Protein (view, download) , Domain (view, download)
CG7236_Dmel     -----------------------------------------------------MDR----
CDKL5_Mmus      MK--------------------------------------------IPNIGNVMNK----
CDKL4_Mmus      -----------------------------------------------------MEK----
CDKL3_Mmus      -----------------------------------------------------MEM----
CDKL2_Mmus      -----------------------------------------------------MEK----
CDKL1_Mmus      -----------------------------------------------------MEK----
CDKL1_Hsap      M----------------------------------------------------MEK----
CDKL2_Hsap      -----------------------------------------------------MEK----
CDKL5_Hsap      MK--------------------------------------------IPNIGNVMNK----
CDKL4_Hsap      -----------------------------------------------------MEK----
CDKL3_Hsap      -----------------------------------------------------MEM----
Y42A5A.4_Cele   -----------------------------------------------------MDK----
10873_Tthe      -----------------------------------------------------MNK----
17811_Tthe      -----------------------------------------------------MKSLVNL
29899_Tthe      -----------------------------------------------------MNK----
7414_Tthe       -----------------------------------------------------MNK----
CDKL2_Spur      MGPARKSVDAAFACQSGQRNTIDLFSRVRVAEVVPKQSEPPLPLMKGPAL--AMEK----
CDKL1_Spur      -----------------------------------------------------MDK----
CDKL5_Spur      -----------------------------------------------------MNK----
AqueK106_Aque   -----------------------------------------------------MEK----
AqueK107_Aque   -----------------------------------------------------MEK----
GK026_Glam      -----------------------------------------------------MNK----
                                                                     *.

CG7236_Dmel     ------------------------------------------------------------
CDKL5_Mmus      ------------------------------------------------------------
CDKL4_Mmus      ------------------------------------------------------------
CDKL3_Mmus      ------------------------------------------------------------
CDKL2_Mmus      ------------------------------------------------------------
CDKL1_Mmus      ------------------------------------------------------------
CDKL1_Hsap      ------------------------------------------------------------
CDKL2_Hsap      ------------------------------------------------------------
CDKL5_Hsap      ------------------------------------------------------------
CDKL4_Hsap      ------------------------------------------------------------
CDKL3_Hsap      ------------------------------------------------------------
Y42A5A.4_Cele   ------------------------------------------------------------
10873_Tthe      ------------------------------------------------------------
17811_Tthe      KILGLYFGSRNQIGGQGMSYLGQQLLHLQNLNKFSLGLGEENKLSENSLKNFGESFNHIN
29899_Tthe      ------------------------------------------------------------
7414_Tthe       ------------------------------------------------------------
CDKL2_Spur      ------------------------------------------------------------
CDKL1_Spur      ------------------------------------------------------------
CDKL5_Spur      ------------------------------------------------------------
AqueK106_Aque   ------------------------------------------------------------
AqueK107_Aque   ------------------------------------------------------------
GK026_Glam      ------------------------------------------------------------


CG7236_Dmel     ------------------------------------------------------------
CDKL5_Mmus      ------------------------------------------------------------
CDKL4_Mmus      ------------------------------------------------------------
CDKL3_Mmus      ------------------------------------------------------------
CDKL2_Mmus      ------------------------------------------------------------
CDKL1_Mmus      ------------------------------------------------------------
CDKL1_Hsap      ------------------------------------------------------------
CDKL2_Hsap      ------------------------------------------------------------
CDKL5_Hsap      ------------------------------------------------------------
CDKL4_Hsap      ------------------------------------------------------------
CDKL3_Hsap      ------------------------------------------------------------
Y42A5A.4_Cele   ------------------------------------------------------------
10873_Tthe      ------------------------------------------------------------
17811_Tthe      SLTHIDLDIYKHNLKNNDFGNIGNALSMCKKLQFLKIKVDQEHQITQNNIKLFANNLSQN
29899_Tthe      ------------------------------------------------------------
7414_Tthe       ------------------------------------------------------------
CDKL2_Spur      ------------------------------------------------------------
CDKL1_Spur      ------------------------------------------------------------
CDKL5_Spur      ------------------------------------------------------------
AqueK106_Aque   ------------------------------------------------------------
AqueK107_Aque   ------------------------------------------------------------
GK026_Glam      ------------------------------------------------------------


CG7236_Dmel     ------------------------------------------------------------
CDKL5_Mmus      ------------------------------------------------------------
CDKL4_Mmus      ------------------------------------------------------------
CDKL3_Mmus      ------------------------------------------------------------
CDKL2_Mmus      ------------------------------------------------------------
CDKL1_Mmus      ------------------------------------------------------------
CDKL1_Hsap      ------------------------------------------------------------
CDKL2_Hsap      ------------------------------------------------------------
CDKL5_Hsap      ------------------------------------------------------------
CDKL4_Hsap      ------------------------------------------------------------
CDKL3_Hsap      ------------------------------------------------------------
Y42A5A.4_Cele   ------------------------------------------------------------
10873_Tthe      ------------------------------------------------------------
17811_Tthe      KTVIQIKYSLNLDREDPDDYGNQDEEDEEIEDDLEEENNEILDEENSLQNDQVKEEDEDI
29899_Tthe      ------------------------------------------------------------
7414_Tthe       ------------------------------------------------------------
CDKL2_Spur      ------------------------------------------------------------
CDKL1_Spur      ------------------------------------------------------------
CDKL5_Spur      ------------------------------------------------------------
AqueK106_Aque   ------------------------------------------------------------
AqueK107_Aque   ------------------------------------------------------------
GK026_Glam      ------------------------------------------------------------


CG7236_Dmel     ---------------------------------------------------YEKLSRLGE
CDKL5_Mmus      ---------------------------------------------------FEILGVVGE
CDKL4_Mmus      ---------------------------------------------------YEKLAKIGE
CDKL3_Mmus      ---------------------------------------------------YETLGKVGE
CDKL2_Mmus      ---------------------------------------------------YENLGLVGE
CDKL1_Mmus      ---------------------------------------------------YEKIGKIGE
CDKL1_Hsap      ---------------------------------------------------YEKIGKIGE
CDKL2_Hsap      ---------------------------------------------------YENLGLVGE
CDKL5_Hsap      ---------------------------------------------------FEILGVVGE
CDKL4_Hsap      ---------------------------------------------------YEKLAKTGE
CDKL3_Hsap      ---------------------------------------------------YETLGKVGE
Y42A5A.4_Cele   ---------------------------------------------------YDRLSKLGE
10873_Tthe      ---------------------------------------------------YEILGVNGE
17811_Tthe      DKEGDDMKEDENLSENEGNYQKDDEEFDKEDLENMDIQEFQQDMSYLGNQNSQILSILEE
29899_Tthe      ---------------------------------------------------YEVKGVVGE
7414_Tthe       ---------------------------------------------------YEILGVVGE
CDKL2_Spur      ---------------------------------------------------YESFGLVGE
CDKL1_Spur      ---------------------------------------------------YERLGKIGE
CDKL5_Spur      ---------------------------------------------------YEVLGIVGE
AqueK106_Aque   ---------------------------------------------------YEKISKIGE
AqueK107_Aque   ---------------------------------------------------YENLGLVGE
GK026_Glam      ---------------------------------------------------YEILGVSGE
                                                                    :  .   *

