Protein (view, download) , Domain (view, download)
PDHK4_Hsap_PDHK        MKAARFVLRSAG----------------SL---------------------NGA------
PDHK3_Hsap_PDHK        MRLFRWLLKQ--------------------------------------------------
PDHK2_Hsap_PDHK        MRWVWALLKNA-----------------SL------------------------------
PDHK1_Hsap_PDHK        MRLARLLRGAALA----GPGPGLRAAGFSRSFSSDSG-----------SSPASE------
PDK_Dmel_PDHK          MRLFPVRFSAA-----------------SL---------------------S-M------
PDHK4_Mmus_PDHK        MKAARFVMRSAS----------------SL---------------------SSA------
PDHK3_Mmus_PDHK        MRLFYRLLKQ--------------------------------------------------
PDHK2_Mmus_PDHK        MRWVRALLKNA-----------------SL------------------------------
PDHK1_Mmus_PDHK        MRLARLLRGGTSV----RPLCAVPCASRSLASASASG-----------SGPASE------
BCKDK_Mmus_BCKDK       MILTSVLGSGPRSWSSLWPLLGSSLSLRARSTSATD---------THHVELARERSKTVT
BCKDK_Hsap_BCKDK       MILASVLRSGPGGGLPLRPLLGPALALRARSTSATD---------THHVEMARERSKTVT
YIL042C_Scer_PDHK      MWKIMRSWKCGGM-RWAHR-QRPSHE--LLSQLSFD----------QHYK-I-R------
BCKDK_Spur_BCKDK       MALSTMKANQL-VFK---QALNFKSASYSRSIAITSYRPQSNYSAVHDYSPAKEKSRPVV
PDHK_Spur_PDHK         MVRLTVRLLAM----------------------------------------A-K------
aSWK467_Cele_PDHK      MRFSRKLLGPF------------------------------------------V------
pdhk-2_Cele_PDHK       MRFSRKLLGPF------------------------------------------V------
CC1G_13956_Ccin_BCKDK  MLLRHALRPLARR-RWYST------K--FQQP-------------------N-S------
CC1G_00337_Ccin_BCKDK  MTTFMVGRRVFNL-TTTTPFLQSSLR--YSST-------------------F-N------
CC1G_15212_Ccin_PDHK   MSAGFRITP---------------------------------------------------
                       *

PDHK4_Hsap_PDHK        -GLVPREVEHFSRYSPSPLSMKQLLDFGSENAC--ERTSFAFLRQELPVRL---ANILKE
PDHK3_Hsap_PDHK        --PVPKQIERYSRFSPSPLSIKQFLDFGRDNAC--EKTSYMFLRKELPVRL---ANTMRE
PDHK2_Hsap_PDHK        -AGAPKYIEHFSKFSPSPLSMKQFLDFGSSNAC--EKTSFTFLRQELPVRL---ANIMKE
PDHK1_Hsap_PDHK        -RGVPGQVDFYARFSPSPLSMKQFLDFGSVNAC--EKTSFMFLRQELPVRL---ANIMKE
PDK_Dmel_PDHK          -ASLAKMLDFYSGFNPSPLSIKQFMDFGQ-NAC--EKKSYIFLRKELPVRL---ANIMKE
PDHK4_Mmus_PDHK        -SLVPREVELFSRYSPSPLSMKQLLDFGSENAC--ERTSFAFLRQELPVRL---ANILKE
PDHK3_Mmus_PDHK        --PVPKQIERYSRFSPSPLSIKQFLDFGRDNAC--EKTSYMFLRKELPVRL---ANTMRE
PDHK2_Mmus_PDHK        -AGAPKYIEHFSKFSPSPLSMKQFLDFGSSNAC--EKTSFTFLRQELPVRL---ANIMKE
PDHK1_Mmus_PDHK        -LGVPGQVDFYARFSPSPLSMKQFLDFGSVNAC--EKTSFMFLRQELPVRL---ANIMKE
BCKDK_Mmus_BCKDK       SFYNQSAIDVAAEKPSVRLTPTMMLYSGRSQDGSHLLKSGRYLQQELPVRI---AHRIKG
