CG6114_Dmel MQKENN---------------------------------VTAENCQFVGPYRLEKTLGKG
BRSK2_Mmus MTSTGKDGG-------------------------------GAQHAQYVGPYRLEKTLGKG
BRSK1_Mmus MSSGSKEGGGGS-PAYHL---------------PH-PHPHPPQHAQYVGPYRLEKTLGKG
sad-1_Cele MFEALKEVLGEI-NS-KLAA--VNNELSSKIMSENIVSTRPVAQAQYCGPYKLEKTLGKG
BRSK1_Hsap MVAGLTLGKGPESPDGDVSVPERKDEVAGGGGEEE-EAEERGRHAQYVGPYRLEKTLGKG
BRSK2_Hsap MTSTGKDG--------------------------------GAQHAQYVGPYRLEKTLGKG
DDB0229364_Ddis M------------------------------------------EIHSVGPFIIGKTLGQG
BRSK_Spur MSSG---------------------------------------DTQYVGPYKLEKTLGKG
AqueK058_Aque MATDE-------------------------------------SNTRAVGPYLLQKTLGKG
* . : **: : ****:*
CG6114_Dmel QTGLVKLGVHCVIGKKVAIKIINREKLSE--SVLMKVEREIAIMKLIDHPHVLGLSDVYE
BRSK2_Mmus QTGLVKLGIHCVTCQKVAIKIVNREKLSE--SVLMKVEREIAILKLIEHPHVLKLHDVYE
BRSK1_Mmus QTGLVKLGVHCITGQKVAVKIVNREKLSE--SVLMKVEREIAILKLIEHPHVLKLHDVYE
sad-1_Cele QTGLVKTGTHCITGRKVAIKIVNKEKLSE--SVLQKVEREIAIMKLIEHPHVLHLYDVYE
BRSK1_Hsap QTGLVKLGVHCITGQKVAIKIVNREKLSE--SVLMKVEREIAILKLIEHPHVLKLHDVYE
BRSK2_Hsap QTGLVKLGVHCVTCQKVAIKIVNREKLSE--SVLMKVEREIAILKLIEHPHVLKLHDVYE
DDB0229364_Ddis TTGKVKLGFHKDTGFKVGIKIINKELLINKPSMRRKIEREIVLMKLIDHPNAMKMYEVYE
BRSK_Spur QTGLVKLGVHCVSGKKVAIKIINKEKLSE--SVLMKVEREIAIMKLIEHPHVLGLYDVYE
AqueK058_Aque QTGLVKLGVHCTTGKTVAVKIINREKLSK--SVLMKVEREIAIMKLIDHPHVLGLHDVYE
** ** * * .*.:**:*:* * : *: *:****.::***:**:.: : :***
CG6114_Dmel NKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPEN
BRSK2_Mmus NKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPEN
BRSK1_Mmus NKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPEN
sad-1_Cele NKKYLYLLLEHVSGGELFDYLVRKGRLMSKEARKFFRQIISALDFCHAHNICHRDLKPEN
BRSK1_Hsap NKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPEN
BRSK2_Hsap NKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPEN
DDB0229364_Ddis TSKYLFLILEYVEGGELFDYLVEKGGLESGEALFFFQQIIIGLEYCHSRNICHRDLKPEN
BRSK_Spur NRKYLYLILEHVAGGELFDYLVKKGRLTPREARRFFRQIISAIDFCHSYSICHRDLKPEN
AqueK058_Aque NNVHLYLVLEHVSGGELFDYLVRKGRLSEREARRFFKQIVSAVDFCHKHSVCHRDLKPEN
. :*:*:**:* *********.** * ** **:**: .:::** .:*********
CG6114_Dmel LLLDEKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVIL
BRSK2_Mmus LLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVIL
BRSK1_Mmus LLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVIL
sad-1_Cele LLLDERNNIKVADFGMASLQVEGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVIL
BRSK1_Hsap LLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVIL
BRSK2_Hsap LLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVIL
DDB0229364_Ddis LLLSGDKRIKIADFGMGSIVRKDMLLHTSCGSPHYASPEVVSGIDYDGQKADVWSCGVIL
BRSK_Spur LLLDDKNNIRVADFGMASLQLDSSLLETSCGSPHYACPEVIRGEKYDGRKADVWSAGVIL
AqueK058_Aque LLLDDQRNIKVADFGMASLQVTGTLLETSCGSPHYACPEVIRGENYDGRKADVWSLGVIL
***. ..*::*****.*: . :*.*********.***: * .***::**:** ****
CG6114_Dmel YALLVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAEINR
BRSK2_Mmus FALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQK
BRSK1_Mmus FALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQK
sad-1_Cele YALLVGALPFDDDNLRNLLEKVKRGVFHIPHFVPADVQSLLRAMIEVDPGKRYSLADVFK
BRSK1_Hsap FALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQK
BRSK2_Hsap FALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQK
DDB0229364_Ddis YALLTGKLPFDDENIRRLLNKVKNGAFSMPPYIHKDAQDLLTKMLTVDPSKRISIKEIKE
BRSK_Spur YALLVGALPFDDDNLRNLLEKVKRGVFHIPHFVPPDCQNLLRGMVEVNADKRLTLSQIQR
AqueK058_Aque FALLVGSLPFDDDNLRVLLEKVKRGRFNIPTYVPAGAQELIRGMVDVNPKSRLTLDKVMR
:***.* *****:*:* **:***.* * :* :: . *.*: *: *:. * :: .: .
CG6114_Dmel HPWVTAGGKGE-LELE-LP-MMEVVQTHVIPTATAVDPDVLNAICSLGCFKEKEKLIQEL
BRSK2_Mmus HIWYI-GGKNE-PEPE-QPI-PRKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQDL
BRSK1_Mmus HPWYL-GGKHE-PDPCLEPAPGRRVAMRSLPSNGELDPDVLESMASLGCFRDRERLHREL
sad-1_Cele HPWVS-GTT-K-ADPELELPMSQVVQTHVIPGEDSIDPDVLRHMNCLGCFKDKQKLINEL
BRSK1_Hsap HPWYL-GGKHE-PDPCLEPAPGRRVAMRSLPSNGELDPDVLESMASLGCFRDRERLHREL
BRSK2_Hsap HIWYI-GGKNE-PEPE-QPI-PRKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQDL
DDB0229364_Ddis HPWFV-SNFNQ-FQKA-T-PV-EEINAEPLVDYSQIDEDIFRSLMALGVGT-IDEVKQQL
BRSK_Spur HPWYV-GTRNE-NQPESDIPKKHHIKIPPILGDEDVDPDVIGSMTSLGCFKDRPKLLRNL
AqueK058_Aque HAWFQ-GSFSLDGVIEPVLPMGEVVQTYPLLDRSDIDPDVFDGMTSLGCFRDKHKLMTNL
* * . . : : :* *:: : .** .: :*
CG6114_Dmel LSSSHNTEKVIYFLLLERKRRRPALEDDDEIAQKSRSELDAV-DPPRKRL----------
BRSK2_Mmus LSEEENQEKMIYFLLLDRKERYPSHEDEDLP---PR---NEI-DPPRKRV----------
BRSK1_Mmus RSEEENQEKMIYYLLLDRKERYPSCEDQDLP---PR---NDV-DPPRKRV----------
sad-1_Cele LSPKHNTEKMVYFLLLDRKRRRPAQEDDTEIVLR--GAAQNN-DPPKKRT----------
BRSK1_Hsap RSEEENQEKMIYYLLLDRKERYPSCEDQDLP---PR---NDV-DPPRKRV----------
BRSK2_Hsap LSEEENQEKMIYFLLLDRKERYPSQEDEDLP---PR---NEI-DPPRKRV----------
DDB0229364_Ddis VSNQK-SATLIYYRLLEERKKFDSDVNKYGYKPKE-TRRNSLSDMSLKKIFSGSNNNNNN
BRSK_Spur LSPHHNSEKVIYSLLLDRKQRKPSFEDELEYR--TR--SDSA-DPPRKRV----------
AqueK058_Aque LAPEHNEEKIIYFLLLERKDKKPSLADEARVN--VG---QQR-DPPRKRV----------
: . .::* **:.: : : :. : * . *:
CG6114_Dmel ------------------------------------------------------------
BRSK2_Mmus ------------------------------------------------------------
BRSK1_Mmus ------------------------------------------------------------
sad-1_Cele ------------------------------------------------------------
BRSK1_Hsap ------------------------------------------------------------
BRSK2_Hsap ------------------------------------------------------------
DDB0229364_Ddis NNNNNNNNNNNNNNNNNNNNNNNNNNNININNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
BRSK_Spur ------------------------------------------------------------
AqueK058_Aque ------------------------------------------------------------
CG6114_Dmel ---------DTCRIN------G--TNAP----SYG--QI----SEGS-------------
BRSK2_Mmus ---------DSPMLN------RHGKRRPER-KSMEVLSVTD---GGS-------------
BRSK1_Mmus ---------DSPMLS------RHGKRRPER-KSMEVLSITDAGSGGS-------------
sad-1_Cele ---------DSSRTS------RY---------PMG--SI----ADGS-------------
BRSK1_Hsap ---------DSPMLS------RHGKRRPER-KSMEVLSITDAGGGGS-------------
BRSK2_Hsap ---------DSPMLN------RHGKRRPER-KSMEVLSVTD---GGS-------------
DDB0229364_Ddis NNSAVGKSNDSSSQQPPHIQQPHSQQIPSNSTSQESMQISPSNSANNMAIQQPIINNNNN
BRSK_Spur ---------DSYHR-----------RRSER-KSFD---MT---RDGS-------------
AqueK058_Aque ---------DSQAVL---------------------------------------------
*:
CG6114_Dmel ---------------------------PL----TPRRQAFNFRSYSSTRNHQRRSPTTV-
BRSK2_Mmus ---------------------------PV-----PARRAIEMAQHGQ-RSRS--------
BRSK1_Mmus ---------------------------PV-----PTRRALEMAQHSQ-RSRS--------
sad-1_Cele ---------------------------PI-----NPRKTYGRNQKSG-RHSS--------
BRSK1_Hsap ---------------------------PV-----PTRRALEMAQHSQ-RSRS--------
BRSK2_Hsap ---------------------------PV-----PARRAIEMAQHGQ-RSRS--------
DDB0229364_Ddis NNNNNNNINNNINNNINNNINNNSNNVNRPTSEGLLKQALQ--QHHQQQQQQ-----FNG
BRSK_Spur ---------------------------MS-----PARRAMSH-HNSG-RSRS--------
AqueK058_Aque ----------------------------------------PSSIQMQ-RVRS--------
: .
CG6114_Dmel -TS--SV------RSSSYHSPTRCNSPMSSAQQQANAISRPSSPAAGTRHSTYGDRDRSG
BRSK2_Mmus ---------------ISGASSGLSTSPLSSPRVT--------------------------
BRSK1_Mmus ---------------VSGASTGLSSSPLSSPRSPVFSF--SPEPGAG-------D-----
sad-1_Cele ---------------LG-------GSPTESPRSSTRDLFG--SSSSGSYSARAGEDRDRG
BRSK1_Hsap ---------------VSGASTGLSSSPLSSPRSPVFSF--SPEPGAG-------D-----
BRSK2_Hsap ---------------ISGASSGLSTSPLSSPRVT--------------------------
DDB0229364_Ddis NNNNNTMNVQPLTMSASSSSSSSSTTPSLSPNSS--------------------------
BRSK_Spur ---------------VT-------SSPLASPTHS--------------------------
AqueK058_Aque ---------------QSIGSAGLDVSP---------------------------------
:*
CG6114_Dmel HHSSVSRTPSHSSQKSIEGDVV-----VVR--EPRIERRDSLRQERGGGSPRDRGDC-GI
BRSK2_Mmus ------------------------------------------------------------
BRSK1_Mmus -------------------------------------------EARGGGSPTSKTQ--TL
sad-1_Cele RSASRSTNSYHYYTQPVDPQTLAEAARHVRDAQERRESR---DSGRGSSRKESKDRSDKS
BRSK1_Hsap -------------------------------------------EARGGGSPTSKTQ--TL
BRSK2_Hsap ------------------------------------------------------------
DDB0229364_Ddis ------------------------------------------------------------
BRSK_Spur ------------------------------------------------------------
AqueK058_Aque ------------------------------------------------------------
CG6114_Dmel PPGSPGGNSSGSTSASPSVHHRANSGPTIAII---VNP-----NGSPM---MNN-----S
BRSK2_Mmus --------------PHPSPRGSPLPTPKGT----------------PVHT-PKESPAGTP
BRSK1_Mmus PSRGPRGGGAGEQPPPPSARSTPLPGPPGSPRSSGGTP-----LHSPLHT-PRASPTGTP
sad-1_Cele ASSSSCKNDASSTS------SVPHKYSPPSVMSESVVV-----SSSTMNS-TNSSTNSLI
BRSK1_Hsap PSRGPRGGGAGEQPPPPSARSTPLPGPPGSPRSSGGTP-----LHSPLHT-PRASPTGTP
BRSK2_Hsap --------------PHPSPRGSPLPTPKGT----------------PVHT-PKESPAGTP
DDB0229364_Ddis ----------------------TTSSTSTSPQLSAIK---------PDHYQRRGSMT--A
BRSK_Spur --------------PRQVCR----QH-SGSSLV----------STGSGST-PPASPTATS
AqueK058_Aque --------------PPPRSRGTPSVPPSYTPPTGYYSYSSNQKEKGGGPS-RKISMAGHE
:
CG6114_Dmel SPG-MP----G-SPCNTPGGQLWKTRLTNIKNSFLGSPRFHRRKMQVSA-DEV-H-LTPE
BRSK2_Mmus NPT-PP----S-SP--SVGGVPWRTRLNSIKNSFLGSPRFHRRKLQVPTPEEMSN-LTPE
BRSK1_Mmus GTT-PP----P-SPGGGVGGAAWRSRLNSIRNSFLGSPRFHRRKMQVPTAEEMSS-LTPE
sad-1_Cele AGN-S-------QTSIGSTSGPWRSKLNNIKNSFLGTPRFHRRKMSNGTAESDSEDSQMI
BRSK1_Hsap GTT-PP----P-SPGGGVGGAAWRSRLNSIRNSFLGSPRFHRRKMQVPTAEEMSS-LTPE
BRSK2_Hsap NPT-PP----S-SP--SVGGVPWRARLNSIKNSFLGSPRFHRRKLQVPTPEEMSN-LTPE
DDB0229364_Ddis ST-NPATSPTMS-HRGKTS-SP-----------IE--ITSKVRKLKIS---ESQSN-TPN
BRSK_Spur QQG---------QQQQGGQSTPWRARLNSLKNTILGSPRFHRRKMQPAEPDEL-S-LTPD
AqueK058_Aque CQTLPPTVVTTTAAGETGGASPWKRRLSTTLKTIVSSPRFHRKRFEET-PSEG--G-AVG
: : :::. .
CG6114_Dmel SS--PELTKRSWFGNL---ITTEK--DETFTILVKGKPIAT--VKAH-------------
BRSK2_Mmus SS--PELAKKSWFGNF---INLEK--EEQIFVVIKDKPLSS--IKAD-------------
BRSK1_Mmus SS--PELAKRSWFGNF---ISLDK--EEQIFLVLKDKPLSS--IKAD-------------
sad-1_Cele DT--TDLVKKSWFGSLASSMSVER--DDTHCVPVQGKTLNS--IKAE-------------
BRSK1_Hsap SS--PELAKRSWFGNF---ISLDK--EEQIFLVLKDKPLSS--IKAD-------------
BRSK2_Hsap SS--PELAKKSWFGNF---ISLEK--EEQIFVVIKDKPLSS--IKAD-------------
DDB0229364_Ddis SPIIGSSPKKSWFSYF---FSKNS--SSNNLNAANGSAPSSPSLQSNGVGQLQTTQANYV
BRSK_Spur NS--PEMSKKSWFSSF---MGAERAVDEELSIAVRDKSLSS--IKAE-------------
AqueK058_Aque AS--PQTAKRSWFSNF---KVDKE--NEEVVVVYRDKTGAE--LKQL-------------
. . *:***. : . .. .... ::
CG6114_Dmel --------LIHAFL-----------------------SMAELSHSVVSPTSFRVEYKR--
BRSK2_Mmus --------IVHAFL-----------------------SIPSLSHSVISQTSFRAEYKA--
BRSK1_Mmus --------IVHAFL-----------------------SIPSLSHSVLSQTSFRAEYKA--
sad-1_Cele --------LIRAFL-----------------------QIHELSHSVVGQNCFRVEYKRGP
BRSK1_Hsap --------IVHAFL-----------------------SIPSLSHSVLSQTSFRAEYKA--
BRSK2_Hsap --------IVHAFL-----------------------SIPSLSHSVISQTSFRAEYKA--
DDB0229364_Ddis IESKIDVNLIYVNLEKIIKKYGFELKYQQQQQQQNIKHCIVRSHHINSDGTPQFECEIE-
BRSK_Spur --------LVQAFL-----------------------TIPDMSHSVHSTTSFKAEFKR--
AqueK058_Aque --------LLKAFT------------------------VVNVSSELIGDNLYKCKYQKST
:: . * : . : : :
CG6114_Dmel ---NGNGPVMFQRHVKFQVDISAIC-----------------------KQGDIADMLFAL
BRSK2_Mmus ---TG-GPAVFQKPVKFQVDITYTEGGE----------------------AQKENGIYSV
BRSK1_Mmus ---SG-GPSVFQKPVRFQVDISSSEGPEPSP-----R-----------RDGSSGGGIYSV
sad-1_Cele ---TV-GGSVFSRGIKMNVDIIPSPQQV---------------------VIAGETPTYVV
BRSK1_Hsap ---SG-GPSVFQKPVRFQVDISSSEGPEPSP-----R-----------RDGSGGGGIYSV
BRSK2_Hsap ---TG-GPAVFQKPVKFQVDITYTEGGE----------------------AQKENGIYSV
DDB0229364_Ddis ----I-KPSTFINPVSPSKQHHHHHHQQQQP-----QQQQMPPLNLNGGQNINHDQGFRV
BRSK_Spur ---AG-SGAVFAKPIKFQVEILTPDGSE----------------------AAKENVVHIL
AqueK058_Aque EAESK-GKTILKKKVKFTVAIIPVQRRRGSTVSADMQ-----------TNSVFDGQTHSM
: . : . :
CG6114_Dmel TFTLLSGNIRRFRRICEHIQSQVCSKRFP-GPSS--PPTVTSV-TQAVSES--SSCGSVS
BRSK2_Mmus TFTLLSGPSRRFKRVVETIQAQLLSTHDQPSAQH--LSDTTNCMEVMTGRL--SKCGTPL
BRSK1_Mmus TFTLISGPSRRFKRVVETIQAQLLSTHDQPSVQA--LAD---------------------
sad-1_Cele QFVLLAGPVRRFKRLVEHLSAILQNSTQQRADRQ--QQ-A--ALMVRPRRLSDSSVGSAC
BRSK1_Hsap TFTLISGPSRRFKRVVETIQAQLLSTHDQPSVQA--LAD---------------------
BRSK2_Hsap TFTLLSGPSRRFKRVVETIQAQLLSTHDPPAAQH--LSDTTNCMEMMTGRL--SKCGSPL
DDB0229364_Ddis SIIHKSGSQHKFNNFTSS------------------------------------------
BRSK_Spur HFLLISGPIRRFRRLVELIQARLTSSRVN-STES--LPGPI--------RS--SSTGSSS
AqueK058_Aque TFEQTSGALRRFHRVCDKIQAVMAGDSLTGGVVRPKASSTASGSPIMMGEFVDSE-----
: :* ::*... .
CG6114_Dmel S----ERLSYKRQVI---ENDME---------N----DSIFSYKSGNGRR-ASTTN-N-N
BRSK2_Mmus S----NFFDVIKQLF---SD----------------------EKNGQAAQ-APSTP-AKR
BRSK1_Mmus ------------------------------------------EKNGAQTR-PAGTP-P-R
sad-1_Cele SDSESNASSI--NMIARHSDKTETTSATSSDPYG-PSPSMRSVGSGTANSYKSPTP-HRR
BRSK1_Hsap ------------------------------------------EKNGAQTR-PAGAP-P-R
BRSK2_Hsap S----NFFDVIKQLF---SD----------------------EKNGQAAQ-APSTP-AKR
DDB0229364_Ddis ------------------------------------------------------------
BRSK_Spur S----TSVDY-------------------------------------------AVS-P-R
AqueK058_Aque -----------------------TRSGSSDDTLTLHSTNGVSHDSGKGSS-ASVDVFIHR
CG6114_Dmel NANPV-------D---IPGSPIAVR-SN------SE-------TAEHERNR-E--LQSER
BRSK2_Mmus SAHGP------------LGDSAAAG--PGGDTEYPM-------GKDMAKMG-P---P---
BRSK1_Mmus SLQPP------------PGRSD------------PD-------LSSSPRRG-P---PKDK
sad-1_Cele NTTAVTASSSSASNRYGPSSSSSGSYSNNADYSYHPEYSQRSNGSSAPKNQYSPGSQRSF
BRSK1_Hsap SLQPP------------PGRPD------------PE-------LSSSPRRG-P---PKDK
BRSK2_Hsap SAHGP------------LGDSAAAGPGPGGDAEYPT-------GKDTAKMG-P---P---
DDB0229364_Ddis ------------------------------------------------------------
BRSK_Spur PINPA-----------------FSE--DDGDEVFSD-------GRSVSREG-LMADAAKD
AqueK058_Aque ATNPVL-STGGS-SKVG---------G----ASRPS-I------LD--------------
CG6114_Dmel QATTMSGSAIA
BRSK2_Mmus ----AARREQP
BRSK1_Mmus KLLATNGTPLP
sad-1_Cele AFSMFNKADKV
BRSK1_Hsap KLLATNGTPLP
BRSK2_Hsap ----TARREQP
DDB0229364_Ddis ----LEQILTI
BRSK_Spur RASSQVSNSIC
AqueK058_Aque SSDSDDVLDED