CG7236_Dmel     GSYGVVYKCRDRETGALVAVKRFVESED--DPAIRKIALREIRLLKNLKHPNLVSLLEVF
CDKL5_Mmus      GAYGVVLKCRHKETHEIVAIKKFKDSEE--NEEVKETTLRELKMLRTLKQENIVELKEAF
CDKL4_Mmus      GSYGVVFKCRNKSSGQVVAIKKFVESED--DRVVRKIALREIRMLKQLKHPNLVNLIEVF
CDKL3_Mmus      GSYGTVMKCKHKDTGRIVAIKIFYEKPE---KSVNKIATREIKFLKQFRHENLVNLIEVF
CDKL2_Mmus      GSYGMVMKCRNKDSGRIVAIKKFLESDD--DKMVKKIAMREIKLLKQLRHENLVNLLEVC
CDKL1_Mmus      GSYGVVFKCRNRDTGQIVAIKRFLETED--DPVIKKIALREIRMLKQLKHPNLVNLLEVF
CDKL1_Hsap      GSYGVVFKCRNRDTGQIVAIKKFLESED--DPVIKKIALREIRMLKQLKHPNLVNLLEVF
CDKL2_Hsap      GSYGMVMKCRNKDTGRIVAIKKFLESDD--DKMVKKIAMREIKLLKQLRHENLVNLLEVC
CDKL5_Hsap      GAYGVVLKCRHKATHEIVAIKKFKDSEE--NEEVKETTLRELKMLRTLKQENIVELKEAF
CDKL4_Hsap      GSYGVVFKCRNKTSGQVVAVKKFVESED--DPVVKKIALREIRMLKQLKHPNLVNLIEVF
CDKL3_Hsap      GSYGTVMKCKHKNTGQIVAIKIFYERPE---QSVNKIAMREIKFLKQFHHENLVNLIEVF
Y42A5A.4_Cele   GSYGVVYKCKNRDTGQIVAIKKFVETED--DPHIKKIALREIRMLKQLKHQNLVGLIEVF
10873_Tthe      GAYGVVLKCRNKETQEIVAIKKFKETED--DEIAKKNIQREVKMLRQLRHKNIVDLIEAF
17811_Tthe      ADYFKLYKCLNKETQKIIAIKAYKLNIN--QVEEKKRIEREVKIKKMLHHKNIVDIIEIC
29899_Tthe      GAYGVVLKCMNKENGEYVAIKKFKESDE--DEVVKKTTLREVKILRMLKQENIVQLREAF
7414_Tthe       GAYGVVLKCRNRETNEILAIKKFKETED--DELVRKNIQREVKMLKTLKHKNIVGLVEAF
CDKL2_Spur      GSYGQVLKCRHKETNQVVAIKKFLEGED--DKMVKKIAMREVRMLKQLRHENLVNLIEVF
CDKL1_Spur      GSYGVVFKCRHKDTGTIVAIKRFVESED--DPLIKKIALREIRMLKQLKHENLVNLKEVF
CDKL5_Spur      GAYGVVMKCRHKESKEVMAIKKFKDSEA--NEDVRRTILRELKLLRQLKQENIVEVREAF
AqueK106_Aque   GSYGVVFKCRNKDTGQIVAIKKFVESED--DPIIKKIALREIRMLRQLKHGNLVNLLEVF
AqueK107_Aque   GSYGMVMKCRHKDSSQLVAIKKFLETEN--DRMVKKIALREVRMLKQLRHENLVNLIEVF
GK026_Glam      GAYGVVLKCRNKETNELVAIKKFKDTDDPEDSTFKKTTLREVKILKNAQHPHIVCLKEAF
                . *  : ** .: .   :*:* :           ..   **::: :  :: ::* : *

CG7236_Dmel     RRKRRLHLVFEFCELTVLHELER--HPQGCPEHLTKQICYQTLLGVAYCHK-QGCLHRDI
CDKL5_Mmus      RRRGKLYLVFEYVEKNMLELLEE--MPNGVPPEKVKSYIYQLIKAIHWCHK-NDIVHRDI
CDKL4_Mmus      RRKRKMHLVFEYCDHTLLNELER--NPNGVSDGVIKSVLWQTLQALNFCHK-HNCIHRDV
CDKL3_Mmus      RQKKKIHLVFEFIDHTVLDELQH--YCHGLESKRLRKYLFQILRAIEYLHN-NNIIHRDI
CDKL2_Mmus      KKKKRWYLVFEFVDHTILDDLKL--FPNGLDYQVVQKYLFQIINGIGFCHS-HNIIHRDI
CDKL1_Mmus      RRKRRLHLVFEYCDHTVLHELDR--YQRGVPEPLVKNITWQTLQAVNFCHK-HNCIHRDV
CDKL1_Hsap      RRKRRLHLVFEYCDHTVLHELDR--YQRGVPEHLVKSITWQTLQAVNFCHK-HNCIHRDV
CDKL2_Hsap      KKKKRWYLVFEFVDHTILDDLEL--FPNGLDYQVVQKYLFQIINGIGFCHS-HNIIHRDI
CDKL5_Hsap      RRRGKLYLVFEYVEKNMLELLEE--MPNGVPPEKVKSYIYQLIKAIHWCHK-NDIVHRDI
CDKL4_Hsap      RRKRKMHLVFEYCDHTLLNELER--NPNGVADGVIKSVLWQTLQALNFCHI-HNCIHRDI
CDKL3_Hsap      RQKKKIHLVFEFIDHTVLDELQH--YCHGLESKRLRKYLFQILRAIDYLHS-NNIIHRDI
Y42A5A.4_Cele   KRNRKLHLVFELCDRTVLHELEK--NPHGVNDELIKKIIYQLLEALKFCHS-HKCIHRDV
10873_Tthe      KRKGRIYLVFEYVEKNLLEVLEE--KPTGLDHEVIRIIMYQLLKALHQCHK-QDVIHRDV
17811_Tthe      QKNNEIYIVEEYVEISLSNYLKQGSQQKGLDQNVIPNIMYQVLSSINQCHK-YDIIHQNI
29899_Tthe      RRKGKLYLVFEYVENNLLEILEE--RPNGLDQDDVRKYIYQLCKSISYCNS-MDIIHRDI
7414_Tthe       KRKGRIYLVFEYVEKNLLEVLEE--KPSGLD----------LLKALDHCHK-HNIIHRDI
CDKL2_Spur      RRKKRLYLVFEFMDHTVLDELEK--YPMGLDESLVRKYMWQILKGIEFCHI-NNIIHRDI
CDKL1_Spur      RRKKKLHLVFEYCDYTVLNTLEA--NVNGVPEGQGMNIVYQTLEAVNFCHQ-HNCIHRDV
CDKL5_Spur      RRRGKLYLVFEYVEKNMLELLEE--NPKGVPPEKVRSYIYQLIKAIHWCHR-NDVIHRDI
AqueK106_Aque   RRKRKLHLVFEYCDHTVLNELEA--HPRGLDETSAKRIIWQTLQGVNYCHH-QN------
AqueK107_Aque   RRKKRLYLVFEFVDHTALDELDK--YPSGADESLVKKIMWQVLKGVEFCHQ-HNVIHRDV
GK026_Glam      KRKQRLYLVFEYCEKTLLELIED--SPGGIPIETVKLLTFQMLRGVEFLWEFMEICHRDL
                ::. . ::* *  : .  . :.      *               .:

CG7236_Dmel     KPENILLTAQ---GQVKLCDFGFARMLS-----------PGENYTDYVATRWYRAPELLV
CDKL5_Mmus      KPENLLISHN---DVLKLCDFGFARNLSEG---------NNANYTEYVATRWYRSPELLL
CDKL4_Mmus      KPENILITKQ---GMIKICDFGFARILI-----------PGDAYTDYVATRWYRAPELLV
CDKL3_Mmus      KPENILVSQS---GITKLCDFGFARTLAA----------PGDVYTDYVATRWYRAPELVL
CDKL2_Mmus      KPENILVSQS---GVVKLCDFGFARTLAA----------PGEVYTDYVATRWYRAPELLV
CDKL1_Mmus      KPENILITKQ---SAIKLCDFGFARLLTG----------PGDYYTDYVATRWYRSPELLV
CDKL1_Hsap      KPENILITKH---SVIKLCDFGFARLLTG----------PSDYYTDYVATRWYRSPELLV
CDKL2_Hsap      KPENILVSQS---GVVKLCDFGFARTLAA----------PGEVYTDYVATRWYRAPELLV
CDKL5_Hsap      KPENLLISHN---DVLKLCDFGFARNLSEG---------NNANYTEYVATRWYRSPELLL
CDKL4_Hsap      KPENILITKQ---GIIKICDFGFAQILI-----------PGDAYTDYVATRWYRAPELLV
CDKL3_Hsap      KPENILVSQS---GITKLCDFGFARTLAA----------PGDIYTDYVATRWYRAPELVL
Y42A5A.4_Cele   KPENIFLTRN---DQVKLGDFGFARIIN-----------TTEMYTDYVATRWYRSPELLV
10873_Tthe      KPENLLVNPYN--YELKLCDFGFARTLPSK---------QGEIITDYVATRWYRAPELLL
17811_Tthe      KPMHIYINPSN--YELKLNGFRLARQLPQ----------KGEIVTDYVEARWYKSPEYLL
29899_Tthe      KPENLLISKD---GTLKLCDFGFARVLPQ----------KGGNLTDYVATRWYRAPELLL
7414_Tthe       KPENLLVNSD---GTLKLCDFGFARHMPPK---------QNEILTDYVATRWYRSPELLL
CDKL2_Spur      KPENILVSKS---KVVKLCDFGFARTIAG----------PGEIYTDYVATRWYRAPELLV
CDKL1_Spur      KPENILITKD---GRIKLCDFGFARILTG----------PDDEYTDYVATRWYRAPELLV
CDKL5_Spur      KPENLLISAK---DTLKLCDFGFARNLDGN---------SSANYTDYVATRWYRSPELLL
AqueK106_Aque   ------------------------------------------------------------
AqueK107_Aque   KPENILISKR---GVVKICDFGFARAIAP----------PGEAYTDYVATRWYRAPELLV
GK026_Glam      KPENLLLVKKHGEWTLKLCDFGFARHINGAQTAGAAGNFPQSNLTDYVATRWYRSPELLL


CG7236_Dmel     GDTQYGTPVDVWAIGCLFAELVRGEALWPGRSDVDQLYLIRKTLGDLLPRHIQIFGQNEY
CDKL5_Mmus      GA-PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPR
CDKL4_Mmus      GDTKYGSSVDVWAVGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFRSNQF
CDKL3_Mmus      KDTSYGKPVDIWALGCMIIEMATGHPFLPSSSDLDLLHKIVLKVGNLTPHLHNIFSKSPI
CDKL2_Mmus      GDVKYGKAVDIWAIGCLVIEMLMGQPLFPGESDIDQLHHIMTCLGNLIPRHQELFYKNPV
CDKL1_Mmus      GDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSMNQY
CDKL1_Hsap      GDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQY
CDKL2_Hsap      GDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPV
CDKL5_Hsap      GA-PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPR
CDKL4_Hsap      GDTQYGSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGF
CDKL3_Hsap      KDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPI
Y42A5A.4_Cele   GDVQYGPPVDIWAVGCVYAELLTGEALWPGRSDIDQLYHIRKTLGEFLPRHISIFRTNQF
10873_Tthe      KYPKYSKPVDIWAVACIMGELIDGQPLFPGQNEIDQLYLIQKTLGPLTPEQKELFIKNPR
17811_Tthe      DYRKYGKPEDIWAAACVMAELIDGEPLFPGQGEIDQFYRIVQVIGPLTNQYENLFKKK--
29899_Tthe      GYTDYGKEVDMWAVGCIMGELTDGQPLFPGQNEIDQLYVIQKVLGPLTAEQQEVFLKHPG
7414_Tthe       SDPGYSFPVDNWAIACIMGELIDGQPLFPGENEIDQLYLIQKLLGPLTPDQKEMFIKNPR
CDKL2_Spur      GDTKYGKAIDLWAVGCLQAEMLTGEPLFPGDSDIDQLYHIIRCFGTLIQRHKEIFLKNPL
CDKL1_Spur      GDMVYGPPVDVWAIGCVTAELIAGEALWPGRSDVDQLYLIKQTLGDLIDRHSKIFSTNHF
CDKL5_Spur      GS-AYGKAVDVWAIGCILGELSDGNAIFPGESEIDQLYMIQKILGPLPHYQMAIFDNSPR
AqueK106_Aque   -------------------------PLWPGRSDVDQLHLIIQTQGDLIPYHVKIFQESTY
AqueK107_Aque   GDTNYGRAVDVWAIGCLFSEMLTGEPLFPGESDIDQLYLITKCFGNLIARHREVFSRNPL
GK026_Glam      NATDYNQTVDIWAAALIISEMITSEPLFAGDSDVDQLYLIQRVLGNLTRKQMEKFLRNPK
                                         .  .. .::* :. *    * :       *