BCKDK_Hsap_BCKDK       SFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRI---AHRIKG
YIL042C_Scer_PDHK      -SNIELLIQDYASKPIAPLNYEYFLQYRPPLTK---KEEYMLTIKTINLLLSLTCKRLNA
BCKDK_Spur_BCKDK       SFYNQSAIDVAAKKPSVRLTPATLLYTGKSPDGNHLLRSAQYLHKELPVRV---AHRIAE
PDHK_Spur_PDHK         -KNMQAQMEYYSKFSPSPLSIKQFMDFGQSKDV-DSAKSFVFLRQELPVRI---ANIMKE
aSWK467_Cele_PDHK      -GSLAKKLDYYSQFQPSSLTIQQYLDFGRIGT--S-ANSYTFLKNELLVRL---ANIMQE
pdhk-2_Cele_PDHK       -GSLAKKLDYYSQFQPSSLTIQQYLDFGRIGT--S-ANSYTFLKNELLVRL---ANIMQE
CC1G_13956_Ccin_BCKDK  -AEVTALLAQYGTAAPRPLNLSQLLSFGRPVTPDSVLSSVSYVLYELPRRL---ATRVRY
CC1G_00337_Ccin_BCKDK  -FYQNRQLEQYANREAKPLTLRQLVFFGRHLTEEKILKSANYVRSELPVRI---AHRLRD
CC1G_15212_Ccin_PDHK   --ALWDKIHHFASFPQTGVSLQQMVLFGQNPSQGTLLKASQFLSEELPVRL---AHRVKE
                              :   .      :.    :                     :   :   .  :

PDHK4_Hsap_PDHK        IDILPTQLVNTSSVQLVKSWYIQSLMDLVEFHEKSP------------------------
PDHK3_Hsap_PDHK        VNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSP------------------------
PDHK2_Hsap_PDHK        INLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDP------------------------
PDHK1_Hsap_PDHK        ISLLPDNLLRTPSVQLVQSWYIQSLQELLDFKDKSA------------------------
PDK_Dmel_PDHK          IALLPDNLLHTRSVSEVSSWYVKSFEDVLVYEKAEP------------------------
PDHK4_Mmus_PDHK        IDILPDRLVNTPSVQLVKSWYIQSLMDLVEFHEKSP------------------------
PDHK3_Mmus_PDHK        VNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSP------------------------
PDHK2_Mmus_PDHK        INLLPDRVLGTPSVQLVQSWYVQSLLDIMEFLDKDP------------------------
PDHK1_Mmus_PDHK        ISLLPDNLLRTPSVQLVQSWYIQSLQELLDFKDKSA------------------------
BCKDK_Mmus_BCKDK       FRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIK-------------------------
BCKDK_Hsap_BCKDK       FRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIK-------------------------
YIL042C_Scer_PDHK      IQRLPYNAVINPHIERTNSLYLKSLQTLLSIAYPYE------------------------
BCKDK_Spur_BCKDK       FRGLPFIVGCNPTILHVHELYIRAFHLLSEFPSIR-------------------------
PDHK_Spur_PDHK         INLLPEKLLQMPSVRMVQGWYQQTFEELLEYVEKTE------------------------
aSWK467_Cele_PDHK      FTLLPPKLLQMPSSKMVSNWYAESFEDLLLFEASD-------------------------
pdhk-2_Cele_PDHK       FTLLPPKLLQMPSSKMVSNWYAESFEDLLLFEASD-------------------------
CC1G_13956_Ccin_BCKDK  LESLPFIVGTNPYVAKTLKAFREGFWVLATHPPVTNL-----------------------
CC1G_00337_Ccin_BCKDK  LQALPYVVVTQEGVEKVYKLYWTAFEKFRTYPPITS------------------------
CC1G_15212_Ccin_PDHK   LDELPHNLSDMPSIKRVKNWYAQSFEELINFPHPQLPPEIRQALITSRSDELALPESKPN
                       .  **           .   :   :  .

PDHK4_Hsap_PDHK        ------------------------------------------------DDQKALSDFVDT
PDHK3_Hsap_PDHK        ------------------------------------------------EDPQVLDNFLQV
PDHK2_Hsap_PDHK        ------------------------------------------------EDHRTLSQFTDA
PDHK1_Hsap_PDHK        ------------------------------------------------EDAKAIYDFTDT
PDK_Dmel_PDHK          -------------------------------------------------THDNLQKFVAD
PDHK4_Mmus_PDHK        ------------------------------------------------EDQKALSEFVDT
PDHK3_Mmus_PDHK        ------------------------------------------------EDPRVLDNFLNV
PDHK2_Mmus_PDHK        ------------------------------------------------EDHRTLSQFTDA
PDHK1_Mmus_PDHK        ------------------------------------------------EDAKTIYEFTDT
BCKDK_Mmus_BCKDK       -------------------------------------------------DQADEAQYCQL
BCKDK_Hsap_BCKDK       -------------------------------------------------DQADEAQYCQL
YIL042C_Scer_PDHK      --------------------------------------------------LHNPPKIQAK
BCKDK_Spur_BCKDK       -------------------------------------------------DMDTERQYCKM
PDHK_Spur_PDHK         ------------------------------------------------EEDPVLLRYINQ
aSWK467_Cele_PDHK      ------------------------------------------------SSPEQVARFNDQ
pdhk-2_Cele_PDHK       ------------------------------------------------SSPEQVARFNDQ
CC1G_13956_Ccin_BCKDK  ---------------------------------------------------EENEK----
CC1G_00337_Ccin_BCKDK  --------------------------------------------------IEENTKFCKF
CC1G_15212_Ccin_PDHK   PSLIDTIYGSSPSNGNGNGGNGFNKLRLRVPMERRYYANTSNITHWPPEVQDYNKRFTKL


PDHK4_Hsap_PDHK        LIKVRNRHHNVVPTMAQG------------------------------------------
PDHK3_Hsap_PDHK        LIKVRNRHNDVVPTMAQG------------------------------------------
PDHK2_Hsap_PDHK        LVTIRNRHNDVVPTMAQG------------------------------------------
PDHK1_Hsap_PDHK        VIRIRNRHNDVIPTMAQG------------------------------------------
PDK_Dmel_PDHK          LDLIRNRHNDVVQTMAQG------------------------------------------
PDHK4_Mmus_PDHK        LVKVRNRHHNVVPTMAQG------------------------------------------
PDHK3_Mmus_PDHK        LINIRNRHNDVVPTMAQG------------------------------------------
PDHK2_Mmus_PDHK        LVTIRNRHNDVVPTMAQG------------------------------------------
PDHK1_Mmus_PDHK        VIRIRNRHNDVIPTMAQG------------------------------------------
BCKDK_Mmus_BCKDK       VRQLLDDHKDVVTLLAEG------------------------------------------
BCKDK_Hsap_BCKDK       VRQLLDDHKDVVTLLAEG------------------------------------------
YIL042C_Scer_PDHK      FTELLDDHEDAIVVLAKG------------------------------------------
BCKDK_Spur_BCKDK       VKTLLDDHKDVVTHLAEG------------------------------------------
PDHK_Spur_PDHK         LTTIRNRHVNVVETMAQG------------------------------------------
aSWK467_Cele_PDHK      LTVVLKRHAHVVETMAEG------------------------------------------
pdhk-2_Cele_PDHK       LTVVLKRHAHVVETMAEG------------------------------------------
CC1G_13956_Ccin_BCKDK  ------------------FQ----------------------------------------
CC1G_00337_Ccin_BCKDK  VGSLLDDHAVVIPNLSLG------------------------------------------
CC1G_15212_Ccin_PDHK   LEHIKSRHDPTVTTVAQGRSFRLPAFFGVLGVFWASGLGSVPLPSLYSRSMDPFVICEEH


PDHK4_Hsap_PDHK        -----------------------------------------------------IIEYKDA
