Gene RIOK2 (Human)

RIOK2

Species: Human
Alias: RIOK2, FLJ11159
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 5q14,

Classification

Group: Atypical
Family: RIO
Subfamily: RIO2

Sequence

Name Sequence Type Origin Length Description Download
RIOK2.NA RNA Sugen Kinome 3980 None Fasta, JSON
RIOK2.AA Protein Sugen Kinome 552 None Fasta, JSON
RIOK2.kin_dom Protein Kinase Domain None 247 None Fasta, JSON

Protein domain

Protein domains of RIOK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase RIOK2.AA RIO2 73-308 67 1.2e-205 689.48 In-house 1-260 (260) Show / Hide 
Range on Protein: 73-308
Range on HMM: 1-260/260
Sequence Identity: 67% (176 aa)

YRLTNAGYDYLALKTLSSRQVVESVGNQMGVGKESDIYIVANEEGQQFALKLHRLGRTSFRNLKNKRDYHKHRHNVSWLYLSRLSAMKEFAYMKALYERK
||||||||||||||||||||||.|||||||||||||||...||.|.||..|.||||||||.|.||.||||||||..||.||||||||||...|..||.|.
YRLTNAGYDYLALKTLSSRQVVYSVGNQMGVGKESDIYKCSNENGNQFIMKFHRLGRTSFHNIKNNRDYHKHRHQYSWMYLSRLSAMKEYQFMDMLYKRN

FPVPKPIDYNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKLANHGLIHGDFNEFNLILDESDH------ITMIDFPQMVSTSHPNAEWYFDRDV
||||||||||||.||||||||||.|||||...|..|||..|..||.||||||||.|||||||..|..||      ..||||||||||.|.||.|||||||
FPVPKPIDYNRHIVVMELINGYPMCQIHHHDNPPYVYDQCMCFIVRLANHGLIHCDFNEFNLMIDDNDHDENDCGFIMIDFPQMVSTQHQNAQWYFDRDV

KCIKDFFMKRFSYESELFP------------------TFKDIRREDTLDVEVSASGYTKE
.||..||||||.||...||                  .|.||.|.||||.||.|||..|.
DCIHRFFMKRFNYEPKPFPSMLDTEGFGDGYKYAYPDFFRDIQRTDTLDEEVQASGFNKK
Kinase RIOK2.AA RIO 73-301 43 3.3e-155 521.92 In-house 1-276 (276) Show / Hide 
Range on Protein: 73-301
Range on HMM: 1-276/276
Sequence Identity: 43% (119 aa)

YRLTNAGYDYLALKTLSSRQVVESVGNQMGVGKESDIYIVANEEGQ-----------QFALKLHRLGRTSFRNLKNKRD---YHKHRHN-VSWLYLSRLS
|..||..|..........|..||||||..|||||||||...||.|.           ..|.|.||.|||||...|..||   |.||||. ..|.|..||.
YEQTNDPYTRMIMYKMVNRGMVESVGNCIGVGKESDIYHCSNENGEDEKEDSKVIPTECAIKIHRTGRTSFKDRKKYRDGEFYFKHRHCKHNWRYMHRLW

AMKEFAYMKALYERKFPVPKPIDYNRHAVVMELING-------YPLCQIHHVEDPASVYDEAMELIVKLANHG-LIHGDFNEFNLILDESDH------IT
|.||...||.||...||.|.||||.||..|||.||.       ||.||||..|....||...|.....|..|. |.|.||||||.......|      ..
AEKEMRNMKRLYQSGFPCPEPIDYKRHVLVMEFINHDQMPAPKYPMCQIHEHENMKHVYHQCMCYMRRLYQHCRLVHCDFNEFNMMWHDGKHDENDCGFY

MIDFPQMVSTSHPNAEWYFDRDVKCIKDFFMKRFSYESELFPTFKDIR------------------REDTLDVEVS
||||||||...||.|.|||.||.||...||||||.||........|..                  |.||||.|..
MIDFPQMVEHDHPHALWYFRRDCKCVNMFFMKRFVYEPFPEREMFDFVGFGDGYKYAYPDFKRDVKRTDTLDHENM
Kinase RIOK2.AA RIO1 108-290 33 4.2e-93 290.82 Pfam 1-200 (200) Show / Hide 
Range on Protein: 108-290
Range on HMM: 1-200/200
Sequence Identity: 33% (67 aa)

DIYIVAN-EEGQ-QFALKLHRLGRTSFRNLKNKRDYHKH----RHNVSWLYLSRLSAMKEFAYMKALYERKFPVPKPIDYNRHAVVMELIN---GYPLCQ
..| ..  |.|. ..|.|..|.|.|.|.. | .|||...    .|  .|.|..|..|.|||...|..||. .|.|||||.|||..|||.|    |.|...
NVYHAYSMEDGKDECAVKIYRTGTTCFKKMKRYRDYDFRFRHRYHHHNWRYMVRMWAEKEFRNLKRMYEAGVPCPKPIDWNRHVLVMEFIGDKDGWPAPR

IHHVE--------DPASVYDEAME--LIVKLANHGLIHGDFNEFNLILDESDHITMIDFPQMVSTSHPNAEWYFDRDVKCIKDFFMKRFSYESELFPTFK
...||        .....|||...  ........||.|||..|.|..... .....||.||.|...||.|.....||...| .||.... .|   ...|.
LKDVEMELELSEEEAEEIYDEIIREYMRRMYQECGLVHGDLSEYNILVHDDGKPWIIDWPQAVEHDHPHALEFLERDCRNIINFFRRKGVDER--VMDFR