CG7236_Dmel     FKGITLPVPPT--LEPLEDKMPAKSQQNPLTIDFL-KKCLDKDPTKRWSCEKLTKHSYFD
CDKL5_Mmus      FHGLRFPAVNH--PQSLERRYLGIL--NSVLLDLM-KNLLKLDPADRYLTEQCLNHPTFQ
CDKL4_Mmus      FRGISIPEPED--METLEEKFSN---VQPVALSFM-KGCLKMNPDERLTCAQLLDSAYFE
CDKL3_Mmus      FAGVVLPQVQH--PKTARKKYPK---LNGLLADIV-HACLQIDPAERTSSTDLLRHDYFT
CDKL2_Mmus      FAGVRLPEVKDAEAEPLESRYPK---LPEAVISLA-KKCLHIDPDKRPFCADLLRHDFFQ
CDKL1_Mmus      FSGVKIPDPED--METLELKFPN---ISYSALGFL-KGCLHMDPAERLTCEQLLQHPYFD
CDKL1_Hsap      FSGVKIPDPED--MEPLELKFPN---ISYPALGLL-KGCLHMDPTQRLTCEQLLHHPYFE
CDKL2_Hsap      FAGVRLPEIKE--REPLERRYPK---LSEVVIDLA-KKCLHIDPDKRPFCAELLHHDFFQ
CDKL5_Hsap      FHGLRFPAVNH--PQSLERRYLGIL--NSVLLDLM-KNLLKLDPADRYLTEQCLNHPTFQ
CDKL4_Hsap      FHGISIPEPED--METLEEKFSD---VHPVALNFM-KGCLKMNPDDRLTCSQLLESSYFD
CDKL3_Hsap      FAGVVLPQVQH--PKNARKKYPK---LNGLLADIV-HACLQIDPADRISSSDLLHHEYFT
Y42A5A.4_Cele   FFGLSIPEPEH--LEPLPSKLPN---ASSAQLDFL-QKCFEMSPDRRFSCSELMLHGIFS
10873_Tthe      FIGTKFPEINK--PETIERRYLGKL--SKKALNIM-KLMLKMDPDERITAEEAMKHPYFD
17811_Tthe      YKDLKFPIIKN--FNSIELRYQGK--INAEGLDLM-KMMLKMNPDERITAEQSLSHPFFD
29899_Tthe      FLGVKLPEISK--PETIEKRYLGKL--SKKALSFM-KNLLKMDPSQRMSADEALQHPYFD
7414_Tthe       YVGLKFPEIPK--PETIERRYLGKL--SKKALTFM-KGLLKMDPRERMNVQEAMAHPLFD
CDKL2_Spur      FVGMRLPEVKN--VEPLEKRFPT---LSGLSISMM-KSCLHLDPDQRPTCTQFLKHEFFK
CDKL1_Spur      FKGMSIPEPER--RIPLKDKVRN---LNSTALTFL-EACLQMDPADRLSCQELMEMPFFD
CDKL5_Spur      FSGLKVTILSI---Q-FKRSIF-RI--FSCLLAVL-------------------------
AqueK106_Aque   FKDTSIPCPDK--REPISALYPQ---FSQQILSFLEQGCLAMDPIARQTAEELLDHPVFD
AqueK107_Aque   FIGMRLPEARE--IQPFERRYHR---LSPAAMDII-KWSLRLDPADRPTCTQLLKHELFQ
GK026_Glam      FIGVEFPTS-R--PEGLEKKLTGKIK-DKQAISLL-KMMLKMDPAERPSATQCLDHEFFD
                : .  ..                          .

CG7236_Dmel     D--YIA--KQR-ELE------H-VNSLEAA----------------N---LRQQ------
CDKL5_Mmus      T--QRLLDRSPSRST--KRKP-YHVESSTLSNR------------NQ---STKGAALQTH
CDKL4_Mmus      S--FQE--DQ---MK------R-KARSEGRS---------------R---RRQQ------
CDKL3_Mmus      RDGFIE--KFIPELR--AKLLQ-EAKVNSFIKP------------KE---NF-KEN----
CDKL2_Mmus      MDGFAE--RFSQELQ--LKIEK-DARNNSLPKK------------SQ---NRKKEK----
CDKL1_Mmus      S--IRE--VGE--LT------R-QHDKPARK---------------T---LRQS------
CDKL1_Hsap      N--IRE--IED--LA------K-EHNKPTRK---------------T---LRKS------
CDKL2_Hsap      MDGFAE--RFSQELQ--LKVQK-DARNVSLSKK------------SQ---NRKKEK----
CDKL5_Hsap      T--QRLLDRSPSRSA--KRKP-YHVESSTLSNR------------NQ---AGKSTALQSH
CDKL4_Hsap      S--FQE--AQ---IK------R-KARNEGRN---------------R---RRQQ------
CDKL3_Hsap      RDGFIE--KFMPELK--AKLLQ-EAKVNSLIKP------------KE---SS-KEN----
Y42A5A.4_Cele   N--WIL--RIR-Q--------D-ES-TPTGL---------------T---SKRS------
10873_Tthe      G--VRE--QFDKDDN--VTKP-VSAVTIDLKRE------------NS---HLKKMP----
17811_Tthe      K--LKS--KIDNEKG--AFIQN------------------------K---LS--------
29899_Tthe      G--IRD--KEIQQTIKHGRIE-ERVESATIKEP------------KQINQNGTNSGFYNQ
7414_Tthe       G--IRE--LYDDDND--HNSQSQHNKSIEKNQE------------NQ---NIRSYGS---
CDKL2_Spur      KDGFCD--VFPSELS--LKVQK-EFEGNPLLKSLLGDEKGDEEKKPK---HRSKKQ----
CDKL1_Spur      R--HKG--LDD-R-H------S-DSTNVRRH-----------------------------
CDKL5_Spur      ------------------------------------------------------------
AqueK106_Aque   D--FRD--WFQPELE--MLLAR-EAKKVHKSKA-------------K---VQQA------
AqueK107_Aque   RNGWAD--KYSIELR--SKIQH-EFDDNPLLKNLGVTIYGSL-YDSQ---HAAMKE----
GK026_Glam      S--VRQ--RALQLEMK---CME-DMGIRPLVKE------------PQ---YSSNTL----


CG7236_Dmel     ------------------------------------------------------------
CDKL5_Mmus      HRSNSKDIQNLSVGLPRAEEGLPANESFLNGNLAGATLSPMHTKTYQASTQPGSSSKDLT
CDKL4_Mmus      ------------------------------------------------------------
CDKL3_Mmus      ------------------------------------------------------------
CDKL2_Mmus      ------------------------------------------------------------
CDKL1_Mmus      ------------------------------------------------------------
CDKL1_Hsap      ------------------------------------------------------------
CDKL2_Hsap      ------------------------------------------------------------
CDKL5_Hsap      HRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLT
CDKL4_Hsap      ------------------------------------------------------------
CDKL3_Hsap      ------------------------------------------------------------
Y42A5A.4_Cele   ------------------------------------------------------------
10873_Tthe      ------------------------------------------------------------
17811_Tthe      ------------------------------------------------------------
29899_Tthe      QTQNAST-----------------------------------------------------
7414_Tthe       ------------------------------------------------------------
CDKL2_Spur      ------------------------------------------------------------
CDKL1_Spur      ------------------------------------------------------------
CDKL5_Spur      ------------------------------------------------------------
AqueK106_Aque   ------------------------------------------------------------
AqueK107_Aque   ------------------------------------------------------------
GK026_Glam      ------------------------------------------------------------


