CG7236_Dmel -----------------------------------------------------MDR----
CDKL5_Mmus MK--------------------------------------------IPNIGNVMNK----
CDKL4_Mmus -----------------------------------------------------MEK----
CDKL3_Mmus -----------------------------------------------------MEM----
CDKL2_Mmus -----------------------------------------------------MEK----
CDKL1_Mmus -----------------------------------------------------MEK----
CDKL1_Hsap M----------------------------------------------------MEK----
CDKL2_Hsap -----------------------------------------------------MEK----
CDKL5_Hsap MK--------------------------------------------IPNIGNVMNK----
CDKL4_Hsap -----------------------------------------------------MEK----
CDKL3_Hsap -----------------------------------------------------MEM----
Y42A5A.4_Cele -----------------------------------------------------MDK----
10873_Tthe -----------------------------------------------------MNK----
17811_Tthe -----------------------------------------------------MKSLVNL
29899_Tthe -----------------------------------------------------MNK----
7414_Tthe -----------------------------------------------------MNK----
CDKL2_Spur MGPARKSVDAAFACQSGQRNTIDLFSRVRVAEVVPKQSEPPLPLMKGPAL--AMEK----
CDKL1_Spur -----------------------------------------------------MDK----
CDKL5_Spur -----------------------------------------------------MNK----
AqueK106_Aque -----------------------------------------------------MEK----
AqueK107_Aque -----------------------------------------------------MEK----
GK026_Glam -----------------------------------------------------MNK----
*.
CG7236_Dmel ------------------------------------------------------------
CDKL5_Mmus ------------------------------------------------------------
CDKL4_Mmus ------------------------------------------------------------
CDKL3_Mmus ------------------------------------------------------------
CDKL2_Mmus ------------------------------------------------------------
CDKL1_Mmus ------------------------------------------------------------
CDKL1_Hsap ------------------------------------------------------------
CDKL2_Hsap ------------------------------------------------------------
CDKL5_Hsap ------------------------------------------------------------
CDKL4_Hsap ------------------------------------------------------------
CDKL3_Hsap ------------------------------------------------------------
Y42A5A.4_Cele ------------------------------------------------------------
10873_Tthe ------------------------------------------------------------
17811_Tthe KILGLYFGSRNQIGGQGMSYLGQQLLHLQNLNKFSLGLGEENKLSENSLKNFGESFNHIN
29899_Tthe ------------------------------------------------------------
7414_Tthe ------------------------------------------------------------
CDKL2_Spur ------------------------------------------------------------
CDKL1_Spur ------------------------------------------------------------
CDKL5_Spur ------------------------------------------------------------
AqueK106_Aque ------------------------------------------------------------
AqueK107_Aque ------------------------------------------------------------
GK026_Glam ------------------------------------------------------------
CG7236_Dmel ------------------------------------------------------------
CDKL5_Mmus ------------------------------------------------------------
CDKL4_Mmus ------------------------------------------------------------
CDKL3_Mmus ------------------------------------------------------------
CDKL2_Mmus ------------------------------------------------------------
CDKL1_Mmus ------------------------------------------------------------
CDKL1_Hsap ------------------------------------------------------------
CDKL2_Hsap ------------------------------------------------------------
CDKL5_Hsap ------------------------------------------------------------
CDKL4_Hsap ------------------------------------------------------------
CDKL3_Hsap ------------------------------------------------------------
Y42A5A.4_Cele ------------------------------------------------------------
10873_Tthe ------------------------------------------------------------
17811_Tthe SLTHIDLDIYKHNLKNNDFGNIGNALSMCKKLQFLKIKVDQEHQITQNNIKLFANNLSQN
29899_Tthe ------------------------------------------------------------
7414_Tthe ------------------------------------------------------------
CDKL2_Spur ------------------------------------------------------------
CDKL1_Spur ------------------------------------------------------------
CDKL5_Spur ------------------------------------------------------------
AqueK106_Aque ------------------------------------------------------------
AqueK107_Aque ------------------------------------------------------------
GK026_Glam ------------------------------------------------------------
CG7236_Dmel ------------------------------------------------------------
CDKL5_Mmus ------------------------------------------------------------
CDKL4_Mmus ------------------------------------------------------------
CDKL3_Mmus ------------------------------------------------------------
CDKL2_Mmus ------------------------------------------------------------
CDKL1_Mmus ------------------------------------------------------------
CDKL1_Hsap ------------------------------------------------------------
CDKL2_Hsap ------------------------------------------------------------
CDKL5_Hsap ------------------------------------------------------------
CDKL4_Hsap ------------------------------------------------------------
CDKL3_Hsap ------------------------------------------------------------
Y42A5A.4_Cele ------------------------------------------------------------
10873_Tthe ------------------------------------------------------------
17811_Tthe KTVIQIKYSLNLDREDPDDYGNQDEEDEEIEDDLEEENNEILDEENSLQNDQVKEEDEDI
29899_Tthe ------------------------------------------------------------
7414_Tthe ------------------------------------------------------------
CDKL2_Spur ------------------------------------------------------------
CDKL1_Spur ------------------------------------------------------------
CDKL5_Spur ------------------------------------------------------------
AqueK106_Aque ------------------------------------------------------------
AqueK107_Aque ------------------------------------------------------------
GK026_Glam ------------------------------------------------------------
CG7236_Dmel ---------------------------------------------------YEKLSRLGE
CDKL5_Mmus ---------------------------------------------------FEILGVVGE
CDKL4_Mmus ---------------------------------------------------YEKLAKIGE
CDKL3_Mmus ---------------------------------------------------YETLGKVGE
CDKL2_Mmus ---------------------------------------------------YENLGLVGE
CDKL1_Mmus ---------------------------------------------------YEKIGKIGE
CDKL1_Hsap ---------------------------------------------------YEKIGKIGE
CDKL2_Hsap ---------------------------------------------------YENLGLVGE
CDKL5_Hsap ---------------------------------------------------FEILGVVGE
CDKL4_Hsap ---------------------------------------------------YEKLAKTGE
CDKL3_Hsap ---------------------------------------------------YETLGKVGE
Y42A5A.4_Cele ---------------------------------------------------YDRLSKLGE
10873_Tthe ---------------------------------------------------YEILGVNGE
17811_Tthe DKEGDDMKEDENLSENEGNYQKDDEEFDKEDLENMDIQEFQQDMSYLGNQNSQILSILEE
29899_Tthe ---------------------------------------------------YEVKGVVGE
7414_Tthe ---------------------------------------------------YEILGVVGE
CDKL2_Spur ---------------------------------------------------YESFGLVGE
CDKL1_Spur ---------------------------------------------------YERLGKIGE
CDKL5_Spur ---------------------------------------------------YEVLGIVGE
AqueK106_Aque ---------------------------------------------------YEKISKIGE
AqueK107_Aque ---------------------------------------------------YENLGLVGE
GK026_Glam ---------------------------------------------------YEILGVSGE
: . *
CG7236_Dmel GSYGVVYKCRDRETGALVAVKRFVESED--DPAIRKIALREIRLLKNLKHPNLVSLLEVF
CDKL5_Mmus GAYGVVLKCRHKETHEIVAIKKFKDSEE--NEEVKETTLRELKMLRTLKQENIVELKEAF
CDKL4_Mmus GSYGVVFKCRNKSSGQVVAIKKFVESED--DRVVRKIALREIRMLKQLKHPNLVNLIEVF
CDKL3_Mmus GSYGTVMKCKHKDTGRIVAIKIFYEKPE---KSVNKIATREIKFLKQFRHENLVNLIEVF
CDKL2_Mmus GSYGMVMKCRNKDSGRIVAIKKFLESDD--DKMVKKIAMREIKLLKQLRHENLVNLLEVC
CDKL1_Mmus GSYGVVFKCRNRDTGQIVAIKRFLETED--DPVIKKIALREIRMLKQLKHPNLVNLLEVF
CDKL1_Hsap GSYGVVFKCRNRDTGQIVAIKKFLESED--DPVIKKIALREIRMLKQLKHPNLVNLLEVF
CDKL2_Hsap GSYGMVMKCRNKDTGRIVAIKKFLESDD--DKMVKKIAMREIKLLKQLRHENLVNLLEVC
CDKL5_Hsap GAYGVVLKCRHKATHEIVAIKKFKDSEE--NEEVKETTLRELKMLRTLKQENIVELKEAF
CDKL4_Hsap GSYGVVFKCRNKTSGQVVAVKKFVESED--DPVVKKIALREIRMLKQLKHPNLVNLIEVF
CDKL3_Hsap GSYGTVMKCKHKNTGQIVAIKIFYERPE---QSVNKIAMREIKFLKQFHHENLVNLIEVF
Y42A5A.4_Cele GSYGVVYKCKNRDTGQIVAIKKFVETED--DPHIKKIALREIRMLKQLKHQNLVGLIEVF
10873_Tthe GAYGVVLKCRNKETQEIVAIKKFKETED--DEIAKKNIQREVKMLRQLRHKNIVDLIEAF
17811_Tthe ADYFKLYKCLNKETQKIIAIKAYKLNIN--QVEEKKRIEREVKIKKMLHHKNIVDIIEIC
29899_Tthe GAYGVVLKCMNKENGEYVAIKKFKESDE--DEVVKKTTLREVKILRMLKQENIVQLREAF
7414_Tthe GAYGVVLKCRNRETNEILAIKKFKETED--DELVRKNIQREVKMLKTLKHKNIVGLVEAF
CDKL2_Spur GSYGQVLKCRHKETNQVVAIKKFLEGED--DKMVKKIAMREVRMLKQLRHENLVNLIEVF
CDKL1_Spur GSYGVVFKCRHKDTGTIVAIKRFVESED--DPLIKKIALREIRMLKQLKHENLVNLKEVF
CDKL5_Spur GAYGVVMKCRHKESKEVMAIKKFKDSEA--NEDVRRTILRELKLLRQLKQENIVEVREAF
AqueK106_Aque GSYGVVFKCRNKDTGQIVAIKKFVESED--DPIIKKIALREIRMLRQLKHGNLVNLLEVF
AqueK107_Aque GSYGMVMKCRHKDSSQLVAIKKFLETEN--DRMVKKIALREVRMLKQLRHENLVNLIEVF
GK026_Glam GAYGVVLKCRNKETNELVAIKKFKDTDDPEDSTFKKTTLREVKILKNAQHPHIVCLKEAF
. * : ** .: . :*:* : .. **::: : :: ::* : *
CG7236_Dmel RRKRRLHLVFEFCELTVLHELER--HPQGCPEHLTKQICYQTLLGVAYCHK-QGCLHRDI
CDKL5_Mmus RRRGKLYLVFEYVEKNMLELLEE--MPNGVPPEKVKSYIYQLIKAIHWCHK-NDIVHRDI
CDKL4_Mmus RRKRKMHLVFEYCDHTLLNELER--NPNGVSDGVIKSVLWQTLQALNFCHK-HNCIHRDV
CDKL3_Mmus RQKKKIHLVFEFIDHTVLDELQH--YCHGLESKRLRKYLFQILRAIEYLHN-NNIIHRDI
CDKL2_Mmus KKKKRWYLVFEFVDHTILDDLKL--FPNGLDYQVVQKYLFQIINGIGFCHS-HNIIHRDI
CDKL1_Mmus RRKRRLHLVFEYCDHTVLHELDR--YQRGVPEPLVKNITWQTLQAVNFCHK-HNCIHRDV
CDKL1_Hsap RRKRRLHLVFEYCDHTVLHELDR--YQRGVPEHLVKSITWQTLQAVNFCHK-HNCIHRDV
CDKL2_Hsap KKKKRWYLVFEFVDHTILDDLEL--FPNGLDYQVVQKYLFQIINGIGFCHS-HNIIHRDI
CDKL5_Hsap RRRGKLYLVFEYVEKNMLELLEE--MPNGVPPEKVKSYIYQLIKAIHWCHK-NDIVHRDI
CDKL4_Hsap RRKRKMHLVFEYCDHTLLNELER--NPNGVADGVIKSVLWQTLQALNFCHI-HNCIHRDI
CDKL3_Hsap RQKKKIHLVFEFIDHTVLDELQH--YCHGLESKRLRKYLFQILRAIDYLHS-NNIIHRDI
Y42A5A.4_Cele KRNRKLHLVFELCDRTVLHELEK--NPHGVNDELIKKIIYQLLEALKFCHS-HKCIHRDV
10873_Tthe KRKGRIYLVFEYVEKNLLEVLEE--KPTGLDHEVIRIIMYQLLKALHQCHK-QDVIHRDV
17811_Tthe QKNNEIYIVEEYVEISLSNYLKQGSQQKGLDQNVIPNIMYQVLSSINQCHK-YDIIHQNI
29899_Tthe RRKGKLYLVFEYVENNLLEILEE--RPNGLDQDDVRKYIYQLCKSISYCNS-MDIIHRDI
7414_Tthe KRKGRIYLVFEYVEKNLLEVLEE--KPSGLD----------LLKALDHCHK-HNIIHRDI
CDKL2_Spur RRKKRLYLVFEFMDHTVLDELEK--YPMGLDESLVRKYMWQILKGIEFCHI-NNIIHRDI
CDKL1_Spur RRKKKLHLVFEYCDYTVLNTLEA--NVNGVPEGQGMNIVYQTLEAVNFCHQ-HNCIHRDV
