IRAKf_k-2_Smoe  LHERFLVGRGASSSVYKCTLKNGKKVAIKRLYNHY--PQNVHEFETELATLGHIKHRNLV
IRAKf_c-1_Smoe  LNKEQEIGRGGFGVVYRAAISDGRTFAVKKLVTAGL-VKSQLEFEKEVQQLGKIEHPNLV
IRAKf_c-2_Smoe  LNKEQEIGRGGFGVVYRAAISDGRTFAVKKLVTAGL-VKSQLEFEKEVQQLGKIEHPNLV
IRAKf_d-1_Smoe  VDKDCVIGYGPLGTVYKAVVDGGVALAVKKLSSLGQ-ITSQEAFEREIAILKNVKHRNVV
IRAKf_d-2_Smoe  VDKDCVIGYGPLGTVYKAVVDGGVALAVKKLSSLGQ-ITSQEAFEREIAILKNVKHRNVV
IRAKf_g_Smoe    LGENDIIGCGGFGTVYKLVMDDGNMFAVKRIAKGG--FGSERLFERELEILGSIKHRNLV
IRAKf_m-2_Smoe  -----IIGRGASSTVYKCSLKNGKTVAIKKLYNHF--PQNIHEFETELETLGHIKHRNLV
IRAKf_g-1_Smoe  LDYKDIIGAGGFGTVYKLCMDEDCVFAVKKVGRSSDGSISERRLEKELDVLGSIQHRNLV
IRAKf_m-1_Smoe  -----IIGRGASSTVYKCSLKNGKTVAIKKLYNHF--PQNIHEFETELETLGHIKHRNLV
IRAKf_g-2_Smoe  LDYKDIIGAGGFGTVYKLCMDEDCVFAVKKVGRSSDGSISEKRLEKELDVLGSIQHRNLV
IRAKf_n-2_Smoe  FSVDYLIGNGGFGATYKAEMMPGLVVAVKRLSIGR--FQGVQQFDTEIRTLGRIQHSNLV
IRAKf_n-1_Smoe  FSVDYLIGNGGFGATYKAEMMPGLVVAVKRLSIGR--FQGVQQFDTEIRTLGRIQHSNLV
IRAKf_a_Smoe    LNKNSEIGRGGFGTVYKATLAAGRTVAVKKLSVPGM-VETQDEFEKRVQFLGKIQHENLV
IRAKf_k-1_Smoe  LHERFLVGRGASSSVYKCTLKNGKKVAIKRLYNHY--PQNVHEFETELATLGHIKHRNLV
IRAKf_b_Smoe    LNKNSEIGRGGFGTVYKATLAAGRTVAVKKLSVPGM-VETQDEFEKRVQFLGKIQHENLV
                      :* *  . .*:  :  .  .*:*::            :: .:  *  ::* *:*

IRAKf_k-2_Smoe  SLYGYSLSSAGNLLFYDFMDNGSLWDILHGPVR-KVTLDWDARLIIALGAAQGLEYLHHN
IRAKf_c-1_Smoe  ALQGYYWTSRMQLLIYDFVPNGSLYSRLHERTFGEPPLSWSERFKIAQGTAMGLSHLHHS
IRAKf_c-2_Smoe  ALQGYYWTSRMQLLIYDFVPNGSLYSRLHERTFGEPPLSWSERFKIAQGTAMGLSHLHHS
IRAKf_d-1_Smoe  TLEGYYWSPPTKLLLTEYLPNDSLFHHLHQRMEGQLPLPWWRRFKIALGAARGLAYLHHD
IRAKf_d-2_Smoe  TLEGYYWSPPTKLLLTEYLPNDSLFHHLHQRMEGQLPLPWWRRFKIALGAARGLAYLHHD
IRAKf_g_Smoe    NLRGYCNSGSARLLIYDFLSHGSLDDLLHEREPHKPSLNWNHRMKAAIGSARGISYLHHD
IRAKf_m-2_Smoe  GLHGYSLSPAGNLLFYDYLENGSLWDVLHGPVR-KVKLDWDTRLKIALGAAQGLAYLHHD
IRAKf_g-1_Smoe  SLKGYCNAPTARLLITDFMPLGSLDEHLHERHAKDSLMTWEARLNIAIGTARGLGHLHHR
IRAKf_m-1_Smoe  GLHGYSLSPAGNLLFYDYLENGSLWDVLHGPVR-KVKLDWDTRLKIALGAAQGLAYLHHD
IRAKf_g-2_Smoe  SLKGYCNAPTARLLITDFMPLGSLDEHLHERHAKDSLMTWEARLNIAIGTARGLGHLHHR
IRAKf_n-2_Smoe  KLIGYHASEGEMFLIYNYFPRGNLESFIHNRSR--GEISWAVVHRIAMGIAEALAYLHDE
IRAKf_n-1_Smoe  KLIGYHASEGEMFLIYNYFPRGNLESFIHNRSR--GEMSWAVVHRIALGIAEALAYLHDE
IRAKf_a_Smoe    NFQGYYFTPKLQLLIYDFVPNGNLHSKLHEQ----SVLPWELRFKVALGAAQGLCYLHHK
IRAKf_k-1_Smoe  SLYGYSLSSAGNLLFYDFMDNGSLWDILHGPVR-KVTLDWDARLIIALGAAQGLEYLHHN
IRAKf_b_Smoe    NFQGYYFTPKLQLLIYDFVPNGNLHSKLHEQ----SVLPWELRFKVALGAAQGLCYLHHK
                 : **  :    :*: ::.  ..*   :*        : *      * * * .: :**.

IRAKf_k-2_Smoe  CSPRIIHRDVKSSNILLDERFEVHLSDFGIAKSICSASTHTS-TYVMGTIGYIDPEYA-R
IRAKf_c-1_Smoe  CQPQVIHYDLKSNNILLGVDNRPLISDYGLANLLPVLDRYAISSKFQGALGYMAPEFASQ
IRAKf_c-2_Smoe  CQPQVIHYDLKSNNILLGVDNRPLISDYGLANLLPVLDRYAISSKFQGALGYMAPEFASQ
IRAKf_d-1_Smoe  CRPQVLLFNLKSTNILLDDEFEPHISDYGLRRLLPKLDTYMTDRKLELAVGYVAPEMAVQ
IRAKf_d-2_Smoe  CRPQVLLFNLKSTNILLDDEFEPHISDYGLRRLLPKLDTYMTDRKLELAVGYVAPEMAVQ
IRAKf_g_Smoe    CSPRIVHRDIKSSNILLDSNFEPHVSDFGLAKLLNENQSHMT-TIVAGTFGYLAPEYM-Q
IRAKf_m-2_Smoe  CSPRIIHRDVKSSNILLDENFDAHISDFGIAKSICPTKTHTS-TFVLGTIGYIDPEYA-R
IRAKf_g-1_Smoe  CVPPIIHRDIKSSNVLLDRNLEACVSDFGLARLLEENDSQVT-TIVAGTFGYLAPEYM-Q
IRAKf_m-1_Smoe  CSPRIIHRDVKSSNILLDENFDAHISDFGIAKSICPTKTHTS-TFVLGTIGYIDPEYA-R
IRAKf_g-2_Smoe  CVPPIIHRDIKSSNVLLDRNLEACVSDFGLAKLLEENDSQVT-TIVAGTFGYLAPEYM-Q
IRAKf_n-2_Smoe  CQPRVLHRDIKPSNILLDNNLTAFLADFGLARLLGASETHAT-TDVAGTFGYVAPEYA-M
IRAKf_n-1_Smoe  CQPRVLHRDIKPSNILLDNNLTAFLADFGLARLLGASETHAT-TDVAGTFGYVAPEYA-M
IRAKf_a_Smoe    CRPRVIHYNFKSSNVLLDDGFNARVSDYGLAKLLHSRDRFVVMNKLQSSLGYLAPECGCE
IRAKf_k-1_Smoe  CSPRIIHRDVKSSNILLDERFEVHLSDFGIAKSICSASTHTS-TYVMGTIGYIDPEYA-R
IRAKf_b_Smoe    CRPRVIHYNFKSSNVLLDDGFNARVSDYGLAKLLHSRDRFVVMNKLQSSLGYLAPECGCE
                * * ::  :.*..*:**.      ::*:*: . :   .       .  :.**: **

IRAKf_k-2_Smoe  TSRLNEKSDVYSFGIVLLELITRQKAVDDEKNLHQWVLSHVNNKSVMEIVDQEVKDTCTD
IRAKf_c-1_Smoe  SSKVTEKCDVYGFGIILLELVTGRR-----------------------------------
IRAKf_c-2_Smoe  SSKVTEKCDVYGFGIILLELVTGRR-----------------------------------
IRAKf_d-1_Smoe  NLRLTDKCDVYSFGVVLLELVTGRRP----------------------------------
IRAKf_d-2_Smoe  NLRLTDKCDVYSFGVVLLELVTGRRP----------------------------------
IRAKf_g_Smoe    SGRVTEKSDVYSFGVVLLELLSGKR-----------------------------------
IRAKf_m-2_Smoe  TSRLNEKSDVYSYGIVLLELIT--------------------------------------
IRAKf_g-1_Smoe  SGRATEKSDVYSYGVVLLELLSGKR-----------------------------------
IRAKf_m-1_Smoe  TSRLNEKSDVYSYGIVLLELIT--------------------------------------
IRAKf_g-2_Smoe  SGRATEKSDVYSYGVVLLELLSGKR-----------------------------------
IRAKf_n-2_Smoe  TCRVSDKADVYSYGVVLLELLSG-------------------------------------
IRAKf_n-1_Smoe  TCRVSDKADVYSYGVVLLELLSG-------------------------------------
IRAKf_a_Smoe    SFKVTEKCDVYGFGVVLLELITGKP-----------------------------------
IRAKf_k-1_Smoe  TSRLNEKSDVYSFGIVLLELITRQKAVDDEKNLHQWVLSHVNNKSVMEIVDQEVKDTCTD
IRAKf_b_Smoe    SFKVTEKCDVYGFGVVLLELITGKP-----------------------------------
                . : .:*.***.:*::****::

IRAKf_k-2_Smoe  PNAIQKLIRLALLCAQKFPAQRPTMHDVVNVI
IRAKf_c-1_Smoe  -------------------------------P
IRAKf_c-2_Smoe  -------------------------------P
IRAKf_d-1_Smoe  -----------------------VQNLETDAV
IRAKf_d-2_Smoe  -----------------------VQNLETDAV
IRAKf_g_Smoe    -------------------------------P
IRAKf_m-2_Smoe  -------------------------------G
IRAKf_g-1_Smoe  -------------------------------P
IRAKf_m-1_Smoe  -------------------------------G
IRAKf_g-2_Smoe  -------------------------------P
IRAKf_n-2_Smoe  -------------------------------K
IRAKf_n-1_Smoe  -------------------------------K
IRAKf_a_Smoe    -------------------------------P
IRAKf_k-1_Smoe  PNAIQKLIRLALLCAQKFPAQRPTMHDVVNVI
IRAKf_b_Smoe    -------------------------------P