKQ----KLDGYRDGENRTVEGQVQQLVQDA
.|       .    |. ...|    ||..  .... |   .. .... .
LDH------LSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase ATM.AA ATR 380-648 32 3.7e-61 207.0 In-house 2-267 (267) Show / Hide 
Range on Protein: 380-648
Range on HMM: 2-267/267
Sequence Identity: 32% (88 aa)

YFDGFEGSITVMRGVNVPKVVLCRGSDGQKYRQLAKSGGDDLRQDAVMEQLFGLVNTLLKDHSETRIRCLQIRTYKVVPFTPSAGALEWVNGTIPLGQYL
|  ||.  . ..  .  || .  .||||. |  . |   ||||.|    .   |.| ...   | | | ...||| |.|    .. .|||| |. |   |
YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKP-KDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL

LGSSKVPGAHTRYSVADWTFAECREHIVKESNKSAAF-QTVCKNFRPVFRYFFRENFSRAADWFEKRLNYTRSVAASSMVGYVVGLGDRHSMNILIDQAN
    |.      |.          .   .|..|  .| . .     |.|. .|   |  . .|.  | || || |. .||||..||||||. |||||. |
---DKLWKEKKQYMQFYQLRQCMDKKSREEWEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKIN

ADVVHIDLGVAFDQGLMLKTPETIPFRLTRDVIDGMGVTGVEGVFRRCCEATLSVLRANKEALLTIIEVF
 ..||.|  . | .|  .. ||..|||||. .. |||  . .|.||| || .. ..| ... .. ... |
GECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF
Kinase ATM.AA FRAP 541-658 47 5.9e-42 145.7 In-house 133-251 (251) Show / Hide 
Range on Protein: 541-658
Range on HMM: 133-251/251
Sequence Identity: 47% (56 aa)

WFEKRLNYTRSVAASSMVGYVVGLGDRHSMNILIDQANADVVHIDLGVAFDQGLML-KTPETIPFRLTRDVIDGMGVTGVEGVFRRCCEATLSVLRANKE
|||.| ||||| |  ||.||. ||||||  ||...     .|||| |  |.  .   | || |||||||  .  | ..|.|| .|  ||  . |.| .||
WFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIEGNYRNTCELVMKVIREHKE

ALLTIIEVFIHDPLYRWAL
 .. ..| |. |||. | |
SVMAVLEAFVYDPLFYWRL
Kinase ATM.AA PI3_PI4_kinase 520-658 27 1.6e-41 149.03 Pfam 138-300 (300) Show / Hide 
Range on Protein: 520-658
Range on HMM: 138-300/300
Sequence Identity: 27% (45 aa)

CKNFRPVFRYFFRENFSRA-ADWFEKRLNYTRSVAASSMVGYVVGLGDRHSMNILI--DQANADVVHIDLGVAFD--QGLMLKTPETIPFRLTR------
.|...|... .|....  |  .|.| | |..||.|  ..|.|. |.||||. ||..  |  .  ..||| | .|.  ..  .. ||..|||.|.      
MKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKK

DVIDGM------GVTGVEGVFRRCCEATLSVLRANKEALLTII-------EVFIHDPLYRWAL
. ...|      ...| .| ||..|. .. .|| ....... .       | ..||.| .|  
PMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS
Kinase ATM.AA DNAPK 559-658 31 6.6e-21 72.68 In-house 201-301 (301) Show / Hide 
Range on Protein: 559-658
Range on HMM: 201-301/301
Sequence Identity: 31% (32 aa)

GYVVGLGDRHSMNILIDQANADVVHIDLGVAFD-QGLMLKTPETIPFRLTRDVIDGMGVTGVEGVFRRCCEATLSVLRANKEALLTIIEVFIHDPLYRWA
... | ||||  | ..   | |.. || | .|   .. |  ||  ||||||  |  |   .. |...      .  .|  .  |.  ..||| ||.  | 
HWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFDWK

L
 
N
Kinase ATM.AA SMG1 540-600 49 1.1e-19 61.74 In-house 182-242 (242) Show / Hide 
Range on Protein: 540-600
Range on HMM: 182-242/242
Sequence Identity: 49% (30 aa)

DWFEKRLNYTRSVAASSMVGYVVGLGDRHSMNILIDQANADVVHIDLGVAFDQGLMLKTPE
.|.     | || |  |||||..||||||  |.|||    .|||||  . |..|  |. ||
EWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE
Kinase ATM.AA DNAPK 381-480 37 1.1e-17 60.85 In-house 4-102 (301) Show / Hide 
Range on Protein: 381-480
Range on HMM: 4-102/301
Sequence Identity: 37% (37 aa)

FDGFEGSITVMRGVNVPKVVLCRGSDGQKYRQLAKSGGDDLRQDAVMEQLFGLVNTLLKDHSETRIRCLQIRTYKVVPFTPSAGALEWVNGTIPLGQYLL
  ||.  .|||  .  || .. || |      . | |. |||||   ||||   |  .   .    | || ||| ..| |   | .|||. |  |   |.
IAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYK-GIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDILN
Kinase ATM.AA FATC 702-734 51 8.3e-17 56.88 Pfam 1-33 (33) Show / Hide 
Range on Protein: 702-734
Range on HMM: 1-33/33
Sequence Identity: 51% (17 aa)

ENRTVEGQVQQLVQDAQDPENLCLLFPGWAAWL
|. .||.||..|.|.| |||||| ...||..|.
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW
Kinase ATM.AA PI3_PI4_kinase 415-475 25 4.7e-15 57.37 Pfam 1-91 (300) Show / Hide 
Range on Protein: 415-475
Range on HMM: 1-91/300
Sequence Identity: 25% (23 aa)

KS-----GGDDLR--QDAVMEQLF-----------------------GLVNTLLKDHSETRIRCLQIRTYKVVPFTPSAGALEWVNGTIPL
 .     ||||||  ||. |.|..                       .|.|...| ....| | .|...|...|  |  | .|||. . ..
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTF
Kinase ATM.AA FRAP 409-470 40 4e-12 40.97 In-house 1-61 (251) Show / Hide 
Range on Protein: 409-470
Range on HMM: 1-61/251
Sequence Identity: 40% (25 aa)

KYRQLAKSGGDDLRQDAVMEQLFGLVNTLLKDHSETRIRCLQIRTYKVVPFTPSAGALEWVN
 |  | | | .|.|||    |||||.|.||.   ||. . | |. | ..|    .| . ||.
EYHFLLK-GHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVH
Kinase ATM.AA SMG1 388-475 34 4.6e-09 26.02 In-house 1-87 (242) Show / Hide 
Range on Protein: 388-475
Range on HMM: 1-87/242
Sequence Identity: 34% (30 aa)

ITVMRGVNVPKVVLCRGSDGQKYRQLAKSGGDDLRQDAVMEQLFGLVNTLLKDHSETRIRCLQIRTYKVVPFTPSAGALEWVNGTIPL
||..     || .|  ||||. |  | | | .||  |  . |   .|||.              | | | |    .| . || |  ||
ITILPTKTKPKKLLFLGSDGKSYPYLFK-GLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPL
Kinase ATM.AA ATM 681-694 57 0.040694 2.1 In-house 291-304 (304) Show / Hide 
Range on Protein: 681-694
Range on HMM: 291-304/304
Sequence Identity: 57% (8 aa)

NKDATRALMRVKQK
|| | | |||.. |
NKVAERVLMRLQEK