CG7236_Dmel     ------------------------------------------------------------
CDKL5_Mmus      NNNIPHLLSPKEAKSKTEFDFNIDTKPSEGPGTKYLKSSTRS--QQN-------------
CDKL4_Mmus      ------------------------------------------------------------
CDKL3_Mmus      ---------------------------------EPVRDEKK---SVF-------------
CDKL2_Mmus      --------------------------------DDALGEERK---TLV-------------
CDKL1_Mmus      ------------------------------------------------------------
CDKL1_Hsap      ------------------------------------------------------------
CDKL2_Hsap      -----------------------------EK-DDSLVEERK---TLV-------------
CDKL5_Hsap      NNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYLKSNSRS--QQN-------------
CDKL4_Hsap      ------------------------------------------------------------
CDKL3_Hsap      ---------------------------------ELRKDERK---TVY-------------
Y42A5A.4_Cele   ------------------------------------------------------------
10873_Tthe      -----------------------------QT-DKQINLSRKV--DII-------------
17811_Tthe      ------------------------------------------------------------
29899_Tthe      ------------------------IKPKDKPPQQQ-AIPPKN--Q-T-------------
7414_Tthe       -------------KNNI------DEKKNEDQDERDSQFEKKS--QTI-------------
CDKL2_Spur      -----------------------------SS-SEKLERE---------------------
CDKL1_Spur      ------------------------------------------------------------
CDKL5_Spur      ------------------------------------------------------------
AqueK106_Aque   ------------------------------------------------------------
AqueK107_Aque   -----------------------------SS-GEETVPNRLTTKHDYATGFSSGAEATGS
GK026_Glam      -----------------------------SG-DIS--STQLQ--QNL-------------


CG7236_Dmel     -------------------------QLAS-----QQFML---------------------
CDKL5_Mmus      RHSFMESSQSKAG---TLQPSEKQS----RH--------------SYI-DTIPQS-SRSP
CDKL4_Mmus      ------------------------------------------------------------
CDKL3_Mmus      TNTLLYGNPSLYG---KEVDRDKRA----KELK-VRVIKAKGGKG------DVPD-QKKP
CDKL2_Mmus      V---------------QDTNADPKI----KDSK---VFKVKGSKI------DVEK-MEKG
CDKL1_Mmus      -------------------------R-KH-----L-------------------------
CDKL1_Hsap      -------------------------R-KH-----HCFTE---------------------
CDKL2_Hsap      V---------------QDTNADPKI----KDYK---LFKIKGSKI------DGEK-AEKG
CDKL5_Hsap      RHSFMESSQSKAG---TLQPNEKQS----RH--------------SYI-DTIPQS-SRSP
CDKL4_Hsap      ------------------------------------------------------------
CDKL3_Hsap      TNTLLS--SSVLG---KEIEKEKKP----KEIK-VRVIKVKGGRG------DISE-PKKK
Y42A5A.4_Cele   ------------------------------------------------------------
10873_Tthe      GKTES--NDIDEKNNGMVQ--NNED----HN--------------EYGESYGKQSMKLEK
17811_Tthe      ------------------------------------------------------------
29899_Tthe      QQPPLGSNKQKAL---QQQPDQQQQ----RV-------------NNFVKNGVRQE-KNTP
7414_Tthe       HHEQNQKNGIYAK---LNKENNNQS----QK--------------ILGKNYFSQN-KLPP
CDKL2_Spur      ---------------------REKEKSRKRHSETEKLKRSSTPTR------DAHH-ESSP
CDKL1_Spur      -------------------------R-SK-----L--GL---------------------
CDKL5_Spur      ------------------------------------------------------------
AqueK106_Aque   -------------------------SRSK-----GHLGG---------------------
AqueK107_Aque   G---------------ADESAIKKEKKKK-----IKVHREKAANG------LPLQ-EPKP
GK026_Glam      QHNLHTTS---------------------SH-------------------------SINP


CG7236_Dmel     -----AT-----------------------------------------------------
CDKL5_Mmus      SYR---TKAKSHG------ALSDSKSV---------------------------S----N
CDKL4_Mmus      ------------------------------------------------------------
CDKL3_Mmus      E---YEGDHRQQG----------------------------------------TA-----
CDKL2_Mmus      S---RASNA---N------CLHDNGT---------------------------NH-----
CDKL1_Mmus      ------------------------------------------------------------
CDKL1_Hsap      ------------------------------------------------------------
CDKL2_Hsap      N---RASNA---S------CLHDSRT---------------------------SH-----
CDKL5_Hsap      SYR---TKAKSHG------ALSDSKSV---------------------------S----N
CDKL4_Hsap      ------------------------------------------------------------
CDKL3_Hsap      E---YEGGLGQQD----------------------------------------AN-----
Y42A5A.4_Cele   ------------------------------------------------------------
10873_Tthe      ------------------------QFM---------------------------Q-----
17811_Tthe      ------------------------------------------------------------
29899_Tthe      SHE---NNRIIKKDIYPHPQI---NFM---------------------------QSSYSN
7414_Tthe       QYL------------------QNSKMM---------------------------Q-----
CDKL2_Spur      KYDVKKSNP---S------TVTESQKKS-------------STIAS---TSNTSG-----
CDKL1_Spur      ------------------------------------------------------------
CDKL5_Spur      ------------------------------------------------------------
AqueK106_Aque   ------------------------------------------------------------
AqueK107_Aque   K-----------T------MIPSSLLQGNMAALGGPSGSPYGSQHALLRAQQPSP-----
GK026_Glam      T----------------------AQSG---------------------------Q----N


CG7236_Dmel     ------------------------------------------------------------
CDKL5_Mmus      LSE-------ARA-----QITETNTSRY------------FP----------------SS
CDKL4_Mmus      ------------------------------------------------------------
CDKL3_Mmus      -------------------------DDT------------QP----------------SS
CDKL2_Mmus      -------------------------KGL-------------A----------------ST
CDKL1_Mmus      ------------------------------------------------------------
CDKL1_Hsap      ------------------------------------------------------------
CDKL2_Hsap      -------------------------NKI------------VP----------------ST
CDKL5_Hsap      LSE-------ARA-----QIAEPSTSRY------------FP----------------SS
CDKL4_Hsap      ------------------------------------------------------------
CDKL3_Hsap      -------------------------ENV------------HP----------------MS
Y42A5A.4_Cele   ------------------------------------------------------------
10873_Tthe      ------------------------------------------------------------
17811_Tthe      ------------------------------------------------------------
29899_Tthe      IPDIYIKTKNAQNQQYNYEIQENYQPDFHNEDPDDSQQPSVPQVLIRNDTHGNHNNMVNV
7414_Tthe       ------------------------------------------------------------
CDKL2_Spur      -------------------------PSI------------QS----------------IS
CDKL1_Spur      ------------------------------------------------------------
CDKL5_Spur      ------------------------------------------------------------
AqueK106_Aque   ------------------------------------------------------------
AqueK107_Aque   -------------------------YMY------------KP----------------ST
GK026_Glam      IGA-------SSL-----GIGYP--ATT------------VP----------------TS


