RIOK2_Hsap M---------GKVNVAKLRYMSRDDFRVLT--AVEMGMKNHEIVPGSLIASIASLKH-GG
CG11859_Dmel M---------GKLNVTVLRYLTKEDFRVLT--AIEMGMKNHELVPGPLAAAIANLKS-GG
aSWK440_Cele M---------GRMNVSMMRYLEGDHFRVLI--AVEMGMKNHEVVPLALVSAIAGIHR-GG
RIO2_Scer M----------KLDTSHMRYLTTDDFRVLQ--AVEQGSRSHEVVPTPLIHQISGMRSQSG
RIOK2_Mmus M---------GKVNVAKLRYMSRDDFRVLT--AVEMGMKNHEIVPCSLIASIASLKH-GG
Rio2_Ddis M----------KLDPKALRYLSKDDFRTLV--AVEMGMKNHELVPVSLICTIANLKY-GG
27105_Tthe M----------RLDPSYLEYMTKDEFRVLT--AIEIGMRNHELVPMHLIERISHLKR-VC
RIO2_Spur M--------------AAERKISRDRFNAYCSDQLEMGMKNHEIVPSNLVASIANLRH-GG
CC1G_13652_Ccin M----------KLDATDLRYVTSEEFRVLT--AVEMGSKNHEIVPTHLIVQISGLRG-GG
AqueK050_Aque M---------GRLDVSLLRYLTSQDFRVLT--GVEMGMKNHEIVPAELISSIAGIRS-SG
RIO2-2_Smoe M----------KLDVNVLRYLSKDEFRVLT--AVEMGMKNHEIVPAELIDRIAGLKT-GG
RIO2-1_Smoe M----------KLDVNVLRYLSKDEFRVLT--AVEMGMKNHEIVPAELIDRIAGLKT-GG
GK011_Glam MSKFISLIAMPNLDVSYVDSLPPSYYRVLT--AVEMGMKNHDYVPLNLVISLSGIRH-GS
* : . :.. :* * :.*: ** * :: ::
RIOK2_Hsap CNKVLRELVKHKLIAWERTKTVQGYRLTNAGYDYLALKTLSSRQVVESVGNQMGVGKESD
CG11859_Dmel VHKLLKELCKHKLLAYERGKKYDGYRLTNTGYDYLALKSLTLRGSVSSFGNQIGIGKESN
aSWK440_Cele VARTLNDLCKHSLVAFERSKKFDGYRLTIRGYDYLALRALCSREVVGSVGNQIGIGKESD
RIO2_Scer TNRAISDLAKLSLISKMRNVKYDGYRLTYNGIDYLALKTMLNRDTVYSVGNTIGVGKESD
RIOK2_Mmus CNKILRELVKHKLIAWERTKTVQGYRLTNAGYDYLALKTLSSRQVVESVGNQMGVGKESD
Rio2_Ddis TKKSIQTLHKFKLLFHDG-RNYDGYKLTYLGYDFLALKTLVSRGVCSYVGNQIGVGKESD
27105_Tthe ASKVVKLLLKNKFIAHEN-KKFDGYKLTYLGYDYLALQVFIRRGAIKEVLGKVGCGKESD
RIO2_Spur CHKVLKELVRNKLIAWEH-GKVSGYRLTYPGYDYLALKALVARDAVASVGNQIGVGKESD
CC1G_13652_Ccin VNKLIGSLAKRNLISKVQNAKYEGYRLTYGGYDYLAMRALSKRDSMTSVGNQIGVGKESD
AqueK050_Aque CYKILRELAKHRLVTYEH-QKVCGYRLTNAGYDYLALRALVSKDVIYSVGNQIGVGKES-
RIO2-2_Smoe AYKNIRTLLRHKLVHHDS-TKYDGYRLTNLGYDFLAIKTMVNRGLIVGVGRQIGVGKESD
RIO2-1_Smoe AYKNIRTLLRHKLVHHDS-TKYDGYRLTNLGYDFLAIKTMVNRGLIVGVGRQIGVGKESD
GK011_Glam IPHIVQELLKIKLISHIG-APIDGYALTYMGYDYLSLNVMKRRGVISAIGSRIGVGKEAD
: : * : :: ** ** * *:*::. : : . :* ***:
RIOK2_Hsap IYIVANEEGQQFALKLHRLGRTSFRNLKNKRDYHKHR-HNVSWLYLSRLSAMKEFAYMK-
CG11859_Dmel IYVVADEEGTPICLKLHRLGRTCFRNVKAKRDYHGRR-HKASWLYLSRISATREFAYMS-
aSWK440_Cele VYVGGDPELNDLCLKFHRLGRTSFRKIKEKRDYHKKR-KSASWLYLSRLAAAKEFAFLK-
RIO2_Scer IYKVSDKNGNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAANKEYQFMS-
RIOK2_Mmus IYIVANEAGQQLALKLHRLGRTSFRNLKNKRDYHKHR-HNVSWLYLSRLSAMKEFAYMK-
Rio2_Ddis IYIVANDDNQEMVLKLHRLGRVSFKTIKNNRDYLKHR-KSASWLYLSRLAALKEFAYMK-
27105_Tthe IYKCVNENGDFVILKFTRLGRTSFRTIKKNRDYIQHR-TSYSWLYLSRLSAIKEYTFMD-
RIO2_Spur IYIVANDNDEQLALKLHRLGRTSFRKLKEKRDYLGKR-KSASWLYLSRLAAMKEFAFMK-
CC1G_13652_Ccin IYVVANAEGDEMVLKLHRLGRISFRSIKTKRDYMGKR-KSASWMYLSRLSAQKEYAFMK-
AqueK050_Aque -------------------GRTSFRKVKEKRDYHRHR-QTTSWLYLSRLAAQKEYTFMKC
RIO2-2_Smoe IFEVVAEDGQTLALKLHRLGRTSFRAVKSKRDYLKHR-SSFNWLYLSRLAALKEFAFMK-
RIO2-1_Smoe IFEVVAEDGQTLALKLHRLGRTSFRAVKSKRDYLKHR-SSFNWLYLSRLAALKEFAFMK-
GK011_Glam VYMAMRPNGQYVVLKLHKLGRTSFKTAKTKRDYMGPR-KSASWMYLSRLAAVREFGFMV-
** .*: : :*** .*::***::* :*: ::
RIOK2_Hsap ---------------------ALYERKFPVPKPIDYNRHAVVMELINGYPLCQIHHVE--
CG11859_Dmel ---------------------ALYDRGFPVPKPIDFNRHCVLMDLVKGWPMTQVHELL--
aSWK440_Cele ---------------------ALQERGFPVPKAVDVCRHLVVMQLVVGQTLCNVTHVE--
RIO2_Scer ---------------------MLYSKGFKVPEPFDNSRHIVVMELIEGYPMRRLRKHK--
RIOK2_Mmus ---------------------ALYERKFPVPKPIDYNRHAVIMELINGYPLCQIHHVE--
Rio2_Ddis ---------------------ALYENGFPVPTPIDYNRHCIVMSRARGYPLTQIVQLR--
27105_Tthe ---------------------LLHKNNFPTPIPIEQNRHGIVMSLINGVPMQNISEID--
RIO2_Spur ---------------------ALYDHGFPVPTPIDFSRHCVVMELMNAYPLNQVHTLD--
CC1G_13652_Ccin ---------------------VLYEHGFPIPKPIDQARHCVLMEFINAYPLRQISEVP--
AqueK050_Aque TCLMKNTFTVSISALFILSFQVLHERGFPVPQPMDVNRHCVVMELINGYPLCQVRSLS--
RIO2-2_Smoe ---------------------ALHEHGFPTPKAVDWNRHCVLMTLVPGYPLVQVKELK--
RIO2-1_Smoe ---------------------ALHEHGFPTPKAVDWNRHCVLMTLVPGYPLVQVKELK--
GK011_Glam ---------------------ALKERSFPVPDPISINRHCVCMSYVEGIPMHAIKDIDIE
* .. * * ... ** : * . .: :
RIOK2_Hsap DPASVYDEAMELIVKLANHGLIHGDFNEFNLILDES---------DHITMIDFPQMVSTS
CG11859_Dmel DAPQVYDDLMNLIVRLGNSGVIHGDFNEFNLMVTDA---------GKPILIDFPQMMSTS
aSWK440_Cele DAGALYDRLMALIVKMARHGVIHGDFNEFNLIMLED---------ERIVMIDFPQMVSID
RIO2_Scer NIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDE---NDCGFVVIDFPQCISIQ
RIOK2_Mmus DPASVYDEAMELIVKLGNHGLIHGDFNEFNLMLDKD---------DHITMIDFPQMVSTS
Rio2_Ddis HPSKVYSDLMNLIVKLASYGLIHGDFNEFNILINDE---------EEITLIDFPQMVSTS
27105_Tthe NPKYVFDQCFYLIKRLAENGLIHSDFNEFNLMVEDN---------GKVIMIDFPQMVSTK
RIO2_Spur DPASVYDDLMNLIVRLANHGLIHGDFNEFNLMLDDQ---------DQITLIDFPQMVSTS
CC1G_13652_Ccin SPGKLYSTLMDLIVRFAQAGLIHGDFNEFNILIREE--------TGEPVVIDFPQMVSTS
AqueK050_Aque KPEVLFNTLMALLVRLASHGLLHCDFNEFNIIISDE---------DKPTLIDFPQMVSTS
RIO2-2_Smoe NPALVFDTVISLIVRLAEHGLIHCDFNEFNLLIDDD---------EKVTMIDFPQMVSIS
RIO2-1_Smoe NPALVFDTVISLIVRLAEHGLIHCDFNEFNLLIDDD---------EKVTMIDFPQMVSIS
GK011_Glam AANLLAKDIHTQMVRMLRYGIVHGDCNEFNAIVQTSDPENCTPETTRVVIIDFPQVIQSI
: . : : *::* * **** :: :***** :.
RIOK2_Hsap HPNAEW----YFDRDVKCIKDFFMKRFSYES-----------------ELFPTFK-DIRR
CG11859_Dmel HENAEF----FFERDVNCVREMFRRKFGYES-----------------EDYPKFS-DLVR
aSWK440_Cele HPNAEY----YFDRDVTCVRTFFKRKFDYES-----------------EDWPKFD-EVER
RIO2_Scer HQDADY----YFQRDVDCIRRFFKKKLKYEPKPDSSMLDTEGFGDGYKYAYPDFKRDVKR
RIOK2_Mmus HPNAEW----YFDRDVKCIREFFMKRFSYES-----------------ELYPTFS-DIRK
Rio2_Ddis HLNAEM----YFDRDVTCIRVFFEKRFNFI-----------------GERWPKFK-DCQN
27105_Tthe HKNAQF----YFDRDVECIHVFFERRFNYQ-----------------ITDTLDFN-KIAR
RIO2_Spur HENAEW----YFNRDVQCVVDFFNRRFNYKS-----------------ELYPKFS-DITC
CC1G_13652_Ccin HENAEW----YFNRDVECIRTFFRRRFRYESN-----------------LYPRFK-RTMA
AqueK050_Aque HPDAARYTINYFERDVHCVAEFFSKRFQWRPD----------------EALPSLN-DIMK
RIO2-2_Smoe HRNAES----YFDRDVDCIYKFFLKRFNYVPGGNARTLQGIDNNVDEDDTRPDFE-NLAR
RIO2-1_Smoe HRNAES----YFDRDVDCIYKFFLKRFNYVPGGNARTLQGIDNNVDEDDTRPDFV-NLAR
GK011_Glam APEAEE----QFNRDVMSVEGFFNRRFGAD-----------------I-VLPRYN-EVMR
:* *:*** .: :* :::
RIOK2_Hsap -ED-------TLDVE----VSA-SG--YTKEMQADD--EL-L-HPLGPDD----------
CG11859_Dmel -ED-------DLDAE----VHC-TGYGFTKEMEQDL--LEE----YGMVD----------
aSWK440_Cele -KG-------NMDVL----LEA-SG--FTKKMALDL--NKA----YDEGD----FLAHCE
RIO2_Scer -TD-------NLDEL----VQA-SG--FSKKHPGDRGLETAV-ESMRNAV----------
RIOK2_Mmus -ED-------SLDVE----VSA-SG--YTKEMQADD--EL-L-HPVGPDD----------
Rio2_Ddis -IH-------SLDVE----ISA-SG--FTRDMEKEF--QDLS-K-QQDDDEINNN-----
27105_Tthe -LN-------DLDVQ----VKA-SG--FIKKEIKNI--DDFDIDLRGSDD----------
RIO2_Spur -EK-------TLDVD----VAA-SG--FSKEMEQSL--EEGT-DALKMDG----------
CC1G_13652_Ccin -EGSADGNDFRLDVI----VEA-SG--FSKNDMKV--LEEYM-EAADLEE----------
AqueK050_Aque -VA-------SLDVE----VNA-SG--AIKEKSAGV--E---------------------
RIO2-2_Smoe TAG-------ALDKE----LAA-SG--FTHQNQEDL------------------------
RIO2-1_Smoe TAG-------ALDKE----LAA-SG--FTHQNQEDL------------------------
GK011_Glam -QI-------SEEELVGQRIDATEA--FVKEMVAKY--D--------PD-----------
: : . . :.
RIOK2_Hsap ----KNIETKEGSEFSFSDGEVAEKAEVYGSENESERNCLEESEGCYCRS-S-GDPEQIK
CG11859_Dmel ----QADEEDEGEDLEEEEEPPTLVTAA-SVEIDECRRQVENE---VIYS-E-AKPTQKS
aSWK440_Cele QELRNRQEEDLGEDEDDSDDSKSM-EDI-QEEPEDLEKDHEEL---Q-AQ-E---NTVKQ
RIO2_Scer ----YNSD-DDMSND-EAEEENGEG-D------YSEEDE---------------------
RIOK2_Mmus ----KITETEEDSDFTFSDEEMLEKAKVWRSELEKEADPADESGGSWCCS-S-TDSKQIK
Rio2_Ddis ----DSDENDEDDDEDDDDDDENND------DDENNDNNIE-------------------
27105_Tthe ----DGDDD-NSDDENEQNDLDKNI------EQEDSDNEIEES-NKRIQNLNILNDEDIS
RIO2_Spur ----DC-EDDETDEEDEEEEGVVEE-------MKNPHDGLQDS---------------GS
CC1G_13652_Ccin ----EGTGDEEDESE-ESEEEEEEE--------EEEEEEGEES--------E--------
AqueK050_Aque -------EENEGEEEESKEFECSLASHVKGIHITD-------------------------
RIO2-2_Smoe ------------------------------------------------------------
RIO2-1_Smoe ------------------------------------------------------------
GK011_Glam -------------EELE---------------IKEGDEAVDEC-SNS-------------
RIOK2_Hsap EDSLSEESADARSFEMTEFNQA---LEEIKGQV-----VENNSVTEF-SEEKNRTENYNR
CG11859_Dmel DDAVRRYIESCTQ-YLGNLS-VGPEVPDQTMPKKLDISLPAETPDVIPFEAETSATNTVE
aSWK440_Cele QKIVLSQTTRFTD-WLSDA-------TNQLEAV---------DLDALKSEEGYKDIELPP
RIO2_Scer ---------------------------------------------------YYDSELDN-
RIOK2_Mmus DGGLPEESAHVSSFEVTALSQA---VEEMERQV-----LPHRSVTEF-SEESRRTENDG-
Rio2_Ddis -NENEENIKKSSKVNK---KEVGKEIKK----------------------EEEENNNSE-
27105_Tthe QDENEEEQKNNKKQKK---HHLKKQSK-----------------------SKSKKQNQE-
RIO2_Spur EDKNSEEVQSIREDDTGGMSGVGQDNDDQEHC------IMV--MDGN-EQEQSG------
CC1G_13652_Ccin EGGLS---------------------------------MPAQ--------RTYDGPSEG-
AqueK050_Aque EDKLRENVSEFDSISSIPLDEIPLES-----------------------EDKDYVNN-K-
RIO2-2_Smoe ------------------------------------------------------------
RIO2-1_Smoe ------------------------------------------------------------
GK011_Glam ----------------------------------------------------------M-
RIOK2_Hsap QDGQRVQGGVPAG--SDEYEDECP-------------HLIALSSL-NREFR--PFRDEEN
CG11859_Dmel EDV-K----SI--SSNDLDTDEVP-------------ELVGLDPN-SRMYR--LKMVEQM
aSWK440_Cele EDF-K----RPADSENDDENDEDE-------------EE--GEEE-DADGH--VAVEEQV
RIO2_Scer ESS-E----DDSE--DAQEEENER-------------IIEAL------------------
RIOK2_Mmus QPGQR----SPAG--SEDCDDEPP-------------HLIALSSV-NREFR--PFRDEES
Rio2_Ddis EED--------EE--EEEEEDSDSE-ESVEDNTPVIEEFKGLSLNKNRDFKFSNLKDEDQ
27105_Tthe QEG--------KD--GEDDEDNQKNNFSPDLSEISIEDLKELQK-VNQDL-FS---DDDN
RIO2_Spur -----------KE--KENHSDDDD-------------DLEDIGAS-NKQYR--PHRSEAS
CC1G_13652_Ccin ESR-Q----KTSE--STQQEDGTP-------------DISVL------------------
AqueK050_Aque EDTLE----YISD--SEEY-----------------------------------------
RIO2-2_Smoe ------------------------------------------------------------
RIO2-1_Smoe ------------------------------------------------------------
GK011_Glam V-------------------------------------------------------DDDA
RIOK2_Hsap V-GAM--------------------NQYRT--RTLSITSSGS-AVSCSTIPPE-------
CG11859_Dmel L-ND---------------------------AR--SQRS---YSTTTSTIAPS-------
aSWK440_Cele A-KVV--------------------K-----KK--RVPS---GARSVASSAAT-------
RIO2_Scer -------------------------S----------------------------------
RIOK2_Mmus M-SSV--------------------TRHRT--RTLSVTSAGS-ALSCSTIPPE-------
Rio2_Ddis N-APIVLR--KEFIENL---DENQPTEPKK--EKVELTEEEK-QRRKEEKRQK-------
27105_Tthe EDDPLALNEVKDINGNIVVPEQKEKKKPKK--KMVDIANEQD-QDNKQDLKEKIYIKESE
RIO2_Spur M-SKA--------------------NAHSLNARSRNSDSISSYTSTSSTMNPA-------
CC1G_13652_Ccin -------------------------N--------ISRESSRS-ASP----EPD-------
AqueK050_Aque -------------------------------------E-SSS-EGEETSIASK-------
RIO2-2_Smoe ------------------------------------------------------------
RIO2-1_Smoe ------------------------------------------------------------
GK011_Glam DP--V-----------------DKSKEPRM--RKV------------VDIRQA-------
RIOK2_Hsap ---LVKQKVKRQLT----KQQKSAVRRRL-QKGEANIFTKQRRENMQNIKSSLEAASFWG
CG11859_Dmel ---VITDRIRRNMD----IKEKREQRKKCVAKGEASAVHRHRKENKDV----VKEYAGWD
aSWK440_Cele ---FTAEDVKRRLALD--RKRNKEKI-RLKVKGKQSAVGRNRKDNKDV----IAEYAG-W
RIO2_Scer ----------------------------------------SGVENLKM--D--KLGNYIL
RIOK2_Mmus ---LVKQKVKRQLT----RQQKAAARRRL-QKGEANVFTKQRRENMQNIKSSLEAASFWG
Rio2_Ddis ---MITDKVKRQL----GKTMR----EK-VS------VRNNV-KSRTK--KEVQAHI-SS
27105_Tthe LAEKAKAYIQRQV----EKQFK----QK-YK-----ILKKNT-KSSNS---NKVLAS-EY
RIO2_Spur ---LVRSKVRGNLK----KKQKAAVRHRLARKGEASQTTAKRRENRDTVNQS--LGSI-W
CC1G_13652_Ccin ---TVKDDIKARAAAEVSKRQNQQRRKYHSKKSVRNAGRPQGSKGKQDTRV--KLDS-FW
AqueK050_Aque ---DLKKQVKKTTL----KKHHAHLKQSS-KKSQRKLPTSSGRRGQKGNRLKIRQALS-D
RIO2-2_Smoe -----------------------------------------------------------D
RIO2-1_Smoe -----------------------------------------------------------D
GK011_Glam --------VQRQL----RKEQW----RR-IQ------HQRQS-KGTEK---HRDNYR-RD
RIOK2_Hsap E
CG11859_Dmel F
aSWK440_Cele I
RIO2_Scer E
RIOK2_Mmus D
Rio2_Ddis Y
27105_Tthe M
RIO2_Spur S
CC1G_13652_Ccin A
AqueK050_Aque W
RIO2-2_Smoe Q
RIO2-1_Smoe Q
GK011_Glam L