PDHK3_Hsap_PDHK        -----------------------------------------------------VIEYKEK
PDHK2_Hsap_PDHK        -----------------------------------------------------VLEYKDT
PDHK1_Hsap_PDHK        -----------------------------------------------------VIEYKES
PDK_Dmel_PDHK          -----------------------------------------------------VIEMKEN
PDHK4_Mmus_PDHK        -----------------------------------------------------ILEYKDT
PDHK3_Mmus_PDHK        -----------------------------------------------------VIEYKEK
PDHK2_Mmus_PDHK        -----------------------------------------------------VLEYKDT
PDHK1_Mmus_PDHK        -----------------------------------------------------VTEYKES
BCKDK_Mmus_BCKDK       -----------------------------------------------------LRESRKH
BCKDK_Hsap_BCKDK       -----------------------------------------------------LRESRKH
YIL042C_Scer_PDHK      -----------------------------------------------------LQEIQSC
BCKDK_Spur_BCKDK       -----------------------------------------------------FRECRKH
PDHK_Spur_PDHK         -----------------------------------------------------ILEMRES
aSWK467_Cele_PDHK      -----------------------------------------------------LIELRES
pdhk-2_Cele_PDHK       -----------------------------------------------------LIELRES
CC1G_13956_Ccin_BCKDK  ----------------------------------------------------------E-
CC1G_00337_Ccin_BCKDK  -----------------------------------------------------LSLSS--
CC1G_15212_Ccin_PDHK   ALTELSIPFTLPQCLHAPLLGFLSLSLTHALASRLPPTFLVTGPRLPRTDLLCVLEWKRS


PDHK4_Hsap_PDHK        CT--VDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIFSD-S---QTGN--PSHIGSIDP
PDHK3_Hsap_PDHK        FG--FDPFISTNIQYFLDRFYTNRISFRMLINQHTLLFGGDT---NPVH--PKHIGSIDP
PDHK2_Hsap_PDHK        YG--DDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGST---NPAH--PKHIGSIDP
PDHK1_Hsap_PDHK        FG--VDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKG-KGSPSH--RKHIGSINP
PDK_Dmel_PDHK          EGGQVDAPTESSIQYFLDRLYMSRISIRMLINQHTLLFGG-N---PHAG--GRHIGCLDP
PDHK4_Mmus_PDHK        CT--VDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIFSD-S---KTGN--PSHIGSIDP
PDHK3_Mmus_PDHK        FG--FDPFISSNIQYFLDRFYTNRISFRMLINQHTLLFGGDT---NPAH--PKHIGSIDP
PDHK2_Mmus_PDHK        YG--DDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGST---NPAH--PKHIGSIDP
PDHK1_Mmus_PDHK        FG--VDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKG---SPSH--RKHIGSINP
BCKDK_Mmus_BCKDK       IQ------DEKLVRYFLDKTLTSRLGIRMLATHHLALHED--------K--PDFVGIICT
BCKDK_Hsap_BCKDK       IE------DEKLVRYFLDKTLTSRLGIRMLATHHLALHED--------K--PDFVGIICT
YIL042C_Scer_PDHK      -------YPKFQISQFLNFHLKERITMKLLVTHYLSLMAQNK---GDTN--KRMIGILHR
BCKDK_Spur_BCKDK       IT------DESLIHNFLDRILTSRLGIRMLAEHHLFLHQD--------K--NDSIGIIAT
PDHK_Spur_PDHK         YK--VDQHEENNVQYFLDRFYISRISIRMLINQHTLMFGQ-I---PTTH--PLLVGSIDP
aSWK467_Cele_PDHK      DG--VDIASEKGIQYFLDRFYINRISIRMLQNQHLVVFGN-V---LPES--PRHVGCIDP
pdhk-2_Cele_PDHK       DG--VDIASEKGIQYFLDRFYINRISIRMLQNQHLVVFGN-V---LPES--PRHVGCIDP
CC1G_13956_Ccin_BCKDK  -S--AKYMSFEDINAFLDGAIRNRISVRLIAEQHIAVTRALH--DPPQD--GKDVGVIDT
CC1G_00337_Ccin_BCKDK  -----PFLSPDKLDSFMRRMLVSRISRRVLAEHHIALSKTYLAKDSPAHEAEPRVGIIYT
CC1G_15212_Ccin_PDHK   QN--ARH-IGLDIQAWLDRFYMSRIGIRFLIGQHVALNTQ------QAH--EDYVGIICT
                                   :  ::     .*:  :.:  ::  :                 :* :

