mkk-4_Cele      LQDLGAIGNGNFGTVYKMRHKETGKLIAVKRIRCNN--IG---HREQIRLLREHDTIVKS
VZC374L.1_Cele  LRHLSQVGAGYYGTVHKMQHNESGRLIAVKKIRYN----N---ICDQTRLLKEHDTHMKS
ZC449.6_Cele    LQELELLGNGSFGVVRKMLHRPSNVEMAVKQISLINNGPDDAFNKSMQRFRLEVEATKAA
Mkk4_Dmel       LEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRST---VD---EKEQKQLLMDLEVVMKS
MAP2K4_Mmus     LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRST---VD---EKEQKQLLMDLDVVMRS
MAP2K4_Hsap     LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRST---VD---EKEQKQLLMDLDVVMRS
MKK4_Spur       LEDMGEIGRGAFGSVNKMWHKQSQSIMAVKRIRST---VD---EKDQKQLLMDLDVVKRS
AqueK244_Aque   ---VSEIGRGQFGQVNKMTHMVTGKVMAVKRIRVT---PD---QAKSKSLLMEWKVPKNS
AqueK245_Aque   LDVEEELGRGQYGQVNRMKHKPTGKIMAVKRIRAT---PD---QAENKRLLMDYNVAMRS
AqueK246_Aque   LQDIGSIGEGHFGVVSKMNHTTAKHIMAVKKIPMK----D---LRTSGGNVLELDVIKKV
                      :* * :* * :* .      :***:*       .            : ..

mkk-4_Cele      EKGPNIVKFYGAIFSEGDCWICMELMDISMDLLYKRVYMVKNSRLNENVVGHITVCTVDA
VZC374L.1_Cele  ENVPNIVKFFGACFSEGDCWICMELMDISIDFLYKRVYSVKKSRLNENIIGHITVCIVDA
ZC449.6_Cele    SNCDEIVRYYGITFNEGVAWMCMELMDLSLDKLYMIAHDIQKVEIPEQILGAVAVATIRA
Mkk4_Dmel       NECIYIVQFYGALFKEGDCWICMELMDTSLDKFYKYIYEKQQRHIPESILAKITVATVNA
MAP2K4_Mmus     SDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKA
MAP2K4_Hsap     SDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKA
MKK4_Spur       ANCVYIIKFFGALFKEGDCWICMELMDSSLDKFYRFVHEVQNTYIPENIMGKVAYATVKA
AqueK244_Aque   VECPYTILFYGAFFCENDVWICMELMDRSLEELYHLVYDKLKESIPEL--------TLKA
AqueK245_Aque   IDCPFTITFYGALFREGDVWICMELMDKSLDKLYQLVYKKLNEKIPEVIVGKMADSTLKA
AqueK246_Aque   KECPFIVHFYGCLLREGHVWICMELLDSSMAQVSEIVYNKMNERIPEDILGKMTVAVINA
                 .    : ::*  : *.  *:****:. *:  .    :   .  : *          : *

mkk-4_Cele      LDYLKKELKIIHRDVKPSNILVDGTGAVKLCDFGICGQLEESFAKTHDAGCQPYLAPERI
VZC374L.1_Cele  LDYLKRKLNRIHRDVKPSNILINAAGDVKLCDFGICGDLVGSYAITVEAGCVQYLAPERI
ZC449.6_Cele    LEHLKTTHHIIHRDIKPSNILLDRHGCVKLCDFGICGYLQNSVAQSVDVGCRPYMAPERL
Mkk4_Dmel       LNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERI
MAP2K4_Mmus     LNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERI
MAP2K4_Hsap     LNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERI
MKK4_Spur       LNYLKETLKIIHRDVKPSNILLDRGGNIKLCDFGISGQLVDSIARTMDAGCKPYMAPERI
AqueK244_Aque   LTYLHDKLNVMHRDVKPSNILINQNGEIKLCDFGIAGELVDSLAKT-DIGCRPYLAPERI
AqueK245_Aque   LTYLHDELQVMHRDVKPSNILINKKGEIKLCDFGIAGELVNSLAKT-DIGCRPYLAPERI
AqueK246_Aque   LHFLQKELKIIHRDVKPSNILVSKVGEFKLCDFGISGKLVDSIARTMDVGCRPYMAPERI
                * .*:   : :***:******:   * .*******.* *  * * : : **  *:****:

mkk-4_Cele      TS---SDKYDVRSDVWSLGITLYEIATGKFPYQ--EWN--SLFDQIATVVSGDPPILHPD
VZC374L.1_Cele  EN---MDKYDIRSDVWSLGITLYEIATGVYPYR--GWS--NQMEHIEIVVNGDSPILLQN
ZC449.6_Cele    APN--GDGYDIKSEVWSLGITMVEVANGKYPYD--GFMDAPILDQVRMVVYGDPPILDSD
Mkk4_Dmel       DPER-AKGYDVRSDVWSLGITLMEVATGNFPYR--KWD--SVFEQLCQVVQGEPPRLLTS
MAP2K4_Mmus     DPSASRQGYDVRSDVWSLGITLYELATGRFPYP--KWN--SVFDQLTQVVKGDPPQLSNS
MAP2K4_Hsap     DPSASRQGYDVRSDVWSLGITLYELATGRFPYP--KWN--SVFDQLTQVVKGDPPQLSNS
MKK4_Spur       DPFQSRPGYDIRSDVWSLGITMYEVATGEFPYP--KWN--SVFEQLSQVVKGDPPRLKHN
AqueK244_Aque   DEP--QHEYDHRSDVWSLGITMYEIAMGEFPYPVDTLR--SIFGLIEMIVKGSPPRLTSD
AqueK245_Aque   YGG--QHKYDHRSDVWSLGITLCELATGEFPYP--PYR--NLFEQIKLVVEGAPPQLPDD
AqueK246_Aque   DPARACLGYTIQSDVWSYGITLVELAQGSFPYK--KWN--TIFDQLNAVVSGDPPSLPPE
                        *  :*:*** ***: *:* * :**          :  :  :* * .* *  .

mkk-4_Cele      SDDFHYSLPLVKFINTCLTKDRRHRPKYDTLKSFDFY
VZC374L.1_Cele  MHNLHYTDPLCRFINTCLRKNKDDRPKYVNLKTFSFY
ZC449.6_Cele    ---HEVSMSMKRFIALCTIKDRNLRASFDDLKK---T
Mkk4_Dmel       YNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFI
MAP2K4_Mmus     -EEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFI
MAP2K4_Hsap     -EEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFI
MKK4_Spur       -DFYSYSEDFISFVNKCLTKDEKYRPKYKNLLEYKFI
AqueK244_Aque   ----RFSGEHKDFVAQCLTKSRDSRPRYKDLNAHSFI
AqueK245_Aque   ---GTFSEDFRDFVSKCLTKERDERPRYEVLNGHKFI
AqueK246_Aque   ----NFTRELREFTAACLVKDSDQRPNYVQLQEKEFF
                      :     *   *  *.   *. :  *