Protein (view, download) , Domain (view, download)
MAP3K2_Mmus     MDDQQALNSIMQDLAVLHKASRPALSLQ---------------------------ETR-K
MAP3K3_Mmus     MDEQEALDSIMKDLVALQMSRRTRLSGY---------------------------ETM-K
MAP3K2_Hsap     MDDQQALNSIMQDLAVLHKASRPALSLQ---------------------------ETR-K
MAP3K3_Hsap     MDEQEALNSIMNDLVALQMNRRHRMPGY---------------------------ETM-K
MEKK2_Spur      MRFQRALEIITLTLAPAAVSAHSAFQGIILPVDPAADSNQVISEITDNLISLRVQGNRNR
AqueK227_Aque   MADGQLPSIEAGDR----------------------------------------------
                *   .  .

MAP3K2_Mmus     AKPS-SPKK-------------------------------QNDVRVKFEHRGEKRILQVT
MAP3K3_Mmus     NKDTGHPNR-------------------------------QSDVRIKFEHNGERRIIAFS
MAP3K2_Hsap     AKSS-SPKK-------------------------------QNDVRVKFEHRGEKRILQFP
MAP3K3_Hsap     NKDTGHSNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIAFS
MEKK2_Spur      GRGS-SSSH-------------------------------STEIRVKFEFNGEKRILQIP
AqueK227_Aque   ------------------------------------------SVRRRVDEDIHRHLIAGF
                                                          .:* :.:   .::::

MAP3K2_Mmus     RPVKLEDLRSKSKIAFGQSMDLHYTNN----ELVIPLTTQDDLDKAVELLDRSIHMKSLK
MAP3K3_Mmus     RPVRYEDVEHKVTTVFGQPLDLHYMNN----ELSILLKNQDDLDKAIDILDRSSSMKSLR
MAP3K2_Hsap     RPVKLEDLRSKAKIAFGQSMDLHYTNN----ELVIPLTTQDDLDKAVELLDRSIHMKSLK
MAP3K3_Hsap     RPVKYEDVEHKVTTVFGQPLDLHYMNN----ELSILLKNQDDLDKAIDILDRSSSMKSLR
MEKK2_Spur      RPLKYDDILLKARTTFGQPVDMFLTNHNTTFSLLIPIRDQTDLNHAVEITDNNPNAKSLR
AqueK227_Aque   HPIDPV-------GGGGHNMKPPSLGHT---RTISGLSTQNELDFALSIYERFTGITSLR
                :*:             *: :.    .:         :  * :*: *:.: :.    .**:

MAP3K2_Mmus     ILLVVNGS-----------TQA-TNLEPSPSP--------------------EDLNNTP-
MAP3K3_Mmus     ILLLSQDRNHTSSSPHSGVSRQ-VRIKPSQSA--------------------GDINTIY-
MAP3K2_Hsap     ILLVINGS-----------TQA-TNLEPLPSL--------------------EDLDNTV-
MAP3K3_Hsap     ILLLSQDRNHNSSSPHSGVSRQ-VRIKASQSA--------------------GDINTIY-
MEKK2_Spur      LHLELATPGSSSN--NNGSSKRDLYDTAIRSSSTIPQSKHTSPSRSQSVPQDHHVHTSH-
AqueK227_Aque   VVLSRQPVTITAP--PT-----DVLSSASPTPDNLKEQVAKFTQRSQSEPYFMR-NTTEG
                : *                        .  :                        ..

MAP3K2_Mmus     --LGAE----RKKRLSVV--GPPNRDRSSPPPGYIPDELHQIARNGSFTSINSEGEFIPE
MAP3K3_Mmus     --QAPE----PRSRHLSV--SSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPE
MAP3K2_Hsap     --FGAE----RKKRLSII--GPTSRDRSSPPPGYIPDELHQVARNGSFTSINSEGEFIPE
MAP3K3_Hsap     --QPPE----PRSRHLSV--SSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPE
MEKK2_Spur      --DT------THKRYSTQEMPTRDNANPSPPPGYVPANAMVDMGHQSRLQTFGEGTFIPE
AqueK227_Aque   FRESPDMYFHTYHGFRNI--PEEPSRRDSPPPGFIDEPSTPVPLD---IGGKEGGKFIPE
                                          . *****::         .         * ****

MAP3K2_Mmus     SMDQ-MLDPLSLSSPENSGSGSCPSLDSPLDGE---SYP-KSRMPRAQSYPDNHQEFTDY
MAP3K3_Mmus     TSEQCMLDPLS--SAENSLSGSCQSLDRSADSP---SFR-KSQMSRARSFPDNRKECSDR
MAP3K2_Hsap     SMDQ-MLDPLSLSSPENSGSGSCPSLDSPLDGE---SYP-KSRMPRAQSYPDNHQEFSDY
MAP3K3_Hsap     TSEQCMLDPLS--SAENSLSGSCQSLDRSADSP---SFR-KSRMSRAQSFPDNRQEYSDR
MEKK2_Spur      PPEERIM--V-------SPNGSQQSLDKLRMGSHSLGSA-TGKMFKSQSCA-NHDDFEN-
AqueK227_Aque   VEDD-DLDNASPAS-------IPSTLDMSFISEENLSITGVDGLLR-------HHEYSLY
                  ::  :                 :**    .    .    . : :       :.:

MAP3K2_Mmus     DNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPR-ARRTQGTSFR-SPVSFSPTDHSL
MAP3K3_Mmus     ETQLYDKGVKGGTYPRRYHVSVHHKDYNDGRRTFPR-IRRHQGNLF-----TLVPSSRSL
MAP3K2_Hsap     DNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPR-ARRTQGTSLR-SPVSFSPTDHSL
MAP3K3_Hsap     ETQLYDKGVKGGTYPRRYHVSVHHKDYSDGRRTFPR-IRRHQGNLF-----TLVPSSRSL
MEKK2_Spur      -SQVGRGMIKGGTFPSRQSVKPSRIDTEDGRKTFPSRGKRPPLASMHDDQHSISDSLSSL
AqueK227_Aque   DDKEHGAESLTRTYPREKSYSMGELPSHTHKAM--------YGT---Y-PLNPPPKLHPP
                            *:* .   .  .      :                    .   .  .

MAP3K2_Mmus     STSSGSSVFTPEYD-DSRIRRRGSDIDNPTLT-----VTDISPPSRSPRAPTNWRLGKLL
MAP3K3_Mmus     STNGENMGVAVQYL-DPRGRLRSADSEN-ALT-----VQERNVPTKSPSAPINWRRGKLL
MAP3K2_Hsap     STSSGSSIFTPEYD-DSRIRRRGSDIDNPTLT-----VMDISPPSRSPRAPTNWRLGKLL
MAP3K3_Hsap     STNGENMGLAVQYL-DPRGRLRSADSEN-ALS-----VQERNVPTKSPSAPINWRRGKLL
MEKK2_Spur      GRSS-SSGISPDYDTDSSIPRRWTEGDLEGLAGGHPKSFNLADNTRSPRAPTNWQRGKLL
AqueK227_Aque   LSSHYHHKMVPGSS-DSR---RLQDSELPIQK-----LASLT-VSHKITAPARWSKGRLL
                  .     .      *.    *  : :            .    ::.  ** .*  *:**

MAP3K2_Mmus     GQGAFGRVYLCYDVDTGRELAVKQVQFN--------PESPETSKEVNALECEIQLLKNLL
MAP3K3_Mmus     GQGAFGRVYLCYDVDTGRELASKQVQFD--------PDSPETSKEVSALECEIQLLKNLQ
MAP3K2_Hsap     GQGAFGRVYLCYDVDTGRELAVKQVQFD--------PDSPETSKEVNALECEIQLLKNLL
MAP3K3_Hsap     GQGAFGRVYLCYDVDTGRELASKQVQFD--------PDSPETSKEVSALECEIQLLKNLQ
MEKK2_Spur      GQGAFGVVYVCYDADTGRELAVKQVPTE--------NSNTDARKEVQSLKQEIELLRNLQ
AqueK227_Aque   GTGAFGQVFLCTDLDTQMDMAVKVVDIDHIENIKPSLDSLKMSKEVRSFETEVQLLKNIH
                * **** *::* * **  ::* * *  :         .. .  *** ::: *::**:*:

MAP3K2_Mmus     HERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYL
MAP3K3_Mmus     HERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYL
MAP3K2_Hsap     HERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYL
MAP3K3_Hsap     HERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYL
MEKK2_Spur      HPRIVQYFGCLEE--NGTLSIFMEFMSGGSVKDELRLYGPLTDTVTRKYTRQILEGTAYL
AqueK227_Aque   HERVVGYYGTER--REGKLFIFMEYLAGGSIYQHLKNTGALSEALTRKYTRQILEGVAFL
                * *:* *:*  .   :  * ****::.***: :.*:  *.*:: :***********  :*

MAP3K2_Mmus     HSNMIVHRDIKGANILRDSTGNIKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVIS
MAP3K3_Mmus     HSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVIS
MAP3K2_Hsap     HSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVIS
MAP3K3_Hsap     HSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVIS
MEKK2_Spur      HDHHIVHRDIKGANVLR-SSGNVKLADFGASTRLQTIHSHITGMKTVTGTPYWMSPEIIN
AqueK227_Aque   HGMKIVHRDIKGANILRDSNGNVKLADFGASKRLQTIR---SGIGSVHGTPYWMAPEVIK
                *.  **********:** * **:**.*****.*****    :*: :* ******:**:*.

MAP3K2_Mmus     GE-GYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDF
MAP3K3_Mmus     GE-GYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDF
MAP3K2_Hsap     GE-GYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDF
MAP3K3_Hsap     GE-GYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDF
MEKK2_Spur      GE-GYGRRADVWSIGCTVVEMLTTKPPWADYEAMAAIFKIATKETEPVLPQSVSQDARNF
AqueK227_Aque   GDDPYTFKADIWSVGATVVEMLKCRPPWSDFEPTAAMFKIVMNDTKPDLPPHCSEQAHNF
                *:  *  :**:**:..******. :***:::*. **:***. : *:* **   *:  ::*

MAP3K2_Mmus     LKRIFVEA-KLRPSAEELLRHMFVH---YH
MAP3K3_Mmus     LRRIFVEA-RQRPSAEELLTHHFAQL--VY
MAP3K2_Hsap     LKRIFVEA-KLRPSADELLRHMFVH---YH
MAP3K3_Hsap     LRRIFVEA-RQRPSAEELLTHHFAQL--MY
MEKK2_Spur      LTLCFKKILADRPSAAELLRHNFVRTAPMD
AqueK227_Aque   IELCFIKDKNERPSAMDLLSHSFCSVFPNT
                :   * :    **** :** * *