PDHK4_Hsap_PDHK        N-----------------------------------------------------------
PDHK3_Hsap_PDHK        T-----------------------------------------------------------
PDHK2_Hsap_PDHK        N-----------------------------------------------------------
PDHK1_Hsap_PDHK        N-----------------------------------------------------------
PDK_Dmel_PDHK          A-----------------------------------------------------------
PDHK4_Mmus_PDHK        N-----------------------------------------------------------
PDHK3_Mmus_PDHK        T-----------------------------------------------------------
PDHK2_Mmus_PDHK        N-----------------------------------------------------------
PDHK1_Mmus_PDHK        N-----------------------------------------------------------
BCKDK_Mmus_BCKDK       R-----------------------------------------------------------
BCKDK_Hsap_BCKDK       R-----------------------------------------------------------
YIL042C_Scer_PDHK      D-----------------------------------------------------------
BCKDK_Spur_BCKDK       K-----------------------------------------------------------
PDHK_Spur_PDHK         S-----------------------------------------------------------
aSWK467_Cele_PDHK      A-----------------------------------------------------------
pdhk-2_Cele_PDHK       A-----------------------------------------------------------
CC1G_13956_Ccin_BCKDK  R-----------------------------------------------------------
CC1G_00337_Ccin_BCKDK  A-----------------------------------------------------------
CC1G_15212_Ccin_PDHK   KAVRVPPSPSPFDTLFHFFGTSSAIEPHTDETAFLFLFRMRLVVVVVDVIVMDTLVVVMR


PDHK4_Hsap_PDHK        ------------------------------------------CDVVAVVQDAFECSRMLC
PDHK3_Hsap_PDHK        ------------------------------------------CNVADVVKDAYETAKMLC
PDHK2_Hsap_PDHK        ------------------------------------------CNVSEVVKDAYDMAKLLC
PDHK1_Hsap_PDHK        ------------------------------------------CNVLEVIKDGYENARRLC
PDK_Dmel_PDHK          ------------------------------------------CDLSDVVRDAYENARFLC
PDHK4_Mmus_PDHK        ------------------------------------------CDVVAVVQDAFECAKMLC
PDHK3_Mmus_PDHK        ------------------------------------------CNVADVVKDAYETAKMLC
PDHK2_Mmus_PDHK        ------------------------------------------CSVSDVVKDAYDMAKLLC
PDHK1_Mmus_PDHK        ------------------------------------------CDVVEVIKDGYENARRLC
BCKDK_Mmus_BCKDK       ------------------------------------------LSPKKIIEKWVDFARRLC
BCKDK_Hsap_BCKDK       ------------------------------------------LSPKKIIEKWVDFARRLC
YIL042C_Scer_PDHK      ------------------------------------------LPIAQLIKHVSDYVNDIC
BCKDK_Spur_BCKDK       ------------------------------------------MSLKKVIEKWVSFAREQC
PDHK_Spur_PDHK         ------------------------------------------CDIVAVIRDAYDSAKYLC
aSWK467_Cele_PDHK      ------------------------------------------CDVESVVYDAFENARFLC
pdhk-2_Cele_PDHK       ------------------------------------------CDVESVVYDAFENARFLC
CC1G_13956_Ccin_BCKDK  ------------------------------------------CSPKEMVDVCGSFVGDLC
CC1G_00337_Ccin_BCKDK  ------------------------------------------LDVKRCIDRCSTILRDRP
CC1G_15212_Ccin_PDHK   SRYLDSTRLGRCDVFGIWFCLDLGGYGAISRTFYTCAVISGLWNVHDIVQEAIENARFVC
                                                                       :

PDHK4_Hsap_PDHK        -------DQYYLS--SPELKLTQVNGKFP-DQPIHIVYVPSHLHHMLFELFKNAMRATVE
