Gene PDHK2 (Human)
PDHK2
Sequence
Protein domains of PDHK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| BCDHK_Adom3 | PDHK2.AA | BCDHK_Adom3 | 29-193 | 40 | 6.7e-89 | 306.44 | Pfam | 1-199 (199) | Show / Hide |
Range on Protein: 29-193 Range on HMM: 1-199/199 Sequence Identity: 40% (81 aa) SPLSMKQFLDFGSSNACEKT---SFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIME-F---------------LDKDPED---- .|||..|...||..|.|||| |. |...|||.|||....|...||. ....|..|.|..||.||. ...| | . |..|| TPLSLRQMMQFGRPNPCEKTLFKSAQFCHEELPIRLAHRIRELQNLPYGLNKMPHIQQVYNWYYQSFEELRECFPKPISELKHLRYYEPPPKTLEDWLHD -HRTLSQFTDALVTIRNRHN-DVVPTMAQGVLEYK-DTYGDDPVSNQ----NIQYFLDRFYLSRISI---RMLINQHTLIFD-GSTNPAH---PKHIGSI .. |.| | .|..||. .|||||||||||.| ..|| |..... .|||||||||.|||.| ||||.||...|. ...||.| |...|.| YNEK---FCDMLRDIKDRHDRNVVPTMAQGVLEWKCRYYGQDNQPDDLHWFQIQYFLDRFYMSRIGINFIRMLIGQHIALFEFNYHNPHHFEHPDYVGII DP .. CT |
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| Kinase | PDHK2.AA | PDHK | 240-363 | 83 | 1.3e-102 | 347.21 | In-house | 1-125 (125) | Show / Hide |
Range on Protein: 240-363 Range on HMM: 1-125/125 Sequence Identity: 83% (104 aa) YVPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTG-GTPLAGFGYGLPISRLYAK |||||||||||||||||||||||.||...|.|||||||.||.|||.|||||||||||||||.|||.|||||||.||..|. ..|||||||||||.||||| YVPSHLYHMLFELFKNAMRATVEHHENRKIYPPIKVMVTLGKEDLTIKMSDRGGGVPLRKIDRLFNYMYSTAPRPQMETSRAAPLAGFGYGLPICRLYAK YFQGDLQLFSMEGFGTDAVIYLKAL ||||||.|.||||.||||||||||| YFQGDLKLYSMEGYGTDAVIYLKAL |
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| Kinase | PDHK2.AA | PDHK | 240-363 | 70 | 4e-97 | 328.98 | In-house | 1-140 (140) | Show / Hide |
Range on Protein: 240-363 Range on HMM: 1-140/140 Sequence Identity: 70% (99 aa) YVPSHLYHMLFELFKNAMRATVESHESSL-ILPPIKVMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPT----PQP----------GTG-GTPL |||.|||||||||||||||||.|.||... ..||||||||||.|||.|||||||||||.|||.|||.|||||||. |.. .|. ..|. YVPMHLYHMLFELFKNAMRATMEHHEDRPYNYPPIKVMVALGDEDLTIKMSDRGGGVPHRKIDRLFNYMYSTAPRSTQDPRMSPLFGHLDMHETSRAAPM AGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLKAL .||||||||.|||||||||||||.||||.||||||||||| HGFGYGLPICRLYAKYFQGDLQLYSMEGYGTDAVIYLKAL |
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| Kinase | PDHK2.AA | HATPase_c | 240-363 | 25 | 3.4e-22 | 79.48 | Pfam | 1-120 (120) | Show / Hide |
Range on Protein: 240-363 Range on HMM: 1-120/120 Sequence Identity: 25% (33 aa) YVPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVPL------RKIERLFSYMYSTAPTPQPGTGGTPLAG--FGYGLP .| .|.... .| ||...| |. . |.| | .....| .| | |.| .|.|.| |.| | . | .|.|| GDPDRLHQVVWNLVDNAIKHTPEG-------GHITVRVHRDDDHVRITVEDNGPGIPPEMHSIAEDIPRIFEPFYRTDPD----SR-RKYGGGLTGLGLY ISRLYAKYFQGDLQLFSMEGFGTDAVIYLKAL |.| ... ..|.... | .| || ...|. ICRRIVEQHGGTIWVESEPGGGTTFTFTLPLE |
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| Kinase | PDHK2.AA | HATPase_c | 240-364 | 20 | 9.2e-16 | 59.61 | SMART | 1-130 (130) | Show / Hide |
Range on Protein: 240-364 Range on HMM: 1-130/130 Sequence Identity: 20% (29 aa) YVPSHLYHMLFELFKNAMRATVESHESS----LILPPIKVMVALGEEDLSIKMSDRGGGVPL------RKIERLFSYMYSTAP---TPQPGTGGTPLAG- | .|...| .| .|| ..| |.| .. . .. | . .| .| | |.| .|.|.| .|.|.. .. |. . . | GDPDRLRQVLWNLLDNAIKHTPEGHADPDLHDGKPGGGRITVRVH----RITVEDNGPGIPPEMHKSIEDIPRIFEPFYRTDDSPSRMCPDSRSRKYGGG -FGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLKALS .|.||.|.. ... ..|.... | ...|. LTGLGLSICKRIVEQHGGTIWVE------TTFTFTLPLER |
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