Gene mes-1 (Nematode worm)

mes-1

Species: Nematode worm
Alias: F54F7.5, mes-1, CE28237, aSWK262
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: X: 11861223-11866103, WormBase Genetic Map location: X:6.52033,

Classification

Group: Other
Family: Worm1

Sequence

Name Sequence Type Origin Length Description Download
mes-1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 287 Kinase domain by global Sugen HMM Fasta, JSON
mes-1.AA Protein Genbank 966 None Fasta, JSON

Protein domain

Protein domains of mes-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase mes-1.AA Worm1 671-957 73 9.20000000001e-265 885.29 In-house 1-301 (301) Show / Hide 
Range on Protein: 671-957
Range on HMM: 1-301/301
Sequence Identity: 73% (222 aa)

ATVVDVVRRELYSLKVPKDYTPETISAMRKELEFLRTLAPHGNCRRFEGVVIGRWDDLPRQVIGILIENTRGGTLRNYIAAVGSVFR---NCSLATDHDS
.||||||||..||||.||||||.|.||||||||||.||.||.|||||.|||||||||.|.||||||.||.|||||.|||..||||||   .|...|||||
TTVVDVVRRHCYSLKIPKDYTPQTMSAMRKELEFLQTLPPHQNCRRFDGVVIGRWDDNPYQVIGILMENCRGGTLHNYIISVGSVFRRQVMCTPVTDHDS

FASQQD------MNSTQHP---FDKLSTEAD--ENNSKKVKIQEITDSLSIRFCQFAEQVSSALEHLHSAGSVHTRVTTLNIYLLHNYSDPFDMLPDQVV
|.||.|      |||||||   .||.||..|  .|....|.||...|..||||||||||.||||||||.||.|||||||.||||||||.||||||.||.|
FQSQHDDHPLRIMNSTQHPSSGYDKFSTKDDKAPNCHQDVDIQQHFDRVSIRFCQFAEQISSALEHLHCAGIVHTRVTTINIYLLHNYTDPFDMLCDQMV

KLGNFGFAVQNSEDVVLDDNLQPPEVIKGEKYEARGDIWQFGLCLAEMCSLGDLEQSEVGTLKSGHDTFKNLPSTQVLRDAAKRCLSARTRPSASDLCGV
|||||||.||||.||..|.||||||||||.||||||||||||.||||||||||..||.....|||||.|.|||||.||.|||||||.||.||||||||||
KLGNFGFSVQNSDDVIIDQNLQPPEVIKGKKYEARGDIWQFGTCLAEMCSLGDPYQSQKQIPKSGHDEFDNLPSTCVLQDAAKRCLNARNRPSASDLCGV

F
|
F
TyrKc mes-1.AA TyrKc 656-957 13 3e-08 -89.25 SMART 1-280 (280) Show / Hide 
Range on Protein: 656-957
Range on HMM: 1-280/280
Sequence Identity: 13% (49 aa)

HNFNERIEKQAY-------WLMATVVDVVRRELYSLKVPKDYTPETISAMRKELEFLRTL-APHGNCRRFEGVVIGR----WDDLPRQVIGILIENTRGG
  ... .   |.       |     ..|        |. |...   . ....|.. .. |   | |  |. ||..        . |  ..  . ..   |
ITLGKKLGEGAFGEVYKGTWK----IQVA------VKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH---G

TLRNYIAAVGSVFRNCSLATDHDSFASQQDMNSTQHPFDKLSTEADENNSKKVKIQEITDSLSIRFCQFAEQVSSALEHLHSAGSVHTRVTTLNIYLLHN
 |..|. . .                                                       ...|. |...  |.||| . .|    . |. . .|
DLKDYLRKHRPK------------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGEN

YSDPFDMLPDQVVKLGNFGFAVQNSED-------VVLDD----NLQ--------PPEVIKGEKYEARGDIWQFGLCLAEMCSLGDLEQSE----------
.          .|| . || .    .|        . .     .          .||.|.  |.    |.| || |. |....|.   ..          
H----------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQE

-VGTLKSGHDTFKNLP--------STQVLRDAAKRCLSA--RTRPSASDLCGVF
 .  .|.|.   .            .. . .  |.|  .    ||. |...  |
VIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase mes-1.AA TK-Unique 691-908 16 2e-06 18.5 In-house 43-236 (294) Show / Hide 
Range on Protein: 691-908
Range on HMM: 43-236/294
Sequence Identity: 16% (42 aa)

TPETISAMRKELEFLRTLAPHGNCRRFEGVVIGRWDDLPRQVIGILIENTRGGTLRNYIAAVGSV-------------------------FRNCSLATDH
|... ... ||..... | .| |  ...|. .   ..   .   |..|  ..|.|..|.   . .                            ..|..  
TDTDKQDFLKEIQMMKELGDHPNIVQCLGCCT---KSD--EPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYH--

DSFASQQDMNSTQHPFDKLSTEADENNSKKVKIQEITDSLSIRFCQFAEQVSSALEHLHS--AGSVHTRVTTLNIYLLHNYSDPFDMLPDQVVKLGNFGF
                                              || |. ...|.|.|   . || .. . |. | .          | |.|...||.
----------------------------------------------FAWQIACGMEYLASQRKKIVHRDLCARNVLLTE----------DKVCKICDFGM

A--VQNSEDVVLDDNLQ---------PPEVIK--GEKY-EARGDIWQFGLCLAEMCSLG
|  |..  . |.. . .         .||..|  .. |   ..|.| ||  . |...||
ARDVYT--NGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLG
Kinase mes-1.AA TKL 808-957 12 1.2e-05 16.32 In-house 133-364 (364) Show / Hide 
Range on Protein: 808-957
Range on HMM: 133-364/364
Sequence Identity: 12% (30 aa)

RFCQFAEQVSSALEHLHSAG--------SVHTRVTTLNIYLLHNYSDPF----DMLPDQVVKLGNFGFAVQNSEDVVLDDNL------------------
..|..| ........||| .         .|   .. || .  |. .      .   | ..|.. ||..  .|..    |.                   
QRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMT

-------QPPEVIKGE----------------KYEARGDIWQFGLCLAEMCS--LGDLEQS--------------EVGTLKSGHDTFKNLPS--------
        .|||..|.                .|  . |.. ||..| |...  .   ..               ..  .|. . . .. ..        
QCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPC

TQV---LRDAAKRCLSA--RTRPSASDLCGVF
...   ... ...| ..  . |||....   .
PDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase mes-1.AA NEK2 880-907 46 1.7e-05 14.31 In-house 233-260 (319) Show / Hide 
Range on Protein: 880-907
Range on HMM: 233-260/319
Sequence Identity: 46% (13 aa)

PEVIKGEKYEARGDIWQFGLCLAEMCSL
||...| ||  . |||  |  . |||.|
PEQMHGQKYNEKSDIWSVGCLIYEMCAL
Kinase mes-1.AA Delta 880-904 52 6.1e-05 13.73 In-house 169-193 (259) Show / Hide 
Range on Protein: 880-904
Range on HMM: 169-193/259
Sequence Identity: 52% (13 aa)

PEVIKGEKYEARGDIWQFGLCLAEM
||.|||.||..  | | ||  . ||
PEIIKGQKYNHSVDWWSFGVLMYEM
S_TKc mes-1.AA S_TKc 656-958 16 0.0001 -107.6 SMART 1-231 (231) Show / Hide 
Range on Protein: 656-958
Range on HMM: 1-231/231
Sequence Identity: 16% (53 aa)

HNFNERIEKQAYWLMATVVDVVRRELYSLKVPKDYTPETISAMRKELEFLRTLAPHGNCRRFEGVVIGRWDDLPRQVIGILIENTRG--GTLRNYIAAVG
  . . | | |.     ....   ... .|. |         .|.|.. |.    | |  .. .|          . . .  |   |  |.|. ||   |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRG

SVFRNCSLATDHDSFASQQDMNSTQHPFDKLSTEADENNSKKVKIQEITDSLSIRFCQFAEQVSSALEHLHSAGSVHTRVTTLNIYLLHNYSDPFDMLPD
.  ... .   |                                            . .. |. .|||..|| | .|  .   || | .           
RHGLRFPFPE-H-------------------------------------------ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----------

QVVKLGNFGFAVQNSEDVVLDDNLQ------PPEVIKGEKYEA-RGDIWQFGLCLAEMCS----LGDLEQSEVGTLKSGHDTFKNLPSTQVLRDAAKRCL
 ..|.. ||.| |        . .       .|||.   .|   . |.| .| .|.||..                   . .||..  .. ..|  ..||
-HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-----------QMQMMFKKIG-SPEAKDFIRKCL

S--ARTRPSASDLCG--------VFK
    . ||.| ..           . 
QKDPEKRPTA-EALQDEWDIKCHPWF
Kinase mes-1.AA NEK10 880-907 46 0.00011 11.11 In-house 189-216 (279) Show / Hide 
Range on Protein: 880-907
Range on HMM: 189-216/279
Sequence Identity: 46% (13 aa)

PEVIKGEKYEARGDIWQFGLCLAEMCSL
||... | |  . |.| || || .|| |
PEIVQSEPYGEKADVWAFGCCLYQMCTL
Kinase mes-1.AA Ciliate-E6 809-840 40 0.000186 10.5 In-house 55-86 (154) Show / Hide 
Range on Protein: 809-840
Range on HMM: 55-86/154
Sequence Identity: 40% (13 aa)

FCQFAEQVSSALEHLHSAGSVHTRVTTLNIYL
| .|. | ..|.|.||| . |.   |  ||.|
FFKFCCQLFHAVEYLHSKNYVLQNITLKNIFL
Kinase mes-1.AA NKF4 815-862 31 0.00024 9.28 In-house 144-189 (336) Show / Hide 
Range on Protein: 815-862
Range on HMM: 144-189/336
Sequence Identity: 31% (15 aa)

QVSSALEHLHSAGSVHTRVTTLNIYLLHNYSDPFDMLPDQVVKLGNFG
| ..|..|||. . .|   .  ||      ..  |. |  ||| . ||
QLAQAMAHLHKNHIIHRDLKPYNIIIVEGRKGQSDLEP--VVKVADFG
Kinase mes-1.AA MKC 879-904 46 0.000272 12.36 In-house 169-194 (260) Show / Hide 
Range on Protein: 879-904
Range on HMM: 169-194/260
Sequence Identity: 46% (12 aa)

PPEVIKGEKYEARGDIWQFGLCLAEM
.|| |... .    ||| || ||.||
SPEMIQQKQHSYPCDIWSFGICLLEM
Kinase mes-1.AA Ciliate-A2 809-825 47 0.000838 9.43 In-house 104-120 (272) Show / Hide 
Range on Protein: 809-825
Range on HMM: 104-120/272
Sequence Identity: 47% (8 aa)

FCQFAEQVSSALEHLHS
|. ||.|...|.|.||.
FVHFACQILDAIEYLHN
Kinase mes-1.AA Ciliate-E6 884-898 26 0.086338 1.91 In-house 140-154 (154) Show / Hide 
Range on Protein: 884-898
Range on HMM: 140-154/154
Sequence Identity: 26% (4 aa)

KGEKYEARGDIWQFG
.... .. ||||  .
YKVNWTQEGDIWSVC
Kinase mes-1.AA Ciliate-A2 879-901 33 0.101114 2.12 In-house 175-210 (272) Show / Hide 
Range on Protein: 879-901
Range on HMM: 175-210/272
Sequence Identity: 33% (12 aa)

PPEVIKG------EKYEAR-------GDIWQFGLCL
|||...       |.  .        |||| || ||
PPECHFQCFEMNGEQNKKQQIKQTFMGDIWAFGICL