PDHK3_Hsap_PDHK        -------EQYYLV--APELEVEEFNAKAP-DKPIQVVYVPSHLFHMLFELFKNSMRATVE
PDHK2_Hsap_PDHK        -------DKYYMA--SPDLEIQEINAANS-KQPIHMVYVPSHLYHMLFELFKNAMRATVE
PDHK1_Hsap_PDHK        -------DLYYIN--SPELELEELNAKSP-GQPIQVVYVPSHLYHMVFELFKNAMRATME
PDK_Dmel_PDHK          -------DQYYLT--SPALEIQQHSSEPGDNLPIRTVYVPSHLYYMLFELFKNSMRAVVE
PDHK4_Mmus_PDHK        -------DQYYLT--SPELNLTQVNGKFP-GQPIHIVYVPSHLHHMLFELFKNAMRATVE
PDHK3_Mmus_PDHK        -------EQYYLV--APELEVEEFNAKAP-NKPIQVVYVPSHLFHMLFELFKNSMRATVE
PDHK2_Mmus_PDHK        -------DKYYMA--SPDLEIQEVNATNA-NQPIHMVYVPSHLYHMLFELFKNAMRATVE
PDHK1_Mmus_PDHK        -------DLYYVN--SPELELEELNAKSP-GQTIQVVYVPSHLYHMVFELFKNAMRATME
BCKDK_Mmus_BCKDK       -------EHKYGN--APRVRINGHV-------AARFPFIPMPLDYILPELLKNAMRATME
BCKDK_Hsap_BCKDK       -------EHKYGN--APRVRINGHV-------AARFPFIPMPLDYILPELLKNAMRATME
YIL042C_Scer_PDHK      -------FVKFNTQRTPVLIHPP-------SQDITFTCIPPILEYIMTEVFKNAFEAQIA
BCKDK_Spur_BCKDK       -------ELRFGY--APSVKINGHT-------GATFPYIIQPLDYMLPELLKNAMRATIE
PDHK_Spur_PDHK         -------DQYYLA--SPDIDVRWIDARDG-SDSIRMVYVPSHLYHIMFELLKNAMRAVME
aSWK467_Cele_PDHK      -------DRYYLT--SPSMKLEMHNAVEK-GKPISIVAVPSHLYHMMFELFKNAMRATVE
pdhk-2_Cele_PDHK       -------DRYYLT--SPSMKLEMHNAVEK-GKPISIVAVPSHLYHMMFELFKNAMRATVE
CC1G_13956_Ccin_BCKDK  -------RATLGS--APEIVVDG-------YPEATFAYIPVHLEYVLTELLKNSFRATVE
CC1G_00337_Ccin_BCKDK  LWVHGNEDVRIDA--WPEVEVEG-------HLDTKFAYIRDHLEYIVFELLKNAMSATVL
CC1G_15212_Ccin_PDHK   -------EEHYAMFKGPPVQLIC-------PPSLTFAYVPGHLSHICFELLKNSLRAVVE
                                       * :                   :   * ::  *::**:: * :

PDHK4_Hsap_PDHK        HQE-NQ--PSLTPIEVIVVLGKED-----------------LTIKISDRGGGVPLR----
PDHK3_Hsap_PDHK        LYE-DR-KEGYPAVKTLVTLGKED-----------------LSIKISDLGGGVPLR----
PDHK2_Hsap_PDHK        SHE-SS--LILPPIKVMVALGEED-----------------LSIKMSDRGGGVPLR----
PDHK1_Hsap_PDHK        HHA-NR--GVYPPIQVHVTLGNED-----------------LTVKMSDRGGGVPLR----
PDK_Dmel_PDHK          HHGHDN-NDTLPPLKVAICKGKED-----------------ICVKISDQGGGIPRS----
PDHK4_Mmus_PDHK        HQE-NR--PSLTPVEATVVLGKED-----------------LTIKISDRGGGVPLR----
PDHK3_Mmus_PDHK        LHE-DK-KEGYPAVKTLVTLGKED-----------------LSIKISDLGGGVPLR----
PDHK2_Mmus_PDHK        SHE-SS--LTLPPIKIMVALGEED-----------------LSIKMSDRGGGVPLR----
PDHK1_Mmus_PDHK        HHA-DK--GVYPPIQVHVTLGEED-----------------LTVKMSDRGGGVPLR----
BCKDK_Mmus_BCKDK       SHL-DT-PYNVPDVVITIANNDID-----------------LIIRISDRGGGIAHK----
BCKDK_Hsap_BCKDK       SHL-DT-PYNVPDVVITIANNDVD-----------------LIIRISDRGGGIAHK----
YIL042C_Scer_PDHK      LG---KE--H-MPIEINLLKP----------------DDDELYLRIRDHGGGITPE----
BCKDK_Spur_BCKDK       SHL-DT-PMNLPDVVITIASNEVDFIISFGWQNQLIEYDNDVLNRISDRGGGIPHS----
PDHK_Spur_PDHK         HKG-PS-ASEFPPIGILVTKGKED-----------------VTIKVSDEGGGIPKS----
aSWK467_Cele_PDHK      YHG-VD--DDLPDIKVYVVKGQED-----------------LSIKICDRGGGVSRT----
pdhk-2_Cele_PDHK       YHG-VD--DDLPDIKVYVVKGQED-----------------LSIKICDRGGGVSRT----
CC1G_13956_Ccin_BCKDK  HHARSKERGSLPPIQITLSPPPASSH--SG---HNVDRPNFFSIRIRDQGGGVSRQ----
CC1G_00337_Ccin_BCKDK  KHHDS--GSSLPPIRVTIVAG-----------------EDDISLRISDQGGGLTSVNAPT
CC1G_15212_Ccin_PDHK   RYGVDA-EDHFPPIKVIVVEG-----------------KEDITIKISDEGGGIARS----
                                    :   :                       .  :: * ***:.

PDHK4_Hsap_PDHK        -IIDRLFSYTYSTAPTPVMDNS--------------------------------------
PDHK3_Hsap_PDHK        -KIDRLFNYMYSTAPRPSLEPT--------------------------------------
PDHK2_Hsap_PDHK        -KIERLFSYMYSTAPTPQP-GT--------------------------------------
PDHK1_Hsap_PDHK        -KIDRLFNYMYSTAPRPRVETS--------------------------------------
PDK_Dmel_PDHK          -QTDQLFKYMYSTAPQPSKSDL--------------------------------------
PDHK4_Mmus_PDHK        -ITDRLFSYTYSTAPTPVMDNS--------------------------------------
PDHK3_Mmus_PDHK        -KIDRLFNYMYSTAPRPSLEPT--------------------------------------
PDHK2_Mmus_PDHK        -KIERLFSYMYSTAPTPQP-GT--------------------------------------
PDHK1_Mmus_PDHK        -KIDRLFNYMYSTAPRPRVETS--------------------------------------
BCKDK_Mmus_BCKDK       -DLDRVMDYHFTTAEASTQDPR----------------INPLFGHL--------------
BCKDK_Hsap_BCKDK       -DLDRVMDYHFTTAEASTQDPR----------------ISPLFGHL--------------
YIL042C_Scer_PDHK      -VEALMFNYSYSTHTQQSADSES---------------T---------------------
BCKDK_Spur_BCKDK       -LLKKVFQYHFTTANDDESVSDNGGALGTMIEAVNQPTAGPLCGISDRGGGIP---HSLL
PDHK_Spur_PDHK         -EIDLLFNYMYSTAPAPPKPGV--------------------------------------
aSWK467_Cele_PDHK      -ILERLYNYMYSTAPPPPRDG---------------------------------------
pdhk-2_Cele_PDHK       -ILERLYNYMYSTAPPPPRDG---------------------------------------
CC1G_13956_Ccin_BCKDK  -HLERIFSYAFTTVKTGDDEGPD---------------W---------------------
CC1G_00337_Ccin_BCKDK  NDPMDLFSFSHIRNAS-RLEDSR---------------LG--ALRTASEEGLRATVDEQL
CC1G_15212_Ccin_PDHK   -AIPLIWTYMYTTMEHQTSLDED-------------------------------------
                            :  : .

PDHK4_Hsap_PDHK        -------------------------------------RNAPLAGFGYGLPISRLYAKYFQ
PDHK3_Hsap_PDHK        -------------------------------------RAAPLAGFGYGLPISRLYARYFQ
PDHK2_Hsap_PDHK        -------------------------------------GGTPLAGFGYGLPISRLYAKYFQ
PDHK1_Hsap_PDHK        -------------------------------------RAVPLAGFGYGLPISRLYAQYFQ
PDK_Dmel_PDHK          -------------------------------------HTVPLAGYGYGLPISRLYARYFH
PDHK4_Mmus_PDHK        -------------------------------------RNAPLAGFGYGLPISRLYAKYFQ
PDHK3_Mmus_PDHK        -------------------------------------RAAPLAGFGYGLPISRLYARYFQ
PDHK2_Mmus_PDHK        -------------------------------------GGTPLAGFGYGLPISRLYAKYFQ
PDHK1_Mmus_PDHK        -------------------------------------RAVPLAGFGYGLPISRLYAQYFQ
BCKDK_Mmus_BCKDK       --------------D-----------------MHSGGQSGPMHGFGFGLPTSRAYAEYLG
BCKDK_Hsap_BCKDK       --------------D-----------------MHSGAQSGPMHGFGFGLPTSRAYAEYLG
YIL042C_Scer_PDHK      --------------------------------DLPGEQINNVSGMGFGLPMCKTYLELFG
BCKDK_Spur_BCKDK       KKVFQYHFTTA-NDDESVSDNGGA--LGTMIEAVNQPTAGPLCGFGFGLPVSKAYAEYLG
PDHK_Spur_PDHK         ------------------------------------SIIPPLAGYGYGLPISRLYAKYFH
aSWK467_Cele_PDHK      ------------------------------------T-QAPLAGYGYGLPLSRLYARYFL
pdhk-2_Cele_PDHK       ------------------------------------T-QAPLAGYGYGLPLSRLYARYFL
CC1G_13956_Ccin_BCKDK  --------------DT-SDSREDEPFLGVMTQRTLQTGLGTIAGLGYGLPMSKLYTKYFG
CC1G_00337_Ccin_BCKDK  SRWQKHSYYQPKNRDK-LEEHGTA--------PSQEIMNIVRSRIGIGLPMSNIYATYFG
CC1G_15212_Ccin_PDHK   --------------------------------FQASDFKAPMAGFGYGLPLSRLYARYFG
                                                                    * *** .. *   :

PDHK4_Hsap_PDHK        GDLNLYSLSGYGTDAIIYLKALSSESIEKLPVFNKSAFKHYQMSSEADDWCIPSREPKNL
PDHK3_Hsap_PDHK        GDLKLYSMEGVGTDAVIYLKALSSESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDA
PDHK2_Hsap_PDHK        GDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNT
PDHK1_Hsap_PDHK        GDLKLYSLEGYGTDAVIYIKALSTDSIERLPVYNKAAWKHYNTNHEADDWCVPSREPKDM
PDK_Dmel_PDHK          GDIVLLSCEGFGTDAIIYLKALSDEANELLPIFNKTSSKFYRATVPTGDWSNQVKYAKKK
PDHK4_Mmus_PDHK        GDLNLYSMSGYGTDAIIYLKALSSESVEKLPVFNKSAFKHYQMSSEADDWCIPSREPKNL
PDHK3_Mmus_PDHK        GDLKLYSMEGVGTDAVIYLKALSSESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDA
PDHK2_Mmus_PDHK        GDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNT
PDHK1_Mmus_PDHK        GDLKLYSLEGYGTDAVIYIKALSTESVERLPVYNKAAWKHYKANHEADDWCVPSREPKDM
BCKDK_Mmus_BCKDK       GSLQLQSLQGIGTDVYLRLRHIDGRE----------------------------------
BCKDK_Hsap_BCKDK       GSLQLQSLQGIGTDVYLRLRHIDGRE----------------------------------
YIL042C_Scer_PDHK      GKIDVQSLLGWGTDVYIKLKGPSKTA-L--------------------------------
BCKDK_Spur_BCKDK       GSISLETMQGIGTDVYLRLRHIDGKQ----------------------------------
PDHK_Spur_PDHK         GDLTLSSMDGYGTDAVVYLKVLSSEASELLPIYNSAVSRYYKTPTPASDWSTPGYFIRNY
aSWK467_Cele_PDHK      GDLFLVSMEGHGTDACIYLKAVPVEASEVLPIYSTSSRRNLTMGPQVADWSHH--VPGQG
pdhk-2_Cele_PDHK       GDLFLVSMEGHGTDACIYLKAVPVEASEVLPIYSTSSRRNLTMGPQVADWSHH--VPGQG
CC1G_13956_Ccin_BCKDK  GSLDLISLEGWGSDVYIKLRCLDEAG-D--------------------------------
CC1G_00337_Ccin_BCKDK  GSLELVSLDGWGTDVFLRLPKLGTNL-E--------------------------------
CC1G_15212_Ccin_PDHK   GDLRLIAMDGFGTDVYIHLNRLSSSR-E--------------------------------
                       *.: : :  * *:*. : :

PDHK4_Hsap_PDHK        AK----------EVAM
PDHK3_Hsap_PDHK        SKYKAKQDKIKTNRTF
PDHK2_Hsap_PDHK        ST----------YRVS
PDHK1_Hsap_PDHK        TT----------FRSA
PDK_Dmel_PDHK          KTS---------AVSQ
PDHK4_Mmus_PDHK        AKE---------KLAV
PDHK3_Mmus_PDHK        SKYKAKQDKIKSNRTF
PDHK2_Mmus_PDHK        ST----------YRVS
PDHK1_Mmus_PDHK        TT----------FRSS
BCKDK_Mmus_BCKDK       -E----------SFRI
BCKDK_Hsap_BCKDK       -E----------SFRI
YIL042C_Scer_PDHK      ------------LSKK
BCKDK_Spur_BCKDK       -E----------SFRI
PDHK_Spur_PDHK         TTK---------RYGK
aSWK467_Cele_PDHK      NR----------PAQS
pdhk-2_Cele_PDHK       NR----------PAQS
CC1G_13956_Ccin_BCKDK  -------------SNI
CC1G_00337_Ccin_BCKDK  ------------GIEV
CC1G_15212_Ccin_PDHK   -------------PLP