89234.m00107

Species: T.vaginalis
Alias: 89234.m00107, TvagK0874
External Links:
Annotation:

Classification

Group: Other
Family: VPS15

Sequence

Name Sequence Type Origin Length Description Download
89234.m00107.AA Protein None 969 None Fasta, JSON
89234.m00107.kin_dom Protein Kinase Domain None 170 None Fasta, JSON

Protein domain

Protein domains of 89234.m00107.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 89234.m00107.AA VPS15 86-296 26 2.3e-23 77.75 In-house 61-296 (296) Show / Hide
Range on Protein: 86-296
Range on HMM: 61-296/296
Sequence Identity: 26% (64 aa)

IIDYSNIIINDRYAFLIRPKKQYTLPQRLEEYPRLEEIEKRWVVFQIYSAISSLHSIN-LVHGALNPDNIFVDWDISTTVG------DLAPFKPTQIRAD
.  |. .|  |..| ..|     .|  |.   | |..|||.|. ||.  |.. .|  .  .||.. . || |      |..      | |.|||. .  |
CCPYQKVIETDKAAYMMRQYVKHNLYDRISTRPFLQMIEKKWIAFQTLCALEQCHKQGNVCHGDIKSENILV------TSWNWCYLTDFACFKPCYLPED

KPNVYHHYFSTSTRNGCYLAPEQII----TEDNVLD----------------PLFFSNLKISADLFSIGCIVYYLYT-G-THLFNFSTLIQFKEG--KFN
 |  .  .| || |. ||.|||  .      . ...                |  |  |. . | || ||..  |.. | . .|..| |  .. |   .|
NPADFTFFFDTSRRRTCYIAPERFVSNTEQDQDSNNGNMRDIHTDSIDRQQNPWLFGELTPAMDIFSAGCVIAELFCEGDQPPFDYSQLCKYRSGEYHPN

LDAKLQALPD-KIRNFARTLLDID-PNSRQEVNTSLSKYFPPCF
 .. ..   | .|||    ....| |  | .    |.|.  . |
REQIMEKIQDEHIRNLCHHMIQKDNPMKRMSCEEYLNKW--RGF

S_TKc 89234.m00107.AA S_TKc 23-292 15 4.5e-09 -43.81 SMART 1-231 (231) Show / Hide
Range on Protein: 23-292
Range on HMM: 1-231/231
Sequence Identity: 15% (46 aa)

ITVKNSIDSGTFLLTLDCVNQY-NEPLIVKAYEYTESLEKGNLGVDNSRKYFNHLTDKIQATQCIIDYSNIIINDRYAFLIRPKKQY---TLPQRLEEYP
 .. . | .|.|     |..   ..   .|               .. |.  . |         |. .  .. .  . ...         .| .......
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK---HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

R------LEEIEKRWVVFQIYSAISSLHSINLVHGALNPDNIFV-------DWDISTTVGDLAPFKPTQIRADKPNVYHHYFSTSTRNGCYLAPEQIITE
|      . | . | .. || .|.  .|| . .|  | |.||..       |  ... .                   ...  |      |.||| .   
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL-------------------TTFCGTP----WYMAPEVL---

DNVLDPLFFSNLKI-SADLFSIGCIVYYLYTGTHLFNFSTLIQFKEGKFNLDAKLQALPDKIRNFARTLLDIDPNSRQEVNTSLS--------KYF
               ..|  |.|||.| ...|  .|       ||  .          ..  ..| | .|. ||. |  .   |          .|
----------GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 89234.m00107.AA Ciliate-E2 220-281 17 4.1e-08 23.94 In-house 276-352 (365) Show / Hide
Range on Protein: 220-281
Range on HMM: 276-352/365
Sequence Identity: 17% (14 aa)

SADLFSIGCIVYYLYTGTHLFNFSTLIQFKEGKFNLDAKL---------------QALPDKIRNFART----LLDIDPNSR
..|..|.|.| |.. .| . |    ..| |..|.... .                . ....  .. .     .|. ||. |
KCDIWSLGVILYEMLFGKPPF----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKR

Kinase 89234.m00107.AA ERK7 120-157 39 4.3e-07 19.97 In-house 97-134 (292) Show / Hide
Range on Protein: 120-157
Range on HMM: 97-134/292
Sequence Identity: 39% (15 aa)

LEEIEKRWVVFQIYSAISSLHSINLVHGALNPDNIFVD
|..| |. ...|.  ||  .|| |..|  | | || .|
LKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLD

Kinase 89234.m00107.AA TBCK 130-157 39 1.7e-05 15.57 In-house 87-114 (346) Show / Hide
Range on Protein: 130-157
Range on HMM: 87-114/346
Sequence Identity: 39% (11 aa)

FQIYSAISSLHSINLVHGALNPDNIFVD
.|| ...| .|. ..||..| |.||  |
YQILCGLSYMHKHHIVHRFLHPHNIYLD

Kinase 89234.m00107.AA Ciliate-E6 131-157 40 3.1e-05 13.02 In-house 61-87 (154) Show / Hide
Range on Protein: 131-157
Range on HMM: 61-87/154
Sequence Identity: 40% (11 aa)

QIYSAISSLHSINLVHGALNPDNIFVD
|. .|.. ||| |.|.. . . |||.|
QLFHAVEYLHSKNYVLQNITLKNIFLD

Kinase 89234.m00107.AA IRE 222-240 55 6.8e-05 12.43 In-house 214-233 (292) Show / Hide
Range on Protein: 222-240
Range on HMM: 214-233/292
Sequence Identity: 55% (11 aa)

DLFSIGCIVYYLYT-GTHLF
| || ||..||..| |.| |
DIFSMGCVFYYVMTNGQHPF

Kinase 89234.m00107.AA Ciliate-E2a 222-281 24 0.0001 9.86 In-house 198-263 (275) Show / Hide
Range on Protein: 222-281
Range on HMM: 198-263/275
Sequence Identity: 24% (16 aa)

DLFSIGCIVYYLYTGTHLFNF----STLIQFKEGKFNLDAKL--QALPDKIRNFARTLLDIDPNSR
|..|.|.| | | .|. .|.      .|.| |. |.... .   . ...   .. . .|. ||. |
DMWSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKR

Kinase 89234.m00107.AA Ciliate-D1 222-240 42 0.000101 16.51 In-house 1-19 (19) Show / Hide
Range on Protein: 222-240
Range on HMM: 1-19/19
Sequence Identity: 42% (8 aa)

DLFSIGCIVYYLYTGTHLF
|..|.||| |.. .| . |
DIWSFGCILYEMLFGQPPF

Kinase 89234.m00107.AA Ciliate-E2-Unclassified 219-281 15 0.000312 10.61 In-house 249-340 (352) Show / Hide
Range on Protein: 219-281
Range on HMM: 249-340/352
Sequence Identity: 15% (14 aa)

ISADLFSIGCIVYYLYTGTHLFNFST-------------------LIQFK-EGKFNLDAKLQ-----ALPDKIRNFAR----TLLDIDPNSR
...| .| |.| |.. .|.. |.  .                   |.| . ..... .   .      ....  .| .     .|. .||.|
YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKR

Kinase 89234.m00107.AA PLK1 120-166 27 0.000371 9.27 In-house 96-142 (253) Show / Hide
Range on Protein: 120-166
Range on HMM: 96-142/253
Sequence Identity: 27% (13 aa)

LEEIEKRWVVFQIYSAISSLHSINLVHGALNPDNIFVDWDISTTVGD
. | | |. . ||  ..  ||  ...|  |   |.|.. ..   .||
ITEPECRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGD

Kinase 89234.m00107.AA PLK1 222-293 28 0.000553 8.69 In-house 181-253 (253) Show / Hide
Range on Protein: 222-293
Range on HMM: 181-253/253
Sequence Identity: 28% (21 aa)

DLFSIGCIVYYLYTGTHLFNFSTLIQ-FKEGKFNLDAKLQALPDKIRNFARTLLDIDPNSRQEVNTSLSKYFP
|..|||||.| |  |   |  ..| . ..  | |     . .    ... | .|| ||..| ...  |.. | 
DIWSIGCIMYILLFGQPPFETKCLKETYSRIKKNEYRIPSHISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF

Kinase 89234.m00107.AA Ciliate-E2-Unclassified 106-157 17 0.003651 6.85 In-house 104-178 (352) Show / Hide
Range on Protein: 106-157
Range on HMM: 104-178/352
Sequence Identity: 17% (13 aa)

KQYTLPQRLEEYPR-----------------LEEIEKR-----WVVFQIYSAISSLHSIN-LVHGALNPDNIFVD
.. .| | .....                  ..| . .         || .....||. |  .|  . |.||..|
EGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFD

Kinase 89234.m00107.AA IRE 131-157 40 0.106987 1.16 In-house 124-150 (292) Show / Hide
Range on Protein: 131-157
Range on HMM: 124-150/292
Sequence Identity: 40% (11 aa)

QIYSAISSLHSINLVHGALNPDNIFVD
|. . .. ||| | ||  |.| || ..
QCMNGLQHLHSQNIVHRDLKPHNILIH

Kinase 89234.m00107.AA Ciliate-E2 112-156 23 0.142127 1.15 In-house 131-194 (365) Show / Hide
Range on Protein: 112-156
Range on HMM: 131-194/365
Sequence Identity: 23% (15 aa)

QRLEEYP---RLEEIEKRWVVFQIYS---------------AISSLHSIN-LVHGALNPDNIFV
.|..| .   .. | | . .  || .               |. .||| |  .|  . |.||..
KRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF