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Doa_Dmel         MCVRFQMPRT--------------------------------------------------
CLK4_Mmus        MRHSKRT-----------------------------------------------------
CLK3_Mmus        MPVLSARRKRLASTAGPR-RG------------S--------------------------
CLK2_Mmus        MPHPRRYH---SSERGSR--G------------S--------------------------
CLK1_Mmus        MRHSKRT-----------------------------------------------------
E02H4.3_Cele     MPILHQKI---ASTGGQPSTN------------S--------------------------
C16A11.3_Cele    MEHDSSEDSD--QFEPPR--APVSS-----------------------------------
KNS1_Scer        MSQNIQIGT---------------------------------------------------
CLK4_Hsap        MRHSKRT-----------------------------------------------------
CLK3_Hsap        MPVLSARRRELADHAGSG-RR------------S--------------------------
CLK2_Hsap        MPHPRRYH---SSERGSR--G------------S--------------------------
CLK1_Hsap        MAAGRRPA---SALWPER-RG------------SPL----RGDLLGFQNVREPSSCGETL
Y111B2A.1_Cele   MKRASTCLQH--HSLPAK--K---------------------------------------
ClkA_Ddis        MDRFQTKRKTYSYNGYSN--N------------D--------------------------
22369_Tthe       MGSKDRTKNYRE-YRGSI--S------------KKYKNNQSGNYSKFQN-RQNSRSRSRS
CLK_Spur         MSRGASSPDS---IHGMP------------------------------------------
CC1G_01467_Ccin  MLASDRGHS---VQYS----ALVQDL----------------------------------
CC1G_10232_Ccin  MDTTPLLPPG--LSFPYR--RNGSRFELWLIKMS--------------------------
CC1G_15475_Ccin  MLPAHELKR---------------------------------------------------
CC1G_06417_Ccin  MSAAVHPLNPHHISHYSR--S---------------------------------------
AqueK109_Aque    MLTTMCVRGNA-------------------------------------------------
CLK_a_Smoe       MLIDIWLVQFA-P-AG--------------------------------------------
CLK_d_Smoe       SPPW--------------------------------------------------------
CLK_b_Smoe       MVGT--------------------------------------------------------
CLK_c_Smoe       MVTAAALQV---------------------------------------------------
GK028_Glam       MALSSRPNT---ARR---------------------------------------------


Doa_Dmel         ------------------------------------------------------------
CLK4_Mmus        ------------------------------------------------------------
CLK3_Mmus        -GPSLAVRWVPPLGPEPSSDRGRAPMR----------------------PRGPT---CST
CLK2_Mmus        -----------------------------------------------------Y------
CLK1_Mmus        ------------------------------------------------------------
E02H4.3_Cele     ----LALRRLP-------------------------------------------------
C16A11.3_Cele    ------------------------------------------------------------
KNS1_Scer        ------------------------------------------------------------
CLK4_Hsap        ------------------------------------------------------------
CLK3_Hsap        -GPSPTARSGPHL----SALRA-QPARAAH-LS----------------GRGTY---VRR
CLK2_Hsap        -----------------------------------------------------Y------
CLK1_Hsap        SG----------------------------------------------------------
Y111B2A.1_Cele   ------------------------------------------------------------
ClkA_Ddis        -----------------------------------------------------YGYYN--
22369_Tthe       Q-----------------QQRN-APAQYQNSFQNNEKLRYDNNNNRYQQNQYSQ---NDR
CLK_Spur         ------------------------------------------------------------
CC1G_01467_Ccin  ------------------------------------------------------------
CC1G_10232_Ccin  -----------------------FPLL---------------------------------
CC1G_15475_Ccin  ------------------------------------------------------------
CC1G_06417_Ccin  ------------------------------------------------------------
AqueK109_Aque    ------------------------------------------------------------
CLK_a_Smoe       ------------------------------------------------------------
CLK_d_Smoe       ------------------------------------------------------------
CLK_b_Smoe       ------------------------------------------------------------
CLK_c_Smoe       ------------------------------------------------------------
GK028_Glam       ------------------------------------------------------------


Doa_Dmel         ------------------------------------------------------------
CLK4_Mmus        ------------------------------------------------------------
CLK3_Mmus        TRRGAGRGPRLLPGPPGRD---------LHRCRPDPGGAGQSPRVCEFGARAVRPLGRVE
CLK2_Mmus        ------------------------------------------------------------
CLK1_Mmus        ------------------------------------------------------------
E02H4.3_Cele     ------------------------------------------------------------
C16A11.3_Cele    ------------------------------------------------------------
KNS1_Scer        ------------------------------------------------------------
CLK4_Hsap        ------------------------------------------------------------
CLK3_Hsap        DTAGGGPGQARPLGPPGTS---------LLGRGARRSGEGWCPGAFESGARAARPPSRVE
CLK2_Hsap        ------------------------------------------------------------
CLK1_Hsap        ------------------------------------------------------------
Y111B2A.1_Cele   ------------------------------------------------------------
ClkA_Ddis        ------------------------------------------------------------
22369_Tthe       DFRGGSVERRYDQGPNNQYSRNEGRDNNNFGRNNYKNDTGY-------------------
CLK_Spur         ------------------------------------------------------------
CC1G_01467_Ccin  ------------------------------------------------------------
CC1G_10232_Ccin  ------------------------------------------------------------
CC1G_15475_Ccin  ------------------------------------------------------------
CC1G_06417_Ccin  ------------------------------------------------------------
AqueK109_Aque    ------------------------------------------------------------
CLK_a_Smoe       ------------------------------------------------------------
CLK_d_Smoe       ------------------------------------------------------------
CLK_b_Smoe       ------------------------------------------------------------
CLK_c_Smoe       ------------------------------------------------------------
GK028_Glam       ------------------------------------------------------------


Doa_Dmel         ---------------------------------------------------RRL------
CLK4_Mmus        ------------------------------------------------------------
CLK3_Mmus        PGPPTAASREGAVLPRAEARAGSGRGARSGEWGLAAAGAWETMHH-----CKRY------
CLK2_Mmus        ------------------------------------------------------------
CLK1_Mmus        ------------------------------------------------------------
E02H4.3_Cele     --------------------------------------------LVVIPRKRKY------
C16A11.3_Cele    ------------------------------------------------------------
KNS1_Scer        -------------------------------------------------R-KRS------
CLK4_Hsap        ------------------------------------------------------------
CLK3_Hsap        PRLATAASREGAGLPRAEVAAGSGRGARSGEWGLAAAGAWETMHH-----CKRY------
CLK2_Hsap        ------------------------------------------------------------
CLK1_Hsap        ------------------------------------------MRH-----SKRT------
Y111B2A.1_Cele   ------------------------------------------------------------
ClkA_Ddis        -----------------------------------------------------NNCSNVN
22369_Tthe       -------SRGG-------------------------------------------------
CLK_Spur         --------------------------------------------V-----AHCM------
CC1G_01467_Ccin  ---------------------------------------------T-----IFA------
CC1G_10232_Ccin  --------------------------------------------FT-----ILL------
CC1G_15475_Ccin  ------------------------------------------------------------
CC1G_06417_Ccin  ------------------------------------------------------------
AqueK109_Aque    ------------------------------------------------------------
CLK_a_Smoe       ------------------------------------------LD----PR-RRV------
CLK_d_Smoe       ------------------------------------------------------------
CLK_b_Smoe       ------------------------------------------------------------
CLK_c_Smoe       ------------------------------------------------PN----------
GK028_Glam       ------------------------------------------------------------


Doa_Dmel         -----H--HSR--------DRS--------------------------------------
CLK4_Mmus        -----H--CPD--------WDSRE--------------------------------SWGH
CLK3_Mmus        -----R--SPE--------PDP--------------------------------------
CLK2_Mmus        -------------------HEH--------------------------------------
CLK1_Mmus        -----Y--CPD--------WDERD-------------------------------WDYGT
E02H4.3_Cele     -----KNYVSR--------RRN--------------------------------------
C16A11.3_Cele    ----------I--------KIECQ---------------------------------CGT
KNS1_Scer        -----R--ANM--------NNSTT---------------------------------TGP
CLK4_Hsap        -----H--CPD--------WDSRE--------------------------------SWGH
CLK3_Hsap        -----R--SPE--------PDP--------------------------------------
CLK2_Hsap        -------------------REH--------------------------------------
CLK1_Hsap        -----Y--CPD--------WDDKD-------------------------------WDYGK
Y111B2A.1_Cele   ------------------------------------------------------------
ClkA_Ddis        YNNDIH--YKNNNYNNNNNNNNSNSGNNFNNNNNNNNNNNNNNNNNNNNNNNNNNYTYGN
22369_Tthe       -------------------------------------------------------RDYSP
CLK_Spur         -----H--CTQ--------HCT--------------------------------------
CC1G_01467_Ccin  ---------------------------------------------------------YGE
CC1G_10232_Ccin  -----H--LEL--------DDLRQ---------------------------------LGA
CC1G_15475_Ccin  ------------------------------------------------------------
CC1G_06417_Ccin  -----N--LPA--------VTQSI---------------------------------AGP
AqueK109_Aque    ------------------------------------------------------------
CLK_a_Smoe       -----L--CN-----------SSY---------------------------------AWP
CLK_d_Smoe       ------------------------------------------------------------
CLK_b_Smoe       ------------------------------------------------------------
CLK_c_Smoe       ------------------------------------------------------------
GK028_Glam       ------------------------------------------------------------


Doa_Dmel         ------------------------------------------S-----------------
CLK4_Mmus        --------------------------------E---------S-----------------
CLK3_Mmus        ------------------------------------------Y-----------------
CLK2_Mmus        ------------------------------------------Y-----------------
CLK1_Mmus        --------------------------------W---------R-----------------
E02H4.3_Cele     ------------------------------------------TQLLASLRRCVSDPN-VY
C16A11.3_Cele    N--------------------------------------NTNN-----------------
KNS1_Scer        ANNT--------------------------------------------------------
CLK4_Hsap        --------------------------------E---------S-----------------
CLK3_Hsap        ------------------------------------------Y-----------------
CLK2_Hsap        ------------------------------------------Y-----------------
CLK1_Hsap        --------------------------------W---------R-----------------
Y111B2A.1_Cele   ------------------------------------------------------------
ClkA_Ddis        NNNNNSNNNNNNINNNGNSNNNNNNSNGSENNY---------F-----------------
22369_Tthe       --------------------------------QR--------SNGVDSRRKSLSQKNQR-
CLK_Spur         ------------------------------------------L------RTCLV------
CC1G_01467_Ccin  SDR-----------------------------YLSILPFVRAL-----------------
CC1G_10232_Ccin  T--------------------------------------SQRL-----------------
CC1G_15475_Ccin  ------------------------------------------------------------
CC1G_06417_Ccin  SVMA----------------------------N---------A-----------------
AqueK109_Aque    ------------------------------------------------------------
CLK_a_Smoe       TSS---------------------------------------------------------
CLK_d_Smoe       ------------------------------------------------------------
CLK_b_Smoe       ------------------------------------------------------------
CLK_c_Smoe       ------------------------------------------------------------
GK028_Glam       ------------------------------------------------------------


