Cdk4_Dmel       YQELNIIGEGAYGTVYRARDVIT-GNIVALKKVRISLN---ENGVPMSTLREISLLKQLN
CDK6_Mmus       YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTS---EEGMPLSTIREVAVLRHLE
CDK4_Mmus       YEPVAEIGVGAYGTVYKARDPHS-GHFVALKSVRVPNGGAAGGGLPVSTVREVALLRRLE
cdk-4_Cele      --LFQALGKGAYGNVYRVRSLHD-GKDYALKQIMISSK---NEGIPQSVLREITVMKHLA
CDK4_Hsap       YEPVAEIGVGAYGTVYKARDPHS-GHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE
CDK6_Hsap       YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTG---EEGMPLSTIREVAVLRHLE
CDK4_Spur       YVQAAEIGSGAYGIVYKARDTET-GHFVALKSVRIPIG---EEGMPVSTIREISLLRHLC
                      :* **** *::.*.    *.  *** : :        *:* *.:**::::::*

Cdk4_Dmel       ASNHANIVKLYEVCQFLERDG-QLLILLVFEHVEQDLSDLIDRLPKSGMSPPTIQRLSRE
CDK6_Mmus       TFEHPNVVRLFDVCTVSRTDR-ETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ
CDK4_Mmus       AFEHPNVVRLMDVCATSRTDR-DIKVTLVFEHIDQDLRTYLDKAPPPGLPVETIKDLMRQ
cdk-4_Cele      RKAHPNIISLKSVFHQLDPVRAILKINMIMERCDWDLHTFLRNIP-RGVPEQQAKHVTAQ
CDK4_Hsap       AFEHPNVVRLMDVCATSRTDR-EIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ
CDK6_Hsap       TFEHPNVVRLFDVCTVSRTDR-ETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ
CDK4_Spur       QLDHPNIVKLLDVCDVMDVGRSEMMLTLVFELVDQDLAQYLEKCPPPGLSPCTIKFLMHQ
                   *.*:: * .*            : :::*  : **   : . *  *:.    : :  :

Cdk4_Dmel       LLTGVDFLHSHRIIHRDLKPQNLLVSSQGHLKIADFGLAKTYGSEMKLTSVVVTLWYRAP
CDK6_Mmus       LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAP
CDK4_Mmus       FLSGLDFLHANCIVHRDLKPENILVTSNGTVKLADFGLARIYSYQMALTPVVVTLWYRAP
cdk-4_Cele      IVRALDFLHTHSIIHRDLKPQNILLNRDQTVKLADFGLSKEYSNTTAFTTLVVTLWYRSP
CDK4_Hsap       FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAP
CDK6_Hsap       LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAP
CDK4_Spur       LLSGVEYLHSHRVTHRDLKPQNILVASDKKLKLTDFGLSRVYSFQMALTPVVVTMWYRAP
                :: .:::**:: : ******:*:*:     :*::****:: *.    :*.:***:***:*

Cdk4_Dmel       EVLLAQPYNSTVDIWSAACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQQWPQTIS
CDK6_Mmus       EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDIIGLPGEEDWPRDVA
CDK4_Mmus       EVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPREVS
cdk-4_Cele      EVLLQSYYNSTVDMWALGCIVSEIYCRQPLFVGQNEAEQLTDIFKKMGTPVGKDWPSESV
CDK4_Hsap       EVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS
CDK6_Hsap       EVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA
CDK4_Spur       EVLLQASYATPVDMWSVGCIFAELYRRRPLFRGQSDKDQLHKIFEVIGLPPEDQWP-DVA
                ****   * :.**:*: .**. *:: *:.** * .: :**  *:.  * *  .:**

Cdk4_Dmel       VALEHFPQRHPKRPKDFCPHLCKYADDLLNKMLSYDLHLRPSALACLEHDYF
CDK6_Mmus       LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYGALNHPYF
CDK4_Mmus       LPRGAFAPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL
cdk-4_Cele      IARDSFPQYRPTNLKDLSPQMSKQAIEFVQQCLRYDHSKRLSARGALSHPFL
CDK4_Hsap       LPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL
CDK6_Hsap       LPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
CDK4_Spur       LPWSSFRQTGQRSFLDLVQEICNQGLDLLERMLCFNPDHRMTAEQGLLHGFF
                :.   *         ..  .: : . ::: . * ::   * :*   * * ::