CaMKII_Dmel MAA---------PAACTRFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLT
CaMK2g_Mmus MAT---------TATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLS
CaMK2d_Mmus MAS---------TTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLS
CaMK2b_Mmus MAT---------TVTCTRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLS
CaMK2a_Mmus MAT----------ITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLS
CaMK2a_Hsap MAT----------ITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLS
CaMK2b_Hsap MAT---------TVTCTRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLS
CaMK2d_Hsap MAS---------TTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLS
CaMK2g_Hsap MAT---------TATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLS
unc-43_Cele MMN-----------ASTKFSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLS
CAMK2_Spur ------------------------------------------------------------
AqueK055_Aque MTG---------IKEDKAFSEQFEVKEDLGKGAFSIVRKVVHTSSGVDYAAKIINTKRLS
AqueK056_Aque MWIKIAFMGVVCPGKEKIFSELYDLKEDLGKGAFSIVKKCIGREDKIEYAAKIINKKRLT
CaMKII_Dmel ARDFQKLEREARICRKLHHPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEA
CaMK2g_Mmus ARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEA
CaMK2d_Mmus ARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEA
CaMK2b_Mmus ARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEA
CaMK2a_Mmus ARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEA
CaMK2a_Hsap ARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEA
CaMK2b_Hsap ARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEA
CaMK2d_Hsap ARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEA
CaMK2g_Hsap ARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEA
unc-43_Cele ARDFQKLEREARICRKLQHPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEA
CAMK2_Spur --------------------NVVRLHDSIAEEGFHYLVFDLVTGGELFEDIVAREYYSEA
AqueK055_Aque ARDLQKLEREVKICRMLQHNNIVRLHNVFQEGHVRYMIFDLITGGELFDDIVAREFYSEK
AqueK056_Aque GRDISKLQKEEKICRQLQHPNIVLLHDVISESFTHYLVFELITGGELFDEIVAREYYSES
*:* **: : * :*::*:*:******::*****:***
CaMKII_Dmel DASHCIQQILESVNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQG-DHQA
CaMK2g_Mmus DASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQG-EQQA
CaMK2d_Mmus DASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQG-DQQA
CaMK2b_Mmus DASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQG-DQQA
CaMK2a_Mmus DASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEG-EQQA
CaMK2a_Hsap DASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEG-EQQA
CaMK2b_Hsap DASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQG-DQQA
CaMK2d_Hsap DASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQG-DQQA
CaMK2g_Hsap DASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQG-EQQA
unc-43_Cele DASHCIQQILESIAYCHSNGIVHRDLKPENLLLASKAKGAAVKLADFGLAIEVN--DSEA
CAMK2_Spur DASHCIQQILESVEHCHKNLIVHRDLKPENLLLASKLKGAAVKLADFGLAIELDN-GE-Q
AqueK055_Aque DASSCIQQILDSVSYCHKMGIIHRDIKPENLLLSSKKPGASVKLADFGLAVETEK--KKH
AqueK056_Aque DASHCVQQILDGIAYCHRMGIMHRDLKPENLLLASRAKNAAVKLADFGLAVQLETPDQVE
