ATR

Species: S.moellendorffii
Alias: ATR
External Links:
Annotation:

Classification

Group: Atypical
Family: PIKK
Subfamily: ATR

Sequence

Name Sequence Type Origin Length Description Download
ATR.AA Protein None 1990 None Fasta, JSON
ATR.NA RNA None 5973 None Fasta, JSON

Protein domain

Protein domains of ATR.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
UME ATR.AA UME 399-502 24 3.7e-27 93.95 Pfam 1-112 (112) Show / Hide
Range on Protein: 399-502
Range on HMM: 1-112/112
Sequence Identity: 24% (28 aa)

LPSFLRQHFVRLLNNIDRKLLR---SEDVQMQKQALRCIERLLE-MIGSHLSAFIPKIMALLS---QPQ--DLQYESLSVWLSFVKRLAQVSPANLKTVA
.. ||..||. ... .. ...    . ... .|...| ||.... |.| |.|.. |.|||.|    . .  .|.|.....|  |...|. | |. |....
MADFLQDHFLGIITRFSMVMHDFQGRQPYFEKKRCIRSIEEMIKYMCGKHISSARPQIMACLQSALEIPEEELRYHCFRCWHVFIQTLDEV-PEHLGPLI

SQIVVALMPCLES
.|..|.. | ...
DQTFVIIIPYWDT

UME ATR.AA UME 399-502 26 1.7e-25 91.95 SMART 1-115 (115) Show / Hide
Range on Protein: 399-502
Range on HMM: 1-115/115
Sequence Identity: 26% (31 aa)

LPSFLRQHFVRLLNNIDRKLLRSE---DVQMQKQALRCIERLLE-MIGSHLSAFIPK---IMALLSQ---PQDLQYESLSVWLSFVKRLAQVSPAN-LKT
.. || .||. .......... |.   ... .|.||| ||.... |.| |.|.| |.   |||.|       .|.......| .|.|.|. ||..  ...
FADFLQDHFLGIMQWFNMIMHDSHGKKPYYEKKRALRSIEFMIKYMMGKHISSFRPQIIQIMACLQTALEIPELRHHCCRCWHCFIKHLNEVSCEHYIGP

VASQIVVALMPCLES
. .||.... | ...
LIDQIFAIILPYWPT

TPR_1 ATR.AA TPR_1 1012-1031 45 0.001915 16.01 Pfam 15-34 (34) Show / Hide
Range on Protein: 1012-1031
Range on HMM: 15-34/34
Sequence Identity: 45% (9 aa)

GNWAEALTFCEQALELEPKS
||. ||. ....||||.|. 
GNYDEAIECYQKALELNPNN

TPR_2 ATR.AA TPR_2 1012-1031 40 0.003655 15.28 Pfam 15-34 (34) Show / Hide
Range on Protein: 1012-1031
Range on HMM: 15-34/34
Sequence Identity: 40% (8 aa)

GNWAEALTFCEQALELEPKS
|...||. ..|.||.|.|. 
GDYDEAIEYYEKALKLDPNN

FAT ATR.AA FAT 1070-1432 18 3.6e-54 181.59 Pfam 1-408 (408) Show / Hide
Range on Protein: 1070-1432
Range on HMM: 1-408/408
Sequence Identity: 18% (79 aa)

YMRGVQAAWRLGQWDL--INEYVHGSE-LEAGSTE------SDSA----FDLSLAKVLQTL--RSKDQV--KFQEQLTHARLALLAPLAA-ASMESYVRA
   ...|||||||||.  . ||.     |. |  .      .||     .| |. . .. |  . ...    ....   ||  |.  ..|  ..||| |.
APLAAEAAWRLGQWDETYMDEYISVMKKLL-GE-DQLTFIDEDSPDEPTWDRSFFQAILCLYKHHNQFDTYEAHRYIDKARQLLDTEWTACLPGESYNRH

YPVIVKLHMLRELEDFF---SLADKG--------GDNKDQLFENWNGRLKMT-LPSLSTREPILALRRLLFS----------VCDLQSEMGGCWLQYAKL
|||.|...|| |||..    | .. .         .. ......|. ||...  . ..  ..||..|.. ||           ... .|   .|...|.|
YPVMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQRYMNSFCYRGPHEDMWMWIKFANL