CDKL5_Spur RRRGKLYLVFEYVEKNMLELLEE--NPKGVPPEKVRSYIYQLIKAIHWCHR-NDVIHRDI
AqueK106_Aque RRKRKLHLVFEYCDHTVLNELEA--HPRGLDETSAKRIIWQTLQGVNYCHH-QN------
AqueK107_Aque RRKKRLYLVFEFVDHTALDELDK--YPSGADESLVKKIMWQVLKGVEFCHQ-HNVIHRDV
GK026_Glam KRKQRLYLVFEYCEKTLLELIED--SPGGIPIETVKLLTFQMLRGVEFLWEFMEICHRDL
::. . ::* * : . . :. * .:
CG7236_Dmel KPENILLTAQ---GQVKLCDFGFARMLS-----------PGENYTDYVATRWYRAPELLV
CDKL5_Mmus KPENLLISHN---DVLKLCDFGFARNLSEG---------NNANYTEYVATRWYRSPELLL
CDKL4_Mmus KPENILITKQ---GMIKICDFGFARILI-----------PGDAYTDYVATRWYRAPELLV
CDKL3_Mmus KPENILVSQS---GITKLCDFGFARTLAA----------PGDVYTDYVATRWYRAPELVL
CDKL2_Mmus KPENILVSQS---GVVKLCDFGFARTLAA----------PGEVYTDYVATRWYRAPELLV
CDKL1_Mmus KPENILITKQ---SAIKLCDFGFARLLTG----------PGDYYTDYVATRWYRSPELLV
CDKL1_Hsap KPENILITKH---SVIKLCDFGFARLLTG----------PSDYYTDYVATRWYRSPELLV
CDKL2_Hsap KPENILVSQS---GVVKLCDFGFARTLAA----------PGEVYTDYVATRWYRAPELLV
CDKL5_Hsap KPENLLISHN---DVLKLCDFGFARNLSEG---------NNANYTEYVATRWYRSPELLL
CDKL4_Hsap KPENILITKQ---GIIKICDFGFAQILI-----------PGDAYTDYVATRWYRAPELLV
CDKL3_Hsap KPENILVSQS---GITKLCDFGFARTLAA----------PGDIYTDYVATRWYRAPELVL
Y42A5A.4_Cele KPENIFLTRN---DQVKLGDFGFARIIN-----------TTEMYTDYVATRWYRSPELLV
10873_Tthe KPENLLVNPYN--YELKLCDFGFARTLPSK---------QGEIITDYVATRWYRAPELLL
17811_Tthe KPMHIYINPSN--YELKLNGFRLARQLPQ----------KGEIVTDYVEARWYKSPEYLL
29899_Tthe KPENLLISKD---GTLKLCDFGFARVLPQ----------KGGNLTDYVATRWYRAPELLL
7414_Tthe KPENLLVNSD---GTLKLCDFGFARHMPPK---------QNEILTDYVATRWYRSPELLL
CDKL2_Spur KPENILVSKS---KVVKLCDFGFARTIAG----------PGEIYTDYVATRWYRAPELLV
CDKL1_Spur KPENILITKD---GRIKLCDFGFARILTG----------PDDEYTDYVATRWYRAPELLV
CDKL5_Spur KPENLLISAK---DTLKLCDFGFARNLDGN---------SSANYTDYVATRWYRSPELLL
AqueK106_Aque ------------------------------------------------------------
AqueK107_Aque KPENILISKR---GVVKICDFGFARAIAP----------PGEAYTDYVATRWYRAPELLV
GK026_Glam KPENLLLVKKHGEWTLKLCDFGFARHINGAQTAGAAGNFPQSNLTDYVATRWYRSPELLL
CG7236_Dmel GDTQYGTPVDVWAIGCLFAELVRGEALWPGRSDVDQLYLIRKTLGDLLPRHIQIFGQNEY
CDKL5_Mmus GA-PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPR
CDKL4_Mmus GDTKYGSSVDVWAVGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFRSNQF
CDKL3_Mmus KDTSYGKPVDIWALGCMIIEMATGHPFLPSSSDLDLLHKIVLKVGNLTPHLHNIFSKSPI
CDKL2_Mmus GDVKYGKAVDIWAIGCLVIEMLMGQPLFPGESDIDQLHHIMTCLGNLIPRHQELFYKNPV
CDKL1_Mmus GDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSMNQY
CDKL1_Hsap GDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQY
CDKL2_Hsap GDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPV
CDKL5_Hsap GA-PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPR
CDKL4_Hsap GDTQYGSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGF
CDKL3_Hsap KDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPI
Y42A5A.4_Cele GDVQYGPPVDIWAVGCVYAELLTGEALWPGRSDIDQLYHIRKTLGEFLPRHISIFRTNQF
10873_Tthe KYPKYSKPVDIWAVACIMGELIDGQPLFPGQNEIDQLYLIQKTLGPLTPEQKELFIKNPR
17811_Tthe DYRKYGKPEDIWAAACVMAELIDGEPLFPGQGEIDQFYRIVQVIGPLTNQYENLFKKK--
29899_Tthe GYTDYGKEVDMWAVGCIMGELTDGQPLFPGQNEIDQLYVIQKVLGPLTAEQQEVFLKHPG
7414_Tthe SDPGYSFPVDNWAIACIMGELIDGQPLFPGENEIDQLYLIQKLLGPLTPDQKEMFIKNPR
CDKL2_Spur GDTKYGKAIDLWAVGCLQAEMLTGEPLFPGDSDIDQLYHIIRCFGTLIQRHKEIFLKNPL
CDKL1_Spur GDMVYGPPVDVWAIGCVTAELIAGEALWPGRSDVDQLYLIKQTLGDLIDRHSKIFSTNHF
CDKL5_Spur GS-AYGKAVDVWAIGCILGELSDGNAIFPGESEIDQLYMIQKILGPLPHYQMAIFDNSPR
AqueK106_Aque -------------------------PLWPGRSDVDQLHLIIQTQGDLIPYHVKIFQESTY
AqueK107_Aque GDTNYGRAVDVWAIGCLFSEMLTGEPLFPGESDIDQLYLITKCFGNLIARHREVFSRNPL
GK026_Glam NATDYNQTVDIWAAALIISEMITSEPLFAGDSDVDQLYLIQRVLGNLTRKQMEKFLRNPK
. .. .::* :. * * : *
CG7236_Dmel FKGITLPVPPT--LEPLEDKMPAKSQQNPLTIDFL-KKCLDKDPTKRWSCEKLTKHSYFD
CDKL5_Mmus FHGLRFPAVNH--PQSLERRYLGIL--NSVLLDLM-KNLLKLDPADRYLTEQCLNHPTFQ
CDKL4_Mmus FRGISIPEPED--METLEEKFSN---VQPVALSFM-KGCLKMNPDERLTCAQLLDSAYFE
CDKL3_Mmus FAGVVLPQVQH--PKTARKKYPK---LNGLLADIV-HACLQIDPAERTSSTDLLRHDYFT
CDKL2_Mmus FAGVRLPEVKDAEAEPLESRYPK---LPEAVISLA-KKCLHIDPDKRPFCADLLRHDFFQ
CDKL1_Mmus FSGVKIPDPED--METLELKFPN---ISYSALGFL-KGCLHMDPAERLTCEQLLQHPYFD
CDKL1_Hsap FSGVKIPDPED--MEPLELKFPN---ISYPALGLL-KGCLHMDPTQRLTCEQLLHHPYFE
CDKL2_Hsap FAGVRLPEIKE--REPLERRYPK---LSEVVIDLA-KKCLHIDPDKRPFCAELLHHDFFQ
CDKL5_Hsap FHGLRFPAVNH--PQSLERRYLGIL--NSVLLDLM-KNLLKLDPADRYLTEQCLNHPTFQ
CDKL4_Hsap FHGISIPEPED--METLEEKFSD---VHPVALNFM-KGCLKMNPDDRLTCSQLLESSYFD
CDKL3_Hsap FAGVVLPQVQH--PKNARKKYPK---LNGLLADIV-HACLQIDPADRISSSDLLHHEYFT
Y42A5A.4_Cele FFGLSIPEPEH--LEPLPSKLPN---ASSAQLDFL-QKCFEMSPDRRFSCSELMLHGIFS
10873_Tthe FIGTKFPEINK--PETIERRYLGKL--SKKALNIM-KLMLKMDPDERITAEEAMKHPYFD
17811_Tthe YKDLKFPIIKN--FNSIELRYQGK--INAEGLDLM-KMMLKMNPDERITAEQSLSHPFFD
29899_Tthe FLGVKLPEISK--PETIEKRYLGKL--SKKALSFM-KNLLKMDPSQRMSADEALQHPYFD
7414_Tthe YVGLKFPEIPK--PETIERRYLGKL--SKKALTFM-KGLLKMDPRERMNVQEAMAHPLFD
CDKL2_Spur FVGMRLPEVKN--VEPLEKRFPT---LSGLSISMM-KSCLHLDPDQRPTCTQFLKHEFFK
CDKL1_Spur FKGMSIPEPER--RIPLKDKVRN---LNSTALTFL-EACLQMDPADRLSCQELMEMPFFD
CDKL5_Spur FSGLKVTILSI---Q-FKRSIF-RI--FSCLLAVL-------------------------
AqueK106_Aque FKDTSIPCPDK--REPISALYPQ---FSQQILSFLEQGCLAMDPIARQTAEELLDHPVFD
AqueK107_Aque FIGMRLPEARE--IQPFERRYHR---LSPAAMDII-KWSLRLDPADRPTCTQLLKHELFQ
GK026_Glam FIGVEFPTS-R--PEGLEKKLTGKIK-DKQAISLL-KMMLKMDPAERPSATQCLDHEFFD
: . .. .
CG7236_Dmel D--YIA--KQR-ELE------H-VNSLEAA----------------N---LRQQ------
CDKL5_Mmus T--QRLLDRSPSRST--KRKP-YHVESSTLSNR------------NQ---STKGAALQTH
CDKL4_Mmus S--FQE--DQ---MK------R-KARSEGRS---------------R---RRQQ------
CDKL3_Mmus RDGFIE--KFIPELR--AKLLQ-EAKVNSFIKP------------KE---NF-KEN----
CDKL2_Mmus MDGFAE--RFSQELQ--LKIEK-DARNNSLPKK------------SQ---NRKKEK----
