BCR

Species: Human
Alias: BCR1, CML, D22S11, PHL, D22S662, ALL, FLJ16453, FGFR1/BCR, BCR/FGFR1, BCR
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 22q11.1-q11.23,

Classification

Group: Atypical
Family: BCR

Sequence

Name Sequence Type Origin Length Description Download
BCR.NA RNA Sugen Kinome 6927 None Fasta, JSON
BCR.AA Protein Sugen Kinome 1271 None Fasta, JSON

Protein domain

Protein domains of BCR.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Bcr-Abl_Oligo BCR.AA Bcr-Abl_Oligo 1-79 78 4.5e-62 217.34 Pfam 1-89 (89) Show / Hide
Range on Protein: 1-79
Range on HMM: 1-89/89
Sequence Identity: 78% (70 aa)

MVDPVGFAEAWKAQFPD--SEPPRMELRSVGD--------IEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRWGFRR
|||||||||.|.|||||  .|||.||.||.||        .|||||||||||||||||||.|||||||||||||||.||||||||||||
MVDPVGFAEWWRAQFPDWFQEPPYMECRSMGDRWVSLRSPMEQELERCKASIRRLEQEVNKERFRMIYLQTLLAKERKSYDRQRWGFRR

RhoGEF BCR.AA RhoGEF 502-690 32 3.6e-54 187.81 Pfam 1-196 (196) Show / Hide
Range on Protein: 502-690
Range on HMM: 1-196/196
Sequence Identity: 32% (65 aa)

VLSGILASEETYLSHLEALLLPM-KPLKAAATTSQPVLTSQQIETIFFKVPELYEIHKEFYDGLFP--RVQQW--SHQQR--VGDLF--QK-LASQLGVY
|.  |. .|..|. .|. ..    |||. .|  ..|.|....|.|||  ..|.||.|..|.. |    |...|  ...|.  .||.|   | ... . .|
VIQEIIQTERSYVRDLNIIIEHYMKPLRNCA--NPPILSPDEIHTIFSNIEEIYEFHQRFLEDLEERDRMECWNPPDYQCQTIGDCFMFLKHMFPFFKMY

RAFVDNYGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPT-TKNS-LETLLYKPVDRVTRSTLVLHDLLKHTPA-SHP-DHPLLQDALRISQNFLSS
  .. ||  ||.. .||.. | .|... ......     .||   . . |. .| ||| |..|  | | .||||||  .|| |.. || ||   ....|.
SEYCNNYPKAMKLLKKCRKKNPKFQQFLKWCEKE-----NDPCCRRLDLLQSFLIKPVQRIPRYPLLLKELLKHTPPCDHPKDYEDLQKALEAMKEVASH

INE
|||
INE

RhoGEF BCR.AA RhoGEF 502-690 26 2.7e-52 180.99 SMART 1-211 (211) Show / Hide
Range on Protein: 502-690
Range on HMM: 1-211/211
Sequence Identity: 26% (57 aa)

VLSGILASEETYLSHLEALLL-PMKPLKAAATTSQ-PVLTSQQIETIFF-KVPELYEIHKEFYDGLFPRVQQWS---------------HQQRVGDLFQK
|.  ....|..|. .|. ..   |||..  ..... |.|. .....||.  ..|.||.|..|.| |  |...|                ...|.||.|.|
VIQELMQTERNYVRDLHIIVQHYMKPMQKEEKCHKLPFLSPDEVNHIFGPNIEEIYEFHRRFLDELEERIEEWDCSMDWKSFRNFQIRDICDRIGDCFMK

L---ASQLGVYRAFVDNYGVAMEMAEK--CCQANAQFAEISENLRARSNKDAKDP-TTKNSLETLLYKPVDRVTRSTLVLHDLLKHTPASHPDHPLLQDA
.   .... .| ....|.  |... .|  ||. | .|..  . . ...| . .     . .||..| ||. |.|.  | |...|||||..|||.  ||.|
WFHAEEMFKMYSEYCNNHPYALKHLKKWMCCKKNPRFQKFCKECESHPNCRSN-SEH-RLTLEDFLIKPMQRITKYPLLLKEILKHTPPDHPDYEDLQKA

LRISQNFLSSINE
|..........||
LDCMKDVAQHCNE

PH BCR.AA PH 709-868 14 8.3e-11 43.15 SMART 1-82 (82) Show / Hide
Range on Protein: 709-868
Range on HMM: 1-82/82
Sequence Identity: 14% (23 aa)

LLKDSFMVELVEGARKLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREKRANKGS
..|  ..  .    .| |...||.| |...| |          ..|  |||.|..... .                                        
VIKEGWLYKKSK-RWKKRWFVLFNDCLYYYKDK----------KPKGSIPLSDCTVRE-P----------------------------------------

KATERLKKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFLISSDYERAEWRENIREQQKKC
                        .|..|. .. .|.|  .|. |. || . |.. ....
------------------------CFEIHH-DR-TYYFQCESEEEMQEWMQAIQKAIHNN

PH BCR.AA PH 834-866 21 0.011822 12.22 Pfam 61-92 (92) Show / Hide
Range on Protein: 834-866
Range on HMM: 61-92/92
Sequence Identity: 21% (7 aa)

FRVHSRNGKSYTFLISSDYERAEWRENIREQQK
|.... ....|.|  .|. |. .| . |.. ..
FQIRT-DRRTYYFQAESEEEMNDWMQAIQSACR

PH BCR.AA PH 709-764 24 0.116308 8.64 Pfam 1-49 (92) Show / Hide
Range on Protein: 709-764
Range on HMM: 1-49/92
Sequence Identity: 24% (14 aa)

LLKDSFMVELV-EGARKLRHVFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSF
. |  ..  ..  . .| |...||.. |.. | .|        |..| .||| |...
VIKEGWLHKKGKRKSWKKRWFVLFNNCLYYYKDDK--------YRPKGSIPLSDCQV

C2 BCR.AA C2 912-1017 15 2.3e-14 54.97 SMART 1-92 (92) Show / Hide
Range on Protein: 912-1017
Range on HMM: 1-92/92
Sequence Identity: 15% (19 aa)

FLNVIVHSATGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTA---EPNWNE---EFEIELEGSQTLRILCYEKCYNKTKIPKEDGESTDRLMGKGQVQ-
 |.| ...| . .   . |....           ||.| ..|     | |||   .|....   | ||. ....                ...|. ..  
TLTVHIIEARNLP---DPYVKVY-----------KTKVVKNTLSGFNPVWNEWMETFYFDVHP-Q-LRFEVWDH----------------DFIGHCCIPP

-------------LDPQALQDRDWQR
             |.    ..|. . 
NNPHWHQWDGCIHLSDIL-GYRH-WW

C2 BCR.AA C2 913-1002 21 3.8e-13 47.29 Pfam 1-90 (90) Show / Hide
Range on Protein: 913-1002
Range on HMM: 1-90/90
Sequence Identity: 21% (21 aa)

LNVIVHSATGFKQ-------SSNLYCTLEVDSFGYFVNKAKTRVYRDTAEPNWNEEFEIE--LEGSQT-LRILCYEKCYNKTKIPKEDGESTDRLMGKGQ
|.| |..| . .        .|. |......  .  ..| ||.| ..|  | |||.|...  ..  |  ||. .. ..  .           | ..|. .
LRVHVIEARNLPPMDWDKNGKSDPYVKVYLGGDPKDTQKYKTKVIKNTLNPVWNETFTFDVPPPDLQHTLRFTVWDWDRFGR----------DDFIGQCC





RhoGAP BCR.AA RhoGAP 1065-1249 34 1.4e-72 248.34 SMART 1-193 (193) Show / Hide
Range on Protein: 1065-1249
Range on HMM: 1-193/193
Sequence Identity: 34% (72 aa)

SKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDV-----------SVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIA
| .| |||.|.|.||..||...||||..|... ||.|..||| ... .           ... .| ||...|| ||.|||||||||.|.| |..| | . 
SHIPIIVRKCIEYIEKHGMDTEGIYRKCGNQSRIQELRNAFDRGPD-DLCSTDNYITHEFNDWEEWDVHDVAGVLKQYFRELPEPLITFELYEEFIEAMK

L--------------SDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESKLPANPSQPITMTDSWSLEV
.              .|....  ....|. .||.... |. .|. ||.||||...||||..||||..|||||..|.               |.|.    .
CYQIEQTSRKQWNHSEDEEERIHALHQLISQLPPCHRNTLRYLM-HLNRVAEHSDVNKMNAHNLAICFGPTLFWPP---------------MMDMRHQNK

MSQVQVLLYF
. ....  |.
CVEFLIEHYD

RhoGAP BCR.AA RhoGAP 1068-1221 43 1.5e-72 248.14 Pfam 1-156 (156) Show / Hide
Range on Protein: 1068-1221
Range on HMM: 1-156/156
Sequence Identity: 43% (68 aa)

PYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAE--GIALSDPVAKESCML
| |||.|.|.||..|....||||||| .. |..|..||| .  ....  .. ||...|. ||.|||||||||||.|.|..| |     . |.  . ..| 
PMIVRKCIEYIEQHGLDTEGIYRVSGNKSRIKELREAFDRGPDVDLNDWEWHDVHDVASVLKQYFRELPEPLFTFELYEEFIEAMAAKIEDEEERIEAMR

NLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESKL
 |. .||..|. |. .|..||.|||. ..||||. ||||..|||.|..|....|..
ELIRKLPPPNYDTLRYLMRHLHRVAQHSDVNKMNAHNLAICFGPNLFWPPDDDSMD