Cdk8_Dmel ---EGCKVGRGTYGHVYKAKWKET--S-DGKEYALKQ----------IDGTGLSMSACRE
CDK8_Mmus FEYEGCKVGRGTYGHVYKAKRKDG--K-DDKDYALKQ----------IEGTGISMSACRE
CDK19_Mmus FEYEGCKVGRGTYGHVYKARRKDG--K-DEKEYALKQ----------IEGTGISMSACRE
F39H11.3_Cele FENSK-EIGRGTYGLVYKAVPKKQNGQFPNKEYALKM----------IEGQGFSMSACRE
SSN3_Scer YEVIG-YIAAGTYGKVYKAKRQIIKKP-LTVFYAIKKFKTEKDGVEQLHYTGISQSACRE
CDK19_Hsap FEYEGCKVGRGTYGHVYKARRKDG--K-DEKEYALKQ----------IEGTGISMSACRE
CDK8_Hsap FEYEGCKVGRGTYGHVYKAKRKDG--K-DDKDYALKQ----------IEGTGISMSACRE
Cdk8_Ddis FSY---EIGSGTYGMVYKADDKKRPN----NKVAVKKFRS------TKEGEGLSLTAYRE
CDK8_Spur ------KVGRGTYGHVYKATTKKE----PKKEYALKQ----------IEGTGISMSACRE
CC1G_07887_Ccin YAILG-FISSGTYGRVYKAQSINGGE-----LLAIKKFKPDKEG-DVVTYTGISQSAIRE
AqueK099_Aque MD-SGF---------ID------------------------------------ALSQK--
CDK8_Smoe YELLG-KIGEGTYGLVYLAKSKLVSN--RGVKIAIKKFKQ------SKEGDGVSPTAIRE
: : :
Cdk8_Dmel IALLRELKHQNVITLIRVFLSHNDRKVFLLIDYAEHDLWHIIKFHRAAKATKK-QVVVPR
CDK8_Mmus IALLRELKHPNVISLLKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKK-PVQLPR
CDK19_Mmus IALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKK-PMQLPR
F39H11.3_Cele IALFRELRHPNLICLQRVFLTN-EKKVWLLLDYAEHDLWHVIKHHRTAKSKKV-PIMVPR
SSN3_Scer MALCRELHNKHLTTLVEIFLE--RKCVHMVYEYAEHDLLQIIHFHSHPE-----KRMIPP
CDK19_Hsap IALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKK-PMQLPR
CDK8_Hsap IALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKK-PVQLPR
Cdk8_Ddis IGLLKELSNENIVKLLDVCLNPKDKLLYLIFDYAEFDLFGIIKYHRENG------SHFSD
CDK8_Spur VALLRELRHPNVICLRRVFLSHSDRKVYLLCDFSEHDLWHIIKYHRANKASKKGPTSVPP
CC1G_07887_Ccin IALNREINHENVVALREVILE--DKSIYMVFEYAEHDFLQVIHHYYQTI-----RTSIPT
AqueK099_Aque -----------------------------------REKVEDLKYHRAVKGGKKPQVQVPK
CDK8_Smoe IMLLRECMHENVVKLVDVHINHADMSLYLAFEYAEHDLYEIIRHHREKL-----LFQINP
: ::.: .
Cdk8_Dmel GMVKSLLYQILDGIHYLHSNWVLHRDLKPANILV--------------------------
CDK8_Mmus GMVKSLLYQILDGIHYLHANWVLHRDLKPANILV--------------------------
CDK19_Mmus SMVKSLLYQILDGIHYLHANWVLHRDLKPANILV--------------------------
F39H11.3_Cele NMVKNILFQILSGMHYLHSNWVLHRDLKPANILL--------------------------
SSN3_Scer RMVRSIMWQLLDGVSYLHQNWVLHRDLKPANIMV--------------------------
CDK19_Hsap SMVKSLLYQILDGIHYLHANWVLHRDLKPANILV--------------------------
CDK8_Hsap GMVKSLLYQILDGIHYLHANWVLHRDLKPANILV--------------------------
Cdk8_Ddis ATIKSLIWQVLNGIHYLHSNWVIHRDLKPSNILV--------------------------
CDK8_Spur VMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGSERGRVKIADMGFARLFNSPLK
CC1G_07887_Ccin AVLKSLIYQLFNGLIYLHASHILHRDLKPANILI--------------------------
AqueK099_Aque TMVKSLMYQILSGIHYLHSNWVLHRDLKPANILV--------------------------
CDK8_Smoe YTVKSLLWQILNGINYLHSNWIIHRDLKPSNILV--------------------------
::.:::*::.*: *** . ::******:**::
Cdk8_Dmel ------------------------------------------------------------
CDK8_Mmus ------------------------------------------------------------
CDK19_Mmus ------------------------------------------------------------
F39H11.3_Cele ------------------------------------------------------------
SSN3_Scer ------------------------------------------------------------
CDK19_Hsap ------------------------------------------------------------
CDK8_Hsap ------------------------------------------------------------
Cdk8_Ddis ------------------------------------------------------------
CDK8_Spur PLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSN
CC1G_07887_Ccin ------------------------------------------------------------
AqueK099_Aque ------------------------------------------------------------
CDK8_Smoe ------------------------------------------------------------
Cdk8_Dmel -------------------------------------------------------MG---
CDK8_Mmus -------------------------------------------------------MG---
CDK19_Mmus -------------------------------------------------------MG---
F39H11.3_Cele -------------------------------------------------------MG---
SSN3_Scer -------------------------------------------------------TI---
CDK19_Hsap -------------------------------------------------------MG---
CDK8_Hsap -------------------------------------------------------MG---
Cdk8_Ddis -------------------------------------------------------MG---
CDK8_Spur PYHHDQLDRIFNVMGFPQVPPVMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMG---
CC1G_07887_Ccin -------------------------------------------------------TS---
AqueK099_Aque -------------------------------------------------------MG---
CDK8_Smoe -------------------------------------------------------MGVSG
Cdk8_Dmel DGN--ERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWA
CDK8_Mmus EGP--ERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWA
CDK19_Mmus EGP--ERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWA
F39H11.3_Cele DGPPDMRGRVKIADLGFSRIYANPLKPMAELDPVVVTFWYRAPELLLGAKHYTKAIDVWA
SSN3_Scer D------GCVKIGDLGLARKFHNMLQTLYTGDKVVVTIWYRAPELLLGARHYTPAVDLWS
CDK19_Hsap EGP--ERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWA
CDK8_Hsap EGP--ERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWA
Cdk8_Ddis EGK--ECGTVKIGDFGLARIFQSPLKPLNE-NGVVVTIWYRSPELLLGSKHYTRAVDIWA
CDK8_Spur EGS--ERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWA
CC1G_07887_Ccin Q------GVVKIGDLGLARLCYEPLQPLFAGDKVVVTIWYRAPELLMGAKHYNKAIDCWA
AqueK099_Aque DGP--ERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGAKHYTKAIDIWA
CDK8_Smoe DGD--EQGLVKIGDFGLARIYQAPLKPLSD-NGVVVTIWYRAPELLLGAKHYTCAVDMWA
: * ***.*:*::* *:.: : ****:***:****:*::**. *:* *:
Cdk8_Dmel IGCIFAELLTSEPIFHCRQE--DIKTSNPYHHDQLDRIFNVMGFPQDKDWEDIKKMPEHH
CDK8_Mmus IGCIFAELLTSEPIFHCRQE--DIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHS
CDK19_Mmus IGCIFAELLTSEPIFHCRQE--DIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYP
F39H11.3_Cele IGCIFAELLTAEPLFFCKEE--DIKAQNPYHYDQVKRIFHLLGYPSDADWPDMKKMPDHQ
SSN3_Scer VGCIFAELIGLQPIFKGEEAKLDSKKTVPFQVNQLQRILEVLGTPDQKIWPYLEKYPEYD
CDK19_Hsap IGCIFAELLTSEPIFHCRQE--DIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYP
CDK8_Hsap IGCIFAELLTSEPIFHCRQE--DIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHS
Cdk8_Ddis IGCIFAELITTKPLFPGKEK--DPKIPSLFQDDQVEKIIRVLGKPTLDMWPDIKHLPEWK
CDK8_Spur IGCIFAELLTSEPIFHCRQE--DIKTSNPYHHDQLDRIFNVMGFPQEKDWEDIKKMPEHG
CC1G_07887_Ccin VGCVMAELASLRPIFKGEEAKLDSKKNVPFQRDQLIKIFEVLGTPDERDWPGVVDMPEYR
AqueK099_Aque IGCIFAELLTFEPIFHCRQE--DVEASSPYHREQLERIFLVMGFPHDRDWDDMKHMPEYS
CDK8_Smoe VGCIFAELLTLKPLFQGA-E--DKTGPNPFQLDQLDKIFKVLGHPTTERWPMLSNLPHWL
:**::*** .*:* * :: :*: :*: ::* * * : . *.
Cdk8_Dmel TLTKDFKRS-----TYSTCSLAKYMERHKIKPDSKAFHLLQKLLLMDPNKRITSEQAMQD
CDK8_Mmus TLMKDFRRN-----TYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQD
CDK19_Mmus TLQKDFRRT-----TYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQD
F39H11.3_Cele RLLSDARNEGTPIQTFPN-SLHRYFDKWKINSQSSPYRLLVKLLTVDPTKRVSCEEAMND
SSN3_Scer QITKFP--------KYRD-NLATWYH-SAGGRDKHALSLLYHLLNYDPIKRIDAFNALEH
CDK19_Hsap TLQKDFRRT-----TYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQD
CDK8_Hsap TLMKDFRRN-----TYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQD
Cdk8_Ddis RLSSM---E-----AFPN-SLAKC---VGIDENSQAYDLLSKMILYDPSKRITASEALDH
CDK8_Spur NLMKDFRRS-----NYASCCLPKYMEKHKVPKDSKAFQLLSKLLTMDPTKRMTSEQAMED
CC1G_07887_Ccin NMKLLD--------HFSN-RLSDWCH-T-RIRSPQGYDLLRQLFAYDPDNRLTAEQAIQH
AqueK099_Aque TLMRDFGRQK---ANFANCASQKYMDKHNVKHDTSAFKLLTKFLVMDPNKRITSDQAMLD
CDK8_Smoe ANRQLIQSR-----KYDNPGLHTV---VNLQPKGLAFDLLSRMLEYDPVKRITAAQALDH
: . ** ::: ** :*: . :*: .
Cdk8_Dmel QYF
CDK8_Mmus PYF
CDK19_Mmus PYF
F39H11.3_Cele IYF
SSN3_Scer KYF
CDK19_Hsap PYF
CDK8_Hsap PYF
Cdk8_Ddis PYF
CDK8_Spur QYF
CC1G_07887_Ccin KWF
AqueK099_Aque TYF
CDK8_Smoe EYF
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