Doa_Dmel         ------------------------------------------------------------
CLK4_Mmus        ------------------------------------------------------------
CLK3_Mmus        ------------------------------------------------------------
CLK2_Mmus        ------------------------------------------------------------
CLK1_Mmus        ------------------------------------------------------------
E02H4.3_Cele     KSYNHWKALLRPMTPIKSGAPTPKTVTPMPVPQIPPHQKMTPNPTPTQNPVQLPLPHAVS
C16A11.3_Cele    ------------------------------------------------------------
KNS1_Scer        ------------------------------------------------------------
CLK4_Hsap        ------------------------------------------------------------
CLK3_Hsap        ------------------------------------------------------------
CLK2_Hsap        ------------------------------------------------------------
CLK1_Hsap        ------------------------------------------------------------
Y111B2A.1_Cele   ------------------------------------------------------------
ClkA_Ddis        ------------------------------------------------------------
22369_Tthe       ------------------------------------------------------------
CLK_Spur         ------------------------------------------------------------
CC1G_01467_Ccin  ------------------------------------------------------------
CC1G_10232_Ccin  ------------------------------------------------------------
CC1G_15475_Ccin  ------------------------------------------------------------
CC1G_06417_Ccin  ------------------------------------------------------------
AqueK109_Aque    ------------------------------------------------------------
CLK_a_Smoe       ------------------------------------------------------------
CLK_d_Smoe       ------------------------------------------------------------
CLK_b_Smoe       ------------------------------------------------------------
CLK_c_Smoe       ------------------------------------------------------------
GK028_Glam       ------------------------------------------------------------


Doa_Dmel         ------------------------------------------------------------
CLK4_Mmus        ------------------------------------------------------------
CLK3_Mmus        ------------------------------------------------------------
CLK2_Mmus        ------------------------------------------------------------
CLK1_Mmus        ------------------------------------------------------------
E02H4.3_Cele     EKPGDKKSTGPT-PSPVPSKAPISAAKLPGTVTKVAPLLSAAQPPPKT------------
C16A11.3_Cele    ------------------------------------------------------------
KNS1_Scer        ------------------------------------------------------------
CLK4_Hsap        ------------------------------------------------------------
CLK3_Hsap        ------------------------------------------------------------
CLK2_Hsap        ------------------------------------------------------------
CLK1_Hsap        ------------------------------------------------------------
Y111B2A.1_Cele   ------------------------------------------------------------
ClkA_Ddis        ------------------------------------------------------------
22369_Tthe       ---------YYSQNQYSQGGN-------------------QAQSYPYQQNSFNQAQQSHY
CLK_Spur         ------------------------------------------------------------
CC1G_01467_Ccin  ------------------------------------------------------------
CC1G_10232_Ccin  ------------------------------------------------------------
CC1G_15475_Ccin  ------------------------------------------------------------
CC1G_06417_Ccin  ------------------------------------------------------------
AqueK109_Aque    ------------------------------------------------------------
CLK_a_Smoe       ------------------------------------------------------------
CLK_d_Smoe       ------------------------------------------------------------
CLK_b_Smoe       ------------------------------------------------------------
CLK_c_Smoe       ------------------------------------------------------------
GK028_Glam       ------------------------------------------------------------


Doa_Dmel         ------------------------------------------------------------
CLK4_Mmus        ------------------------------------------------------------
CLK3_Mmus        ------------------------------------------------------------
CLK2_Mmus        ------------------------------------------------------------
CLK1_Mmus        ------------------------------------------------------------
E02H4.3_Cele     -------LAPAPGASETNSGSGPVSKQVSGKLTEL--K-------------------SKN
C16A11.3_Cele    ------------------------------------------------------------
KNS1_Scer        ------------------------------------------------------------
CLK4_Hsap        ------------------------------------------------------------
CLK3_Hsap        ------------------------------------------------------------
CLK2_Hsap        ------------------------------------------------------------
CLK1_Hsap        ------------------------------------------------------------
Y111B2A.1_Cele   ------------------------------------------------------------
ClkA_Ddis        ------------------------------------------------------------
22369_Tthe       GNSYPNHQQSSYNNNNNNSNSNYKKENVEDYYKNRDYKDWNNRDGNRNDRQNNNYSSNNN
CLK_Spur         ------------------------------------------------------------
CC1G_01467_Ccin  ------------------------------------------------------------
CC1G_10232_Ccin  ------------------------------------------------------------
CC1G_15475_Ccin  ------------------------------------------------------------
CC1G_06417_Ccin  ------------------------------------------------------------
AqueK109_Aque    ------------------------------------------------------------
CLK_a_Smoe       ------------------------------------------------------------
CLK_d_Smoe       ------------------------------------------------------------
CLK_b_Smoe       ------------------------------------------------------------
CLK_c_Smoe       ------------------------------------------------------------
GK028_Glam       ------------------------------------------------------------


Doa_Dmel         ------------------------------------------------------------
CLK4_Mmus        ------------------------------------------------------------
CLK3_Mmus        ------------------------------------------------------------
CLK2_Mmus        ------------------------------------------------------------
CLK1_Mmus        ------------------------------------------------------------
E02H4.3_Cele     GTVTEKTEKAVLRIPSSAST--RAKAASAVAPEANPAPVPTATKPSPFAPAIAPLRDGAP
C16A11.3_Cele    ------------------------------------------------------------
KNS1_Scer        ------------------------------------------------------------
CLK4_Hsap        ------------------------------------------------------------
CLK3_Hsap        ------------------------------------------------------------
CLK2_Hsap        ------------------------------------------------------------
CLK1_Hsap        ------------------------------------------------------------
Y111B2A.1_Cele   ------------------------------------------------------------
ClkA_Ddis        ------------------------------------------------------------
22369_Tthe       GNHNNSNNSRFTNNPSGHSTINNS------------------------------------
CLK_Spur         ------------------------------------------------------------
CC1G_01467_Ccin  ------------------------------------------------------------
CC1G_10232_Ccin  ------------------------------------------------------------
CC1G_15475_Ccin  ------------------------------------------------------------
CC1G_06417_Ccin  ------------------------------------------------------------
AqueK109_Aque    ------------------------------------------------------------
CLK_a_Smoe       ------------------------------------------------------------
CLK_d_Smoe       ------------------------------------------------------------
CLK_b_Smoe       ------------------------------------------------------------
CLK_c_Smoe       ------------------------------------------------------------
GK028_Glam       ------------------------------------------------------------


Doa_Dmel         ------------------------------------------------------------
CLK4_Mmus        ------------------------------------------------------------
CLK3_Mmus        ------------------------------------------------------------
CLK2_Mmus        ------------------------------------------------------------
CLK1_Mmus        ------------------------------------------------------------
E02H4.3_Cele     AQPPAPIQASAPLRPPVAKQNSLQKPPEPKRSVGAPPKALPSELVNKIDGIEFLPQS---
C16A11.3_Cele    ------------------------------------------------------------
KNS1_Scer        ------------------------------------------------------------
CLK4_Hsap        ------------------------------------------------------------
CLK3_Hsap        ------------------------------------------------------------
CLK2_Hsap        ------------------------------------------------------------
CLK1_Hsap        ------------------------------------------------------------
Y111B2A.1_Cele   ------------------------------------------------------------
ClkA_Ddis        ------------------------------------------------------------
22369_Tthe       -------------------NNSYDKRNESYRQAN----TFPSDQYSRGNGSGNGNQNSFN
CLK_Spur         ------------------------------------------------------------
CC1G_01467_Ccin  ------------------------------------------------------------
CC1G_10232_Ccin  ------------------------------------------------------------
CC1G_15475_Ccin  ------------------------------------------------------------
CC1G_06417_Ccin  ------------------------------------------------------------
AqueK109_Aque    ------------------------------------------------------------
CLK_a_Smoe       ------------------------------------------------------------
CLK_d_Smoe       ------------------------------------------------------------
CLK_b_Smoe       ------------------------------------------------------------
CLK_c_Smoe       ------------------------------------------------------------
GK028_Glam       ------------------------------------------------------------


Doa_Dmel         ------------------------------------------------------------
CLK4_Mmus        ------------------------------------------------------------
CLK3_Mmus        ------------------------------------------------------------
CLK2_Mmus        ------------------------------------------------------------
CLK1_Mmus        ------------------------------------------------------------
E02H4.3_Cele     -------------------SNQNTDDGQQ-------------------------------
C16A11.3_Cele    ------------------------------------------------------------
KNS1_Scer        ------------------------------------------------------------
CLK4_Hsap        ------------------------------------------------------------
CLK3_Hsap        ------------------------------------------------------------
CLK2_Hsap        ------------------------------------------------------------
CLK1_Hsap        ------------------------------------------------------------
Y111B2A.1_Cele   ------------------------------------------------------------
ClkA_Ddis        ------------------------------------------------------------
22369_Tthe       KNDNNSNYNSYNGNRSYKNEYQNSSQGHKQYGNNNNNYDNKRVSSQNYRNLTGGGGSYNN
CLK_Spur         ------------------------------------------------------------
CC1G_01467_Ccin  ------------------------------------------------------------
CC1G_10232_Ccin  ------------------------------------------------------------
CC1G_15475_Ccin  ------------------------------------------------------------
CC1G_06417_Ccin  ------------------------------------------------------------
AqueK109_Aque    ------------------------------------------------------------
CLK_a_Smoe       ------------------------------------------------------------
CLK_d_Smoe       ------------------------------------------------------------
CLK_b_Smoe       ------------------------------------------------------------
CLK_c_Smoe       ------------------------------------------------------------
GK028_Glam       ------------------------------------------------------------


Doa_Dmel         ----------------------AGTRDK-R------------------------------
CLK4_Mmus        ----------------------YSGSHKRK------------------------------
CLK3_Mmus        ----------------------LSYRWK-R------------------------------
CLK2_Mmus        ----------------------QSRKHK-R------------------------------
CLK1_Mmus        ----------------------SSSSHKRK------------------------------
E02H4.3_Cele     -------------------PTTSTGGAKAL------------------------------
C16A11.3_Cele    ----------------------RLI-----------------------------------
KNS1_Scer        ------------------------SSNKTF------LDNFEETRTNKLLDEMFARQNSFL
CLK4_Hsap        ----------------------YRGSHKRK------------------------------
CLK3_Hsap        ----------------------LSYRWK-R------------------------------
CLK2_Hsap        ----------------------RSRKHK-R------------------------------
CLK1_Hsap        ----------------------SSSSHKRR------------------------------
Y111B2A.1_Cele   ------------------------------------------------------------
ClkA_Ddis        ----------------------QSENQS-N------------------------------
22369_Tthe       NGNFRRSNSNRNRSNNNYKNYG--------------------------------------
CLK_Spur         ----------------------QGTSHQ-VGTPVAIV-----------------KGG---
CC1G_01467_Ccin  ----------------------RGMVNV-R------------------------------
CC1G_10232_Ccin  ----------------------RNLINAYR------------------------------
CC1G_15475_Ccin  ------------------------------------------------------------
CC1G_06417_Ccin  ----------------------SPVTTRKR------------------------------
AqueK109_Aque    ----------------------DGVSDK-K------------------------------
CLK_a_Smoe       ------------------------------------------------------------
CLK_d_Smoe       ------------------------------------------------------------
CLK_b_Smoe       ------------------------------------------------------------
CLK_c_Smoe       ------------------------------------------------------------
GK028_Glam       ------------------------------------------------------------