CG7236_Dmel     ------------------------------------------------------------
CDKL5_Mmus      CLDLNSPTSPT---PT-RHTDTRTLLSPSGRNNRN---------EGTLDSRRTTTRHSKT
CDKL4_Mmus      ------------------------------------------------------------
CDKL3_Mmus      LDKKPSVLELT---NPL---------NPSENSD---------------------------
CDKL2_Mmus      SLRDCSNVNID---HSR---------NP--------------------------------
CDKL1_Mmus      ------------------------------------------------------------
CDKL1_Hsap      ------------------------------------------------------------
CDKL2_Hsap      SLKDCSNVSVD---HTR---------NP--------------------------------
CDKL5_Hsap      CLDLNSPTSPT---PT-RHSDTRTLLSPSGRNNRN---------EGTLDSRRTTTRHSKT
CDKL4_Hsap      ------------------------------------------------------------
CDKL3_Hsap      PDTKLVTIEPP---NPI---------NPSTNCN---------------------------
Y42A5A.4_Cele   ------------------------------------------------------------
10873_Tthe      ------------------------------------------------------------
17811_Tthe      ------------------------------------------------------------
29899_Tthe      SIEDNTPYSKF---NE-RNKSK-ENIIPKGKKKKSQMSNIENFYQD---NAENSNNQEED
7414_Tthe       ------------------------------------------------------------
CDKL2_Spur      SSSK-LPQHIGGHNGPTNHT----TSHPSG------------------------------
CDKL1_Spur      ------------------------------------------------------------
CDKL5_Spur      ------------------------------------------------------------
AqueK106_Aque   ------------------------------------------------------------
AqueK107_Aque   PKRV-LPHDIP---SPL---------HPNA------------------------------
GK026_Glam      SG---KPG-------S-SHSTYH-TIGPSGTTMG--------------------------


CG7236_Dmel     -------------------------------------------------A---AQQLQTG
CDKL5_Mmus      MEEL------------KLPEHM---DS-----------SH-S--HSLSAP---HESFSY-
CDKL4_Mmus      ------------------------------------------------------------
CDKL3_Mmus      --GVKEDPHAGG--CMIMPPINLTSS---------------------NLL---AANLSSN
CDKL2_Mmus      --------------GTAIPPLTH----------------------NLSAV---APGINAG
CDKL1_Mmus      ------------------------------------------------------------
CDKL1_Hsap      ------------------------------------------------------------
CDKL2_Hsap      --------------SVAIPPLTH----------------------NLSAV---APSINSG
CDKL5_Hsap      MEEL------------KLPEHM---DS-----------SH-S--HSLSAP---HESFSY-
CDKL4_Hsap      ------------------------------------------------------------
CDKL3_Hsap      --GLKENPHCGG--SVTMPPINLTNS---------------------NLM---AANLSSN
Y42A5A.4_Cele   ------------------------------------------------------------
10873_Tthe      -------------------------SS-----------VY-N--YKVSDKNLEEGSFID-
17811_Tthe      ------------------------------------------------------------
29899_Tthe      AEGR------------KSPLLT---NNKLYGTSVAQQKKF-R--FNV--M---AQNIQQ-
7414_Tthe       -------------------------NT-----------VY-N--YNIDKD---DSSFTE-
CDKL2_Spur      -----------QGSSPTQTTINLTMGN-----------ITSNKSN---FT---STNMAGP
CDKL1_Spur      ------------------------------------------------------------
CDKL5_Spur      ------------------------------------------------------------
AqueK106_Aque   -----------------------------------------------------------G
AqueK107_Aque   -----------K--SIGAPPISLLDNQ-----------ASAT--HSITKL---KAGLQSH
GK026_Glam      VSNI------------TGPMVM---SN-----------FG-Q--HHTNYP---AHSVHN-


CG7236_Dmel     PAQA-AAIAAARDK----------------------------------------------
CDKL5_Mmus      ---------------GLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARA
CDKL4_Mmus      ------------------------------------------------------------
CDKL3_Mmus      LSH-----PNSRLTER----------------------TKKR---RTSSQTIGQ------
CDKL2_Mmus      MGTI-PGVQNYRVDEK----------------------TKKY--------CNPF------
CDKL1_Mmus      ------------------------------------------------------------
CDKL1_Hsap      ------------------------------------------------------------
CDKL2_Hsap      MGTETIPIQGYRVDEK----------------------TKKC--------SIPF------
CDKL5_Hsap      ---------------GLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARA
CDKL4_Hsap      ------------------------------------------------------------
CDKL3_Hsap      LFH-----PSVRLTER----------------------AKKR---RTSSQSIGQ------
Y42A5A.4_Cele   ------------------------------------------------------------
10873_Tthe      ---------------QDKNL-------------------------KVNFCM---------
17811_Tthe      ------------------------------------------------------------
29899_Tthe      ---------------NE------EAQEYPRLINIYQKQQQSRANSRSKFYKNGQLQKN--
7414_Tthe       ---------------ANGNS-------------------------KRNSNQFE------N
CDKL2_Spur      P--------PLRPNDK--------M-------------TKKS--------TNSY------
CDKL1_Spur      ------------------------------------------------------------
CDKL5_Spur      ------------------------------------------------------------
AqueK106_Aque   AT-A-SSAA---TI----------------------------------------------
AqueK107_Aque   SNTSITSLHELRPDLQ--------PH-----------RGDAY--------RSP-------
GK026_Glam      ---------------TVNYHYPVQ------------------------------------


CG7236_Dmel     ------------------------------------------------------------
CDKL5_Mmus      NSLQLLSPQPGEQLPPEMTVARP------SVKE----------SSRE---GASSFHT---
CDKL4_Mmus      ------------------------------------------------------------
CDKL3_Mmus      ------------------------------TLS----------NSRQ---------EDTG
CDKL2_Mmus      ------------------------------VKP----------N-------------QPP
CDKL1_Mmus      ------------------------------------------------------------
CDKL1_Hsap      ------------------------------------------------------------
CDKL2_Hsap      ------------------------------VKP----------N-------------RHS
CDKL5_Hsap      NSLQLLSPQPGEQLPPEMTVARS------SVKE----------TSRE---GTSSFHT---
CDKL4_Hsap      ------------------------------------------------------------
CDKL3_Hsap      ------------------------------VMP----------NSRQ---------EDPG
Y42A5A.4_Cele   ------------------------------------------------------------
10873_Tthe      YSKHIQYNLLEEQLRQKLGKEDSSSNTCSSWRP----------NQK-NSFEKKFTM----
17811_Tthe      ------------------------------------------------------------
29899_Tthe      -ANYV--------------------------------------SSQQ---MNVLLHT---
7414_Tthe       TKNRLLYDSMSVQKPPKMGPAGS------SLKK----------NQQINQINKTFYHS---
CDKL2_Spur      ------------------------------YKK----------V-------------GAS
CDKL1_Spur      ------------------------------------------------------------
CDKL5_Spur      ------------------------------------------------------------
AqueK106_Aque   ------------------------------------------------------------
AqueK107_Aque   ------------------------------LSP----------S-------------HPP
GK026_Glam      -----------QSLS-----------------PAAAQARAISNA----------------


