ROR2_Hsap MARGSAL--------------------PRRPLL---------------------------
ROR1_Hsap MHRPRRR--------------------GTRPPL---------------------------
Ror_Dmel MNKYSAF--------------------I--------------------------------
cam-1_Cele MSPRP-------------------------------------------------------
ROR1_Mmus MHRPRRR--------------------GTRPPP---------------------------
ROR2_Mmus MARGWVR--------------------PSRVPL---------------------------
ROR_Spur MEITGIYRWIIAHLLLVHTFYPHVLSDSTTPPPGTPYIAIDAPMNNETVIPGDSVTLNCR
*
ROR2_Hsap ------------------------------------------------------------
ROR1_Hsap ------------------------------------------------------------
Ror_Dmel ------------------------------------------------------------
cam-1_Cele ------------------------------------------------------------
ROR1_Mmus ------------------------------------------------------------
ROR2_Mmus ------------------------------------------------------------
ROR_Spur IRGYPKPTYWWYRNDAIIRDDIGRNVVREFKGGSTLTINNVGTLDTGSYKCIAANDNGTK
ROR2_Hsap -----------------------------------------CIPAVWAAAA---------
ROR1_Hsap ---------------------------------------------LALLAA---------
Ror_Dmel ----------------------------------------------VCISL---------
cam-1_Cele ------------------------------------------------------------
ROR1_Mmus ---------------------------------------------LALLAA---------
ROR2_Mmus -----------------------------------------CARAVWTAAA---------
ROR_Spur SVQGSITLNANSPTYSESSVSDYLDEMSVDEPQCEPYRGSVCSPHIANSQVYIPAGQTQA
ROR2_Hsap ---------------------------------------------------------LLL
ROR1_Hsap ---------------------------------------------------------LLL
Ror_Dmel ---------------------------------------------------------VLL
cam-1_Cele ------------------------------------------------------------
ROR1_Mmus ---------------------------------------------------------LLL
ROR2_Mmus ---------------------------------------------------------LLL
ROR_Spur DIEAALGAAIQQINNDLPITLNQRCTKYLKPSMCLTAFPLCRERPRLAVHRMCYDECRLL
ROR2_Hsap SVSRTSGEVEVLDPNDPLGPLDG----QDGPIP---------------------------
ROR1_Hsap AARGAAAQETELSVSAELVPTSS----WNISSE---------------------------
Ror_Dmel F-----------------------------------------------------------
cam-1_Cele -----EDDDLVIEPADDEGLHYG----NASMEG---------------------------
ROR1_Mmus AARGADAQETELSVSAELVPTSS----WNTSSE---------------------------
ROR2_Mmus WTPWTAGEVEDSEAIDTLGQPDG----PDSPLP---------------------------
ROR_Spur TTEICSSLVDYVDAQPELGLVDMLPICTDLPLPGAVAGANSENSCLRMGMSESGVATITP
ROR2_Hsap ---TLKGYFLNFLEPVNNITI-VQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEP--RRI
ROR1_Hsap ---LNKDSYLTLDEPMNNITT-SLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEP--RRL
Ror_Dmel ------------------------------------------------------------
cam-1_Cele -TSTGQRPYIRLTSQLRNATK-SSGDEVRFKCEALGTPPLKFIWLKNNGPV-EKT--KRV
ROR1_Mmus ---IDKGSYLTLDEPMNNITT-SLGQTAELHCKVSGNPPPSIRWFKNDAPVVQEP--RRI
ROR2_Mmus ---TLKGYFLNFLEPVNNITI-VQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEP--RRV
ROR_Spur FGVPTARYFIIMERPMNNETELHTGDKATLRCRIIGDPTPHYKWYKNDALLTEERRDRRI
ROR2_Hsap IIRKTEYGSRLRIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGP-----------TH
ROR1_Hsap SFRSTIYGSRLRIRNLDTTDTGYFQCVATNGKEVVSSTGVLFVKFGP-----------PP
Ror_Dmel --TKKDVGS----HNVD-------------------------------------------
cam-1_Cele KIRDKENSSRLVITQLDVLDSGYYQCIVSNPAASVNTTSVLRVNNVPDAVKLSQKKGSHH
ROR1_Mmus SFRATNYGSRLRIRNLDTTDTGYFQCVATNGKKVVSTTGVLFVKFGP-----------PP
ROR2_Mmus IIRKTEYGSRLRIQDLDTTDTGYYQCVATNGLKTITATGVLYVRLGP-----------TH
ROR_Spur TTKEYEWGSKLSIRNVDTTDTGYYKCVAENRAGVRSTMGILFARIAS-----------ET
.* ::*
ROR2_Hsap SPNHNFQDDYH---------------------------------------------EDGF
ROR1_Hsap TASPGYSDEYE---------------------------------------------EDGF
Ror_Dmel ---SRIYGFQQ---------------------------------------------SSGI
cam-1_Cele STKHIAFDEYEDYEMMDRGRLPDEEDADLYRVPDSAAGSNYAPVAVSERWLDGIKYRVGD
ROR1_Mmus TASPGSSDEYE---------------------------------------------EDGF
ROR2_Mmus SPNHNFQDDDQ---------------------------------------------EDGF
ROR_Spur T-RPV--AAIP---------------------------------------------SQGY
*
ROR2_Hsap CQPYRGIACARFIGNRTIYVD--SLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSF
ROR1_Hsap CQPYRGIACARFIGNRTVYME--SLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSL
Ror_Dmel CHIYNGTICRDVLSNAHVFVS--PNLTMNDLEERLKAAYGVIKESKDMNANCRMYALPSL
cam-1_Cele CVQYRGEACRQYLSNKFVMMTNESREEMYDIDRNLRAAMLFINGAPTISQKCRQLSQAVA
ROR1_Mmus CQPYRGIACARFIGNRTVYME--SLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSL
ROR2_Mmus CQPYRGIACARFIGNRTIYVD--SLQMQGEIENRITAAFTMIGTSTQLSDQCSQFAIPSF
ROR_Spur CQPYRGMTCSNFISNHSIYVT--DFQAQKLIDERLTQAFLLM--ARDLSPQCQQYAIPSL
* *.* * :.* : : ::..: * .: : :. :* : .
ROR2_Hsap CHFVFPLCDARS------------------------------------------------
ROR1_Hsap CHYAFPYCDETS------------------------------------------------
Ror_Dmel CFSSMPICRTPERTNLLYFANVATNAKQLKNVSIRRKRTKSKDIKNISIFKKKSTIYEDV
cam-1_Cele CHHMYKVCESDS------------------------------------------------
ROR1_Mmus CHYAFPYCDETS------------------------------------------------
ROR2_Mmus CHFVFPLCDARS------------------------------------------------
ROR_Spur CFFAFPFCDETR------------------------------------------------
*. *
ROR2_Hsap -------------RTPKPRELCRDECEVLESDLCRQEYTIARSNPLILM--RLQLPKCEA
ROR1_Hsap -------------SVPKPRDLCRDECEILENVLCQTEYIFARSNPMILM--RLKLPNCED
Ror_Dmel FSTDISSKYPPTRESENLKRICREECELLENELCQKEYAIAKRHPVIGM---VGVEDCQK
cam-1_Cele -------------N-NQIVSICKHDCDVIQNDECPSELALAAQHELVGDTPKALFPLCSR
ROR1_Mmus -------------SVPKPRDLCRDECEVLENVLCQTEYIFARSNPMILM--RLKLPNCED
ROR2_Mmus -------------RAPKPRELCRDECEVLENDLCRQEYTIARSNPLILM--RLQLPKCEA
ROR_Spur -------------QEPRGRELCRDECEILEQDICKTEYQIAKEMPNVI------LPDCSR
. :*:.:*::::. * * :* : . *.
ROR2_Hsap LPMPESPDAANCMRIGIPA------ERLG---RYHQCYNGSGMDYRGTASTTKSGHQCQP
ROR1_Hsap LPQPESPEAANCIRIGIPM-----ADPIN---KNHKCYNSTGVDYRGTVSVTKSGRQCQP
Ror_Dmel LPQ-----HKDCLSLGITI------E-VD---KTENCYWEDGSTYRGVANVSASGKPCLR
cam-1_Cele LSS-----TSNCIPVMSTALQSSPVAEVNRGHLTHWCYVNSGTQYEGTVAQTSSGKQCAP
ROR1_Mmus LPQPESPEAANCIRIGIPM-----ADPIN---KNHKCYNSTGVDYRGTVSVTKSGRQCQP
ROR2_Mmus LPMPESPDAANCMRIGIPA------ERLG---RYHQCYNGSGADYRGMASTTKSGHQCQP
ROR_Spur LPAIGTNANANCIRVGLPD------VAAV---TDHKCYNDTGEDYRGRINTTKSGFACQS
*. :*: : . . ** * *.* : ** *
ROR2_Hsap WALQHPHSHHLSSTDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVR-MELCDVPSCSPRD
ROR1_Hsap WNSQYPHTHTFTALRFPELNGGHSYCRNPGNQKEAPWCFTLDENFK-SDLCDIPACDSKD
Ror_Dmel WSWLMKE-----ISDFPELI-GQNYCRNPGSVENSPWCFVDSSRERIIELCDIPKCADK-
cam-1_Cele WIDST--SRDFNVHRFPELMNSKNYCRNPGGKKSRPWCYSKPM-GQ-EEYCDVPQCPSDM
ROR1_Mmus WNSQYPHTHSFTALRFPELNGGHSYCRNPGNQKEAPWCFTLDENFK-SDLCDIPACDSKD
ROR2_Mmus WALQHPHSHRLSSTEFPELGGGHAYCRNPGGQVEGPWCFTQNKNVR-VELCDVPPCSPRD
ROR_Spur WDKQEPHEHALWPSHYRELAGGHNFCRNPGNGLDKPWCFTTNPDVR-AEKCDIPRCDELT
* : ** .: :*****. . ***: : : **:* *
ROR2_Hsap S------------------SKMGILYILVPS---------IAIPLVIACLFFLVCMCRNK
ROR1_Hsap SK-----------E----KNKMEILYILVPS---------VAIPLAIALLFFFICVCRNN
Ror_Dmel -----------------------IWIAIVGT--------TAAIILIFIIIFAIILFKRR-
cam-1_Cele YPHLNDKKVEGSTKGGVSESVTALWDSLDPTMQVALVGGGVFFSLLLLLLFCCACCCRAK
ROR1_Mmus SK-----------E----KNKMEILYILVPS---------VAIPLAIAFLFFFICVCRNN
ROR2_Mmus G------------------SKMGILYILVPS---------IAIPLVIACLFFLVCMCRNK
ROR_Spur GSG----------V----VSRPTILYIIVPA---------VTVIVVILLICGCVCFCWRQ
: : : . : : :
ROR2_Hsap QKASASTPQRRQLMASPSQ--------------------------D--MEMPL-------
ROR1_Hsap QKSSS-APVQRQPKHVRGQ--------------------------N--VEMSM-------
Ror_Dmel T-IMHYGMRNIHNINTPSADKNIYGNSQLNNAQDAGRGNLGNLSDHVALNSKL-------
cam-1_Cele KKSQKTRHQNAHCSSAPSVINSAANSAYYRKLNGTSTPIMGRVPPHVEMTSLLPSAQHLG
ROR1_Mmus QKSSS-PPVQRQPKPVRGQ--------------------------N--VEMSM-------
ROR2_Mmus QKASASTPQRRQLMASPSQ--------------------------D--MEMPL-------
ROR_Spur TKSQR-----YGGVASRTR--------------------------P--SEVVA-------
ROR2_Hsap --------------------INQHK-QAKLKEISLSAVRFMEELGEDRFGKVYKGHLFGP
ROR1_Hsap --------------------LNAYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHLYLP
Ror_Dmel --------------------IERN-TLLRINHFTLQDVEFLEELGEGAFGKVYKGQLLQP
cam-1_Cele PPPYPMDQHLQQARRFPSQEPIDD-NSYKVFEITPSQLSVREKIGEGQFGVVHSGIYTSG
ROR1_Mmus --------------------LNAYKPKSKAKELPLSAVRFMEELGECTFGKIYKGHLYLP
ROR2_Mmus --------------------ISQHK-QAKLKEISLSTVRFMEELGEDRFGKVYKGHLFGP
ROR_Spur -----------------------LQQKLQVKEIPLAAIKFSEALGDGTFGKVWRGELMGL
: .:. : . * :*: ** : *
ROR2_Hsap APGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSY
ROR1_Hsap GM-DHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEY
Ror_Dmel N--KTTITVAIKALKENASVKTQQDFKREIELISDLKHQNIVCILGVVLNKEPYCMLFEY
cam-1_Cele LFAPEPMAVAVKKCRHDATNAERAQLEQEIRAVATFDHPNVIKLIGVCYMDNSLLAVFEY
ROR1_Mmus GM-DHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEY
ROR2_Mmus APGEPTQAVAIKTLKDKAEGPLREEFRQEAMLRARLQHPNIVCLLGVVTKDQPLSMIFSY
ROR_Spur NNQYSCTSIVIKTLDKEASPALQQDYRNETSVMASLNHPNIITLLGVCTKEKPNCMLFEF
:.:* . : ..* : :.* *:: ::*. .:. :*.:
ROR2_Hsap CSHGDLHEFLVMRSPHSDVGS-TDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHK
ROR1_Hsap INQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHK
Ror_Dmel MANGDLHEFLISNSPTE------------GKSLSQLEFLQIALQISEGMQYLSAHHYVHR
cam-1_Cele MVHGDLHELLKVRVPPADHDMG-------GITEANAEFLYIATQIALGMEYLASMSFVHR
ROR1_Mmus MNQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHK
ROR2_Mmus CSHGDLHEFLVMRSPHSDVGS-TDDDRTVKSALEPPDFVHVVAQIAAGMEFLSSHHVVHK
ROR_Spur LPHGDLHEFLVRHSPNSDVGFGSGDD-DTQSSLDASDFLNIAIQIVSGMDYLSSRHFVHR
:*****:* . * : :*: :. ** **::*:: **:
ROR2_Hsap DLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSD
ROR1_Hsap DLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSD
Ror_Dmel DLAARNCLVNEGLVVKISDFGLSRDIYSSDYYRVQSKSLLPVRWMPSESILYGKFTTESD
cam-1_Cele DLATRNCLVGDTRTIKIADFGLMRTSYGSDYYKMLHRSWMPVRWMSKEAIEQGRFSEASD
ROR1_Mmus DLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSSLPIRWMPPEAIMYGKFSSDSD
ROR2_Mmus DLATRNVLVYDKLNVRISDLGLFREVYSADYYKLMGNSLLPIRWMSPEAVMYGKFSIDSD
ROR_Spur DLAARNCMVGEHHQIKITDFGLARDIYSGDYYRMPSQAVLPIRWMSPEAIMFGRFTVESD
***:** :: : ::*:*:** * *..***:: .: :*:***. *:: *:*: **
ROR2_Hsap IWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPS
ROR1_Hsap IWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPS
Ror_Dmel VWSFGVVLWEIYSYGMQPYYGFSNQEVINLIRSRQLLSAPENCPTAVYSLMIECWHEQSV
cam-1_Cele VWSFGVTLWEIWSFGRQPYEGASNQQVIELVANRHLLECPHNCPTNIYSLMVECWHENIE
ROR1_Mmus IWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPS
ROR2_Mmus IWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRSRQVLPCPDDCPAWVYALMIECWNEFPS
ROR_Spur IWSFGVVLWEIYSYGLQPFYGYNNNEVIEMIRTRHILPSPSGCPQYIYALMTECWSEIPA
:**:**.***::*:* **: * .*::*:::: .*::* .. .** :*:** *** *
ROR2_Hsap RRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSNVSNARY---VGPKQ
ROR1_Hsap RRPRFKDIHVRLRSWEGLSSHTSSTTPSGGNATTQTTSLSASPVSNLSNPRYPNYMFPSQ
Ror_Dmel KRPTFTDISNRLKTWHEGH-----------------------------------------
cam-1_Cele RRPTFSEIRSRLQSWSLASPAHSILQQH--------------------------------
ROR1_Mmus RRPRFKDIHVRLRSWEGLSSHTSSTTPSGGNATTQTTSLSASPVSNLSNPRFPNYMFPSQ
ROR2_Mmus RRPRFKDIHSRLRSWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSNVSNARY---MAPKQ
ROR_Spur RRPPFKVISTRLRALDTVPMHTQNG------------NIYGNPAANF-NPQYSGLYSP--
:** *. * **::
ROR2_Hsap KAPPFPQPQFIPMKGQIRPMVPPPQLYVPVNGYQPVPAYGAYLPNFYPVQIPMQMAPQQV
ROR1_Hsap GITP--QGQ---IAGFIGPPIPQNQRFIPINGYPIPPGYAAFPAAHYQPTGPPRV-IQHC
Ror_Dmel ------------------------------------------------------------
cam-1_Cele -----------------------------------------------------------N
ROR1_Mmus GITP--QGQ---IAGFIGPAIPQNQRFIPINGYPIPPGYAAFPAAHYQPAGPPRV-IQHC
ROR2_Mmus KAQPFPQPQFIPMKGQIRPLVPPAQLYIPVNGYQPVPAYGAYLPNFYPVQIPMQMAPQQV
ROR_Spur --------------------------------------------------------QTHC
ROR2_Hsap PPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSMADRAALLSEGADDTQNAPE-DGAQSTVQ
ROR1_Hsap PP---PKSRSPSSASGSTSTGHVTSLPSSGSNQEANIPLLPHMSI-PNHPGGMGITVFGN
Ror_Dmel ------------------------------------------------------------
cam-1_Cele NR---AGSHSGSSGAGRPPT-HQRGYPSQKLH----------------------------
ROR1_Mmus PP---PKSRSPSSASGSTSTGHVASLPSSGSNQEANVPLLPHMSI-PNHPGGMGITVFGN
ROR2_Mmus PPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSVADRAALLSEGTEDAQNIAE-DVAQSPVQ
ROR_Spur SS---EGKKSHGSSGGSRH-----SQPKMGL-ADKA--MSETSS----------------
ROR2_Hsap EAEEEEEGSVPETELLGDCDTLQVDEA-QVQLEA
ROR1_Hsap KSQKPYKIDSKQASLLGDANIHGHTES-MISAEL
Ror_Dmel -------------------------FKA-SNPEM
cam-1_Cele ---RRVEGA---SPLM-KRHDANYAYS-EDGDSD
ROR1_Mmus KSQKPYKIDSKQSSLLGDSHIHGHTES-MISAEV
ROR2_Mmus EAEEEEEGSVPETELLGDNDTLQVTEAAHVQLEA
ROR_Spur ------------SSHHTRSTGHGKSEK-VEQTAV