Doa_Dmel         ----R-RHDT-------A----------------------DH-SPP--------------
CLK4_Mmus        ----R-RSHS-------S----------------------TQENRH--------------
CLK3_Mmus        ----R-RSYS-------R----------------------EHE-GR--------------
CLK2_Mmus        ----R-RSRS-------W----------------------SSSSDR--------------
CLK1_Mmus        ----K-RSHS-------S----------------------AREQKR--------------
E02H4.3_Cele     ----R-RAYG-------S----------------------KSGTTI--------------
C16A11.3_Cele    ----------------------------------------------KC------------
KNS1_Scer        TDNLR-NSLD-------L----------------------NQADNP--------------
CLK4_Hsap        ----R-RSHS-------S----------------------TQENRH--------------
CLK3_Hsap        ----R-RSYS-------R----------------------EHE-GR--------------
CLK2_Hsap        ----R-RSRS-------W----------------------SSSSDR--------------
CLK1_Hsap        ----K-RSHS-------S----------------------AQENKR--------------
Y111B2A.1_Cele   ------------------------------------------------------------
ClkA_Ddis        ----K-DQNS-------Y----------------------FNSSYL--------------
22369_Tthe       ---------------------------------------------R--------------
CLK_Spur         ---NKGLHLM-------SEIGTEMTGISMPKITGLADIALGAENTT--------------
CC1G_01467_Ccin  ----R-LSLH-------V----------------------SSDNTDYI------------
CC1G_10232_Ccin  ----R-RVWYFPRFLTAW----------------------HL-----GPDIFLAKMELTG
CC1G_15475_Ccin  ------------------------------------------------------------
CC1G_06417_Ccin  ----K-RAHQ-------Y----------------------TVSYS---------------
AqueK109_Aque    ----K-S-SS-------L----------------------SSLSTS--------------
CLK_a_Smoe       --------------------------------------------QT--------------
CLK_d_Smoe       ------------------------------------------------------------
CLK_b_Smoe       ------------------------------------------------------------
CLK_c_Smoe       ------------------------------------------------------------
GK028_Glam       ------------------------------------------------------------


Doa_Dmel         ------------------------------------------L-----------------
CLK4_Mmus        ------------------------------------------CKPHH-------------
CLK3_Mmus        ------------------------------------------LRYPS-------------
CLK2_Mmus        ------------------------------------------TRR---------------
CLK1_Mmus        ------------------------------------------CRYDH-------------
E02H4.3_Cele     ------------------------------------------CA----------------
C16A11.3_Cele    VGCAQWQHAVCMGVRPTDCVTAYKCEDCEPRLLIVTIAEAESFQGVK-------------
KNS1_Scer        ------------------------------------------L-----------------
CLK4_Hsap        ------------------------------------------CKPHH-------------
CLK3_Hsap        ------------------------------------------LRYPS-------------
CLK2_Hsap        ------------------------------------------TRR---------------
CLK1_Hsap        ------------------------------------------CKYNH-------------
Y111B2A.1_Cele   ------------------------------------------------------------
ClkA_Ddis        ------------------------------------------RNPVDNYNHNNNNHNNNA
22369_Tthe       ------------------------------------------DNNNF-------------
CLK_Spur         ------------------------------------------ENL---------------
CC1G_01467_Ccin  LYCLHREGQL--------------------------------SLPRR-------------
CC1G_10232_Ccin  AICAGWQALR--------------------------------FLDRL-------------
CC1G_15475_Ccin  ------------------------------------------------------------
CC1G_06417_Ccin  ------------------------------------------------------------
AqueK109_Aque    --------------------------------------------LPM-------------
CLK_a_Smoe       ------------------------------------------W-----------------
CLK_d_Smoe       ------------------------------------------------------------
CLK_b_Smoe       ------------------------------------------------------------
CLK_c_Smoe       ------------------------------------------------------------
GK028_Glam       ------------------------------------------------------------


Doa_Dmel         --------------------------------A-EAP--SPP------------------
CLK4_Mmus        --------------------------------QFKDS--DCH------------------
CLK3_Mmus        --------------------------------R-REP--PPR------------------
CLK2_Mmus        --------------------------------R-RRE--DSY------------------
CLK1_Mmus        --------------------------------S-KTT--DSY------------------
E02H4.3_Cele     ------------------------------------I--GSP------------------
C16A11.3_Cele    --------------------------------P-PEP--TPAPKIERKTTKVLYIQRFLD
KNS1_Scer        ---------------------------------------------RPRQHQHQLFLDNEN
CLK4_Hsap        --------------------------------QFKES--DCH------------------
CLK3_Hsap        --------------------------------R-REP--PPR------------------
CLK2_Hsap        --------------------------------R-RRE--DSY------------------
CLK1_Hsap        --------------------------------S-KMC--DSH------------------
Y111B2A.1_Cele   ------------------------------------------------------------
ClkA_Ddis        FDNNNYNTQNLGDYSYKNDGYNNDNNNNDNNNSYGDTDREKY------------------
22369_Tthe       ---------------------------------RRNN--SPR------------------
CLK_Spur         --------------------------------H-HHP--KAG------------------
CC1G_01467_Ccin  --------------------------------S-TLP--SLR------------------
CC1G_10232_Ccin  --------------------------------P-PDP--STGLDVFVRIAGAIAL-GRHL
CC1G_15475_Ccin  ------------------------------------------------------------
CC1G_06417_Ccin  --------------------------------EVKEL--DSD---G--------------
AqueK109_Aque    --------------------------------Q-PLP--SKD---A--------------
CLK_a_Smoe       ---------------------------------------------Q--------------
CLK_d_Smoe       ------------------------------------------------------------
CLK_b_Smoe       ------------------------------------------------------------
CLK_c_Smoe       ------------------------------------------------------------
GK028_Glam       ------------------------------------------------------------


Doa_Dmel         -----------------------RIT-NT----HHT----RSAA-------------KRR
CLK4_Mmus        -----------------------YLE-ARC------------LN-------------ERD
CLK3_Mmus        -----------------------RSR-SRS----HD----RIPY-------------QRR
CLK2_Mmus        -----------------------HVR-SRS---SYD----DHSS-------------DRR
CLK1_Mmus        -----------------------YLE-SRS------------IN-------------EKA
E02H4.3_Cele     -----------------------NVP-STS---QPQ----QGDN-------------EKR
C16A11.3_Cele    FLSDKS-ENIKSPLPLTKFFQDYKTK-SNCSQSLAT----AKKK--LLANLFEHIVMSAK
KNS1_Scer        AIELDEEP---------------RII-NTT------------IN-------------NSN
CLK4_Hsap        -----------------------YLE-ARS------------LN-------------ERD
CLK3_Hsap        -----------------------RSR-SRS----HD----RLPY-------------QRR
CLK2_Hsap        -----------------------HVR-SRS---SYD----DRSS-------------DRR
CLK1_Hsap        -----------------------YLE-SRS------------IN-------------EKD
Y111B2A.1_Cele   ------------------------------AYSSCG----EKLE-------------FR-
ClkA_Ddis        -----------------------SIE--KI---CNE-NDYDSV--------------NNN
22369_Tthe       -----------------------RNY-NR-----YD----NRNY-------------ERR
CLK_Spur         -----------------------TAE-TTT---VTG------------------------
CC1G_01467_Ccin  ------------------------HV----VLNSSS----DLLPIASRRDLF-SIVL-TD
CC1G_10232_Ccin  FEAGYVLGRFDVPAI---IQYRQFER----DVLGLS----GGTQIRQLMDTY-GIIA-WF
CC1G_15475_Ccin  ------------------------------------------------------------
CC1G_06417_Ccin  -----------------------KVREVIV---IEDTPPPPTLS-------------PAT
AqueK109_Aque    -----------------------ILP-SSS---SSS----SSS-----------------
CLK_a_Smoe       ------------------------------------------------------------
CLK_d_Smoe       ------------------------------------------------------------
CLK_b_Smoe       ------------------------------------------------------------
CLK_c_Smoe       ------------------------------------------------------------
GK028_Glam       ------------------------------------------------------------


Doa_Dmel         ------------------------------------------------------------
CLK4_Mmus        ------------------------------------------------------------
CLK3_Mmus        ------------------------------------------------------------
CLK2_Mmus        ------------------------------------------------------------
CLK1_Mmus        ------------------------------------------------------------
E02H4.3_Cele     ------------------------------------------------------------
C16A11.3_Cele    YNDDRKAEM-LFAIGLRVEDEFLERLRGRATVEVDDCQRITFYKSKTSTSSPETVSFVLA
KNS1_Scer        ------------------------------------------------------------
CLK4_Hsap        ------------------------------------------------------------
CLK3_Hsap        ------------------------------------------------------------
CLK2_Hsap        ------------------------------------------------------------
CLK1_Hsap        ------------------------------------------------------------
Y111B2A.1_Cele   ------------------------------------------------------------
ClkA_Ddis        ------------------------------------------------------------
22369_Tthe       ------------------------------------------------------------
CLK_Spur         ------------------------------------------------------------
CC1G_01467_Ccin  FMDGRAVDYLAHSLHFDVNRTHLTSLRIRIKAGLDLSQTV-LPTLQENLPKL--------
CC1G_10232_Ccin  PF----------------------------------------KKLVVRLGRR--------
CC1G_15475_Ccin  ------------------------------------------------------------
CC1G_06417_Ccin  ------------------------------------------------------------
AqueK109_Aque    ------------------------------------------------------------
CLK_a_Smoe       ------------------------------------------------------------
CLK_d_Smoe       ------------------------------------------------------------
CLK_b_Smoe       ------------------------------------------------------------
CLK_c_Smoe       ------------------------------------------------------------
GK028_Glam       ------------------------------------------------------------


Doa_Dmel         -----------------------------------------------RHE-LD--AKKAQ
CLK4_Mmus        -----------------------------------------------YRDRRY--IDEYR
CLK3_Mmus        -----------------------------------------------YREHRD--SDTYR
CLK2_Mmus        -----------------------------------------------LYDRRY--CGSYR
CLK1_Mmus        -----------------------------------------------YHSRRY--VDEYR
E02H4.3_Cele     -----------------------------------------------LIEKKL--SL--R
C16A11.3_Cele    ATTAIAEAH-----------------------LSD---ASVIDGISAIEFFKY--IENYA
KNS1_Scer        -----------------------------------------------NHNSSR--VDEDA
CLK4_Hsap        -----------------------------------------------YRDRRY--VDEYR
CLK3_Hsap        -----------------------------------------------YRERRD--SDTYR
CLK2_Hsap        -----------------------------------------------VYDRRY--CGSYR
CLK1_Hsap        -----------------------------------------------YHSRRY--IDEYR
Y111B2A.1_Cele   ---------------------------------------------------RF-------
ClkA_Ddis        -----------------------------------------------NNNRNY--SNSYN
22369_Tthe       -----------------------------------------------DSQSRR--TDKYQ
CLK_Spur         ------------------------------------------------------------
CC1G_01467_Ccin  ETLSVEQPKLNAKEVLTALATNSGWFTEMQCFALNPSAGV-LYER------KKYGI----
CC1G_10232_Ccin  EVVRVSLA-ITNVNPIDFVINNSGCTAMMQI----ITPRR--------------------
CC1G_15475_Ccin  ------------------------------------------------------------
CC1G_06417_Ccin  -----------------------------------------------THNGGY--SASYQ
AqueK109_Aque    ------------------------------------------------------------
CLK_a_Smoe       ------------------------------------------------------------
CLK_d_Smoe       ------------------------------------------------------------
CLK_b_Smoe       ------------------------------------------------------------
CLK_c_Smoe       ------------------------------------------------------------
GK028_Glam       ------------------------------------------------------------


Doa_Dmel         IS-KE-------P------------TF---------------------------------
CLK4_Mmus        -NDYC-------E------------GY---------------------------------
CLK3_Mmus        CEERS-------P------------SF---------------------------------
CLK2_Mmus        RNDYS-------R------------DR---------------------------------
CLK1_Mmus        -NDYM--------------------GY---------------------------------
E02H4.3_Cele     KKKLS---GEGVP------------PA---------------------------------
C16A11.3_Cele    -KDKA-------LLSLCDDLQQKIQGL---------------------------------
KNS1_Scer        -DDDIIFIKEQPI------------QF---------------------------------
CLK4_Hsap        -NDYC-------E------------GY---------------------------------
CLK3_Hsap        CEERS-------P------------SF---------------------------------
CLK2_Hsap        RNDYS-------R------------DR---------------------------------
CLK1_Hsap        -NDYT-------Q------------GC---------------------------------
Y111B2A.1_Cele   ------------------------------------------------------------
ClkA_Ddis        NNNYN-------D------------GNNNYNSNNYNYNNNNNNNNNINNNNNSNSNSNSN
22369_Tthe       NLD---------------------------------------------------------
CLK_Spur         ------------------------------------------------------------
CC1G_01467_Ccin  ------------------------------------------------------------
CC1G_10232_Ccin  ------------------------------------------------------------
CC1G_15475_Ccin  ------------------------------------------------------------
CC1G_06417_Ccin  PPALA-------P------------IR---------------------------------
AqueK109_Aque    ------------------------------------------------------------
CLK_a_Smoe       ------------------------------------------------------------
CLK_d_Smoe       ------------------------------------------------------------
CLK_b_Smoe       ------------------------------------------------------------
CLK_c_Smoe       ------------------------------------------------------------
GK028_Glam       ------------------------------------------------------------


Doa_Dmel         ------------------------------------------------------------
CLK4_Mmus        ------------------------------------------------------------
CLK3_Mmus        ------------------------------------------------------------
CLK2_Mmus        ------------------------------------------------------------
CLK1_Mmus        ------------------------------------------------------------
E02H4.3_Cele     ------------------------------------------------------------
C16A11.3_Cele    ------------------------------------------------------------
KNS1_Scer        ------------------------------------------------------------
CLK4_Hsap        ------------------------------------------------------------
CLK3_Hsap        ------------------------------------------------------------
CLK2_Hsap        ------------------------------------------------------------
CLK1_Hsap        ------------------------------------------------------------
Y111B2A.1_Cele   ------------------------------------------------------------
ClkA_Ddis        SNSNSNSNSNSNSNNNNYNNYGYNNHKSNNGGNRYSDDDDNVFNNNNNNNNNNNNNYNNY
22369_Tthe       ------------------------------------------------------------
CLK_Spur         ------------------------------------------------------------
CC1G_01467_Ccin  ------------------------------------------------------------
CC1G_10232_Ccin  ------------------------------------------------------------
CC1G_15475_Ccin  ------------------------------------------------------------
CC1G_06417_Ccin  ------------------------------------------------------------
AqueK109_Aque    ------------------------------------------------------------
CLK_a_Smoe       ------------------------------------------------------------
CLK_d_Smoe       ------------------------------------------------------------
CLK_b_Smoe       ------------------------------------------------------------
CLK_c_Smoe       ------------------------------------------------------------
GK028_Glam       ------------------------------------------------------------


Doa_Dmel         ----------------D-----DS---IST------------------------------
CLK4_Mmus        ----------------V-----PR---HYH------------------------------
CLK3_Mmus        ----------------G-----ED---CYG------------------------------
CLK2_Mmus        ----------------G-----EA---YYD------------------------------
CLK1_Mmus        ----------------E-----PG---HPY------------------------------
E02H4.3_Cele     ----------------G-----SM---LTGSKSGVE---------------------IGL
C16A11.3_Cele    ----------------EA-----MDKKIQY------------------------------
KNS1_Scer        ----------------SSPLILPS---S----SSINNNNNIVTSNNPGCGTAATSNST--
CLK4_Hsap        ----------------V-----PR---HYH------------------------------
CLK3_Hsap        ----------------G-----ED---YYG------------------------------
CLK2_Hsap        ----------------G-----DA---YYD------------------------------
CLK1_Hsap        ----------------E-----PG---HRQ------------------------------
Y111B2A.1_Cele   ------------------------------------------------------------
ClkA_Ddis        NSNNNYNNDYDYNDGKR-----AN---IYS------------------------------
22369_Tthe       ----------------------RK---YHH------------------------------
CLK_Spur         ----------------G-----EV---TTT------------------------------
CC1G_01467_Ccin  --------------------------QYHY------------------------------
CC1G_10232_Ccin  ------------------------------------------------------------
CC1G_15475_Ccin  ------------------------------------------------------------
CC1G_06417_Ccin  ---------------------------TRA------------------------------
AqueK109_Aque    ------------------------------------------------------------
CLK_a_Smoe       ---------------------VPK---T--------------------------------
CLK_d_Smoe       ------------------------------------------------------------
CLK_b_Smoe       ------------------------------------------------------------
CLK_c_Smoe       ----------------------PV---T--------------------------------
GK028_Glam       ------------------------------------------------------------


Doa_Dmel         -------R--------R-------------------------------R--KER--SKRS
CLK4_Mmus        -------R--------D-------------------------------V--EST--YRIH
CLK3_Mmus        -------S--------S-------------------------------R--SRH--RRRS
CLK2_Mmus        -------T--------D-------------------------------F--RQS--YEYH
CLK1_Mmus        -------G--------E-------------------------------P--GSR--YQMH
E02H4.3_Cele     SSNLTTTN--------N-------------------------------N--NNK--EQTD
C16A11.3_Cele    -------NVLSRVFQAT-------------------------------ISLRKTVQ--KL
KNS1_Scer        ---YI------------------------------------------------T--TPKK
CLK4_Hsap        -------R--------D-------------------------------I--ESG--YRIH
CLK3_Hsap        -------P--------S-------------------------------R--SRH--RRRS
CLK2_Hsap        -------T--------D-------------------------------Y--RHS--YEYQ
CLK1_Hsap        -------R--------D-------------------------------H--ESR--YQNH
Y111B2A.1_Cele   ------------------------------------------------------------
ClkA_Ddis        -------R--------NNSNNNNNSKSGNNNSNNYNHNNSNNNGGYNNY--NNG--YNNY
22369_Tthe       -------S--------D-------------------------------R--SN----KFQ
CLK_Spur         -------I--------I-------------------------------T--SEM--TS--
CC1G_01467_Ccin  -------RELRWLFDEI--------------------------------SASRKFL--KA
CC1G_10232_Ccin  ---------SISIFPAH--------------------------------TFIKRVSFLLH
CC1G_15475_Ccin  -------------------------------------------------LIERRF-----
CC1G_06417_Ccin  -------R--------A-------------------------------A--AEA--QAMS
AqueK109_Aque    ---------------------------------------------------SKK--KPRG
CLK_a_Smoe       -----------------------------------------------------T--YPIS
CLK_d_Smoe       ------------------------------------------------------------
CLK_b_Smoe       ------------------------------------------------------------
CLK_c_Smoe       -----------------------------------------------------G------
GK028_Glam       ------------------------------------------------------------


Doa_Dmel         -H----------------------R--------------KSP-----------------A
CLK4_Mmus        -C----------------------S--------------KSS-----------------V
CLK3_Mmus        -R----------------------E--------------RAP-----------------Y
CLK2_Mmus        -R----------------------E--------------NSS-----------------Y
CLK1_Mmus        -S----------------------S--------------KSS-----------------G
E02H4.3_Cele     -E----------------------Q--------------RAK--------KTVNAVAAAF
C16A11.3_Cele    -TKCGEMSKNGNLMARKFKNQQFFS--------------KMF-----------------V
KNS1_Scer        FK----------------------KQRTISLPQLPLSKLSYQSNYFNVPDQTNAIVPRVT
CLK4_Hsap        -C----------------------S--------------KSS-----------------V
CLK3_Hsap        -R----------------------E--------------RGP-----------------Y
CLK2_Hsap        -R----------------------E--------------NSS-----------------Y
CLK1_Hsap        -S----------------------S--------------KSS-----------------G
Y111B2A.1_Cele   ------------------------------------------------------------
ClkA_Ddis        -N----------------------N--------------NNS-----------------N
22369_Tthe       KA----------------------N--------------KSY-----------------Y
CLK_Spur         ---------------------------------------GTK-----------------A
CC1G_01467_Ccin  -M----------------------------------------------------------
CC1G_10232_Ccin  -T----------------------D--------------KDA-----------------V
CC1G_15475_Ccin  ------------------------------------------------------------
CC1G_06417_Ccin  -S----------------------S--------------SSS-----------------V
AqueK109_Aque    -F----------------------K--------------MVV-----------------G
CLK_a_Smoe       -K----------------------K--------------GSET-----------------
CLK_d_Smoe       ------------------------------------------------------------
CLK_b_Smoe       ------------------------------------------------------------
CLK_c_Smoe       ------------------------------------------------------------
GK028_Glam       ------------------------------------------------------------


Doa_Dmel         AS------------------------------RR--------------------------
CLK4_Mmus        RS------------------------------RR--------------------------
CLK3_Mmus        RT------------------------------RK--------------------------
CLK2_Mmus        RS------------------------------QR--------------------------
CLK1_Mmus        RS------------------------------GR--------------------------
E02H4.3_Cele     ST------------QAGSGNATTVDDPASTTTSK--------------------------
C16A11.3_Cele    FP------------------------------LK--------------------------
KNS1_Scer        QTENELLHLTGSCAKTLEGNKAVNLTIAHS------------------------------
CLK4_Hsap        RS------------------------------RR--------------------------
CLK3_Hsap        RT------------------------------RK--------------------------
CLK2_Hsap        RS------------------------------QR--------------------------
CLK1_Hsap        RS------------------------------GR--------------------------
Y111B2A.1_Cele   ------------------------------------------------------------
ClkA_Ddis        NS------------------------------NHNSSYNNNNNNNYNNNNNNNNNNNNNN
22369_Tthe       NS------------------------------NR--------------------------
CLK_Spur         RT------------------------------EN--------------------------
CC1G_01467_Ccin  --------------------------------SI--------------------------
CC1G_10232_Ccin  KC------------------------------AI--------------------------
CC1G_15475_Ccin  ------------------------------------------------------------
CC1G_06417_Ccin  LT------------------------------AP--------------------------
AqueK109_Aque    SS------------------------------KK--------------------------
CLK_a_Smoe       ----------------TL------------------------------------------
CLK_d_Smoe       ------------------------------------------------------------
CLK_b_Smoe       ------------------------------------------------------------
CLK_c_Smoe       ------------------------------------------------------------
GK028_Glam       ------------------------------------------------------------


Doa_Dmel         ------------------------------------------------------------
CLK4_Mmus        ------------------------------------------------------------
CLK3_Mmus        ------------------------------------------------------------
CLK2_Mmus        ------------------------------------------------------------
CLK1_Mmus        ------------------------------------------------------------
E02H4.3_Cele     ----------------------------------------------------------EN
C16A11.3_Cele    ------------------------------------------------------------
KNS1_Scer        ----------------------------------------------------------TS
CLK4_Hsap        ------------------------------------------------------------
CLK3_Hsap        ------------------------------------------------------------
CLK2_Hsap        ------------------------------------------------------------
CLK1_Hsap        ------------------------------------------------------------
Y111B2A.1_Cele   ------------------------------------------------------------
ClkA_Ddis        NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNISNNSNNNNFNYNNDNDRNNSNG
22369_Tthe       ------------------------------------------------------------
CLK_Spur         ------------------------------------------------------------
CC1G_01467_Ccin  ------------------------------------------------------------
CC1G_10232_Ccin  ------------------------------------------------------------
CC1G_15475_Ccin  ------------------------------------------------------------
CC1G_06417_Ccin  ------------------------------------------------------------
AqueK109_Aque    ------------------------------------------------------------
CLK_a_Smoe       ------------------------------------------------------------
CLK_d_Smoe       ------------------------------------------------------------
CLK_b_Smoe       ------------------------------------------------------------
CLK_c_Smoe       ------------------------------------------------------------
GK028_Glam       ------------------------------------------------------------


Doa_Dmel         --------------QHKYRYRDETSH--------S--------------SSR-------R
CLK4_Mmus        -------------------------------------------------SSP-------K
CLK3_Mmus        -------------------------------------------------HAH-------H
CLK2_Mmus        -------------------------------------------------SSR-------R
CLK1_Mmus        -------------------------------------------------SSY-------K
E02H4.3_Cele     PAAQPPKPKSAAVQNLISQLQLPASV--------S--------------AKVDKIIACGD
C16A11.3_Cele    -------------------------------------------------KTF-------K
KNS1_Scer        PFSNPPAQ-IASL-------P-------------Q--------------SNL-------K
CLK4_Hsap        -------------------------------------------------SSP-------K
CLK3_Hsap        -------------------------------------------------HAH-------H
CLK2_Hsap        -------------------------------------------------SSR-------R
CLK1_Hsap        -------------------------------------------------SSY-------K
Y111B2A.1_Cele   ------------------------------------------------------------
ClkA_Ddis        NYNNNSSN-I-----------NNNNNNNNNSNSYHNSCISYSNGGSNSKNSN-------K
22369_Tthe       -------------------------------------------------SNS-------I
CLK_Spur         -------------------------------------------------ATV-------G
CC1G_01467_Ccin  -------------------------------------------------G---------T
CC1G_10232_Ccin  -------------------------------------------------SMH-------E
CC1G_15475_Ccin  ------------------------------------------------------------
CC1G_06417_Ccin  -------------------------------------------------APK-------K
AqueK109_Aque    --------------QS---VKDKESH--------Q-------------------------
CLK_a_Smoe       --------------------S-------------N--------------FS--------K
CLK_d_Smoe       ------------------------------------------------------------
CLK_b_Smoe       ------------------------------------------------------------
CLK_c_Smoe       ------------------------------------------------------------
GK028_Glam       ------------------------------------------------------------


Doa_Dmel         R----------------------------HR----------DRAKD--------------
CLK4_Mmus        R----------------------------------------KRNRP--------------
CLK3_Mmus        C----------------------------HK----------RRTRS--------------
CLK2_Mmus        K----------------------------HR----------RRRRR--------------
CLK1_Mmus        S----------------------------K-----------HRSRH--------------
E02H4.3_Cele     K----------------------------AR----------KPSRS--------------
C16A11.3_Cele    F----------------------------QM----------KRTRA--------------
KNS1_Scer        K----------------------------------------QIGSS--------------
CLK4_Hsap        R----------------------------------------KRNRH--------------
CLK3_Hsap        C----------------------------HK----------RRTRS--------------
CLK2_Hsap        K----------------------------HR----------RRRRR--------------
CLK1_Hsap        S----------------------------K-----------HRIHH--------------
Y111B2A.1_Cele   ------------------------------------------------------------
ClkA_Ddis        N----------------------------NYNNQQSNANGNHVGNS--------------
22369_Tthe       K----------------------------------------YKGQKDNQYNRQGYQQSDG
CLK_Spur         D----------------------------TE----------GLGDA--------------
CC1G_01467_Ccin  VIYVP---------LGRDGKYIEAKTASDKR----------WWNSK--------------
CC1G_10232_Ccin  KYPIPFEISSSCRGFPPDGFPLGVRWLADNT----------CWIQP--------------
CC1G_15475_Ccin  ------------------------------------------------------------
CC1G_06417_Ccin  R----------------------------------------KRDHQ-------DEVRAPP
AqueK109_Aque    ------------------------------------------------------------
CLK_a_Smoe       L----------------------------------------FHGRA--------------
CLK_d_Smoe       ------------------------------------------------------------
CLK_b_Smoe       ------------------------------------------------------------
CLK_c_Smoe       ------------------------------------------H-----------------
GK028_Glam       ------------------------------------------------------------


Doa_Dmel         ----------------ERD-----------SGRNNR-Q-SQ--AKTAK---PVI----QD
CLK4_Mmus        ----------------CAS-----------HQSHSK-S-HR--RK-RS---RSI----ED
CLK3_Mmus        ----------------CSS-----------ASSRSQ-Q-SS--KR-SS---RSV----ED
CLK2_Mmus        ----------------SRT-----------FSRSSS-Q-HS--SR-RA---KSV----ED
CLK1_Mmus        ---------------HTSQ-----------HHSHGK-S-HR--RK-RS---RSV----ED
E02H4.3_Cele     --------------GLQAS-----------QARPKV-P-EI--VSSQR---TQH----QD
C16A11.3_Cele    ---------------PKEQ-----------NPSEIK-K-IR--R-KSETDNENVAGNREN
KNS1_Scer        ----------------LRK-----------FTSNGS-S-ES--ASSNK---SNF----KT
CLK4_Hsap        ----------------CSS-----------HQSRSK-S-HR--RK-RS---RSI----ED
CLK3_Hsap        ----------------CSS-----------ASSRSQ-Q-SS--KR-SS---RSV----ED
CLK2_Hsap        ----------------SRT-----------FSRSSS-Q-HS--SR-RA---KSV----ED
CLK1_Hsap        ---------------STSH-----------RRSHGK-S-HR--RK-RT---RSV----ED
Y111B2A.1_Cele   ----------------VDF-----------HGTTDK-S-FR--T----------------
ClkA_Ddis        ---------------KNNE-----------SCNNTN-T-NI--EK-SN---KSM----WD
22369_Tthe       TSKKYYKDNKSKQTHSSSS-----------KSSSSK-D-SF--V-SGA---SKD----RS
CLK_Spur         ----------------QIA-----------IQRCKS-R-HR--EEGHR---ASV----ID
CC1G_01467_Ccin  ---------------FSDS---------VD---RF----PQ--C-HFS---DWE----AL
CC1G_10232_Ccin  ---------------VNDELVLDYLIQDYEHQYAAG-Q-GK--P-SLA---TTV----YN
CC1G_15475_Ccin  ------------------------------------------------------------
CC1G_06417_Ccin  AKKAAAGGQQSNATNAANA---------WDNRTVAA-T-DD--S-SKG---APP----CD
AqueK109_Aque    ----------------SSS-----------SRKEKD-EVHRVPPPITP---AKV----ED
CLK_a_Smoe       -------------------------------ASKGMIN-KC--NVSFH---SCH----ED
CLK_d_Smoe       -----------------------------------------------------R----ED
CLK_b_Smoe       -----------------------------------------------------S----K-
CLK_c_Smoe       ------------------------------------L--NV--VVPPQ---ACH----ED
GK028_Glam       --------------------------------SSAR-S-GA--L-GPD---TST----QN


Doa_Dmel         DADGHLIYHTGDILH--HRYK---------------------------------------
CLK4_Mmus        DEEGHLICQSGDVLR--ARYE---------------------------------------
CLK3_Mmus        DKEGHLVCRIGDWLQ--ERYE---------------------------------------
CLK2_Mmus        DAEGHLIYHVGDWLQ--ERYE---------------------------------------
CLK1_Mmus        DEEGHLICQSGDVLS--ARYE---------------------------------------
E02H4.3_Cele     DKDGHLIYSKGDFIL--NRFT---------------------------------------
C16A11.3_Cele    LPKNPILT----SSG--AQLK---------------------------------------
KNS1_Scer        DKDGHYVYQENDIFGSGGRFV---------------------------------------
CLK4_Hsap        DEEGHLICQSGDVLR--ARYE---------------------------------------
CLK3_Hsap        DKEGHLVCRIGDWLQ--ERYE---------------------------------------
CLK2_Hsap        DAEGHLIYHVGDWLQ--ERYE---------------------------------------
CLK1_Hsap        DEEGHLICQSGDVLS--ARYE---------------------------------------
Y111B2A.1_Cele   ------------NWG--TDLE---------------------------------------
ClkA_Ddis        DENDYYKVQVGEYLN--NRYK---------------------------------------
22369_Tthe       KDAGHYKFKNGETFD-DGRYV---------------------------------------
CLK_Spur         DDEGHLIYRPGDCLQ--ARYA---------------------------------------
CC1G_01467_Ccin  DKSGHYIPHLVCAVH--LRFQPGRIKVIQIDYDSPLSLAFLTMLSAKDLKGVVELHWRDK
CC1G_10232_Ccin  GAVTLRRIEIGDFLD--KKFC---------------------------------------
CC1G_15475_Ccin  --------------E--ERAS---------------------------------------
CC1G_06417_Ccin  DKEGHYIIVPDDMIF--KRYR---------------------------------------
AqueK109_Aque    DEDGHLIYKKGDYLD--SRYE---------------------------------------
CLK_a_Smoe       DKDGHFVFELGENIT--PRYK---------------------------------------
CLK_d_Smoe       DKDGHYVFELGENIT--PRYK---------------------------------------
CLK_b_Smoe       ------------------------------------------------------------
CLK_c_Smoe       DKDGHFVFELGENIT--PRYK---------------------------------------
GK028_Glam       LEEGHINPGPNEVLG--GRYA---------------------------------------


Doa_Dmel         ------IMATLGEGTFG---RVV-KVKDMER-DYCMALKIIKNVEKYR--EA-AK-LEIN
CLK4_Mmus        ------IVDTLGEGAFG---KVV-ECIDHGMDGLHVAVKIVKNVGRYR--EA-AR-SEIQ
CLK3_Mmus        ------IVGNLGEGTFG---KVV-ECLDHARGKSQVALKIIRNVGKYR--EA-AR-LEIN
CLK2_Mmus        ------IVSTLGEGTFG---RVV-QCVDHRRGGTQVALKIIKNVEKYK--EA-AR-LEIN
CLK1_Mmus        ------IVDTLGEGAFG---KVV-ECIDHKVGGRRVAVKIVKNVDRYC--EA-AQ-SEIQ
E02H4.3_Cele     ------IYDTLGEGTFG---KVV-RVNDSLS-DTFMALKIIKNVSKYR--EA-AK-LEVK
C16A11.3_Cele    ------IIAKLGEGVFG---AVY-KVVDHSN--KKYAVKLFKEEHSEV-----GEQSWAR
KNS1_Scer        ------VKDLLGQGTFG---KVL-KCIDNKYEPNYVAVKVIRAVDRYR--EA-AK-TELR
CLK4_Hsap        ------IVDTLGEGAFG---KVV-ECIDHGMDGMHVAVKIVKNVGRYR--EA-AR-SEIQ
CLK3_Hsap        ------IVGNLGEGTFG---KVV-ECLDHARGKSQVALKIIRNVGKYR--EA-AR-LEIN
CLK2_Hsap        ------IVSTLGEGTFG---RVV-QCVDHRRGGARVALKIIKNVEKYK--EA-AR-LEIN
CLK1_Hsap        ------IVDTLGEGAFG---KVV-ECIDHKAGGRHVAVKIVKNVDRYC--EA-AR-SEIQ
Y111B2A.1_Cele   ------NVSVLGEGVFG---TVF-EVADAEK-KKKFALKLFKAGHTQFGCEDWVRESELS
ClkA_Ddis        ------VLCTVGSGTFS---TVV-ECWDTNS-SGQVAIKIVRSAKKYT--ED-AL-VEID
22369_Tthe       ------VVKHLSDGTFG---RVL-EVQDRQNGNKLYALKVIRAVERYV--DA-AQ-IETE
CLK_Spur         ------ITSTLGEGTFG---KVV-QCRDNMSGGAKIALKIIKNIEKYR--EA-AK-LEIN
CC1G_01467_Ccin  GDPRHGAVKFTGSISC-AFHKCVWTGTDMRS-RERVVVKAIALA------DD-SE-HEVT
CC1G_10232_Ccin  ------VY-QLG--SFSGPCQTI-RAREIRT-GRSLLLRAIRKSSVLP--DA-LF-KDLQ
CC1G_15475_Ccin  ------IESTIS---A-NFHKCLFKGFDHRF-GVKIIIKAIATG------TD-ER-FERK
CC1G_06417_Ccin  ------TVRLLGQGTFG---KVV-EAIDTQT-NNRVAIKIIRAIPKYR--DA-SK-IEVR
AqueK109_Aque    ------VLRTLGEGTFG---KVV-CCHDRLT-GKDVAVKIIKNVPKYR--AA-AR-IEIR
CLK_a_Smoe       ------IIGKMGEGTFG---RVL-ECWDRDT-QEYVAIKLIRNVQKYR--DA-AM-IEID
CLK_d_Smoe       ------VISKMGEGTFG---RVL-ECWDRKY-QEFVAVKVIRNVPKYR--EA-AL-IEID
CLK_b_Smoe       -------------SIES---NLV-VNQSRKY-QEFVAIKVIRNVPKYR--EA-TL-IEID
CLK_c_Smoe       ------IIGKMGEGTFG---RVL-ECWDRDT-QEYVAIKLIRNVQKYR--DA-AM-IEID
GK028_Glam       ------IFARLGHGTFG---RVY-ACYDKSRDDTEVAVKVIRAIDRYT--AA-GK-AEEA
                                            .         :: .

Doa_Dmel         -------ALEKIAQKDP-HCD--------------------HLCVKM--I-DWFDYHGHM
CLK4_Mmus        -------VLEHLNSTDP-NSV--------------------FRCVQM--L-EWFDHHGHV
CLK3_Mmus        -------VLKKIKEKDK-ENK--------------------FLCVLM--S-DWFNFHGHM
CLK2_Mmus        -------VLEKINEKDP-DNK--------------------NLCVQM--F-DWFDYHGHM
CLK1_Mmus        -------VLEHLNTTDP-HST--------------------FRCVQM--L-EWFEHRGHI
E02H4.3_Cele     -------VLQKLAEKDP-EKK--------------------NWVIHM--G-SYFDYNGHI
C16A11.3_Cele    ----ETAIMKAVTAINSANLIRM------------------EDSWRI--NESVPNGFLKI
KNS1_Scer        -------ILQTILNNDP-QGQ--------------------FQCLLL--R-ECFDYKNHI
CLK4_Hsap        -------VLEHLNSTDP-NSV--------------------FRCVQM--L-EWFDHHGHV
CLK3_Hsap        -------VLKKIKEKDK-ENK--------------------FLCVLM--S-DWFNFHGHM
CLK2_Hsap        -------VLEKINEKDP-DNK--------------------NLCVQM--F-DWFDYHGHM
CLK1_Hsap        -------VLEHLNTTDP-NST--------------------FRCVQM--L-EWFEHHGHI
Y111B2A.1_Cele   IPN-YLQIMKSVAAAHHPNLIKL------------------VKSGKM--A-SVPEGYLRI
ClkA_Ddis        -------ILRNLEKTGNSNGKYL------------------SHCIRL--L-DSFLFKDHI
22369_Tthe       -------IIRKIQAADP-ENK--------------------YRIVKL--E-STFKHGANF
CLK_Spur         -------VLEKINEKEG-VGK--------------------SLCVKM--Y-DWFDYHGHV
CC1G_01467_Ccin  RLQRLTRCLDHAK---A-KGLT--------------------LFVDILAS-EVTNVYSVV
CC1G_10232_Ccin  -------AVEVVSKAED-H------------------------FVRF--T-RLFQTELDT
CC1G_15475_Ccin  RIRRLTNALDRAANMFP-HVQS---------------------LATL--M-DYEVHPSHT
CC1G_06417_Ccin  -------VLQKLKERDP-LNR--------------------NKCIHL--L-HWFDHRNHI
AqueK109_Aque    -------VLEQIRDIVE-DGQ--------------------ELCVQL--R-DWFDYYGHI
CLK_a_Smoe       -------VLNELARYDR-NGS--------------------RRCVQL--K-RWFDFRNHI
CLK_d_Smoe       -------VLRALRKHDK-NGK--------------------RGCLQM--K-EWFDYRNHV
CLK_b_Smoe       -------VLKALQKHDK-NGK--------------------RGCLQM--K-EWFDYRNHV
CLK_c_Smoe       -------VLNELARYDR-NGS--------------------RRCVQL--K-RWFDFRNHI
GK028_Glam       -------VLNKIKQAAK-KAQHTGYSSSLMNSYYAKLCWNNCNLAYL--E-RSFQHNNHI
                         :                                     :

Doa_Dmel         CIVFEMLGLSVFDFLRE-------NNYEPYPLDQVRHMAYQLCYSVKFLHDNRLTHTDLK
CLK4_Mmus        CIVFELLGLSTYDFIKE-------NSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLK
CLK3_Mmus        CIAFELLGKNTFEFLKE-------NNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLK
CLK2_Mmus        CISFELLGLSTFDFLKD-------NNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLK
CLK1_Mmus        CIVFELLGLSTYDFIKE-------NSFLPFRMDHIRKMAYQICKSVNFLHSNKLTHTDLK
E02H4.3_Cele     CLLFDLMGSSIFDFLKA-------NHYKPYPMEQTLHITWQLCNAVKFLHDNKLTHTDLK
C16A11.3_Cele    AISFELKGRSVFEVMDSTKGKMPAGSEISFEINAIRVMGKQLLEAMEKLESVKIVHLDLK
KNS1_Scer        CLVTDLYGRSIYDFMCS-------NGIARFPGSHIQAIARQLIRSVCFLHDLGIIHTDLK
CLK4_Hsap        CIVFELLGLSTYDFIKE-------NSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLK
CLK3_Hsap        CIAFELLGKNTFEFLKE-------NNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLK
CLK2_Hsap        CISFELLGLSTFDFLKD-------NNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLK
CLK1_Hsap        CIVFELLGLSTYDFIKE-------NGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLK
Y111B2A.1_Cele   AILMELRGKSLFSVMDSTKSE-VPNKEISFPIATIREIGAQILSAMKKLEKMEIVHLDLK
ClkA_Ddis        CLVFKRYGLSLYEFLKK-------NRYRPLPLSQIQNISKQLLTAIYSMHKLSLVHTDLK
22369_Tthe       CMIFEKLGLSLYELLKK-------NNYIGYKIRLVQSFFKQILESVGFLHSIHLTHTDLK
CLK_Spur         CISFEILGLSIFDFLKD-------NNYQPYPLDQIKRMSHQLCSAVKFLHDMKITHTDLK
CC1G_01467_Ccin  C--LTAHGMSLRDVLDI-------KELVPLPLNQVKAFSHQILSGIQYLHTQDIIHTDIT
CC1G_10232_Ccin  FLVFEDEGVPLSSIIRN-------NNIATFSPRQVREIVWQTANALDFLHSHGITHGDLC
CC1G_15475_Ccin  FLVFKAYGKTLTEVMTM-------QQLLPLPSSQIKGIAFQILSALRFLHGEDIAHTDIK
CC1G_06417_Ccin  CLVSELLGMCVYDFLKE-------NDFAPFPRHHIQDFARQLFGSVAFLHELRLIHTDLK
AqueK109_Aque    SLTFDMLGLSVFDFLKD-------NNYHPYSLSQVRHISWQLIKAVRYLHQTRLTHTDLK
CLK_a_Smoe       CMVFEKLGPSLYDFLRK-------NEYRPYAIDLVREFGRQLLESVAYMHDLTLIHTDLK
CLK_d_Smoe       CIVSEKLGPSLYDFLKK-------NSYRPFSIEHVRDIGWQLLNSVAYLHELSLIHTDLK
CLK_b_Smoe       CIVSEKLGPSLYDFLKK-------NSYRPFSIE---HVGWQLLNSVAYLHELSLIHTDLK
CLK_c_Smoe       CMVFEKLGPSLYDFLRK-------NEYRPYAIDLVREFGRQLLESVAYMHDLTLIHTDLK
GK028_Glam       CLVFPKYGISLLDLLKA-------NNFRGFNIDWTRELSRSFMVGVGFLHDLGYIHTDIK
                        *    ..:                      .  .   .:  :.     * *:

Doa_Dmel         PENILFVDSDYT--SHY-NHK--I------------------------------------
CLK4_Mmus        PENILFVKSDYV--VKY-NSK--M------------------------------------
CLK3_Mmus        PENILFVNSEFE--TLY-NEH--K------------------------------------
CLK2_Mmus        PENILFVNSDYE--LTY-NLE--K------------------------------------
CLK1_Mmus        PENILFVKSDYT--EAY-NPK--M------------------------------------
E02H4.3_Cele     PENILFVDSRYT--TKL-VDK--K------------------------------------
C16A11.3_Cele    PENICFSSSCTFK--T----TV--------------------------------------
KNS1_Scer        PENILICDETHI--AQKLPLKTVQSL----------------------------------
CLK4_Hsap        PENILFVKSDYV--VKY-NSK--M------------------------------------
CLK3_Hsap        PENILFVNSEFE--TLY-NEH--K------------------------------------
CLK2_Hsap        PENILFVNSDYE--LTY-NLE--K------------------------------------
CLK1_Hsap        PENILFVQSDYT--EAY-NPK--I------------------------------------
Y111B2A.1_Cele   PENICFTSTCTFT--T----EI--------------------------------------
ClkA_Ddis        PENILLESSRFT--YFD-NSIPLQFKNSI-------------------------------
22369_Tthe       PENILLASPELR--LVV-ENNSQKDSPSTQ-YQSSDKTNATAGTVSENNQKNEHQNNSTG
CLK_Spur         PENILFVDSRSS--IKY-DPV--K------------------------------------
CC1G_01467_Ccin  PSNVVLVQDDIT--CYQ-EYTA--------------------------------------
CC1G_10232_Ccin  PSNIKLSSIATVQEVYF-DWES--------------------------------------
CC1G_15475_Ccin  PDNIVLVDDAVA--SYE-DFQN--------------------------------------
CC1G_06417_Ccin  PENILLVHNDYR--TIN-VPIP-G------------------------------------
AqueK109_Aque    PENILFVSSDYD--MYY-DAR--K------------------------------------
CLK_a_Smoe       PENILLVSPDHV--KVP-DFKGLY------------------------------------
CLK_d_Smoe       PENILLVSSAYV--KTL-DYKVAHFVRSFLVLL---------------------------
CLK_b_Smoe       PENILLVSSAYV--KTL-DYKVVHFVRSFLVIL---------------------------
CLK_c_Smoe       PENILLVSPDHV--KVP-DFKGLY------------------------------------
GK028_Glam       LENILSREKPRA--TRV-R-----------------------------------------
                  .*:

Doa_Dmel         ---------------------N-----------------REVRRVKNTDVRLIDFGSATF
CLK4_Mmus        ---------------------K-----------------RDERTLKNTDIKVVDFGSATY
CLK3_Mmus        ---------------------S-----------------CEEKSVKNTSIRVADFGSATF
CLK2_Mmus        ---------------------K-----------------RDERSVKSTAVRVVDFGSATF
CLK1_Mmus        ---------------------K-----------------RDERTIVNPDIKVVDFGSATY
E02H4.3_Cele     ---------------------V---GKFVLRRFKIDDCFQPLRVLHSTHVRLIDFGSATF
C16A11.3_Cele    ------------------------TG---------N--VCFIQ-PSIFHVCVVDFGNART
KNS1_Scer        -------------------SKRRREA---------S--KGKRKILKNPEIKIIDFGSAIF
CLK4_Hsap        ---------------------K-----------------RDERTLKNTDIKVVDFGSATY
CLK3_Hsap        ---------------------S-----------------CEEKSVKNTSIRVADFGSATF
CLK2_Hsap        ---------------------K-----------------RDERSVKSTAVRVVDFGSATF
CLK1_Hsap        ---------------------K-----------------RDERTLINPDIKVVDFGSATY
Y111B2A.1_Cele   ------------------------RK---------D--VCYISPSEELNVCIIDFGNARK
ClkA_Ddis        --------------------DTTSNN---------S--VDHYCHLVDTDIVVIDFGGATF
22369_Tthe       KRSSSSSSSSSSSSSSSGSHAKSSSK---------N--SKKYWVPVSDEIKIIDFGGATF
CLK_Spur         ---------------------K-----------------RDVRQVVNCDIRLIDFGSATF
CC1G_01467_Ccin  ------------------------TN---------E--VVTKHRLRSIAVKLIDLDG-YF
CC1G_10232_Ccin  ------------------------R----------S--FDTRKVLKSTELRVCFFGSLGV
CC1G_15475_Ccin  ------------------------G----------E--FVTKYLLKNISVKLVDYDDFTD
CC1G_06417_Ccin  ---------------------KRNGA------------TKPKKILNSTEIRLIDFGSATF
AqueK109_Aque    ---------------------K-----------------QDIRVVKSTDVRLIDFGSATF
CLK_a_Smoe       ---------------------QRSGP---------G--RCYVRVPRTSEIKLIDFGSATF
CLK_d_Smoe       ----------------TLFPLQSARP---------D--KHLTRTPTSAEIRLIDFGSATF
CLK_b_Smoe       ----------------TLFPLQSARL---------D--KHLTRTPTSAEIRLIDFGSATF
CLK_c_Smoe       ---------------------QRSGP---------G--RCYVRVPRTSEIKLIDFGSATF
GK028_Glam       -----------------------------------D--R-IFVHPSGAELVLIDLGSSVR
                                                                  : :   ..

Doa_Dmel         DH---EHHSTIVSTRHYRAPEVILEL-GWSQPCDVWSIGCILFELYLGIT-LFQTHDN--
CLK4_Mmus        DD---EHHSTLVSTRHYRAPEVILAL-GWSQPCDVWSIGCILIEYYLGFT-VFQTHDS--
CLK3_Mmus        DH---EHHTTIVATRHYRPPEVILEL-GWAQPCDVWSIGCILFEYYRGFT-LFQTHEN--
CLK2_Mmus        DH---EHHSTIVSTRHYRAPEVILEL-GWSQPCDVWSIGCIIFEYYVGFT-LFQTHDN--
CLK1_Mmus        DD---EHHSTLVSTRHYRAPEVILAL-GWSQPCDVWSIGCILIEYYLGFT-VFPTHDS--
E02H4.3_Cele     DH---EHHSIIVSTRHYRAPEVILEL-GWSQPCDVWSIGCILYELYTGVT-LFQTHEN--
C16A11.3_Cele    IRQDKPPKYALVQTQNYRAPEIFLGL-PFSVKSDIWSFGCILSELYTGDL-LFYGNSKSD
KNS1_Scer        HY---EYHPPVISTRHYRAPEIVLGL-GWSFPCDIWSIACVLVELVIGES-LYPIHEN--
CLK4_Hsap        DD---EHHSTLVSTRHYRAPEVILAL-GWSQPCDVWSIGCILIEYYLGFT-VFQTHDS--
CLK3_Hsap        DH---EHHTTIVATRHYRPPEVILEL-GWAQPCDVWSIGCILFEYYRGFT-LFQTHEN--
CLK2_Hsap        DH---EHHSTIVSTRHYRAPEVILEL-GWSQPCDVWSIGCIIFEYYVGFT-LFQTHDN--
CLK1_Hsap        DD---EHHSTLVSTRHYRAPEVILAL-GWSQPCDVWSIGCILIEYYLGFT-VFPTHDS--
Y111B2A.1_Cele   SNQEDLKSSEVVQTQNYRAPEIFMGL-PFSTRSDVWSFGCILSELYTGEL-LFYGNDEHD
ClkA_Ddis        EN---THHTAIVCSRPYRPPEIILGM-GWSYPCDIWGVGCILVELYLGYT-LFDTHNN--
22369_Tthe       ED---EHHSDIINTRQYRAPEVILGCCKWNEVSDVWSIGCIIMELYSGEL-FFPTHEK--
CLK_Spur         DH---EHHSTIVSTRHYRALEVILEL-GWSQPCDVWSIGCIIFELYTGFT-LFQTHDN--
CC1G_01467_Ccin  DWRVQCEPRYAAGTRGYRAPEISLGI-PWTKGIDIFSFGCTLWELHSGGA-LFNPSDD--
CC1G_10232_Ccin  DNR---SRN----HDRFRSPEVVAGI-GVDYKTDIFSLGCLMKELIINRPFLYDCMDSMF
CC1G_15475_Ccin  LHAIP-RPRHLVGTSIYRPPEVILNM-PWSTPVDIFAFGCTIAELYLGRP-LFPHSTG--
CC1G_06417_Ccin  ES---EYHSTVVCTRHYRAPEIILGL-GWSFPCDAYSLGCILVEFYTGLA-LYQTHDN--
AqueK109_Aque    DD---EHHSTVVSTRHYRAPEVILEL-GWSHPCDMWSVGCIMFELYRGHT-LFQTHDN--
CLK_a_Smoe       NS---HYHCSVISTRHYRAPEVILGL-GWSYSCDIWSIGCILVELCSGST-LFQTHEN--
CLK_d_Smoe       EN---QHHSSIVSTRQYRAPEIILGL-GWSYACDLWSVGCILVELFSGDP-LFQTHEN--
CLK_b_Smoe       EN---QHHSSIVSTRQYRAPEIILGL-GWSYACDLWSVGCILVELFSGDP-LFQTHEN--
CLK_c_Smoe       NS---HYHCSVISTRHYRAPEVILGL-GWSYSCDIWSIGCILVELCSGST-LFQTHEN--
GK028_Glam       LSD--HRRPSLVCTRQYRPPEAYLGL-PFDQTLDIWSCGCVIFEILTGRT-LFRTHNS--
                                 :*. *            * :. .* : *   .   .:

Doa_Dmel         --REHLAMMERILG-QIPYRMAR-KT-K-----T---------------KYF-YH-G-KL
CLK4_Mmus        --KEHLAMMERILG-PIPAHMIQ-KTRK-----R---------------KYF-HH-N-QL
CLK3_Mmus        --REHLVMMEKILG-PIPSHMIH-RTRK-----Q---------------KYF-YK-G-GL
CLK2_Mmus        --REHLAMMERILG-PVPSRMIR-KTRK-----Q---------------KYF-YR-G-RL
CLK1_Mmus        --REHLAMMERILG-PLPKHMIQ-KTRK-----R---------------RYF-HH-D-RL
E02H4.3_Cele     --REHLAMMERVLG-DIPLRMAK-RT-K-----T---------------KFF-IN-G-RL
C16A11.3_Cele    TEELQFELMQMIVQ-QPPSCAMLREAEK---IKS---------------TKIRIEN-GNV
KNS1_Scer        --LEHMAMMQRINGTPFPTDIID-KMFY---KSKHKLGNSPSDLNSTVIKHF-DRKTLSL
CLK4_Hsap        --KEHLAMMERILG-PIPQHMIQ-KTRK-----R---------------KYF-HH-N-QL
CLK3_Hsap        --REHLVMMEKILG-PIPSHMIH-RTRK-----Q---------------KYF-YK-G-GL
CLK2_Hsap        --REHLAMMERILG-PIPSRMIR-KTRK-----Q---------------KYF-YR-G-RL
CLK1_Hsap        --KEHLAMMERILG-PLPKHMIQ-KTRK-----R---------------KYF-HH-D-RL
Y111B2A.1_Cele   TEQLQFELMQLILQ-QAPSYLMMRKAAE---NKK---------------KMI-CID-GNV
ClkA_Ddis        --VQHLAMMEKVMG-PFPNSMSN-VS-------K---------------KYF-ND-YGTL
22369_Tthe       --IEHLAMIEKVCG-PIPQWMAQ-RSDN---SVNSHFK--------VTEEHF-QQNGTYF
CLK_Spur         --REHLAMAERILG-NFPSWMIK-RTRK-----S---------------KYF-YH-D-RV
CC1G_01467_Ccin  -WTKQLRIIERFAG-KLSSNFFE-RLRI---DGS---------------PYS-KED-FKL
CC1G_10232_Ccin  YVRDKLWVMENILG-SFPQELAE-TIEA---KHA---------------GVF------TP
CC1G_15475_Ccin  -PSHQLAIIEERLG-RFPHSFID-RVNR---GGF---------------NVF-RPN-GEV
CC1G_06417_Ccin  --LEHLAMMEMVMG-KMPERFAR-AGAR---SKP---------------EFF-KE-GAKL
AqueK109_Aque    --LEHLAMMETILG-PLPVRFVR-ESRK-----S---------------KYF-WH-G-KL
CLK_a_Smoe       --LEHLAMMERIIG-PLPAHMIE-KADR---RAE---------------KYF-KN-KVEL
CLK_d_Smoe       --LEHLAMMERILG-PISRRIID-NVDR---KAQ---------------KYF-KN-GREL
CLK_b_Smoe       --LEHLAMMERILG-PIPRRIID-NVDR---KAQ---------------KYF-KN-GREL
CLK_c_Smoe       --LEHLAMMERIIG-PLPAHMIE-KADR---RAE---------------KYF-KN-KVEL
GK028_Glam       --VVHLCMMERLLG-PMPDTVIE-QMDIYNSKYQ---------------EFF-CR-T-KK
                     :: : :       .

Doa_Dmel         DWDEKSSAGRYV-R--DHCKP-------L-FLC-QL------------------------
CLK4_Mmus        DWDEHSSAGRYV-R--RRCKP-------L-KEF-ML------------------------
CLK3_Mmus        VWDENSSDGRYV-K--ENCKP-------L-KSY-ML------------------------
CLK2_Mmus        DWDENTSAGRYV-R--ENCKP-------L-RRY-LT------------------------
CLK1_Mmus        DWDEHSSAGRYV-S--RRCKP-------L-KEF-ML------------------------
E02H4.3_Cele     DWVNTSADAAYV-R--DNCKP-------L-RRS-MS------------------------
C16A11.3_Cele    YM-KRKSKS--S-F--EPPKP-------L-HKQ-RR------------------------
KNS1_Scer        QWPEKNKRGDTI-TTEKSMKRVLQSCDRL-DIY-IS---KVLKQDYGDSLSINWNLPPEK
CLK4_Hsap        DWDEHSSAGRYV-R--RRCKP-------L-KEF-ML------------------------
CLK3_Hsap        VWDENSSDGRYV-K--ENCKP-------L-KSY-ML------------------------
CLK2_Hsap        DWDENTSAGRYV-R--ENCKP-------L-RRY-LT------------------------
CLK1_Hsap        DWDEHSSAGRYV-S--RRCKP-------L-KEF-ML------------------------
Y111B2A.1_Cele   YM-KKRAKS--S-F--DPPLP-------L-YKQ-RR------------------------
ClkA_Ddis        NRPQNSDEIKSM-ERV---EG-------L-KQL-KE------------------------
22369_Tthe       DWPKNDTSRKSI-SN---VKN-------L-LSF-DD------------------------
CLK_Spur         DWNQDNSSGRYV-C--ENCHP-------F-RYY-LD------------------------
CC1G_01467_Ccin  SWRHAEDRESQM-I--QI------------------------------------------
CC1G_10232_Ccin  WWRVATSSEDHF-D--DKIVE-------FVGDSDTL------------------------
CC1G_15475_Ccin  DCAEPVAQHLAV-E--ER-K--------------HI------------------------
CC1G_06417_Ccin  DWPKAKSTRQSK-KDVKSTRP-------L-ALT-ARQDVI--------------------
AqueK109_Aque    DWDPESPDGRYI-R--EHCRK-------L-KRY-IL------------------------
CLK_a_Smoe       NWPEGAVSRESV-RAVRKLPR-------L-RNM-IL------------------------
CLK_d_Smoe       NWPDAASSLESI-RTVKRLPR-------L-KEL-VQ------------------------
CLK_b_Smoe       NWPDAASSLESI-RTVKRLPR-------L-KEL-VQ------------------------
CLK_c_Smoe       NWPEGAVSRESV-RAVRKLPR-------L-RNM-IL------------------------
GK028_Glam       SWSLPTDLDPQERRHYEELLP-------L-ERE-ID------------------------


Doa_Dmel         ------------------------SDS----EDHCELFSLIKKMLEYEPSSRITLGEALH
CLK4_Mmus        ------------------------CHD----EEHEKLFDLVRRMLEYDPARRITLDEALQ
CLK3_Mmus        ------------------------QDS----LEHVQLFDLMRRMLEFDPAQRITLAEALL
CLK2_Mmus        ------------------------SEA----EDHHQLFDLIENMLEYEPAKRLTLGEALQ
CLK1_Mmus        ------------------------SQD----AEHELLFDLIGKMLEYDPAKRITLKEALK
E02H4.3_Cele     ------------------------CTD----PEHVELFELIENMLMFEPLARMKLPEALQ
C16A11.3_Cele    ------------------------PKD----LEAIPLFDLLECILIVDPSRRPSLRDISS
KNS1_Scer        NWSLINSKLAWKRQTHSSSSSTTDELDKETFLFWYWFIDLLRKMFEFDPTKRITAKDALD
CLK4_Hsap        ------------------------CHD----EEHEKLFDLVRRMLEYDPTQRITLDEALQ
CLK3_Hsap        ------------------------QDS----LEHVQLFDLMRRMLEFDPAQRITLAEALL
CLK2_Hsap        ------------------------SEA----EEHHQLFDLIESMLEYEPAKRLTLGEALQ
CLK1_Hsap        ------------------------SQD----VEHERLFDLIQKMLEYDPAKRITLREALK
Y111B2A.1_Cele   ------------------------RND----RAAIPLFELLERILIFDPTRRLTFSEISS
ClkA_Ddis        ------------------------YFH----PCHDSFFDLASRLLEYQPSKRISASDALS
22369_Tthe       ------------------------ILK----PEHRILGDLVRKCLIIDPNQRITCAQALQ
CLK_Spur         ------------------------SNA----DEHRLLFDTIEEMLEFDPFKRATLSQVLD
CC1G_01467_Ccin  --------------------------------RRPDLRDLLKACLQGDDRVRVGVDQALQ
CC1G_10232_Ccin  ------------------------PEL----IRDRDALEVIRSMTAYRPSDRPSIWVLTS
CC1G_15475_Ccin  ------------------------SLC----ILRPNLLDLLKLCLHHDDKKRCSAKAALQ
CC1G_06417_Ccin  -----------------------PPYD----HINRQFLNLVQKLLAFDPAQRITVREALA
AqueK109_Aque    ------------------------SAE----PEHEHLFDLITQLLTYEPRKRMTASEALK
CLK_a_Smoe       -----------------------QHVD----QYPNVLLDLLQGLLRYEPTERLSAKQALS
CLK_d_Smoe       -----------------------LHVE----HSASSLTDLLEGLLRYGASDRLTAKEALR
CLK_b_Smoe       -----------------------LHVE----HSASSLTDLLEGLLRYGASDRLTAKEALR
CLK_c_Smoe       -----------------------QHVD----QYPNVLLDLLQGLLRYEPTERLSAKQALS
GK028_Glam       -----------------------KYGY----GYHTSLIHLLRVMLSWDARKRFSVPECMA
                                                                    *

Doa_Dmel         HPFFDRLPPHHRVGEVSN--------K------------QPL-SSGS---------SSRE
CLK4_Mmus        HPFFDLL-----------------------------------------------------
CLK3_Mmus        HPFFAGLTPE------------------------------------E---------RSFH
CLK2_Mmus        HPFFACLRTEPPN---------------------------------T---------KLWD
CLK1_Mmus        HPFFYPLK----------------------------------------------------
E02H4.3_Cele     HRYFNRLPENLKIPC------------------------------KM---------DAST
C16A11.3_Cele    RTFF--------------------------------------------------------
KNS1_Scer        HEWFNLGILDD----------------------------------------------GIA
CLK4_Hsap        HPFFDLL-----------------------------------------------------
CLK3_Hsap        HPFFAGLTPE------------------------------------E---------RSFH
CLK2_Hsap        HPFFARLRAEPPN-------------------------------------------KLWD
CLK1_Hsap        HPFFDLLK----------------------------------------------------
Y111B2A.1_Cele   ETFF--------------------------------------------------------
ClkA_Ddis        HPFLFETIEND-------------------------------------------------
22369_Tthe       HEFFSM------------------------------------------------------
CLK_Spur         HPYFADIHYRG-----------------------------------------------NR
CC1G_01467_Ccin  HRFYNS------------------------------------------------------
CC1G_10232_Ccin  ADYFRT------------------------------------------------------
CC1G_15475_Ccin  HRFFK-------------------------------------------------------
CC1G_06417_Ccin  HPYFSLTIP---------------------------------------------------
AqueK109_Aque    HSFFAPYHTRSSTNNPTNSSSLVAQNK------------RNL-SSQG---------SSSS
CLK_a_Smoe       HPFFW-------------------------------------------------------
CLK_d_Smoe       HPFFKE------------------------------------------------------
CLK_b_Smoe       HPFFKE------------------------------------------------------
CLK_c_Smoe       HPFFW-------------------------------------------------------
GK028_Glam       HPFFEEEPRESKQTQTSG--------RNLANDQNMGTLMRDLLSAIDRTHPRYNDLKNAV
                   :

Doa_Dmel         RSHSLSR
CLK4_Mmus        ----KRK
CLK3_Mmus        SSRNPSR
CLK2_Mmus        SSRDISR
CLK1_Mmus        ----KHT
E02H4.3_Cele     NPRINGD
C16A11.3_Cele    ------K
KNS1_Scer        TYNNTQG
CLK4_Hsap        ----KKK
CLK3_Hsap        TSRNPSR
CLK2_Hsap        SSRDISR
CLK1_Hsap        ----KSI
Y111B2A.1_Cele   ------K
ClkA_Ddis        --CFGPI
22369_Tthe       ----KFD
CLK_Spur         DMHSISR
CC1G_01467_Ccin  -----LS
CC1G_10232_Ccin  -----EF
CC1G_15475_Ccin  -----RR
CC1G_06417_Ccin  ----EEN
AqueK109_Aque    SSSSDNE
CLK_a_Smoe       ------H
CLK_d_Smoe       -----RR
CLK_b_Smoe       -----RR
CLK_c_Smoe       ------H
GK028_Glam       DIAFGIN