CG7236_Dmel     ------------------------------------------------------------
CDKL5_Mmus      --R---QKSEGGVYHDPHS-DD-GTAPKENRH-------LYNDPVPRRVGSFYRVPSPRP
CDKL4_Mmus      ------------------------------------------------------------
CDKL3_Mmus      PTQ---VQTEKGAFNERTG-QN-DQ-----------------------------------
CDKL2_Mmus      PA-------GIYNMNVSTSVSGEKY-----------------------------------
CDKL1_Mmus      ------------------------------------------------------------
CDKL1_Hsap      ------------------------------------------------------------
CDKL2_Hsap      PS-------GIYNINVTTLVSSEKN-----------------------------------
CDKL5_Hsap      --R---QKSEGGVYHDPHS-DD-GTAPKENRH-------LYNDPVPRRVGSFYRVPSPRP
CDKL4_Hsap      ------------------------------------------------------------
CDKL3_Hsap      PIQ---SQMEKGIFNERTG-HS-DQ-----------------------------------
Y42A5A.4_Cele   ------------------------------------------------------------
10873_Tthe      -----------------KE-D--------DKQ-------Y--------------------
17811_Tthe      ------------------------------------------------------------
29899_Tthe      --EEGPDYEEKGLNLNSNT-NN-NNMNVNNNNISSQNMME--------------------
7414_Tthe       --IIGGHGSQGGLQISDRI-D--------PK-----------------------------
CDKL2_Spur      GS-------EKTMIHEKTL-QFDAM-----------------------------------
CDKL1_Spur      ------------------------------------------------------------
CDKL5_Spur      ------------------------------------------------------------
AqueK106_Aque   ------------------------------------------------------------
AqueK107_Aque   PV----------------------------------------------------------
GK026_Glam      ------------------------------------------------------------


CG7236_Dmel     --------------------------------SKTSNTSLPLLPS---------------
CDKL5_Mmus      DNSFH----EN--NV------------------STRVSSLPSDSSSGTNHSKRQPGFDP-
CDKL4_Mmus      ------------------------------------NQLLPLIPG---------------
CDKL3_Mmus      --------------ISSGNKRKLNFPKCDRK-----EFHFPELPFT--------------
CDKL2_Mmus      --------------LLQANKKRKEYPKADVRLPELNYNHLPE---L--------------
CDKL1_Mmus      ----------------------------------TGLQYLPQLTS---------------
CDKL1_Hsap      ---------------------------------TSKLQYLPQLTG---------------
CDKL2_Hsap      --------------LFWASKKRREYSRTDVRLPELNYNHLPE---L--------------
CDKL5_Hsap      DNSFH----EN--NV------------------STRVSSLPSESSSGTNHSKRQPAFDP-
CDKL4_Hsap      ------------------------------------NQLLPLIPG---------------
CDKL3_Hsap      --------------MANENKRKLNFSRSDRK-----EFHFPELPVT--------------
Y42A5A.4_Cele   ------------------------------------PNYLPLLNG---------------
10873_Tthe      -AQFKQTQRDN--NI------------------MSQKQVLPSIT----KKF--L--IDNG
17811_Tthe      ------------------------------------------------------------
29899_Tthe      -QQVM----GN--EI------------------FQSTSQLPYIQQSSSN-----------
7414_Tthe       -SSYNSTIGMS--TL------------------GISGGALPTIN----NHNKKFA-TNN-
CDKL2_Spur      --------------MSSQRKSKKDVSNTSPRESDREVTHLPN---L--------------
CDKL1_Spur      ---------------------------------RKDNSHLPQLNS---------------
CDKL5_Spur      ------------------------------------------------------------
AqueK106_Aque   --------------------------------PNESSALVPQLPAL--------------
AqueK107_Aque   ---------------------KKQLSNA-------GTIGLPQ---L--------------
GK026_Glam      -------TRQSHYAL------------------NVEDSGLPFLPASRSGS----------


CG7236_Dmel     ---------------TQ--H-----------HHHPHQ--DYV------------------
CDKL5_Mmus      WKSPENISHADQLKE--KE----KQGF-FRSMKKKKK--KTQTVPNTDGPDLLTLQKAIH
CDKL4_Mmus      ---------------SH--I-------------SPTP--D--------------------
CDKL3_Mmus      ------------VQAKEMKG------MEVKQIKVLKR--ESKKTDSSKIPTLLSMDPNQE
CDKL2_Mmus      -------------RALE--G------I-ARNSRLIKK--ENKCLSESRIPSLAAIDLHVS
CDKL1_Mmus      ---------------SR--I-------------LPAL--D--------------------
CDKL1_Hsap      ---------------SS--I-------------LPAL--D--------------------
CDKL2_Hsap      -------------RALG--G------I-ARNSRLTKK--ESKILSESRIPSLAAIDLHTP
CDKL5_Hsap      WKSPENISHSEQLKE--KE----KQGF-FRSMKKKKK--KSQTVPNSDSPDLLTLQKSIH
CDKL4_Hsap      ---------------SH--I-------------SPTP--D--------------------
CDKL3_Hsap      ------------IQSKDTKG------MEVKQIKMLKR--ESKKTESSKIPTLLNVDQNQE
Y42A5A.4_Cele   ---------------NS--N------N----LVSKNF--SLQ------------------
10873_Tthe      ANSNSPTSRTA------------KLSL-GSTSQFTKQTNGQFINPS----------G---
17811_Tthe      ---------------NQ--I-------------K--------------------------
29899_Tthe      --------YNPNFK------------F-YNMYHQQQ---KQTQKPSGKMSTQHNNNTNQ-
7414_Tthe       EKGGSPSSHHS------------KMSF-GSTQNYNK---MYFQSPT----------NQIN
CDKL2_Spur      -------------TGKD--A------K-TSERQEKKL--KAKKSHHTTMPQI--------
CDKL1_Spur      ---------------QG--L-------------QESL--SKG------------------
CDKL5_Spur      ------------------------------------------------------------
AqueK106_Aque   -------------AATN--N-----------IIQQQI--DTE------------------
AqueK107_Aque   -------------NDPS--NSHLRL-T-AKSPLVPAY--THSSYSQIHSTSGAEIDHHTH
GK026_Glam      ---------------------------------RAA---KVREAP-SRGNSLTV------


CG7236_Dmel     ------------------------------------------------------------
CDKL5_Mmus      SSSTASS--RPKEWRPEKLSDLQTQSQPLKSLRKLLHLSSSTNHPASSDPRFQPLTAQ--
CDKL4_Mmus      ------------------------------------------------------------
CDKL3_Mmus      K-----------------------------------------------------------
CDKL2_Mmus      S----------------------------------------V------------------
CDKL1_Mmus      ------------------------------------------------------------
CDKL1_Hsap      ------------------------------------------------------------
CDKL2_Hsap      S----------------------------------------I------------------
CDKL5_Hsap      SASTPSS--RPKEWRPEKISDLQTQSQPLKSLRKLLHLSSASNHPASSDPRFQPLTAQ--
CDKL4_Hsap      ------------------------------------------------------------
CDKL3_Hsap      K-----------------------------------------------------------
Y42A5A.4_Cele   ------------------------------------------------------------
10873_Tthe      -----ST--TN-------------------------ANSTSRLVNDMNFSKFHNLNVI--
17811_Tthe      ------------------------------------------------------------
29899_Tthe      ------NMNYD-------------------------QYTYSMHPYDQQDQEMKNLNII--
7414_Tthe       VSTGAAG--AN-------------------------GMTASKLLNDINMQKIQNLNVI--
CDKL2_Spur      ------------------------------------------------------------
CDKL1_Spur      ------------------------------------------------------------
CDKL5_Spur      ------------------------------------------------------------
AqueK106_Aque   ------------------------------------------------------------
AqueK107_Aque   G----------------------------------------MLSSGVPRASYQLTPSGRM
GK026_Glam      ------------------------------------------------------MN----


CG7236_Dmel     --------------------------KL-Q--------PLNKN-----------------
CDKL5_Mmus      ---QAKNSFSEIR------IHPLSQAtGGSSNIRQEPTPKGRPALQLPGQMD----P---
CDKL4_Mmus      ----------------------------------------GRK-----------------
CDKL3_Mmus      --------QE---------TEPCVTVNE-W--------PDQER-----------------
CDKL2_Mmus      ------------------AS------HQ-G--------AG-SP-----------------
CDKL1_Mmus      ----------------------------------------NKK-----------------
CDKL1_Hsap      ----------------------------------------NKK-----------------
CDKL2_Hsap      ------------------TL------HQ-V--------SG-PP-----------------
CDKL5_Hsap      ---QTKNSFSEIR------IHPLSQASGGSSNIRQEPAPKGRPALQLPDGGCDGRRQRHH
CDKL4_Hsap      ----------------------------------------GRK-----------------
CDKL3_Hsap      --------QE---------FIPLSLLSACC--------PIF-------------------
Y42A5A.4_Cele   --------------------------GG-N--------HG-NN-----------------
10873_Tthe      ---YNTNTYNYN--------MPLTQ-----------------------------------
17811_Tthe      ------------------------------------------------------------
29899_Tthe      ---YNNNTYNYN------------------------------------------------
7414_Tthe       ---YNTNTYNYNN------VQPVNQVGNAFINQN----SQ--------------------
CDKL2_Spur      ---AN---QS---------D------HG-G--------HG-FN-----------------
CDKL1_Spur      --------------------------HQ-N--------LGHKK-----------------
CDKL5_Spur      ------------------------------------------------------------
AqueK106_Aque   --------------------------RR------------G-------------------
AqueK107_Aque   RHPPH---QDPGPQSGFSLL------HQ-K--------PS-SP-----------------
GK026_Glam      -------------------------VGGNN--MFLNPPKYGIP-----------------


CG7236_Dmel     ------------------------------------------------------------
CDKL5_Mmus      --------------------------GWHVSSVTRSATEGPSYSEQLGAKS---------
CDKL4_Mmus      ------------------------------------------------------------
CDKL3_Mmus      ------------------------------------------------------------
CDKL2_Mmus      ------------------------------------------------------------
CDKL1_Mmus      ------------------------------------------------------------
CDKL1_Hsap      ------------------------------------------------------------
CDKL2_Hsap      ------------------------------------------------------------
CDKL5_Hsap      SGPQDRRFMLRTTEQQGEYFCCGDPKKPHTPCVPNRAL------------HRPISSPAPY
CDKL4_Hsap      ------------------------------------------------------------
CDKL3_Hsap      ------------------------------------------------------------
Y42A5A.4_Cele   ------------------------------------------------------------
10873_Tthe      ------------------------------------------------------------
17811_Tthe      ------------------------------------------------------------
29899_Tthe      ------------------------------------------------------------
7414_Tthe       ------------------------------------------------------------
CDKL2_Spur      ------------------------------------------------------------
CDKL1_Spur      ------------------------------------------------------------
CDKL5_Spur      ------------------------------------------------------------
AqueK106_Aque   ------------------------------------------------------------
AqueK107_Aque   ------------------------------------------------------------
GK026_Glam      ------------------------------------------------------------


CG7236_Dmel     -------------------------------------------------AN--L-LHRTE
CDKL5_Mmus      -----------GPN---------------G--------------HPYNRTNRSRMPNLND
CDKL4_Mmus      -------------------------------------------------QV--VQ-LK-F
CDKL3_Mmus      ----------------------------------------------REPTGRGGHRVEMA
CDKL2_Mmus      -------------------------------------------------LSD-DSEADLP
CDKL1_Mmus      -------------------------------------------------YH--CSTKRFN
CDKL1_Hsap      -------------------------------------------------YY--CDTKKLN
CDKL2_Hsap      -------------------------------------------------LSD-DSGADLP
CDKL5_Hsap      PVLQVRGTSMCPTLQVRGTDAFSCPTQQSGFSFFVRHVMREALIHRAQVNQAALLTYHEN
CDKL4_Hsap      -------------------------------------------------QV--LQ-LK-F
CDKL3_Hsap      ----------------------------------------------TNICSQLTIRVEMA
Y42A5A.4_Cele   ------------------------------------------------NNN--GNGIN-R
10873_Tthe      ---------------------------------------------------KAANNTKKT
17811_Tthe      -------------------------------------------------EN--L-KNQAH
29899_Tthe      ------------------------------------------------I---NNSPLWNS
7414_Tthe       --------------------------------------------------SKKSFGTGTM
CDKL2_Spur      -------------------------------------------------AN--ASYSSTD
CDKL1_Spur      ------------------------------------------------VEN--EKLLK-R
CDKL5_Spur      -----------------------------------------------------------K
AqueK106_Aque   ------------------------------------------------HQH--QKSDS-V
AqueK107_Aque   -------------------------------------------------RV--LRTSETS
GK026_Glam      ----------------------------------------------KNPQSR--GALLPK


CG7236_Dmel     HHLP----TI
CDKL5_Mmus      LKE----TAL
CDKL4_Mmus      DHLP----NI
CDKL3_Mmus      IVR----GRI
CDKL2_Mmus      RMEH----QH
CDKL1_Mmus      YHFP----NI
CDKL1_Hsap      YRFP----NI
CDKL2_Hsap      QMEH----QH
CDKL5_Hsap      AAL----TGK
CDKL4_Hsap      DHLP----NI
CDKL3_Hsap      IAR----GRI
Y42A5A.4_Cele   NFLP---TIS
10873_Tthe      KPK----YQI
17811_Tthe      QDLQ----KN
29899_Tthe      ISK----KKI
7414_Tthe       YKK----KNY
CDKL2_Spur      HNLP----AV
CDKL1_Spur      DRLPNIDSFK
CDKL5_Spur      NNH----IHM
AqueK106_Aque   DHLP---SLT
AqueK107_Aque   QLAP----TN
GK026_Glam      IRD----TRY