CRTSGHYETANRAILQAQAAG----------APNAHRERAKLFWDMKKTHRAIDELQQVLVNVPLSVLGTASGAALSGLVLNTSQTESALELTV-EEQVC
|| .|... . ......              .|. . ...|..|. .. . |. .|.. . .   . ||... . ..   .    . .  . |  |..  
CRKHGRMQLCEKTLKMLYTYDPSEEDWHPRAPPQWTYAYLKYMWATGQQQEAFQHLREFTSCHMQHDLGVHNNNEIN-GLTY---NLEVINNTNLEYFYT

NDAA-KTLLLLGRWAHCT--------GQKQKEDVISIYTRVKDLQPMWEK-GYFYMARYYDDLLVDARKRQEENKEHRSNTTKRGSNADDKP---WWTYL
   | .  ...|.| .          .|.||....  | ..  . |.|.|  ....|.|.. ..   .....  ..               .    ....
KLLAMRCYHKQGMWQWKLYEEQYMNWNQEQKDEILQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQPQREEQN--------------YTHMIIQHV

PDTVLCYAKTLHRSHH-HLFQALPRLLT
   | |. . .. |.  . .| ..|||.
VPAVKCFFHSIALSQGSNSRQDTLRLLW

TPR_2 ATR.AA TPR_2 1252-1285 14 0.393404 8.09 Pfam 1-34 (34) Show / Hide
Range on Protein: 1252-1285
Range on HMM: 1-34/34
Sequence Identity: 14% (5 aa)

PNAHRERAKLFWDMKKTHRAIDELQQVLVNVPLS
. |.. .... . ...  .||. ....|   |  
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN

TPR_1 ATR.AA TPR_1 1252-1279 21 9.499493 3.11 Pfam 1-28 (34) Show / Hide
Range on Protein: 1252-1279
Range on HMM: 1-28/34
Sequence Identity: 21% (6 aa)

PNAHRERAKLFWDMKKTHRAIDELQQVL
..|.  .. ..  |..   ||. .|..|
AEAWYNLGNCYYKMGNYDEAIECYQKAL

FATC ATR.AA FATC 1309-1317 55 15.636119 1.5 Pfam 1-9 (33) Show / Hide
Range on Protein: 1309-1317
Range on HMM: 1-9/33
Sequence Identity: 55% (5 aa)

LELTVEEQV
..|.||.||
EPLSVEQQV

Kinase ATR.AA ATR 1626-1894 44 4.8e-104 351.96 In-house 1-267 (267) Show / Hide
Range on Protein: 1626-1894
Range on HMM: 1-267/267
Sequence Identity: 44% (121 aa)

STIFAIRDDVEILVSLQRPKKVVLVASDGTEHPFLCKPKDDLRKDARMMEFTGMINRLLSKDPSSRRRKLYIRTFAVIPLTEDCGMVEWVSHTRGLRHIL
. |  . | |||| |||.|||. |  |||  .  .|||||||||| | |.|  .||... ||  .||| . .||.||||| ..|...|||  | .|| ||
AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL

QDLYVSAGMFTKETNPTIKRIYEDNKDKKISATELMRDKILPMFPPVFHKWFLNTFPEPTAWFQSRLAYAHTTAVWSMVGHIVGLGDRHGENILYDSTTG
. |.   ..  . .   ...  .    ..      .|. .||  ||.|| ||. .||.|. |. || .|  ..|||.||| |.||||||..||| |. .|
DKLWKEKKQ--YMQFYQLRQCMDKKSREEWEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKING

DCVHVDFSCLFDKGLQLEKPELVPFRLTQNMVDGLGITGYEGVFLRTCEITLSVLRANRETLMSVLETF
.|||||. |.| .| |.| ||.||||||.||| |.|  . .|.| | || .. ..| .|. .|||...|
ECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF

Kinase ATR.AA PI3Kc 1658-1979 24 6.9e-84 285.91 SMART 1-336 (336) Show / Hide
Range on Protein: 1658-1979
Range on HMM: 1-336/336
Sequence Identity: 24% (88 aa)

PFLCKPKDDLRKDARMMEFTGMINRLLSKDPSSRRRKLYIRTFAVIPLTEDCGMVEWVSHTRGLRHILQDLYVSAG---------MFTKET------NPT
....|..||||.|.|||.. ...|....||  .|||.|..|....||. ..|||.|||...  |. |.  ..  ..         || ...       . 
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMY-

IKRIYEDNKDKKISAT--------ELMRDKILPMFPPVFHKWFLNTFPEP-TAWFQSRLAYAHTTAVWSMVGHIVGLGDRHGENILYDSTTGDCVHVDFS
   . .. ........        .... .. | .|||...||...||.|  .|...|  ... .|...||..| |.||||..||. | .|| |.|.|| 
MMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFG

CLFDKGLQLEKP-----ELVPFRLTQNMVDGLG----ITGYEGVFLRTCEITLSVLRANRETLMSVLETFIHDPL-VEWTKSHKSSATEVQNPHAQVTGP
..|..|  ....     |.||||||..||.. |    ..||.| | ..|. .. ..| .....|...|....||.  .|...                  
HIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM------------------

FGLCIGTDWAFQRALANIEARLRGV-VVGVAAAPS---------LPLSVEGQAHRLIQEAVSHENL
           . .......|.|   .    ||.          .. |.|.. .|.....    ..
-----------EKDIKYLRQRFRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY

Kinase ATR.AA PI3_PI4_kinase 1656-1904 26 1.6e-77 268.69 Pfam 1-300 (300) Show / Hide
Range on Protein: 1656-1904
Range on HMM: 1-300/300
Sequence Identity: 26% (80 aa)

EHPFLCKPKDDLR--KDARMMEFT-----------------------GMINRLLSKDPSSRRRKLYIRTFAVIPLTEDCGMVEWVSHTRGLRHILQDLYV
..||..| .||||  .|.|||..                        ...|....||  .|||.. .... .||. ..|||.||| .. ....|.   .|
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

SAGMFT--KETNPTIKRIYEDNKDKKISATELMRDKILPMFPPVFHKWFLNTFPEP-TAWFQSRLAYAHTTAVWSMVGHIVGLGDRHGENILY--DSTTG
. ..    || .  .|. ..   ....  .|. . .| . ..|....||. ..|.. ..|...|  ..   |....|..| |.||||..||.   | |||
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG

DCVHVDFSCLFD--KGLQLEKPELVPFRLTQ------NMVDGL------GITGYEGVFLRTCEITLSVLRANRETLMSVL-------ETFIHDPLVEWTK
 ..|.|| . |.  |.  ..|||.||||.|.      .||...      . .|..| | ..|. .. .|| . . .|..|       |...||.|..|..
HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS





Kinase ATR.AA PIKK 1759-1894 48 2.2e-64 220.18 In-house 154-290 (290) Show / Hide
Range on Protein: 1759-1894
Range on HMM: 154-290/290
Sequence Identity: 48% (67 aa)

ELMRDKILPMFPPVFHKWFLNTFPEPTAWFQSRLAYAHTTAVWSMVGHIVGLGDRHGENILYDSTTGDCVHVDFSCLFD-KGLQLEKPELVPFRLTQNMV
|. |.   . .|..|.|||. .|| |..|. .| .|. ..||..||| | ||||||.|||. |..||..||.|| |.|  ..  |. ||.||||||.|||
EVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMV

DGLGITGYEGVFLRTCEITLSVLRANRETLMSVLETF
...|..| |||| |.|| .. ..| .|||||.|.|.|
NAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF

Kinase ATR.AA ATM 1769-1903 48 6.1e-49 154.31 In-house 115-249 (304) Show / Hide
Range on Protein: 1769-1903
Range on HMM: 115-249/304
Sequence Identity: 48% (66 aa)

FPPVFHKWFLNTFPEPTAWFQSRLAYAHTTAVWSMVGHIVGLGDRHGENILYDSTTGDCVHVDFSCLFDKGLQLEKPELVPFRLTQNMVDGLGITGYEGV
| |||  . .  | .|  ||  ||||    |  |.|| |.||||||  |||      . ||.|    |..|  |  || ||||||  .|||.|||| |||
FQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGV

FLRTCEITLSVLRANRETLMSVLETFIHDPLVEWT
| | || |. |.|   |||. . |  . ||| .||
FRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWT

Kinase ATR.AA PIKK 1627-1729 37 9.6e-41 141.68 In-house 1-103 (290) Show / Hide
Range on Protein: 1627-1729
Range on HMM: 1-103/290
Sequence Identity: 37% (39 aa)

TIFAIRDDVEILVSLQRPKKVVLVASDGTEHPFLCKPKDDLRKDARMMEFTGMINRLLSKDPSSRRRKLYIRTFAVIPLTEDCGMVEWVSHTRGLRHILQ
 |  . . |... ..|.||| ..  .|| |.|.|||...|||.|.|.|.. ...|..| ||| ...|.| |||..|||..  || .||| .. .|. |. 
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