*** *::***:.: : * ::***:*******:*: .*:*********:: :
CaMKII_Dmel WFGFAGTPGYLSPEVLKKEPYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGA
CaMK2g_Mmus WFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGA
CaMK2d_Mmus WFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGA
CaMK2b_Mmus WFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGA
CaMK2a_Mmus WFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGA
CaMK2a_Hsap WFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGA
CaMK2b_Hsap WFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGA
CaMK2d_Hsap WFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGA
CaMK2g_Hsap WFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGA
unc-43_Cele WHGFAGTPGYLSPEVLKKDPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGA
CAMK2_Spur WYGFAGTPGYLSPEVLRKDPYGKPVDIWACGLFLFIKFVGFPCLWCEDQQLLYHQAITGL
AqueK055_Aque YYGFAGTPGYLSPEVLRKEPYDKAVDLWACGVVLYILLVGYPPFWDDDQSKMFEQIKQGR
AqueK056_Aque WHGFAGTPGYLSPEVIKREAYGKAVDVWACGVILYILLVGYPPFWDEDQKRLYAQIKMGR
:.*************::::.*.*.**:****:.*:* :**:* :* :** :: * *
CaMKII_Dmel YDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKHPWICQRERVASVVHRQETVDC
CaMK2g_Mmus YDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVEC
CaMK2d_Mmus YDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDC
CaMK2b_Mmus YDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVEC
CaMK2a_Mmus YDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDC
CaMK2a_Hsap YDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDC
CaMK2b_Hsap YDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVEC
CaMK2d_Hsap YDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDC
CaMK2g_Hsap YDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVEC
unc-43_Cele YDYPSPEWDTVTPEAKSLIDSMLTVNPKKRITADQALKVPWICNRERVASAIHRQDTVDC
CAMK2_Spur WQYPSPEWDTVTPEAKNLIDSMLTVNPGKRISACQALKHPWIQNRDRYASAMHRQETVDC
AqueK055_Aque YEYLSPEWDSVTDEVKKLIDGMLTMDPDKRITAEQALSHPWIKNRDKVASMMHRQETIAG
AqueK056_Aque YSFPSPEWDSVTKEVKELISLMLNANPKKRIKAEEALRNPWICKRTEVASNIHRQATIAG
:.: *****:** *.*.**. **. :* ***.* :** **: :* ** :*** *:
CaMKII_Dmel LKKFNARRKLKGAILTTMLATRNFSKF---------------------------------
CaMK2g_Mmus LRKFNARRKLKGAILTTMLVSRNFSVGRQSSAPASPAASAAGLA----------------
CaMK2d_Mmus LKKFNARRKLKGAILTTMLATRNFSAA---------------------------------
CaMK2b_Mmus LKKFNARRKLKGAILTTMLATRNFSVGRQTTAPATMSTAASGTTMG--------------
CaMK2a_Mmus LKKFNARRKLKGAILTTMLATRNFSGG---------------------------------
CaMK2a_Hsap LKKFNARRKLKGAILTTMLATRNFSGG---------------------------------
CaMK2b_Hsap LKKFNARRKLKGAILTTMLATRNFSVGRQTTAPATMSTAASGTTMG--------------
CaMK2d_Hsap LKKFNARRKLKGAILTTMLATRNFSAA---------------------------------
CaMK2g_Hsap LRKFNARRKLKGAILTTMLVSRNFSVGRQSSAPASPAASAAGLA----------------
unc-43_Cele LKKFNARRKLKGAILTTMIATRNLSSKRSYRL--TLGAEKLVISMKNIEYWQVLLNKIFA
CAMK2_Spur LKKFNARRKLK-------------------------------------------------
AqueK055_Aque LKRFNARRKLKAAMHTAMIISRRSSAFIRPT-----------------------------
AqueK056_Aque LKRFNARRKLKGAFLTSLIAVRTHNAA---------------------------------
*::********
CaMKII_Dmel -------TGRSMITKKGEG-SQ--------------------------------------
CaMK2g_Mmus -----GQAAKSLLNKKSDGGVKKRKSSSSVHLMPQSNNKNSLVSPAQEPAPLQTAMEPQT
CaMK2d_Mmus ---------KSLL-KKPDG-VKINNKAN-------------VVTSPKENIP-TPALEPQT
CaMK2b_Mmus ----LVEQAKSLLNKKADG-VKPQTNSTK--------N-SSAITSPKGSLP-PAALEPQT
CaMK2a_Mmus ---------KSGGNKKNDG-VKKRKSSS-------------SV-----------------
CaMK2a_Hsap ---------KSGGNKKSDG-VKKRKSSS-------------SV-----------------
CaMK2b_Hsap ----LVEQAKSLLNKKADG-VKPQTNSTK--------N-SAAATSPKGTLP-PAALEPQT
CaMK2d_Hsap ---------KSLL-KKPDG-VKINNKAN-------------VVTSPKENIP-TPALEPQT
CaMK2g_Hsap -----GQAAKSLLNKKSDGGVKKRKSSSSVHLMPQSNNKNSLVSPAQEPAPLQTAMEPQT
unc-43_Cele TYKIKMKQCRNLLNKKEQG-PP--------------------------------------
CAMK2_Spur ------------------------------------------------------------
AqueK055_Aque ------------------G-SPS-TSS------------SNLASPPTNP-----------
AqueK056_Aque ---------TFALKKKEPE-VKPQSD---------------VVSSTVPEI----------
CaMKII_Dmel ---------VKESTDSSSTTLEDDDIK-A-------------------------------
CaMK2g_Mmus TVVHNATDGIKGSTESCNTTTEDEDLK-AAPL-------RTGNGSLVPEGRSPRDRT---
CaMK2d_Mmus TVIHNP-DGNKESTESSNTTIEDEDVK---------------------------------
CaMK2b_Mmus TVIHNPVDGIKESSDSTNTTIEDEDAK-APRVPDVLSLVRRASGAPEAEGPLSCQSPVPI
CaMK2a_Mmus --------QLMESSESTNTTIEDEDTK---------------------------------
CaMK2a_Hsap --------QLMESSESTNTTIEDEDTK---------------------------------
CaMK2b_Hsap TVIHNPVDGIKESSDSANTTIEDEDAK-APRVPDILSSVRRGSGAPEAEGPLPCPSPAPF
CaMK2d_Hsap TVIHNP-DGNKESTESSNTTIEDEDVK---------------------------------
CaMK2g_Hsap TVVHNATDGIKGSTESCNTTTEDEDLK-AAPL-------RTGNGSSVPEGRSSRDRT---
unc-43_Cele -------STIKESSESSQT-IDDNDSEKGGGQLKHENTVVRADG------ATGIVSS---
CAMK2_Spur ------------------------------------------------------------
AqueK055_Aque ---------------ENLTLIEEADTC-ATPT---------SNATL--------------
AqueK056_Aque ------------------PVAED-------------------------------------
CaMKII_Dmel ------------------------------------------------------------
CaMK2g_Mmus ------------------------------------------------------------
CaMK2d_Mmus ------------------------------------------------------------
CaMK2b_Mmus SPLPTPSPRISDILNSVRRGCGTPEAEGPLSVGPPPCLSPGLLGPLPTPSPRISDILNSV
CaMK2a_Mmus ------------------------------------------------------------
CaMK2a_Hsap ------------------------------------------------------------
CaMK2b_Hsap SPLPAPSPRISDILNSVRRGSGTPEAEGPLSAGPPPCLSPALLGPLSSPSPRISDILNSV
CaMK2d_Hsap ------------------------------------------------------------
CaMK2g_Hsap ------------------------------------------------------------
unc-43_Cele ------------------------------------------------------------
CAMK2_Spur ------------------------------------------------------------
AqueK055_Aque ------------------------------------------------------------
AqueK056_Aque ------------------------------------------------------------
CaMKII_Dmel --------------------------------ARRQEIIKITEQLIEAINSGDFDGYTKI
CaMK2g_Mmus ----------------APSAGMQPQPSLCSSAMRKQEIIKITEQLIEAINNGDFEAYTKI
CaMK2d_Mmus --------------------------------ARKQEIIKVTEQLIEAINNGDFEAYTKI
CaMK2b_Mmus RRGSGTPEAEGLPPVGPPPCPSPTLPGPLPTPSRKQEIIKTTEQLIEAVNNGDFEAYAKI
CaMK2a_Mmus --------------------------------VRKQEIIKVTEQLIEAISNGDFESYTKM
CaMK2a_Hsap --------------------------------VRKQEIIKVTEQLIEAISNGDFESYTKM
CaMK2b_Hsap RRGSGTPEAEGPSPVGPPPCPSPTIPGPLPTPSRKQEIIKTTEQLIEAVNNGDFEAYAKI
CaMK2d_Hsap --------------------------------ARKQEIIKVTEQLIEAINNGDFEAYTKI
CaMK2g_Hsap ----------------APSAGMQPQPSLCSSAMRKQEIIKITEQLIEAINNGDFEAYTKI
unc-43_Cele ----------------SN-SSTASKSSSTNLSAQKQDIVRVTQTLLDAISCKDFETYTRL
CAMK2_Spur ------------------------------------------------------------
AqueK055_Aque -------------------LPSNPDSNGGQYSPEEKEIIDITQLLLNSIGQKDFADYSKR
AqueK056_Aque --------------------------------ETTDEVMKAQQALLMAIRCRDYEAYQKL
CaMKII_Dmel CDPHLTAFEPEALGNLVEGIDFHKFYFENVLGKNCKAINTTILNPHVHLLGEEAACIAYV
CaMK2g_Mmus CDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYI
CaMK2d_Mmus CDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIAYI
CaMK2b_Mmus CDPGLTSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHTTILNPHVHVIGEDAACIAYI
CaMK2a_Mmus CDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYI
CaMK2a_Hsap CDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYI
CaMK2b_Hsap CDPGLTSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHTTILNPHVHVIGEDAACIAYI
CaMK2d_Hsap CDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIAYI
CaMK2g_Hsap CDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYI
unc-43_Cele CDTSMTCFEPEALGNLIEGIEFHRFYFDGN---RKNQVHTTMLNPNVHIIGEDAACVAYV
CAMK2_Spur ------------------------------------------------------------
AqueK055_Aque CSEGMTSFEPEACSQMVTGLDFHKFYFDNMK--ANTPTQNNILKPKVHMLSEGVACIAYT
AqueK056_Aque CDSQVLSFLSTGGCRLLTGVEHHNFFFANVPPYPAE--NITMIEPHVQFLGDNAAYICYV
CaMKII_Dmel RLTQYIDKQGHAHTHQSEETRVWHKRDNKWQNVHFHRSASAKISGATTFDFIPQ------
CaMK2g_Mmus RLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAPA---------APL------
CaMK2d_Mmus RLTQYMDGSGMPKTMQSEETRVWHRRDGKWQNVHFHRSGSPT---------VPIKPPCIP
CaMK2b_Mmus RLTQYIDGQGRPRTSQSEETRVWHRRDGKWQNVHFHCSGAPV---------APL------
CaMK2a_Mmus RITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPS---------VLP------
CaMK2a_Hsap RITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPS---------VLP------
CaMK2b_Hsap RLTQYIDGQGRPRTSQSEETRVWHRRDGKWQNVHFHCSGAPV---------APL------
CaMK2d_Hsap RLTQYMDGSGMPKTMQSEETRVWHRRDGKWQNVHFHRSGSPT---------VPIKPPCIP
CaMK2g_Hsap RLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAPA---------APL------
unc-43_Cele KLTQFLDRNGEAHTRQSQESRVWSKKQGRWVCVHVHRSTQPSTN--T---TVSE------
CAMK2_Spur ------------------------------------------------------------
AqueK055_Aque RLTQSIDNQGTPYSQVSNETRVWKKLNDEWKCVHFHRSS---------------------
AqueK056_Aque RLSQHVDKTGRAGSSECKETCIWEKKEGQWKCVHIHTS----------------------
CaMKII_Dmel ---------------K
CaMK2g_Mmus ---------------Q
CaMK2d_Mmus NGKENFSGGTSLWQNI
CaMK2b_Mmus ---------------Q
CaMK2a_Mmus ---------------H
CaMK2a_Hsap ---------------H
CaMK2b_Hsap ---------------Q
CaMK2d_Hsap NGKENFSGGTSLWQNI
CaMK2g_Hsap ---------------Q
unc-43_Cele ---------------F
CAMK2_Spur ----------------
AqueK055_Aque ---------------Q
AqueK056_Aque ---------------S