Gene DhkE (Slime mold)

DhkE

Species: Slime mold
Alias: DDB0191265, DhkE, DdisK268
External Links: DictyBase Link ,
Annotation:

Classification

Group: Atypical
Family: HisK

Sequence

Name Sequence Type Origin Length Description Download
DhkE.AA Protein None 1699 None Fasta, JSON
DhkE.kin_dom Protein Kinase Domain None 8 None Fasta, JSON

Protein domain

Protein domains of DhkE.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PAS DhkE.AA PAS 325-391 14 3e-07 31.32 SMART 1-68 (68) Show / Hide 
Range on Protein: 325-391
Range on HMM: 1-68/68
Sequence Identity: 14% (10 aa)

KRFRNIFDTSSEALVIH-KNGLIIDVNSTFEKIFQIKQSDLINGTIWEYLPELES-FFQNTNGNSKYTN
 |.|.|...........  .| |...| .....| . . .||  ..|..... .  . .      .  .
ERYRAILENMPDGIWVWDHDGRITYWNPAACQMFGYSPEELIGQSWWDLIHPEDRNLERFQE-HQRLQQ
PAS DhkE.AA PAS 325-375 13 8.5e-05 18.49 Pfam 1-53 (120) Show / Hide 
Range on Protein: 325-375
Range on HMM: 1-53/120
Sequence Identity: 13% (7 aa)

KRFRNIFDT-SSEALVIH-KNGLIIDVNSTFEKIFQIKQSDLINGTIWEYLPE
...|.|... . .. ..  ..| |  .|...|..|......... .. .....
EHYRRIIENNLPDPIFVWDEDGWILYWNRAAERMFGWSREEVMGKMLYDLIHH
HisKA DhkE.AA HisKA 671-736 34 1.7e-22 81.98 SMART 1-89 (89) Show / Hide 
Range on Protein: 671-736
Range on HMM: 1-89/89
Sequence Identity: 34% (31 aa)

AKINFLTTVSHEVRTPINGILASVEILDG----------SQLDVTQ-------------RDFLSCIKQSADYLLDLITDILDFSKIEAG
|| .|| ..||| |||...|.. .|.|            . ||  |             |..|. |...||....|| |.||.|.||||
AKRQFLANMSHELRTPLTAIRGYAELLQDWYYKQRYHHWTDLDPEQRLPMLRREFNCEYREYLETIQREADRMQRLINDLLDLSRIEAG
HisKA DhkE.AA HisKA 671-736 44 3.9e-22 80.12 Pfam 1-69 (69) Show / Hide 
Range on Protein: 671-736
Range on HMM: 1-69/69
Sequence Identity: 44% (31 aa)

AKINFLTTVSHEVRTPINGILASVEILDG-SQLDVTQ--RDFLSCIKQSADYLLDLITDILDFSKIEAG
||  || ..||| |||...|.. .|.|   . ||  |  |..|. |...|.....|| |.||||.||||
AKRQFLANMSHELRTPLTAIRGYAELLQDYTDLDPEQMRREYLETIQREAQRMQRLINDLLDFSRIEAG
HATPase_c DhkE.AA HATPase_c 783-949 26 2.9e-34 121.46 Pfam 1-120 (120) Show / Hide 
Range on Protein: 783-949
Range on HMM: 1-120/120
Sequence Identity: 26% (47 aa)

GDPYRVKQCVLNFLSNAIKFTHK-GQVMVKVSIVDQINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKIVGFSNNNNNNNNNNNNGNNGILNFKLSFSVE
||| |..| |.|...||||.|.. |.. |.|.  |                                                           ....||
GDPDRLHQVVWNLVDNAIKHTPEGGHITVRVHRDD---------------------------------------------------------DHVRITVE

DSGVGIKE------EVLDCLFTPFHQLGG--SPRKYLG--TGLGLSISKKLTTLMGGEIGVKSVYGVGSAFSFTSILS
|.|.|| .      |... .| || . ..  . ||| |  |||||.|....  ..||.| | |  | |. |.||  | 
DNGPGIPPEMHSIAEDIPRIFEPFYRTDPDSR-RKYGGGLTGLGLYICRRIVEQHGGTIWVESEPGGGTTFTFTLPLE
HATPase_c DhkE.AA HATPase_c 783-950 22 2.3e-31 111.46 SMART 1-130 (130) Show / Hide 
Range on Protein: 783-950
Range on HMM: 1-130/130
Sequence Identity: 22% (45 aa)

GDPYRVKQCVLNFLSNAIKFTHK--------------GQVMVKVSIVDQINNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKIVGFSNNNNNNNNNNNNGN
||| |..| ..| |.||||.|..              |.. |.|.                                                       
GDPDRLRQVLWNLLDNAIKHTPEGHADPDLHDGKPGGGRITVRVH-------------------------------------------------------

