sek-1_Cele      M-----------E-RKGRERKLPGMKI----V-MP-TPVETPTMNLEDRCLIKLTNESEE
lic_Dmel        M-----------S-KR--HRL-TPFTI----AKEP-EAAIVPPRNLDSRATIQIGDRT--
MAP2K3_Mmus     MESPAASPPASLPQTKGKSKRKKDLRISC-VSKPP-VSNPTPPRNLDSRTFITIGDRN--
MAP2K6_Mmus     M-----------SQSKGK-KRNPGLKIPKEAFEQP-QTSSTPPRDLDSKACISIGNQN--
MAP2K6_Hsap     M-----------SQSKGK-KRNPGLKIPKEAFEQP-QTSSTPPRDLDSKACISIGNQN--
MAP2K3_Hsap     MESPASSQPASMPQSKGKSKRKKDLRISC-MSKPP-APNPTPPRNLDSRTFITIGDRN--
MEK3_Spur       M-----------A-TKGK-KKFGGVKFKFDAEEAPKREEKKPPGGLDNKATLTVNGHE--
                *              :   :    . :       *      *. .*:.:  : : ..

sek-1_Cele      IEIAATDLVVLEELGKGGYGIVEKMQHRQSGIIMAVKRIKSSINDQSQKQMLNELDACRR
lic_Dmel        FDIDADSLEKICDLGRGAYGIVDKMRHKQTDTVLAVKRIPMTVNIREQHRLVMDLDISMR
MAP2K3_Mmus     FEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNTQEQKRLLMDLDINMR
MAP2K6_Mmus     FEVKADDLEPIVELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDVSMR
MAP2K6_Hsap     FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMR
MAP2K3_Hsap     FEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMR
MEK3_Spur       FQVYARDMIVIENLGRGAYGIVDKTRHEPTESIMAVKKMRAQVNSTEDKRILMDMDVAMR
                ::: * .:  : :**:*.**:*:* :*  :  ::***::   :*  .::::: ::*   *

sek-1_Cele      SDCCPQMVRFYGAMFREGDVWICMEVMDTSLDKFYRHAYK-IGKHIPEPFIGKMALSVIE
lic_Dmel        SSDCPYTVHFYGAMYREGDVWICMEVMSTSLDKFYPKVFL-HDLRMEESVLGKIAMSVVS
MAP2K3_Mmus     TVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLE-KNMKIPEDILGEIAVSIVR
MAP2K6_Mmus     TVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVID-KGQTIPEDILGKIAVSIVK
MAP2K6_Hsap     TVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVID-KGQTIPEDILGKIAVSIVK
MAP2K3_Hsap     TVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLD-KNMTIPEDILGEIAVSIVR
MEK3_Spur       SSDCVYTVEFYGALFQEGDVWICMEVMDTCLDKLYKNKLKPQKIFVPENILSRISFSIVS
                :  *   * ****:::*********:*.*.***:* :        : * .:..::.*::

sek-1_Cele      GLNFMKEQLNLIHRDVKPSNILLNRHGQVKICDFGISGHLTNSMAKTVQAGCKPYMPPER
lic_Dmel        ALHYLHAQLKVIHRDVKPSNILINRAGQVKICDFGISGYLVDSIAKTIDAGCKPYMAPER
MAP2K3_Mmus     ALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPER
MAP2K6_Mmus     ALEHLHSKLSVIHRDVKPSNVLINTLGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPER
MAP2K6_Hsap     ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPER
MAP2K3_Hsap     ALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPER
MEK3_Spur       ALKYLQTRLKVIHRDVKPSNVLANHNGKIKLCDFGISGQLVNSMAKTQDAGSRQYMAPER
                .*..:: :*.:*********:* *  *::*:******* *.:*:*** :**.: **.***

sek-1_Cele      IDGET-KSAYDVRADVWSLGITIIEIAVGTHPYANWKTPFEQLKQVVKEPPPKLPMESGF
lic_Dmel        IDPQGNPAQYDIRSDVWSLGIGMIEMATGRYPYDNWRTPFEQLRQVVEDSPPRLPEG-TF
MAP2K3_Mmus     INPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPAD-QF
MAP2K6_Mmus     INPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD-KF
MAP2K6_Hsap     INPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD-KF
MAP2K3_Hsap     INPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPAD-RF
MEK3_Spur       IDPDMSAKGYDVKSDVWSFGITMIEIATNAYPYERWHDMFQQLTQVVKGTSPALPKE-KF
                *: :     *.:::*:**:** :**:*   .**  *   *:** ***: ..* **    *

sek-1_Cele      SVDCQYFVKRCLEKDYNERPKYPELLAMPFMEQARNEKQFSMARFINEVRFAAIKKTIFL
lic_Dmel        SPEFEDFIAVCLQKEYMARPNYEQLLKHSFIVEHLQ-RNTDISEFVARILDLPD----AQ
MAP2K3_Mmus     SPEFVDFTSQCLRKNPAERMSYLELMEHPFFTLHKT-KKTDIAAFVKEILGE--------
MAP2K6_Mmus     SADFVDFTSQCLKKNSKERPTYPELMQHPFFTVHES-KAADVASFVKLILG---------
MAP2K6_Hsap     SAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHES-KGTDVASFVKLILG---------
MAP2K3_Hsap     SPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKT-KKTDIAAFVKEILGE--------
MEK3_Spur       SEDIQDFINKCLKKNCTERPSYTRLLEHEFIKQHADIGDDDVASFISPIIGDT-------
                * :   *   **.*:   * .* .*:   *:         .:: *:  :

sek-1_Cele      LKN
lic_Dmel        PAQ
MAP2K3_Mmus     -DS
MAP2K6_Mmus     --D
MAP2K6_Hsap     --D
MAP2K3_Hsap     -DS
MEK3_Spur       NSS
                  .