DLY
...
QWC

Kinase ATR.AA FRAP 1787-1904 43 2.5e-34 120.39 In-house 133-251 (251) Show / Hide
Range on Protein: 1787-1904
Range on HMM: 133-251/251
Sequence Identity: 43% (52 aa)

WFQSRLAYAHTTAVWSMVGHIVGLGDRHGENILYDSTTGDCVHVDFSCLFDKGLQLEK-PELVPFRLTQNMVDGLGITGYEGVFLRTCEITLSVLRANRE
||. |  |    |. ||.| | ||||||  ||. .  ||  ||.||   |.  .. || ||..|||||  .|  . ..| || .  |||. . |.| ..|
WFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIEGNYRNTCELVMKVIREHKE

TLMSVLETFIHDPLVEWTK
 .| ||| |. |||  |  
SVMAVLEAFVYDPLFYWRL

Kinase ATR.AA SMG1 1784-1846 52 2.1e-21 67.54 In-house 180-242 (242) Show / Hide
Range on Protein: 1784-1846
Range on HMM: 180-242/242
Sequence Identity: 52% (33 aa)

PTAWFQSRLAYAHTTAVWSMVGHIVGLGDRHGENILYDSTTGDCVHVDFSCLFDKGLQLEKPE
|  |.    .||  ||| |||| |.|||||| .|.| | |||. ||.|.   |.||  |  ||
PDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE

Kinase ATR.AA FATC 1958-1990 60 7.4e-20 66.65 Pfam 1-33 (33) Show / Hide
Range on Protein: 1958-1990
Range on HMM: 1-33/33
Sequence Identity: 60% (20 aa)

LPLSVEGQAHRLIQEAVSHENLGHMYVWWMPWF
.|||||.|. ||||||...||| .||..|.||.
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW

Kinase ATR.AA DNAPK 1627-1725 36 1.3e-18 64.18 In-house 3-101 (301) Show / Hide
Range on Protein: 1627-1725
Range on HMM: 3-101/301
Sequence Identity: 36% (36 aa)

TIFAIRDDVEILVSLQRPKKVVLVASDGTEHPFLCKPKDDLRKDARMMEFTGMINRLLSKDPSSRRRKLYIRTFAVIPLTEDCGMVEWVSHTRGLRHIL
 |    . | .. || |||....   |  ||||. |   ||| | |        |  .  ||    | |  ||. .||.|   |..|||  |  |. ||
RIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDIL

Kinase ATR.AA FRAP 1656-1717 40 4.3e-17 59.45 In-house 1-62 (251) Show / Hide
Range on Protein: 1656-1717
Range on HMM: 1-62/251
Sequence Identity: 40% (25 aa)

EHPFLCKPKDDLRKDARMMEFTGMINRLLSKDPSSRRRKLYIRTFAVIPLTEDCGMVEWVSH
|. || | ..|.| | | |   |.|||||  .| .... | |. ...|||  . |.. || |
EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHH

Kinase ATR.AA DNAPK 1805-1904 29 1.4e-16 56.66 In-house 201-301 (301) Show / Hide
Range on Protein: 1805-1904
Range on HMM: 201-301/301
Sequence Identity: 29% (30 aa)

GHIVGLGDRHGENILYDSTTGDCVHVDFSCLFD-KGLQLEKPELVPFRLTQNMVDGLGITGYEGVFLRTCEITLSVLRANRETLMSVLETFIHDPLVEWT
. | | |||| .| .    .|| . .||   |   .. |  ||| |||||   .  .   .  |..       .  .|  |  |.   . || ||.. | 
HWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFDWK

K
.
N

Kinase ATR.AA ATM 1660-1714 45 7.7e-14 40.2 In-house 3-57 (304) Show / Hide
Range on Protein: 1660-1714
Range on HMM: 3-57/304
Sequence Identity: 45% (25 aa)

LCKPKDDLRKDARMMEFTGMINRLLSKDPSSRRRKLYIRTFAVIPLTEDCGMVEW
| | .||||.|| |     | | || .    |.||| | |. |.||    |..||
LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEW

Kinase ATR.AA SMG1 1635-1715 30 4.8e-11 32.67 In-house 1-81 (242) Show / Hide
Range on Protein: 1635-1715
Range on HMM: 1-81/242
Sequence Identity: 30% (25 aa)

VEILVSLQRPKKVVLVASDGTEHPFLCKPKDDLRKDARMMEFTGMINRLLSKDPSSRRRKLYIRTFAVIPLTEDCGMVEWV
. ||    .|||.. . |||   |.| |  .||  | |.| |  ..| .          .   | ..| ||    |.. ||
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWV