CDC2-S2_b_Smoe  ------------------------------------------------------------
CDC2-S2_g_Smoe  ------------------------------------------------------------
CDC2-S2_a_Smoe  ------------------------------------------------------------
CDC2-S2_j_Smoe  ------------------------------------------------------------
CDC2-S2_f_Smoe  ------------------------------------------------------------
CDC2-S2_d_Smoe  MLPAAC-----------------------------------VRPRLKEFFSFLFTFVIK-
CDC2-S2_n_Smoe  ------------------------------------------------------------
CDC2-S2_o_Smoe  MNLMLAQVYS-----------------------------------------------VTC
CDC2-S2_h_Smoe  MKVLGRYNYASGYGESSAVAHGYNDLGERIVIKNKGKGEEVHKQILKE-----FEIMVNC
CDC2-S2_m_Smoe  ------------------------------------------------------------
CDC2-S2_e_Smoe  ------------------------------------------------------------
CDC2-S2_k_Smoe  ------------------------------------------------------------
CDC2-S2_c_Smoe  ------------------------------------------------------------


CDC2-S2_b_Smoe  ------------------------------------------------------------
CDC2-S2_g_Smoe  ------------------------------------------------------------
CDC2-S2_a_Smoe  ------------------------------------------------------------
CDC2-S2_j_Smoe  ------------------------------------------------------------
CDC2-S2_f_Smoe  ------------------------------------------------------------
CDC2-S2_d_Smoe  ------------INSLFSIFFLKLGAFFC-------------------------------
CDC2-S2_n_Smoe  ------------------------------------------------------------
CDC2-S2_o_Smoe  KQ-------------------------TIARQACVS---------TQLP-----------
CDC2-S2_h_Smoe  KHENVLDVIDMGLDKDGNYYMVKLGDFSCARRLCNNPPETTLKVGTAVDIWSAGILLVGM
CDC2-S2_m_Smoe  --------------------YLKLGAFSD-------------------------------
CDC2-S2_e_Smoe  ------------------------------------------------------------
CDC2-S2_k_Smoe  ------------------------------------------------------------
CDC2-S2_c_Smoe  ------------------------------------------------------------


CDC2-S2_b_Smoe  ------------------------------------------------------------
CDC2-S2_g_Smoe  ------------------------------------------------------------
CDC2-S2_a_Smoe  ------------------------------------------------------------
CDC2-S2_j_Smoe  ------------------------------------------------------------
CDC2-S2_f_Smoe  ------------------------------------------------------------
CDC2-S2_d_Smoe  ------------------------------------------------------------
CDC2-S2_n_Smoe  ------------------------------------------------------------
CDC2-S2_o_Smoe  ---------------------FH------------------------PVKILLRLLHLFL
CDC2-S2_h_Smoe  LLPLEMPELPEKEAKGEVLETIKKFLRALDDLIKDKDALELIKSMLASDPITARQALAFS
CDC2-S2_m_Smoe  ------------------------------------------------------------
CDC2-S2_e_Smoe  ------------------------------------------------------------
CDC2-S2_k_Smoe  -----------------------------------------------PFPLLLRLLHLFL
CDC2-S2_c_Smoe  ------------------------------------------------------------


CDC2-S2_b_Smoe  -------------------------MADYVWASDARLLGAGGDGEVRVGFHRETGDKVAM
CDC2-S2_g_Smoe  -------------------------MADYVWASGARLLGAGPDGEVRVGFHRKTGDKVAM
CDC2-S2_a_Smoe  -------------------------MAEYVWASDARLLGAGADGEVRVGFHRKTGDKVAM
CDC2-S2_j_Smoe  -------------------------MEKYSF---GRVLGCGSEGKVMLGCNNQNHNKVAI
CDC2-S2_f_Smoe  -----------------------------------------------------------M
CDC2-S2_d_Smoe  ----KTNPLG------FPNHSFFRAMADYVWASDARLLGAGGDGEVRVGFHRETGDKVAM
CDC2-S2_n_Smoe  -------------------------MADYVWASGARLLGAGADGEVRVGFHRKTGDKVAM
CDC2-S2_o_Smoe  YGNLTFFPFSPIKSIERNRSKHCSRMDRYDYSTQSPLLGQGTDGVVRLARNRVTGAMVAV
CDC2-S2_h_Smoe  GGALLTIPGS------FPNHSFSRAMADYVWVSGARLLGAGADGEVRVGFHRKTGDKVAM
CDC2-S2_m_Smoe  ----KTNPLG------FPKHSFFRAMADYVWASDARLLGAGADGEVRVGFHRKTGDKVAM
CDC2-S2_e_Smoe  -------------------------MAEYVWASDARLLGAGADGEVRVGFHQKTGDKVAM
CDC2-S2_k_Smoe  YGNLTFFPFSPIKSIERNRSRHCSRMDRYDYSTQSPLLGQGTDGVVRLARNRVTGAMVAV
CDC2-S2_c_Smoe  -------------------------MADYVWASDARLLGAGGDGEVRVGFHRETGDKVAM
                                                                           :

CDC2-S2_b_Smoe  KKMYEHEYLYDAIINESEILEEVA-HDNVVNLLGLTCNNQGTFMVMELMDGSLSDVIL--
CDC2-S2_g_Smoe  KKIYEHECLYDAIINESEILEEVA-HDNVVNFLGLTCNNQGTFMVMELMDGSLSDVIS--
CDC2-S2_a_Smoe  KKMYEHEYLYDTIINESEILEEVA-HDNVVNLLGLTCNNQGTFMVMELMDGSLRDVIS--
CDC2-S2_j_Smoe  KYLGQEHSILNAMVNEVEILEECAGHVNIINLLDVTTNKNGSFMVFELMETDLR---H--
CDC2-S2_f_Smoe  KKMYEHEYLYDAIINGSEILEEVA-HNNVVNLLGLTCNNQGTFMVM--------------
CDC2-S2_d_Smoe  KKMYEHEYLYDAIINESEILEEVA-HDNVVNLLGLTCNNQGTFMVMELMDGSLSDVIS--
CDC2-S2_n_Smoe  KKMYEHEYLYDAIINESEILEEVV-HDNVVNLLGLTCNNQGTFMVMELMDRSLSDVIS--
CDC2-S2_o_Smoe  KKLSSKHDAAD-MMWECATLRACQ-HKNIIHLHSKLVTEQGLFMVFELMDMDLCSYIWDV
CDC2-S2_h_Smoe  KKMYEHEYLYDAIINESEILEEVA-HDNVVNLFGLTCNNQGTFMVMELMDGSLSDVIS--
CDC2-S2_m_Smoe  KKMYEHEYLYDTIINESEILEEVA-HDNVVNLLGLTCNNQGTFMVMELMDGSLRDVVS--
CDC2-S2_e_Smoe  KKMYEHEYLYDTIINESEILEEVA-HDNVVNLLGLTCNNQGTFT----------------
CDC2-S2_k_Smoe  KKLSSKHDAAD-MMWECATLRACQ-HKNIIHLHSKLVTEQGLFMVFELMDEDLFSYIWDV
CDC2-S2_c_Smoe  KKMYEHEYLYDAIINESEILEEVA-HDNVVNLLGLTCNNQGTFMVMELMDGSLGDVIS--
                * : ...   : ::     *.    * *:::: .   .::* *

CDC2-S2_b_Smoe  ---SRKLGEHDIRAVMRQILEGLAWIHAHRIVHQDVKTSNVLVKRDGE-KNKLVVKLADF
CDC2-S2_g_Smoe  ---SRKLGEHDIRAVMRQILEGLAWIHAHGIVHQDVKTSNVLVKRDGE-KNKFVVKLADF
CDC2-S2_a_Smoe  ---SRKLGEHDIKAVMRQILERLAWIHAHRIVHQDIKTSNVLVKRDGE-KNKFVVKLADF
CDC2-S2_j_Smoe  ---HKRFEGHEIRSFMRQILSGLAWIHSNKIVHQDIKPENLLVKG-------GVVKLADF
CDC2-S2_f_Smoe  ---------------VRQILEGLAWIHAHRIVHQDVKTSNVLVKRDGE-KNKFVVKLADF
CDC2-S2_d_Smoe  ---SRKLGEHHIRAVMRQILEGLAWIHAHRVVHQDVKTSNVLVKRDGE-KNKLVVKLADF
CDC2-S2_n_Smoe  ---SRKLGEHDIRAVMRQILKGLVWIHAHRIVHQDVKTSNVL----------FVVKLADF
CDC2-S2_o_Smoe  REREGKIPEVAVRSIMKQILEALAFVHSKGLIHRDVKSSNVLINHNKNLNNSVVIKLIDF
CDC2-S2_h_Smoe  ---SRKLGEHDIRAVMRQILEGLAWIHAHRIVHQDVKTSNVLVKRDGE-KNKFVVKLADF
CDC2-S2_m_Smoe  ---SRKLGEHDIKAVMRQILEGLAWIHAHRIVHQDIKTSNVLVKRDGE-KNKLVVKLADF
CDC2-S2_e_Smoe  ------LGEHDIKAVMRQILEGLAWIHAHRIVHQDIKTSNVLVKRDGE-KNKFVVKLADF
CDC2-S2_k_Smoe  REREGKIPEVAVRSIMKQILEALAFVHSKGLIHRDVKSSNVLINHNKNLNNSVVIKLIDF
CDC2-S2_c_Smoe  ---SRKLGEHDIRAVMRQILEGLAWIHAHRVVHQDVKTSNVLVKRDGE-KNKFVVKLADF
                               ::***. *.::*:: ::*:*:*..*:*           *:** **

CDC2-S2_b_Smoe  AAARRLRTRPWSNKVGTLTFNAPELLKGATS--FGTAIDVWGAGCIFAEMLLGSNPFDVT
CDC2-S2_g_Smoe  ATARRLRTRPWSNKVGTLTFNAPELLKGATS--FGTAIDVWGAGCIFAEMLLGSDPFDVP
CDC2-S2_a_Smoe  TTARRLQTRPWSNKVGTLTFNAPELLKGATS--FGTAIDVWSAGCIFAEMLLGSNPFDVP
CDC2-S2_j_Smoe  GHARRLWEQPR-ECFGTLSYHSPEQLKGERG-LYSTAIDIWAAGCVFAEMVLEFRLFDPI
CDC2-S2_f_Smoe  ATVRRLRTRPWSNKVGTLTFNAPELLTGATS--FGTAIDVWGAGCIFAEMLLGSNPFDVP
CDC2-S2_d_Smoe  AAARRLRTRPWSNKVGTLTFNAPELLKGATS--FGTAIDVWGAGCIFAEMLLGSNPFDVT
CDC2-S2_n_Smoe  ATARRLQTRPWSNKVGTLTFNAPELLKGATS--FGTAIDVWGAGCIFAEMLLGSNPFDVP
CDC2-S2_o_Smoe  SRVCFASAG-SCKNMGNVYYRAPELLLGGEKYIYGREIDIWAAGCIFLELLTGF-PFGDD
CDC2-S2_h_Smoe  ATARAA-----------------DTPLGATS--FGTAIDVWGARCIFAEMLLGSNPFDVP
CDC2-S2_m_Smoe  TTARRLQTRPWSNEVGTLTFNAPELLKGATS--FGTAIDVWGAGCIFAEMLLGSNPFDVP
CDC2-S2_e_Smoe  TTARRLQTRPWSNKVGTLTFNAPELLKGATS--FGTAIDVWSAGCIFEEMLLGSNPFDVP
CDC2-S2_k_Smoe  SRVCFASAG-SCENMGNVYYRAPELLLGGEKYIYGREIDIWAAGCIFLELLTGF-PFGDD
CDC2-S2_c_Smoe  AAARRLRTRPWSNKVGTLTFNAPELLKGATS--FGTAIDVWGAGCIFAEMLLGSNPFDVT
                  .                    :   *     :.  **:*.* *:* *::     *.

CDC2-S2_b_Smoe  D-----EEDWDSLDYFVADFAKKLD----IDGCGMGYQDRRRERARKRILEK-------M
CDC2-S2_g_Smoe  D-------DGDSLNYFVADFAKKLD----IDGCGMGYQDRRRERARERILEK-------M
CDC2-S2_a_Smoe  D-----EEDGDSLNYFVADFAKKLD----IDGCDMGYQDKRRERACERILEK-------M
CDC2-S2_j_Smoe  D-----YEFMNE-------------------------ED-----RKCQMMEL-------I
CDC2-S2_f_Smoe  D-----EEDGDSLDYFVADFAKKLD----IDGCGMGYQDRRRERARKRILEK-------M
CDC2-S2_d_Smoe  D-----EEDWDSLDYFVADFAKKLG----IDGCGMGYQDWCRERARERILEK-------M
CDC2-S2_n_Smoe  D-----EEDGDSLDYFQSREIELLRAGEFPDGCPL-------------------------
CDC2-S2_o_Smoe  DGNFPPNSELDVMNSIVKWI-----GPVD----------ETTWKGV-NKLENYNTYKSSF
CDC2-S2_h_Smoe  D-----EEDGDSLDYFVADFAKKLD----IDGCGMGYQDRRRERARERILEK-------M
CDC2-S2_m_Smoe  D-----EEDGDSLNYFVADFAKKLD----IDGCGMGYQDRRRERARERILEK-------M
CDC2-S2_e_Smoe  D-----EEDGDSLNYFVADFAKKLD----IDGCGMGYQDRRRERARERILQK-------M
CDC2-S2_k_Smoe  DGNFPPNSELDVMNSIVKWI-----GPVD----------ETTWKGV-NKLENYNTYKSSF
CDC2-S2_c_Smoe  D-----EEDWDSFDCFVADFAKKLG----IDGCGMGYQDWCRERARERILEK-------M
                *         :

CDC2-S2_b_Smoe  ARWKA-EDARSGIKDPDAVELLKRMLAIDPARRISAQDALKMPYFQEKAEDT---ARRVL
CDC2-S2_g_Smoe  VWWKA-EDVRSGMKDPDAVELLKRMLAIDPARRISVQNALKMPYFQEKADDT---ATPVL
CDC2-S2_a_Smoe  ------------------------------------------------------------
CDC2-S2_j_Smoe  QAWNSWSELELIVGDKSTVELMARMLKVDPCKRISAQGALKSKYFGSVEVGTP--SMQMV
CDC2-S2_f_Smoe  AWWKA-EDVRSGIKDPDAVELLKRMLAIDLARRISAQNALKMPYFQEKADDT---A---L
CDC2-S2_d_Smoe  ARWKA-EDVRSRIKDPDAVELLKRMLAIDPARRISAQDALKMPYFQEKAEDT---ARRVL
CDC2-S2_n_Smoe  --------------SDEAEDLICGMLAVEPSERLTLDGVLEHPWIVENCSSKTIQKRKRC
CDC2-S2_o_Smoe  PRNP-SNLLQSRLGDSPAYDLLRKMLCLNPRERITAKEALESDYFKTSVWSR---VSKFL
CDC2-S2_h_Smoe  VWWKA-EDVRSGIKDPDAVELLKRMLAIDPARRISAQNALKMPYFQEKADDT---ARPVL
CDC2-S2_m_Smoe  AWWKA-EDVRSGIKDPNAVELLKRMLAIDPARRISAQNALKMPYFQEKADDTFVEARRVL
CDC2-S2_e_Smoe  AWWKA-EDVRSRIKDPNAVELLKRMLAIDPARRISAQNALKMPYFQEKAEDTIVEARRML
CDC2-S2_k_Smoe  PRNP-SNLLQSRLGDSPAYDLLRKMLCLNPRERITAKEALESDYFKTSVWSR---VSKFL
CDC2-S2_c_Smoe  ARWKA-EDVRSRIKDPDAVELLKRMLAIDPARRISAQDALKMPYFQEKAEDT---ARRVL


CDC2-S2_b_Smoe  LTMTTASGNLRPAWIKINNAAPSIATM
CDC2-S2_g_Smoe  LKMTTASGNFRPAWVKFNNAAPSIATM
CDC2-S2_a_Smoe  --------------------------T
CDC2-S2_j_Smoe  GTGVC--KNFNL----------ACIAH
CDC2-S2_f_Smoe  PKMTTASGNFRPVWVKINNAAPSIAIM
CDC2-S2_d_Smoe  PTMTTASGNLRPAWIKINNAAPSIATM
CDC2-S2_n_Smoe  GVKRSAPGFS------SDLVVKKVRAA
CDC2-S2_o_Smoe  YSIFCTRLNL---------------FA
CDC2-S2_h_Smoe  PTMTTASGNFRPAWVKINNAAPSIATM
CDC2-S2_m_Smoe  PTMATASANLRPAWLKINNAAPSIATM
CDC2-S2_e_Smoe  PTMTIASGNLRPAWLKINNTTPSIAIM
CDC2-S2_k_Smoe  YSIFCTTLNL---------------FA
CDC2-S2_c_Smoe  PTMMTASGNLRPAWIKINNAAPSIATM