DI
.|
EI
RIO RIOK2.AA RIO 66-289 23 8.5e-54 185.96 SMART 1-253 (253) Show / Hide 
Range on Protein: 66-289
Range on HMM: 1-253/253
Sequence Identity: 23% (60 aa)

RTKTVQGYRLTNAGYDYLALKTLSSRQVVESVG--NQMGVGKESDIYIV----ANEEGQQFALKLHRLGRTSFRNLKNKRD-YHKHR---HNVSWLYLSR
  .   .|...  ......|...  | ..|...  .. ..|||...| .    . ..|  .| | .|...|.|.. .. .. . . .   |  .|....|
DKEDYATYEEVFDPRTRMTLYKMVNRGYIEEINNHGCISTGKEANVYHAMGGDFDKNGNECAVKIYRTSTTEFKRMWRYIQGDFRFKHGYHHINWRKMVR

LSAMKEFAYMKALYERKFPVPKPIDYNRHAVVMELING--YPLCQIHHVEDPA-------SVYDEAMELIVKLANHG-LIHGDFNEFNLILD-----ESD
|.| |||  .. .||  .|.||||...||..|||.| .  .|  .   ||.          .|.  || ..|... . |.|.|..|.|....     . .
LWAEKEFRNLQRMYEAGVPCPKPIAWRRHVLVMEFIGDDGWPAPRLKDVEWEEWEMDFKWEYYWQIMEYMRKMYHECHLVHADLSEYNMLYHDLEDENDC

HITMIDFPQMVSTSHPNAEWYFDRDVKCIKDFFMKRFSYES----ELFPTFKD
 . .||..| |...|| .. .. ||...| .|| ..  ..     |.|  ...
KVWIIDWSQSVECDHPMWLEFLERDIWNIINFFRRKGVDCDDIYREIFERITG
Rio2_N RIOK2.AA Rio2_N 9-91 59 2.8e-51 175.36 Pfam 1-84 (84) Show / Hide 
Range on Protein: 9-91
Range on HMM: 1-84/84
Sequence Identity: 59% (50 aa)

LRYMSRDDFRVLTAVEMGMKNHEIVPGSLIASIASLK-HGGCNKVLRELVKHKLIAWERTKTVQGYRLTNAGYDYLALKTLSSR
.||.|..||||||||||||.|||.|| .||..|. |. ||||...|..|.|||||. ...|  .|||||. |||||||.|...|
MRYLSKEDFRVLTAVEMGMRNHEWVPTELIHQISRLRSHGGCHYRLSRLCKHKLISHVQNKKYDGYRLTYGGYDYLALHTFVKR
Kinase RIOK2.AA Ciliate-C1 96-123 17 0.000104 7.54 In-house 2-30 (328) Show / Hide 
Range on Protein: 96-123
Range on HMM: 2-30/328
Sequence Identity: 17% (5 aa)

SVGNQMGVGKESDIYIVANEEGQ-QFALK
  . ..| |. ..  .. .. .| ..|.|
KIMKTIGHGYTCKVFYCKMPNNQKVYAVK
Kinase RIOK2.AA RIO1 224-276 33 0.000406 10.31 In-house 164-215 (225) Show / Hide 
Range on Protein: 224-276
Range on HMM: 164-215/225
Sequence Identity: 33% (18 aa)

LIHGDFNEFNLILDESDHITMIDFPQMVSTSHPNAEWYFDRDVKCIKDFFMKR
|.|.|  |.|..  . | . |||  | |   || .  .  .|.| . ..|||.
LVHADLSEYNMLYHN-DKLYMIDVSQSVEHDHPHSLEFLRMDCKNVNMYFMKH
Kinase RIOK2.AA APH 97-219 10 0.004851 11.25 Pfam 1-110 (248) Show / Hide 
Range on Protein: 97-219
Range on HMM: 1-110/248
Sequence Identity: 10% (15 aa)

VGNQMGVGKESDIYIVANEEGQ-QFALKLHRLGRTSFRNLKNKRDYHKHRHNVSWLYLSR---LSAMKEFAYMKALYERKF--PVPKPID-------YNR
 . . . | ... | . ... . .. |..                           | ..    .. .|.. ...| .. .  |||....       . .
WWRPISGGWSNRTYYRTTDD-RPRYVLRR---------------------------YPPPWWAEELHREHRWLRHLAAHGIPVPVPRVLWGCTDDEFHGW

HAVVMELINGYPLCQ-I-HHVEDPASVYDEAMELIVKL
.. .|| . | .| .    | ...  ..... .....|
PWYLMEWLPGEDLWRWHALHCAQRPALLEALARFLARL
Kinase RIOK2.AA APH 223-247 27 0.090836 6.91 Pfam 171-199 (248) Show / Hide 
Range on Protein: 223-247
Range on HMM: 171-199/248
Sequence Identity: 27% (8 aa)

GLIHGDFNEFNLILD---ESDHI-TMIDF
...||||.  |...|   . ...   ||.
CWCHGDFHPGNVMWDPRPDGGRVTGVIDW