ERK4_Mmus MAEKG---------------------DCIASVYGYDLGGRFIDFQPLGFGVNGLVLSATD
ERK3_Mmus MAEKF---------------------ESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVD
Erk4_Hsap MAEKG---------------------DCIASVYGYDLGGRFVDFQPLGFGVNGLVLSAVD
Erk3_Hsap MAEKF---------------------ESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVD
ERK3_Spur MALLFVLFLCTGRLWLNSMARLDSPTEGLYLPH--GIGSRFCDLRPLGYGSSGTVFSAVD
** : : : .:*.*: *::*** * .* *:**.*
ERK4_Mmus SRACRKVAVKKIVLSDARSMKHALREIKIIRRLDHDNIVKVYEVLGPKGSDL--Q---GE
ERK3_Mmus NDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQL--TDDVGS
Erk4_Hsap SRACRKVAVKKIALSDARSMKHALREIKIIRRLDHDNIVKVYEVLGPKGTDL--Q---GE
Erk3_Hsap NDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQL--TDDVGS
ERK3_Spur SECDKSVAIKRVSLTDKKSCKSALREIRILRKLQHENIVKIYDVIFDGNSDNSEDEDISI
. . : **:*:: *:* :* * *****:*:*:*:*:****::::: .:: .
ERK4_Mmus LFKFSVAYIVQEYMETDLACLLEQGTLTEDHAKLFMYQLLRGLKYIHSANVLHRDLKPAN
ERK3_Mmus LTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPAN
Erk4_Hsap LFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPAN
Erk3_Hsap LTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPAN
ERK3_Spur PSELRTLCIVQELVDADLRVVMEQQRISNEHVRLFAYQLLRGLKYLHSANVLHRDLKPEN
:: **** :::** ::** : ::*.:** *********:************ *
ERK4_Mmus IFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWA
ERK3_Mmus LFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWA
Erk4_Hsap IFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWA
Erk3_Hsap LFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWA
ERK3_Spur VLINQEDLVLKIGDFGMARIVDPDYSHKGYLTQNVSTQWYRSPELVLQPTDYTKAIDLWS
::*. ***********:***:* .*****:*::.: *:*****.*:*.*.:******:*:
ERK4_Mmus AGCILAEMLTGKMLFAGAHELEQMQLILDTIPVVREEDKEELLRVMPSFV-SS-TWEVKR
ERK3_Mmus AGCIFAEMLTGKTLFAGAHELEQMQLILDSIPVVHEEDRQELLSVIPVYI-RNDMTEPHR
Erk4_Hsap AGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDELLRVMPSFV-SS-TWEVKR
Erk3_Hsap AGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYI-RNDMTEPHK
ERK3_Spur AGCILAEMVTGKPLFPGDHDLELMMLVLDSVQ-LNDRDLNEILCTLPSKLLKNYNGYPRH
****:***:**: **.* *:** * *:*::: :.:.* :*:* .:* : . ::
ERK4_Mmus PLRKLLPDVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYMSPYSCPEDEPTSQHPFRIED
ERK3_Mmus PLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPTDEPISSHPFHIED
Erk4_Hsap PLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYMSPYSCPEDEPTSQHPFRIED
Erk3_Hsap PLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPMDEPISSHPFHIED
ERK3_Spur PLKEVLCNLDCHALDLLLAMLTFDPSERITAEEALRSPYFKVYSCIRDEAKATHPFHIEN
** ::* :. .*:*:* :***.* :*:*** .* **:. ** **. : ***:**:
ERK4_Mmus EIDDIVLMAASQSQL---------------------------------------------
ERK3_Mmus EVDDILLMDETHSHI---------------------------------------------
Erk4_Hsap EIDDIVLMAANQSQL---------------------------------------------
Erk3_Hsap EVDDILLMDETHSHI---------------------------------------------
ERK3_Spur EIDDLPPIVIKKIILEECLERTDVDVSFGGRTANVCDESEDNSSSSRDLVQSSTEGSLGS
*:**: : .: :
ERK4_Mmus -----------------------------------------------SNWD----RYPVS
ERK3_Mmus -----------------------------------------------YNWE----RYHDC
Erk4_Hsap -----------------------------------------------SNWDTCSSRYPVS
Erk3_Hsap -----------------------------------------------YNWE----RYHDC
ERK3_Spur FSDEEAKEACIDNAFLNRMVSVGNNRSDDSEKNETEESEKSDDEEKEAKWE----DFKEM
:*: :
ERK4_Mmus LS---SDLEWRPDRCQDASE---VQRDPRAGSTP-LAEDVQVDPRKDSQSSSERFLEQSH
ERK3_Mmus QF---SEHDWPIHNNFDIDE---VQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPA
Erk4_Hsap LS---SDLEWRPDRCQDASE---VQRDPRAGSAP-LAEDVQVDPRKDSHSSSERFLEQSH
Erk3_Hsap QF---SEHDWPVHNNFDIDE---VQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPA
ERK3_Spur MSMDPNNLEDREEREGDAIEKGSVESD-NEGSEKS-EADDQISEKRNNQDDEEKRGSKED
.: : .. * * *: * . * : *:. :: ... *: ..
ERK4_Mmus SS---------------MERAFEADYGRS------------------------CDYKVGS
ERK3_Mmus FDTSYSAEPCWQYPDHHENKYCDLECSHT------------------------CNYKTRS
Erk4_Hsap SS---------------MERAFEADYGRS------------------------CDYKVGS
Erk3_Hsap FDTNYSTEPCWQYSDHHENKYCDLECSHT------------------------CNYKTRS
ERK3_Spur LL---------------MEKFEEDNTGDNNKKEEEKTEEGAMSKTARKESLVFMDYEAVE
:: : : . . :*:. .
ERK4_Mmus PSYLDKLLWRD-----------------NKPHHYSEPKLILDLSHW-KQA----------
ERK3_Mmus SPYLDNLVWRE-----------------SEVNHYYEPKLIIDLSNW-KEQ----------
Erk4_Hsap PSYLDKLLWRD-----------------NKPHHYSEPKLILDLSHW-KQA----------
Erk3_Hsap SSYLDNLVWRE-----------------SEVNHYYEPKLIIDLSNW-KEQ----------
ERK3_Spur KAFGDKLQKEKLNEQLSNREFEDGSVRKKESSENKELDLTDTLDILKKQAKSKGKTLDDC
.: *:* .. .: . * .* *. *:
ERK4_Mmus -----------ASAPPRAAVAADP---VSREDEPASLFLEIAQWVK--------------
ERK3_Mmus -----------SKEKSDKRGKSKC---ERNGLVKAQIAL---------------------
Erk4_Hsap -----------AGAPPTATGLADT---GAREDEPASLFLEIAQWVK--------------
Erk3_Hsap -----------SKEKSDKKGKSKC---ERNGLVKAQIAL---------------------
ERK3_Spur LELGTLRLSETSPTPKNTDVVLDKQLYVHKESKGNQEFNDKSEFVEQIRTDNTSVSNERM
: . . .
ERK4_Mmus --------STQSGSERASPPPDAPEPRLSASPPGHPTPIDGGASPQFDLDVFISRALKLC
ERK3_Mmus --------------EEASQQLAE--R---------------ERGQGFDFDSFIAGTIQLS
Erk4_Hsap --------STQGGPEHASPPADDPERRLSASPPGRPAPVDGGASPQFDLDVFISRALKLC
Erk3_Hsap --------------EEASQQLAGKER---------------EKNQGFDFDSFIAGTIQLS
ERK3_Spur GELQKVRCNTQTEKKQGRPKKPDLKEVLYVDIPKASASISPRSSPRGPGKETTTR-----
:.. . . :
ERK4_Mmus TKPE--DLPENKLGDLNGACISEH-----------------PGDLVQTEAFSK-------
ERK3_Mmus AQHQSADV-VDKLNDLNSSVSQLELKSLISKSVSREKQEKGRANLAQLGALYQSSWDSQF
Erk4_Hsap TKPE--DLPDNKLGDLNGACIPEH-----------------PGDLVQTEAFSK-------
Erk3_Hsap SQHEPTDV-VDKLNDLNSSVSQLELKSLISKSVSQEKQEKGMANLAQLEALYQSSWDSQF
ERK3_Spur ------------------------------------------------------------
ERK4_Mmus ------------------------------------------------------------
ERK3_Mmus VSGGEECFLISQFCCEVRKDEHAEKENTYTSYLDKFFSRKEDSEMLETEPVEEGKRGERG
Erk4_Hsap ------------------------------------------------------------
Erk3_Hsap VSGGEDCFFINQFC-EVRKDEQVEKENTYTSYLDKFFSRKEDTEMLETEPVEDGKLGERG
ERK3_Spur ------------------------------------------------------------
ERK4_Mmus ------------------------------------------------------------
ERK3_Mmus REAGLLSGGGEFLLSKQLESIGTPQFHSPVGSPLKSIQATLTPSAMKSSPQIPHKTYSSI
Erk4_Hsap ------------------------------------------------------------
Erk3_Hsap HEEGFLNNSGEFLFNKQLESIGIPQFHSPVGSPLKSIQATLTPSAMKSSPQIPHQTYSSI
ERK3_Spur -------------------------------------RNSLSPRERSVRPKKK-----DW
ERK4_Mmus --ERW
ERK3_Mmus LKHLN
Erk4_Hsap --ERW
Erk3_Hsap LKHLN
ERK3_Spur FYSKH