smi35A_Dmel YEILEVIGK-GSFGQVIRALDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADG
Dyrk3_Dmel YEMLKIIGK-GSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKYN
DYRK4_Mmus YEVLEMIGK-GSFGQVAKCLDHKNNELVALKIIRNKKRFHHQALVELKILEALRRKDKDN
DYRK3_Mmus YEVLKIIGK-GSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG
DYRK2_Mmus YEVLKVIGK-GSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDN
mbk-2_Cele YEVLKVIGK-GSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSDG
C36B7.2_Cele YTIDKVIGQ-GCYGVVGEATDGKTKQKVAIRMVS---KLAPRIYRETEMIMYISSIDPDH
C36B7.1_Cele YSIDEVLSS-GYYAQVFRCTDKKTDKKVCIKLKN---RNLSTTYEETIILLRIHQLNRQN
DYRK4_Hsap YEVLETIGK-GSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDN
DYRK3_Hsap YEVLKIIGK-GSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTG
DYRK2_Hsap YEVLKVIGK-GSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDN
Dyrk2_Ddis FEIVSILGQ-GSFCQVVKGYDYKTGEMVALKILRNQKRFHNQALTEIKILEYLKTNDPNS
5306_Tthe YEIKEFLGK-GSFGQVLKVFDHKRKEYAALKVIRNKQKFHEQALIELNILHYIKEKDYDN
5356_Tthe YELIEALGK-GSFGQVIKVFDHKRKEYSALKIIRNKKNFYNQAIVELNILKYIKDNDPQN
5655_Tthe YELLECLGK-GSFGSVVKVFDHKRKEFLALKVIRNKKKFHNQALIELNILSYIKEQDKDE
DYRK2_Spur YEVLKILGK-GSFGQVVKVYDHKTNQHIAVKMVRNEKRFHRQAQEEIRILEHLRKQDKDN
DYRK4_Spur YEILEVIGK-GSFGQVVKAFDHKLGEMIAIKIIRNKKRFHHQALIEVKILDALRRKDRDN
CC1G_13957_Ccin YEVVDTLGK-GSFGQVLNCRDHCTGESVAVKIIRNKKRFHHQALVEIKILDNLRKWDADE
AqueK112_Aque YEIREIIGK-GSFGQVVKVFDHKTNQHIALKIIRNKKRFHHQALVEVKILDSLRKRDRDN
AqueK113_Aque YEVLKVLGK-GSFGQVLKAYDHKMQTHIALKVVRNEKRFHRQAQEEVKILEHLRRQDKDN
DYRK2_b_Smoe YEILGKLGR-GSFGQVLKCTDHKYKVPRAIKIIRNKKQFTQQAFIEINLLEFLRNKAAEE
DYRK2_a_Smoe YEILGKLGR-GSFGQVLKCTDHKYKVPRAIKIIRNKKQFTQQAFIEINLLEFLRNKAAEE
GK034_Glam YELVSKLGS-GSFGKVYKALDHKEQQFVALKIIKNRKRFQRQGLVEVKILELLRDNDPNG
GK033_Glam YKLLKMVGS-ATFSNVFSCLDLKDNVTYCLKIIKQEKEFFDQAIDEVHLLELLKDIDPNN
GK032_Glam YEIYKTIFEDSAFSVTLKARDLKEGKDVCLKVVNNEKDTLDQCLNEIRLLTYINKHDPTG
: : : . : . * .::: * :: :
smi35A_Dmel --SHNVIHMLDYTYFRKHLCITFELMSLNLYELIKK-NN-----------YNGFSMSLIR
Dyrk3_Dmel --TMNIIHMFDYFTFRNHTCITFELLSINLYELIKK-NG-----------FKGFSLQLVR
DYRK4_Mmus --NHNVVHMKDFFYFRNHLCITFELLGINLYELMKN-NS-----------FHGFNLSIVR
DYRK3_Mmus --SMNVIHMLESFTFRNHVCMAFELLSIDLYELIKK-NK-----------FQGFSVQLVR
DYRK2_Mmus --TMNVIHMLENFTFRNHICMTFELLSMNLYELIKK-NK-----------FQGFSLPLVR
mbk-2_Cele --THNIIHMLDYFNFRNHKCITFELLSINLYELIKR-NK-----------FQGFSLMLVR
C36B7.2_Cele --TFDCVRMLDYNVFRGFHYVVTDLFDTSVKKYIKE-HH-----------PNGIALENVA
C36B7.1_Cele --NSNCVRMLDYDHFRGHHFIVLENYQTDLASYLCGRSK-----------LTP---REYI
DYRK4_Hsap --TYNVVHMKDFFYFRNHFCITFELLGINLYELMKN-NN-----------FQGFSLSIVR
DYRK3_Hsap --SMNVIHMLESFTFRNHVCMAFELLSIDLYELIKK-NK-----------FQGFSVQLVR
DYRK2_Hsap --TMNVIHMLENFTFRNHICMTFELLSMNLYELIKK-NK-----------FQGFSLPLVR
Dyrk2_Ddis --TASIVHLNNYFYFRNHLILTFELLSMNLYDFLKV-NH-----------FQGYNLNLVR
5306_Tthe --QTNIVKIRDFVIFRNHVCLVFELLSINLYDLLRN-NK-----------FQGLSLELIR
5356_Tthe --QTNIVKIKDFVIFRSHVGLL--------------------------------------
5655_Tthe --ATNIVRIKDFVIFRKHV-----------------------------------------
DYRK2_Spur --NMNLIHMFESFSFRNHICITFELLSMNLYELIKK-NK-----------FQGFSLQLVR
DYRK4_Spur --SHNVVHMREYFYYRNHLCITFELLGMNLYELIKK-NN-----------FQGFSVALIR
CC1G_13957_Ccin --KHHVLKMTEHFYFRNHLCIATELLSINLYELIKA-NG-----------FVGFTTALIR
AqueK112_Aque --QYNIIHMFDYFYFRNHLCITFELMGMNLYELIKK-NN-----------FQGFSISLIR
AqueK113_Aque --AHNIIHMIDHFTFRNHVCITFELLSMNLYELIKK-NK-----------FQGFSLALVR
DYRK2_b_Smoe GVDYNIVTIYESFEFRGHLCLSFAVHDISLFDMLKK-NH-----------FEGFNLSLVK
DYRK2_a_Smoe GVDYNIVTIYESFEFRGHLCLSFAVHDISLFDMLKK-NH-----------FEGFNLSLVK
GK034_Glam --DQCCVKVLSSFYFRSHLCIAFELLSINLYELLTK-KD-----------LKGLSLSLVR
GK033_Glam --NINIIKIHDYFYFREHLLLKFTLLGEDLYTHFNR-REK-------KGQPNDYTIPVIR
GK032_Glam --K-HFVRMTDYFYYGHRLIIIFELLTSNLFSYYSA-REAALPRTLLNPLATIFTMPRLQ
: : . :
smi35A_Dmel RFCNSIVKCLRLLYKENIIHCDLKPENILLKQRG------SSSIKVIDFGSSCYVDRK-I
Dyrk3_Dmel KFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQG------RSGIKVIDFGSSCFENQR-I
DYRK4_Mmus RFTFSILKCLHMLYVEKIIHCDLKPENIVLYQRG------QVTVKVIDFGSSCYEHQK-V
DYRK3_Mmus KFAQSILQSLDALHKNKIIHCDLKPENILLKHHG------RSATKVIDFGSSCFEYQK-L
DYRK2_Mmus KFAHSILQCLDALHKNRIIHCDLKPENILLKQQG------RSSIKVIDFGSSCYEHQR-V
mbk-2_Cele KFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQG------RSGIKVIDFGSSCFDDQR-I
C36B7.2_Cele AMGRKILKGLVFLHEHNIVHGDLKPENIMLNLAN------PNDVKLGDFGLSRFAKPYHD
C36B7.1_Cele PMIKSIVHGLKFLHQNKIIHGDLKPANVLLNEWN------RNNLKLTDFGLSTFVNQGPF
DYRK4_Hsap RFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKG------QASVKVIDFGSSCYEHQK-V
DYRK3_Hsap KFAQSILQSLDALHKNKIIHCDLKPENILLKHHG------RSSTKVIDFGSSCFEYQK-L
DYRK2_Hsap KFAHSILQCLDALHKNRIIHCDLKPENILLKQQG------RSGIKVIDFGSSCYEHQR-V
Dyrk2_Ddis RFGAQILTSLRFLSKRNIIHADLKPENILLKSPT------KSGIKLIDFGSSCFENEQ-I
5306_Tthe RFAIQLLNAISFLKENRIIHCDLKPENVLLKQPN------KSGIKIADFGSSCFDDQV-M
5356_Tthe -----------FLTKANIIHCDLKPENILLKQEN------KSGIKIVDFGSSCFENQR-V
5655_Tthe -----ILNSINFLRKNRIIHCDLKPENILLKQAN------KSGVKLIDFGSSCFENER-L
DYRK2_Spur KFAHSLLQCLEGLHRNKIIHCDLKPENILLKQQG------RSGIKVIDFGSSCYEHQR-I
DYRK4_Spur RFAFSLLQCLRMLHKERIIHCDLKPENILLRQKG------QSTIKVIDFGSSCYEHQR-V
CC1G_13957_Ccin RFTTQMLMSLSLMRHHRIVHCDLKPENVLLRHPA------KSAIKVIDFGSSCLEHEK--
AqueK112_Aque RFAYSMLQCLKILYRERIIHCDLKPENILLRLRG------QSSIKVIDFGSSCYEHQR-V
AqueK113_Aque KFAHSILQCLDSLYRNRIIHCDLKPENILLKQPG------RSGIKVIDFGSSCYEYQR-V
DYRK2_b_Smoe CFARQVLVSLQFLHRARIIHGDLKPENILLQQPA------SPKIKLIDFGSSCFEHER-I
DYRK2_a_Smoe CFARQVLVSLQFLHRARIIHGDLKPENILLQQPA------SPKIKLIDFGSSCFEHER-I
GK034_Glam KFSLQLLIAFAYARKLRIIHADVKPENILLREPD------KSSIKVIDWGSGAMVSET-I
GK033_Glam DMARQVLKALDYIHRLGITHLDLKPENLLHGDKNFIGGVNEPSVTLVDFGSSSFIFDK-M
GK032_Glam HIARQILESLDFLHRLNILHLDLKHENLLLVNED----DDSFDIRLVDIGSSAFLYDE-C
: * *:* *:: : * * .
smi35A_Dmel YTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVE--------QL
Dyrk3_Dmel YTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESD--------QL
DYRK4_Mmus YTYIQSRFYRSPEVILGHPYNMAIDMWSLGCIMAELYTGYPLFPGENEVE--------QL
DYRK3_Mmus YTYIQSRFYRAPEIILGCRYSTPIDIWSFGCILAELLTGQPLFPGEDEGD--------QL
DYRK2_Mmus YTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGD--------QL
mbk-2_Cele YTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDEND--------QL
C36B7.2_Cele HVQCQSMFYRAPEAFVRGRYNGATDMWSFGCTVAEMVSGKIFLAGDNCDD--------QF
C36B7.1_Cele FRDYQTLYYKAPEVFCQGKVSVEIDIWSLGCVAAEIVRGTPLFVGDNYFD--------QF
DYRK4_Hsap YTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVE--------QL
DYRK3_Hsap YTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGD--------QL
DYRK2_Hsap YTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGD--------QL
Dyrk2_Ddis FTYIQSRFYRSPEVILGTKYDKSIDIWSLGCILVEIFTGVPLFPGSDEPE--------QL
5306_Tthe YTYIQSRYYRSPEVILGIPYGTEIDMWSFGCIIAELFLGYPIFPGEDENE--------QM
5356_Tthe YTYIQSRFYRAPEIILGLPYGKAIDMWSFGCIMAELYIGYPLFPGENEAE--------QF
5655_Tthe YTYIQSRYYRAPEVILGLPYDTSIDMWSFGCIMAELFIGYPIFPGEDEQE--------QI
DYRK2_Spur YTYIQSRFYRAPEVILGGKYGMPIDMWSLGCILAELLTGYPLLPGEDEGD--------QL
DYRK4_Spur YTYIQSRFYRSPEVILGLPYGLPIDMWSFGCILAELYTGYPLFPGENEVE--------QL
CC1G_13957_Ccin ---------------------------------TELYTGFPIFPGENEQE--------QL
AqueK112_Aque YTYIQSRFYRSPEVILGLPYSMAIDMWSLGCILAELYTGYPLFPGENEVE--------QL
AqueK113_Aque YTYIQSRFYRAPEVILGGKYGMSIDMWSFGCILAELLTGYPLFPGEDEGD--------QL
DYRK2_b_Smoe YTYIQSRFYRAPEVILGLPYDMMIDVWSFACILAELFTGYPLFPGEDEVE--------QL
DYRK2_a_Smoe YTYIQSRFYRAPEVILGLPYDMMIDVWSFACILAELFTGYPLFPGEDEVE--------QL
GK034_Glam YSYIQSRFYRAPEVILGLPYGQEIDIWSIGCVLCELYTGLPIFPGDDERD--------QL
GK033_Glam HSYIQSRSYRAPEVILATPYDSRADIWSFGCVVCELLTGRVLFPNYSVAT--------IL
GK032_Glam STYVQSRSYRCPEVILGLPYDGRADVWSLGPILTELITGKVMFPIPQKADEDHKPYASML
*: * :: . :
smi35A_Dmel ACIMEVLGLPPKVLISVARRRRLFFDS-RDAPRCITN-----------------------
Dyrk3_Dmel ACIIEVLGMPNKNILA--------------------------------------------
DYRK4_Mmus ACIMEVLGLPPAHFTQTASRRQVFFDS-KGLPKNINN-----------------------
DYRK3_Mmus ACMIELLGMPPQKLLEQSKRAKYFINS-KGLPRYCSVST---------------------
DYRK2_Mmus ACMIELLGMPSQKLLDASKRAKNFVSS-KGYPRYCTVTT---------------------
mbk-2_Cele ALIIELLGMPPPKSLETAKRARTFITS-KGYPRYCTATS---------------------
C36B7.2_Cele YLMQEVINIPPPVFFDTFYTNYYFFSTLKEAPKHIVI-----------------------
C36B7.1_Cele ALIQEFFGKPSRKLFNTWGGIHQFYTE-YFFPRHCFEWL---------------------
DYRK4_Hsap ACIMEVLGLPPAGFIQTASRRQTFFDS-KGFPKNITN-----------------------
DYRK3_Hsap ACMMELLGMPPPKLLEQSKRAKYFINS-KGIPRYCSVTT---------------------
DYRK2_Hsap ACMIELLGMPSQKLLDASKRAKNFVSS-KGYPRYCTVTT---------------------
Dyrk2_Ddis ACIMEVLGAPPKSVIDNSTRKDIFFED-DGTPKPVKNS----------------------
5306_Tthe GYIMELLGAPDSEFLKKCSRKKYFFDQ-NDQPLQIPN-----------------------
5356_Tthe QMFMEILGIPEEEFVENCPRRNVFFEN-NKTPKVVKN-----------------------
5655_Tthe GYIWEIIGAPSKDFLQNCTRRKYFFNE-DYTPKLIPN-----------------------
DYRK2_Spur ACMIEVMGMPSQNLIDTSKRSKNFINS-KGQPRYCTVTT---------------------
DYRK4_Spur ACIMEIFGLPPP------------------------------------------------
CC1G_13957_Ccin SCIMEVLGVPDKEYINRSSRKKLFFDT-NGAPRPVVN-----------------------
AqueK112_Aque ACIIEIFGLPDPALLAEAQRKKLFFDS-RGNPRCVTN-----------------------
AqueK113_Aque ACMMEVLGLPSQKMIESTKRGRTFFSS-KGHPRYTTVNI---------------------
DYRK2_b_Smoe AYMMEVLGTPPLSLISQAKRKKMFFDS-DNKPRIVPN-----------------------
DYRK2_a_Smoe AYMMEVLGTPPLSLISQAKRKKMFFDS-DNKPRIVPN-----------------------
GK034_Glam GKICELLGMPPNDMIFKSPRKNDFFVN-IGTGMGVAGVSEGGNPIFSGNLQQLSSVNEYL
GK033_Glam SRICSLIGPIPRDMIMSGRMGQRVLTF-GLVPY---------------------------
GK032_Glam AKLIGIIGPIPRDMILAGRESHKLFTK-DLFLF-ET------------------------
: .:.
smi35A_Dmel --------------------TKGRKR-S-----------PGSKS--------LAHILH-C
Dyrk3_Dmel ------------------------------------------------------------
DYRK4_Mmus --------------------NRGGKR-Y-----------PDSKD--------LTMVVK-T
DYRK3_Mmus ----QTD-GR--VVLLGGRSRRGKKRGP-----------PGSKD--------WATALKGC
DYRK2_Mmus ----LSD-GS--VVLNGGRSRRGKLRGP-----------PESRE--------WGNALKGC
mbk-2_Cele ----MPD-GS--VVLAGARSKRGKMRGP-----------PASRS--------WSTALKNM
C36B7.2_Cele -----TDHGP---IVSFIYTKAADHRKI-----------PGATP--------IGSFFTKT
C36B7.1_Cele ----NPFNGDRTMEIEPHYKLAHPSRKP-----------PLTSS--------LVSKLPGG
DYRK4_Hsap --------------------NRGKKR-Y-----------PDSKD--------LTMVLK-T
DYRK3_Hsap ----QAD-GR--VVLVGGRSRRGKKRGP-----------PGSKD--------WGTALKGC
DYRK2_Hsap ----LSD-GS--VVLNGGRSRRGKLRGP-----------PESRE--------WGNALKGC
Dyrk2_Ddis --------------------TTGELY-T-----------IGTKS--------FKDSIR-S
5306_Tthe --------------------SRGKIR-M-----------PNSKN--------WKSVIG-C
5356_Tthe --------------------SRGKIR-T-----------PATKH--------INYYLR-C
5655_Tthe --------------------SKGKIR-V-----------PNSKI--------LKAVLQ-T
DYRK2_Spur ----LPD-GT--TVLNGGRSRRGKVRGP-----------PGSKD--------LVKALKGC
DYRK4_Spur ------------------------------------------------------------
CC1G_13957_Ccin --------------------SKGRRR-R-----------PGSKT--------LAQVLR-C
AqueK112_Aque --------------------SKGKKR-R-----------PGSKD--------LSSAIK-T
AqueK113_Aque ----NPD-GT--ASYTGGRSRRGKFRGP-----------PGTKD--------MSRALKGC
DYRK2_b_Smoe --------------------SSGTRH-F-----------PSTKD--------LRMVVG-C
DYRK2_a_Smoe --------------------SSGTRH-F-----------PSTKD--------LRMVVG-C
GK034_Glam QATGRGA-GG--SEVPGIRLR--TTH-K-----------VNSKT--------LSGVLN-A
GK033_Glam --------------E-HDEKNRQHFYF-----------TPQQGLLEYWLFGERCANLT-D
GK032_Glam ---------R--EAILGNRDKAEGLRHAEIKGEDYVYVLPKKTTIKAML--GWDSHPE-Y
smi35A_Dmel QDRYFIDFLQRCLEWDPAERMTPDEAAHHEFL
Dyrk3_Dmel SDPLFLNFIRGCLEWDADKRLTPSEALKHPWL
DYRK4_Mmus YDSSFLDFLRRCLVWEPSLRMTPEQALKHAWI
DYRK3_Mmus GDYLFIEFLKRCLQWDPSARLTPAQALRHPWI
DYRK2_Mmus DDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL
mbk-2_Cele GDELFVDFLKRCLDWDPETRMTPAQALKHKWL
C36B7.2_Cele EQKPFNNFILKVFKWMPASRITAKQALDHPFF
C36B7.1_Cele NQKFLARFLMRCFEWDPTERIKSSFILNHPFF
DYRK4_Hsap YDTSFLDFLRRCLVWEPSLRMTPDQALKHAWI
DYRK3_Hsap DDYLFIEFLKRCLHWDPSARLTPAQALRHPWI
DYRK2_Hsap DDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL
Dyrk2_Ddis GDEDFDNFILDCLKWEPSQRITAEQGLKHDWI
5306_Tthe TDDNFIDFIKKCLVWEPSQRLTPRDALLHPWI
5356_Tthe PDENFIDFVSKCFTWKNHERMSPAEALVHDWI
5655_Tthe ESEDFTDFLTKCFVWEPQKRLKPSDALMHPWI
DYRK2_Spur DDPLFLDFLKRCLEWDPSSRMTPSQALRHSWL
DYRK4_Spur -------------------------------H
CC1G_13957_Ccin NDEEFIDFIAKCLVWDPERRMKPQAAMRHPFV
AqueK112_Aque SDLLFLDFIRRCLVWSASERMKPEEALQHAWI
AqueK113_Aque DDPQFLDFLRHCLEWDPAIRMTPPQALRHPWL
DYRK2_b_Smoe SDKSFVNFLSCCLKWDKEQRMTPQQLLKHEWI
DYRK2_a_Smoe SDKSFVNFLSCCLKWDKEQRMTPQQLLKHEWI
GK034_Glam PD-DFISFISLFLQWDPQRRCTPEVAMSHPWI
GK033_Glam EEVLFSDFCRQALIVDPIKRPTAAMLLEHPFI
GK032_Glam CDDLFLDFIETIMRIDPRKRPTAAEALEHPWL