CDKL1_Mmus S--IRE--VGE--LT------R-QHDKPARK---------------T---LRQS------
CDKL1_Hsap N--IRE--IED--LA------K-EHNKPTRK---------------T---LRKS------
CDKL2_Hsap MDGFAE--RFSQELQ--LKVQK-DARNVSLSKK------------SQ---NRKKEK----
CDKL5_Hsap T--QRLLDRSPSRSA--KRKP-YHVESSTLSNR------------NQ---AGKSTALQSH
CDKL4_Hsap S--FQE--AQ---IK------R-KARNEGRN---------------R---RRQQ------
CDKL3_Hsap RDGFIE--KFMPELK--AKLLQ-EAKVNSLIKP------------KE---SS-KEN----
Y42A5A.4_Cele N--WIL--RIR-Q--------D-ES-TPTGL---------------T---SKRS------
10873_Tthe G--VRE--QFDKDDN--VTKP-VSAVTIDLKRE------------NS---HLKKMP----
17811_Tthe K--LKS--KIDNEKG--AFIQN------------------------K---LS--------
29899_Tthe G--IRD--KEIQQTIKHGRIE-ERVESATIKEP------------KQINQNGTNSGFYNQ
7414_Tthe G--IRE--LYDDDND--HNSQSQHNKSIEKNQE------------NQ---NIRSYGS---
CDKL2_Spur KDGFCD--VFPSELS--LKVQK-EFEGNPLLKSLLGDEKGDEEKKPK---HRSKKQ----
CDKL1_Spur R--HKG--LDD-R-H------S-DSTNVRRH-----------------------------
CDKL5_Spur ------------------------------------------------------------
AqueK106_Aque D--FRD--WFQPELE--MLLAR-EAKKVHKSKA-------------K---VQQA------
AqueK107_Aque RNGWAD--KYSIELR--SKIQH-EFDDNPLLKNLGVTIYGSL-YDSQ---HAAMKE----
GK026_Glam S--VRQ--RALQLEMK---CME-DMGIRPLVKE------------PQ---YSSNTL----
CG7236_Dmel ------------------------------------------------------------
CDKL5_Mmus HRSNSKDIQNLSVGLPRAEEGLPANESFLNGNLAGATLSPMHTKTYQASTQPGSSSKDLT
CDKL4_Mmus ------------------------------------------------------------
CDKL3_Mmus ------------------------------------------------------------
CDKL2_Mmus ------------------------------------------------------------
CDKL1_Mmus ------------------------------------------------------------
CDKL1_Hsap ------------------------------------------------------------
CDKL2_Hsap ------------------------------------------------------------
CDKL5_Hsap HRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLT
CDKL4_Hsap ------------------------------------------------------------
CDKL3_Hsap ------------------------------------------------------------
Y42A5A.4_Cele ------------------------------------------------------------
10873_Tthe ------------------------------------------------------------
17811_Tthe ------------------------------------------------------------
29899_Tthe QTQNAST-----------------------------------------------------
7414_Tthe ------------------------------------------------------------
CDKL2_Spur ------------------------------------------------------------
CDKL1_Spur ------------------------------------------------------------
CDKL5_Spur ------------------------------------------------------------
AqueK106_Aque ------------------------------------------------------------
AqueK107_Aque ------------------------------------------------------------
GK026_Glam ------------------------------------------------------------
CG7236_Dmel ------------------------------------------------------------
CDKL5_Mmus NNNIPHLLSPKEAKSKTEFDFNIDTKPSEGPGTKYLKSSTRS--QQN-------------
CDKL4_Mmus ------------------------------------------------------------
CDKL3_Mmus ---------------------------------EPVRDEKK---SVF-------------
CDKL2_Mmus --------------------------------DDALGEERK---TLV-------------
CDKL1_Mmus ------------------------------------------------------------
CDKL1_Hsap ------------------------------------------------------------
CDKL2_Hsap -----------------------------EK-DDSLVEERK---TLV-------------
CDKL5_Hsap NNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYLKSNSRS--QQN-------------
CDKL4_Hsap ------------------------------------------------------------
CDKL3_Hsap ---------------------------------ELRKDERK---TVY-------------
Y42A5A.4_Cele ------------------------------------------------------------
10873_Tthe -----------------------------QT-DKQINLSRKV--DII-------------
17811_Tthe ------------------------------------------------------------
29899_Tthe ------------------------IKPKDKPPQQQ-AIPPKN--Q-T-------------
7414_Tthe -------------KNNI------DEKKNEDQDERDSQFEKKS--QTI-------------
CDKL2_Spur -----------------------------SS-SEKLERE---------------------
CDKL1_Spur ------------------------------------------------------------
CDKL5_Spur ------------------------------------------------------------
AqueK106_Aque ------------------------------------------------------------
AqueK107_Aque -----------------------------SS-GEETVPNRLTTKHDYATGFSSGAEATGS
GK026_Glam -----------------------------SG-DIS--STQLQ--QNL-------------
CG7236_Dmel -------------------------QLAS-----QQFML---------------------
CDKL5_Mmus RHSFMESSQSKAG---TLQPSEKQS----RH--------------SYI-DTIPQS-SRSP
CDKL4_Mmus ------------------------------------------------------------
CDKL3_Mmus TNTLLYGNPSLYG---KEVDRDKRA----KELK-VRVIKAKGGKG------DVPD-QKKP
CDKL2_Mmus V---------------QDTNADPKI----KDSK---VFKVKGSKI------DVEK-MEKG
CDKL1_Mmus -------------------------R-KH-----L-------------------------
CDKL1_Hsap -------------------------R-KH-----HCFTE---------------------
CDKL2_Hsap V---------------QDTNADPKI----KDYK---LFKIKGSKI------DGEK-AEKG
CDKL5_Hsap RHSFMESSQSKAG---TLQPNEKQS----RH--------------SYI-DTIPQS-SRSP
CDKL4_Hsap ------------------------------------------------------------
CDKL3_Hsap TNTLLS--SSVLG---KEIEKEKKP----KEIK-VRVIKVKGGRG------DISE-PKKK
Y42A5A.4_Cele ------------------------------------------------------------
10873_Tthe GKTES--NDIDEKNNGMVQ--NNED----HN--------------EYGESYGKQSMKLEK
17811_Tthe ------------------------------------------------------------
29899_Tthe QQPPLGSNKQKAL---QQQPDQQQQ----RV-------------NNFVKNGVRQE-KNTP
7414_Tthe HHEQNQKNGIYAK---LNKENNNQS----QK--------------ILGKNYFSQN-KLPP
CDKL2_Spur ---------------------REKEKSRKRHSETEKLKRSSTPTR------DAHH-ESSP
CDKL1_Spur -------------------------R-SK-----L--GL---------------------
CDKL5_Spur ------------------------------------------------------------
AqueK106_Aque -------------------------SRSK-----GHLGG---------------------
AqueK107_Aque G---------------ADESAIKKEKKKK-----IKVHREKAANG------LPLQ-EPKP
GK026_Glam QHNLHTTS---------------------SH-------------------------SINP
CG7236_Dmel -----AT-----------------------------------------------------
CDKL5_Mmus SYR---TKAKSHG------ALSDSKSV---------------------------S----N
CDKL4_Mmus ------------------------------------------------------------
CDKL3_Mmus E---YEGDHRQQG----------------------------------------TA-----
CDKL2_Mmus S---RASNA---N------CLHDNGT---------------------------NH-----
CDKL1_Mmus ------------------------------------------------------------
CDKL1_Hsap ------------------------------------------------------------
CDKL2_Hsap N---RASNA---S------CLHDSRT---------------------------SH-----
CDKL5_Hsap SYR---TKAKSHG------ALSDSKSV---------------------------S----N
CDKL4_Hsap ------------------------------------------------------------
CDKL3_Hsap E---YEGGLGQQD----------------------------------------AN-----
Y42A5A.4_Cele ------------------------------------------------------------
10873_Tthe ------------------------QFM---------------------------Q-----
17811_Tthe ------------------------------------------------------------
29899_Tthe SHE---NNRIIKKDIYPHPQI---NFM---------------------------QSSYSN
7414_Tthe QYL------------------QNSKMM---------------------------Q-----
CDKL2_Spur KYDVKKSNP---S------TVTESQKKS-------------STIAS---TSNTSG-----
CDKL1_Spur ------------------------------------------------------------
CDKL5_Spur ------------------------------------------------------------
AqueK106_Aque ------------------------------------------------------------
AqueK107_Aque K-----------T------MIPSSLLQGNMAALGGPSGSPYGSQHALLRAQQPSP-----
GK026_Glam T----------------------AQSG---------------------------Q----N
CG7236_Dmel ------------------------------------------------------------
CDKL5_Mmus LSE-------ARA-----QITETNTSRY------------FP----------------SS
CDKL4_Mmus ------------------------------------------------------------
CDKL3_Mmus -------------------------DDT------------QP----------------SS
CDKL2_Mmus -------------------------KGL-------------A----------------ST
CDKL1_Mmus ------------------------------------------------------------
CDKL1_Hsap ------------------------------------------------------------
CDKL2_Hsap -------------------------NKI------------VP----------------ST
CDKL5_Hsap LSE-------ARA-----QIAEPSTSRY------------FP----------------SS
CDKL4_Hsap ------------------------------------------------------------
CDKL3_Hsap -------------------------ENV------------HP----------------MS
Y42A5A.4_Cele ------------------------------------------------------------
10873_Tthe ------------------------------------------------------------
17811_Tthe ------------------------------------------------------------
29899_Tthe IPDIYIKTKNAQNQQYNYEIQENYQPDFHNEDPDDSQQPSVPQVLIRNDTHGNHNNMVNV
7414_Tthe ------------------------------------------------------------
CDKL2_Spur -------------------------PSI------------QS----------------IS
CDKL1_Spur ------------------------------------------------------------
CDKL5_Spur ------------------------------------------------------------
AqueK106_Aque ------------------------------------------------------------
AqueK107_Aque -------------------------YMY------------KP----------------ST
GK026_Glam IGA-------SSL-----GIGYP--ATT------------VP----------------TS
CG7236_Dmel ------------------------------------------------------------
CDKL5_Mmus CLDLNSPTSPT---PT-RHTDTRTLLSPSGRNNRN---------EGTLDSRRTTTRHSKT
CDKL4_Mmus ------------------------------------------------------------
CDKL3_Mmus LDKKPSVLELT---NPL---------NPSENSD---------------------------
CDKL2_Mmus SLRDCSNVNID---HSR---------NP--------------------------------
CDKL1_Mmus ------------------------------------------------------------
CDKL1_Hsap ------------------------------------------------------------
CDKL2_Hsap SLKDCSNVSVD---HTR---------NP--------------------------------
CDKL5_Hsap CLDLNSPTSPT---PT-RHSDTRTLLSPSGRNNRN---------EGTLDSRRTTTRHSKT
CDKL4_Hsap ------------------------------------------------------------
CDKL3_Hsap PDTKLVTIEPP---NPI---------NPSTNCN---------------------------
Y42A5A.4_Cele ------------------------------------------------------------
10873_Tthe ------------------------------------------------------------
17811_Tthe ------------------------------------------------------------
29899_Tthe SIEDNTPYSKF---NE-RNKSK-ENIIPKGKKKKSQMSNIENFYQD---NAENSNNQEED
7414_Tthe ------------------------------------------------------------
CDKL2_Spur SSSK-LPQHIGGHNGPTNHT----TSHPSG------------------------------
CDKL1_Spur ------------------------------------------------------------
CDKL5_Spur ------------------------------------------------------------
AqueK106_Aque ------------------------------------------------------------
AqueK107_Aque PKRV-LPHDIP---SPL---------HPNA------------------------------
GK026_Glam SG---KPG-------S-SHSTYH-TIGPSGTTMG--------------------------
CG7236_Dmel -------------------------------------------------A---AQQLQTG
CDKL5_Mmus MEEL------------KLPEHM---DS-----------SH-S--HSLSAP---HESFSY-
CDKL4_Mmus ------------------------------------------------------------
CDKL3_Mmus --GVKEDPHAGG--CMIMPPINLTSS---------------------NLL---AANLSSN
CDKL2_Mmus --------------GTAIPPLTH----------------------NLSAV---APGINAG
CDKL1_Mmus ------------------------------------------------------------
CDKL1_Hsap ------------------------------------------------------------
CDKL2_Hsap --------------SVAIPPLTH----------------------NLSAV---APSINSG
CDKL5_Hsap MEEL------------KLPEHM---DS-----------SH-S--HSLSAP---HESFSY-
CDKL4_Hsap ------------------------------------------------------------
CDKL3_Hsap --GLKENPHCGG--SVTMPPINLTNS---------------------NLM---AANLSSN
Y42A5A.4_Cele ------------------------------------------------------------
10873_Tthe -------------------------SS-----------VY-N--YKVSDKNLEEGSFID-
17811_Tthe ------------------------------------------------------------
29899_Tthe AEGR------------KSPLLT---NNKLYGTSVAQQKKF-R--FNV--M---AQNIQQ-
7414_Tthe -------------------------NT-----------VY-N--YNIDKD---DSSFTE-
CDKL2_Spur -----------QGSSPTQTTINLTMGN-----------ITSNKSN---FT---STNMAGP
CDKL1_Spur ------------------------------------------------------------
CDKL5_Spur ------------------------------------------------------------
AqueK106_Aque -----------------------------------------------------------G
AqueK107_Aque -----------K--SIGAPPISLLDNQ-----------ASAT--HSITKL---KAGLQSH
GK026_Glam VSNI------------TGPMVM---SN-----------FG-Q--HHTNYP---AHSVHN-
CG7236_Dmel PAQA-AAIAAARDK----------------------------------------------
CDKL5_Mmus ---------------GLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARA
CDKL4_Mmus ------------------------------------------------------------
CDKL3_Mmus LSH-----PNSRLTER----------------------TKKR---RTSSQTIGQ------
CDKL2_Mmus MGTI-PGVQNYRVDEK----------------------TKKY--------CNPF------
CDKL1_Mmus ------------------------------------------------------------
CDKL1_Hsap ------------------------------------------------------------
CDKL2_Hsap MGTETIPIQGYRVDEK----------------------TKKC--------SIPF------
CDKL5_Hsap ---------------GLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARA
CDKL4_Hsap ------------------------------------------------------------
CDKL3_Hsap LFH-----PSVRLTER----------------------AKKR---RTSSQSIGQ------
Y42A5A.4_Cele ------------------------------------------------------------
10873_Tthe ---------------QDKNL-------------------------KVNFCM---------
17811_Tthe ------------------------------------------------------------
29899_Tthe ---------------NE------EAQEYPRLINIYQKQQQSRANSRSKFYKNGQLQKN--
7414_Tthe ---------------ANGNS-------------------------KRNSNQFE------N
CDKL2_Spur P--------PLRPNDK--------M-------------TKKS--------TNSY------
CDKL1_Spur ------------------------------------------------------------
CDKL5_Spur ------------------------------------------------------------
AqueK106_Aque AT-A-SSAA---TI----------------------------------------------
AqueK107_Aque SNTSITSLHELRPDLQ--------PH-----------RGDAY--------RSP-------
GK026_Glam ---------------TVNYHYPVQ------------------------------------
CG7236_Dmel ------------------------------------------------------------
CDKL5_Mmus NSLQLLSPQPGEQLPPEMTVARP------SVKE----------SSRE---GASSFHT---
CDKL4_Mmus ------------------------------------------------------------
CDKL3_Mmus ------------------------------TLS----------NSRQ---------EDTG
CDKL2_Mmus ------------------------------VKP----------N-------------QPP
CDKL1_Mmus ------------------------------------------------------------
CDKL1_Hsap ------------------------------------------------------------
CDKL2_Hsap ------------------------------VKP----------N-------------RHS
CDKL5_Hsap NSLQLLSPQPGEQLPPEMTVARS------SVKE----------TSRE---GTSSFHT---
CDKL4_Hsap ------------------------------------------------------------
CDKL3_Hsap ------------------------------VMP----------NSRQ---------EDPG
Y42A5A.4_Cele ------------------------------------------------------------
10873_Tthe YSKHIQYNLLEEQLRQKLGKEDSSSNTCSSWRP----------NQK-NSFEKKFTM----
17811_Tthe ------------------------------------------------------------
29899_Tthe -ANYV--------------------------------------SSQQ---MNVLLHT---
7414_Tthe TKNRLLYDSMSVQKPPKMGPAGS------SLKK----------NQQINQINKTFYHS---
CDKL2_Spur ------------------------------YKK----------V-------------GAS
CDKL1_Spur ------------------------------------------------------------
CDKL5_Spur ------------------------------------------------------------
AqueK106_Aque ------------------------------------------------------------
AqueK107_Aque ------------------------------LSP----------S-------------HPP
GK026_Glam -----------QSLS-----------------PAAAQARAISNA----------------
CG7236_Dmel ------------------------------------------------------------
CDKL5_Mmus --R---QKSEGGVYHDPHS-DD-GTAPKENRH-------LYNDPVPRRVGSFYRVPSPRP
CDKL4_Mmus ------------------------------------------------------------
CDKL3_Mmus PTQ---VQTEKGAFNERTG-QN-DQ-----------------------------------
CDKL2_Mmus PA-------GIYNMNVSTSVSGEKY-----------------------------------
CDKL1_Mmus ------------------------------------------------------------
CDKL1_Hsap ------------------------------------------------------------
CDKL2_Hsap PS-------GIYNINVTTLVSSEKN-----------------------------------
CDKL5_Hsap --R---QKSEGGVYHDPHS-DD-GTAPKENRH-------LYNDPVPRRVGSFYRVPSPRP
CDKL4_Hsap ------------------------------------------------------------
CDKL3_Hsap PIQ---SQMEKGIFNERTG-HS-DQ-----------------------------------
Y42A5A.4_Cele ------------------------------------------------------------
10873_Tthe -----------------KE-D--------DKQ-------Y--------------------
17811_Tthe ------------------------------------------------------------
29899_Tthe --EEGPDYEEKGLNLNSNT-NN-NNMNVNNNNISSQNMME--------------------
7414_Tthe --IIGGHGSQGGLQISDRI-D--------PK-----------------------------
CDKL2_Spur GS-------EKTMIHEKTL-QFDAM-----------------------------------
CDKL1_Spur ------------------------------------------------------------
CDKL5_Spur ------------------------------------------------------------
AqueK106_Aque ------------------------------------------------------------
AqueK107_Aque PV----------------------------------------------------------
GK026_Glam ------------------------------------------------------------
CG7236_Dmel --------------------------------SKTSNTSLPLLPS---------------
CDKL5_Mmus DNSFH----EN--NV------------------STRVSSLPSDSSSGTNHSKRQPGFDP-
CDKL4_Mmus ------------------------------------NQLLPLIPG---------------
CDKL3_Mmus --------------ISSGNKRKLNFPKCDRK-----EFHFPELPFT--------------
CDKL2_Mmus --------------LLQANKKRKEYPKADVRLPELNYNHLPE---L--------------
CDKL1_Mmus ----------------------------------TGLQYLPQLTS---------------
CDKL1_Hsap ---------------------------------TSKLQYLPQLTG---------------
CDKL2_Hsap --------------LFWASKKRREYSRTDVRLPELNYNHLPE---L--------------
CDKL5_Hsap DNSFH----EN--NV------------------STRVSSLPSESSSGTNHSKRQPAFDP-
CDKL4_Hsap ------------------------------------NQLLPLIPG---------------
CDKL3_Hsap --------------MANENKRKLNFSRSDRK-----EFHFPELPVT--------------
Y42A5A.4_Cele ------------------------------------PNYLPLLNG---------------
10873_Tthe -AQFKQTQRDN--NI------------------MSQKQVLPSIT----KKF--L--IDNG
17811_Tthe ------------------------------------------------------------
29899_Tthe -QQVM----GN--EI------------------FQSTSQLPYIQQSSSN-----------
7414_Tthe -SSYNSTIGMS--TL------------------GISGGALPTIN----NHNKKFA-TNN-
CDKL2_Spur --------------MSSQRKSKKDVSNTSPRESDREVTHLPN---L--------------
CDKL1_Spur ---------------------------------RKDNSHLPQLNS---------------
CDKL5_Spur ------------------------------------------------------------
AqueK106_Aque --------------------------------PNESSALVPQLPAL--------------
AqueK107_Aque ---------------------KKQLSNA-------GTIGLPQ---L--------------
GK026_Glam -------TRQSHYAL------------------NVEDSGLPFLPASRSGS----------
CG7236_Dmel ---------------TQ--H-----------HHHPHQ--DYV------------------
CDKL5_Mmus WKSPENISHADQLKE--KE----KQGF-FRSMKKKKK--KTQTVPNTDGPDLLTLQKAIH
CDKL4_Mmus ---------------SH--I-------------SPTP--D--------------------
CDKL3_Mmus ------------VQAKEMKG------MEVKQIKVLKR--ESKKTDSSKIPTLLSMDPNQE
CDKL2_Mmus -------------RALE--G------I-ARNSRLIKK--ENKCLSESRIPSLAAIDLHVS
CDKL1_Mmus ---------------SR--I-------------LPAL--D--------------------
CDKL1_Hsap ---------------SS--I-------------LPAL--D--------------------
CDKL2_Hsap -------------RALG--G------I-ARNSRLTKK--ESKILSESRIPSLAAIDLHTP
CDKL5_Hsap WKSPENISHSEQLKE--KE----KQGF-FRSMKKKKK--KSQTVPNSDSPDLLTLQKSIH
CDKL4_Hsap ---------------SH--I-------------SPTP--D--------------------
CDKL3_Hsap ------------IQSKDTKG------MEVKQIKMLKR--ESKKTESSKIPTLLNVDQNQE
Y42A5A.4_Cele ---------------NS--N------N----LVSKNF--SLQ------------------
10873_Tthe ANSNSPTSRTA------------KLSL-GSTSQFTKQTNGQFINPS----------G---
17811_Tthe ---------------NQ--I-------------K--------------------------
29899_Tthe --------YNPNFK------------F-YNMYHQQQ---KQTQKPSGKMSTQHNNNTNQ-
7414_Tthe EKGGSPSSHHS------------KMSF-GSTQNYNK---MYFQSPT----------NQIN
CDKL2_Spur -------------TGKD--A------K-TSERQEKKL--KAKKSHHTTMPQI--------
CDKL1_Spur ---------------QG--L-------------QESL--SKG------------------
CDKL5_Spur ------------------------------------------------------------
AqueK106_Aque -------------AATN--N-----------IIQQQI--DTE------------------
AqueK107_Aque -------------NDPS--NSHLRL-T-AKSPLVPAY--THSSYSQIHSTSGAEIDHHTH
GK026_Glam ---------------------------------RAA---KVREAP-SRGNSLTV------
CG7236_Dmel ------------------------------------------------------------
CDKL5_Mmus SSSTASS--RPKEWRPEKLSDLQTQSQPLKSLRKLLHLSSSTNHPASSDPRFQPLTAQ--
CDKL4_Mmus ------------------------------------------------------------
CDKL3_Mmus K-----------------------------------------------------------
CDKL2_Mmus S----------------------------------------V------------------
CDKL1_Mmus ------------------------------------------------------------
CDKL1_Hsap ------------------------------------------------------------
CDKL2_Hsap S----------------------------------------I------------------
CDKL5_Hsap SASTPSS--RPKEWRPEKISDLQTQSQPLKSLRKLLHLSSASNHPASSDPRFQPLTAQ--
CDKL4_Hsap ------------------------------------------------------------
CDKL3_Hsap K-----------------------------------------------------------
Y42A5A.4_Cele ------------------------------------------------------------
10873_Tthe -----ST--TN-------------------------ANSTSRLVNDMNFSKFHNLNVI--
17811_Tthe ------------------------------------------------------------
29899_Tthe ------NMNYD-------------------------QYTYSMHPYDQQDQEMKNLNII--
7414_Tthe VSTGAAG--AN-------------------------GMTASKLLNDINMQKIQNLNVI--
CDKL2_Spur ------------------------------------------------------------
CDKL1_Spur ------------------------------------------------------------
CDKL5_Spur ------------------------------------------------------------
AqueK106_Aque ------------------------------------------------------------
AqueK107_Aque G----------------------------------------MLSSGVPRASYQLTPSGRM
GK026_Glam ------------------------------------------------------MN----
CG7236_Dmel --------------------------KL-Q--------PLNKN-----------------
CDKL5_Mmus ---QAKNSFSEIR------IHPLSQAtGGSSNIRQEPTPKGRPALQLPGQMD----P---
CDKL4_Mmus ----------------------------------------GRK-----------------
CDKL3_Mmus --------QE---------TEPCVTVNE-W--------PDQER-----------------
CDKL2_Mmus ------------------AS------HQ-G--------AG-SP-----------------
CDKL1_Mmus ----------------------------------------NKK-----------------
CDKL1_Hsap ----------------------------------------NKK-----------------
CDKL2_Hsap ------------------TL------HQ-V--------SG-PP-----------------
CDKL5_Hsap ---QTKNSFSEIR------IHPLSQASGGSSNIRQEPAPKGRPALQLPDGGCDGRRQRHH
CDKL4_Hsap ----------------------------------------GRK-----------------
CDKL3_Hsap --------QE---------FIPLSLLSACC--------PIF-------------------
Y42A5A.4_Cele --------------------------GG-N--------HG-NN-----------------
10873_Tthe ---YNTNTYNYN--------MPLTQ-----------------------------------
17811_Tthe ------------------------------------------------------------
29899_Tthe ---YNNNTYNYN------------------------------------------------
7414_Tthe ---YNTNTYNYNN------VQPVNQVGNAFINQN----SQ--------------------
CDKL2_Spur ---AN---QS---------D------HG-G--------HG-FN-----------------
CDKL1_Spur --------------------------HQ-N--------LGHKK-----------------
CDKL5_Spur ------------------------------------------------------------
AqueK106_Aque --------------------------RR------------G-------------------
AqueK107_Aque RHPPH---QDPGPQSGFSLL------HQ-K--------PS-SP-----------------
GK026_Glam -------------------------VGGNN--MFLNPPKYGIP-----------------
CG7236_Dmel ------------------------------------------------------------
CDKL5_Mmus --------------------------GWHVSSVTRSATEGPSYSEQLGAKS---------
CDKL4_Mmus ------------------------------------------------------------
CDKL3_Mmus ------------------------------------------------------------
CDKL2_Mmus ------------------------------------------------------------
CDKL1_Mmus ------------------------------------------------------------
CDKL1_Hsap ------------------------------------------------------------
CDKL2_Hsap ------------------------------------------------------------
CDKL5_Hsap SGPQDRRFMLRTTEQQGEYFCCGDPKKPHTPCVPNRAL------------HRPISSPAPY
CDKL4_Hsap ------------------------------------------------------------
CDKL3_Hsap ------------------------------------------------------------
Y42A5A.4_Cele ------------------------------------------------------------
10873_Tthe ------------------------------------------------------------
17811_Tthe ------------------------------------------------------------
29899_Tthe ------------------------------------------------------------
7414_Tthe ------------------------------------------------------------
CDKL2_Spur ------------------------------------------------------------
CDKL1_Spur ------------------------------------------------------------
CDKL5_Spur ------------------------------------------------------------
AqueK106_Aque ------------------------------------------------------------
AqueK107_Aque ------------------------------------------------------------
GK026_Glam ------------------------------------------------------------
CG7236_Dmel -------------------------------------------------AN--L-LHRTE
CDKL5_Mmus -----------GPN---------------G--------------HPYNRTNRSRMPNLND
CDKL4_Mmus -------------------------------------------------QV--VQ-LK-F
CDKL3_Mmus ----------------------------------------------REPTGRGGHRVEMA
CDKL2_Mmus -------------------------------------------------LSD-DSEADLP
CDKL1_Mmus -------------------------------------------------YH--CSTKRFN
CDKL1_Hsap -------------------------------------------------YY--CDTKKLN
CDKL2_Hsap -------------------------------------------------LSD-DSGADLP
CDKL5_Hsap PVLQVRGTSMCPTLQVRGTDAFSCPTQQSGFSFFVRHVMREALIHRAQVNQAALLTYHEN
CDKL4_Hsap -------------------------------------------------QV--LQ-LK-F
CDKL3_Hsap ----------------------------------------------TNICSQLTIRVEMA
Y42A5A.4_Cele ------------------------------------------------NNN--GNGIN-R
10873_Tthe ---------------------------------------------------KAANNTKKT
17811_Tthe -------------------------------------------------EN--L-KNQAH
29899_Tthe ------------------------------------------------I---NNSPLWNS
7414_Tthe --------------------------------------------------SKKSFGTGTM
CDKL2_Spur -------------------------------------------------AN--ASYSSTD
CDKL1_Spur ------------------------------------------------VEN--EKLLK-R
CDKL5_Spur -----------------------------------------------------------K
AqueK106_Aque ------------------------------------------------HQH--QKSDS-V
AqueK107_Aque -------------------------------------------------RV--LRTSETS
GK026_Glam ----------------------------------------------KNPQSR--GALLPK
CG7236_Dmel HHLP----TI
CDKL5_Mmus LKE----TAL
CDKL4_Mmus DHLP----NI
CDKL3_Mmus IVR----GRI
CDKL2_Mmus RMEH----QH
CDKL1_Mmus YHFP----NI
CDKL1_Hsap YRFP----NI
CDKL2_Hsap QMEH----QH
CDKL5_Hsap AAL----TGK
CDKL4_Hsap DHLP----NI
CDKL3_Hsap IAR----GRI
Y42A5A.4_Cele NFLP---TIS
10873_Tthe KPK----YQI
17811_Tthe QDLQ----KN
29899_Tthe ISK----KKI
7414_Tthe YKK----KNY
CDKL2_Spur HNLP----AV
CDKL1_Spur DRLPNIDSFK
CDKL5_Spur NNH----IHM
AqueK106_Aque DHLP---SLT
AqueK107_Aque QLAP----TN
GK026_Glam IRD----TRY