NGILNFKLSFSVEDSGVGIKE------EVLDCLFTPFHQLGG---------SPRKYLG--TGLGLSISKKLTTLMGGEIGVKSVYGVGSAFSFTSILST
        ...|||.|.|| .      |... .| || . ..         . ||| |  |||||||.|..  ..||.| |       . |.||  |..
--------RITVEDNGPGIPPEMHKSIEDIPRIFEPFYRTDDSPSRMCPDSRSRKYGGGLTGLGLSICKRIVEQHGGTIWVE------TTFTFTLPLER
Kinase DhkE.AA HisK 783-944 22 9.4e-25 85.9 In-house 1-159 (164) Show / Hide 
Range on Protein: 783-944
Range on HMM: 1-159/164
Sequence Identity: 22% (47 aa)

GDPYRVKQCVLNFLSNAIKFTHKG------QVMVKVSIVDQINN-NNNNNNNNNNNNNNNNNNNNNNNNNNNNKIVGFSNNNNNNNNNNNNGNNGILNFK
 || |.|| ..|..|||.||| ||      .. .||.. .. || .  |                                                .|.
SDPNRIKQILINLISNALKFTQKGGIPFQGYIKIKVEQINTQNNIKY-N-S----------------------------------------------IFI

-----------------LSFSVEDSGVGIKEEVLDCLFTPFHQLGG----------SPRKYL---GTGLGLSISKKLTTLMG--------GEIGVKSVYG
                 . .||.|.|.|..|| .  .| .| .  .            .| .   | ||||.|...| ...|        ..| |.| .|
QKIQENMVQEQLQQKNLIQISVQDTGCGMPEEQQKKIFKMFGNIDDQHQMIKKTFNHQNKKNNQHGCGLGLTICNNLAKGLGPEHNQNGNRGIQVQSEVG

VGSAFSF
.|| |||
KGSTFSF
SprA-related DhkE.AA SprA-related 1212-1535 11 0.00014 17.42 Pfam 1-170 (321) Show / Hide 
Range on Protein: 1212-1535
Range on HMM: 1-170/321
Sequence Identity: 11% (43 aa)

NLPPLDISSSSNGSLNKSNRSNLLRKSSSVYSDHVAITRGMVQVNRSPRPSTPPPLFNLKGNNSNPNSTELNSTNSVNGNPNNDSTLETIEPLNISETVG
..    ..|.| .| . .... . | ..                                                                        
MIITNSYPSISYYSGSPQGTEAARRNNT------------------------------------------------------------------------

DLCSSGSVINNSNFIINNNFLTSSPYGSCLTPNSGTTSPSIPININNNDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSFKKLEPDNFSPPPSILIN
                                                                                                    
----------------------------------------------------------------------------------------------------

DNNIIPALNVTTPITISTSTSSSSSLLINNEINNKSTTSKRPSFIPPLDI-----------------------------------QSKKLIINTADENHK
                             .. |. ...|  .| ..|  .                                   |...    ...|. .
-----------------------------PRENIPQPSSSENSNNFPNSSSDATATSQTSTAVANDQSKQSEDGSTQPQFAKIFGQAQTQNGQASQEQQP

NNCIIDFE-------QIFGQDGKQQPQQQQQ-----QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQK
..   . |       ...||....| |.|..     ||.||.||| ||..||| |||.||||||||||||.
QASQQNDEDKQEQERDEVGQEQPEQQQAQAGFENATQQSQQRQQQDQQTRQQQAQQQEQQQQQQQQQQQQQ
REC DhkE.AA REC 1574-1691 20 7.2e-31 109.8 SMART 1-150 (150) Show / Hide 
Range on Protein: 1574-1691
Range on HMM: 1-150/150
Sequence Identity: 20% (34 aa)

RNALIVDDT----ELNRKVLA------QLLRRMDWS--------VSFAENGI-------EALKEITSER------------CFDIIFMDCQMP-------
 . |||||     ...|..|.      .||.....         |  | .|        |||. . ..|             .|.|.||..||       
MRILIVDDDPAMAPVIREMLRNYTVIQRLLEKEGYENKMWMVEVVDEA-DGETLMNEIWEALELLQEHRDKKEDATTDQSEPPDLIIMDIMMPGDPFEDG

ILDGFETTKLLRLRELENNWKPLNIVALSADSSSSFGQVCFDCGMNGYLGKPITLITLKDTL
 .||.|... .|            |..|.| .. .  . ... |...|. ||...  | ...
GMDGIELCRRIR-----------PIIMLTAHDDEEDRVRALEAGADDYITKPFDPEELLARI
Response_reg DhkE.AA Response_reg 1576-1692 28 3.7e-26 96.27 Pfam 1-115 (115) Show / Hide 
Range on Protein: 1576-1692
Range on HMM: 1-115/115
Sequence Identity: 28% (34 aa)

ALIVDDTELNRKVLAQLLR-RMDW-SVSFAENGIEALKEITSERCFDIIFMDCQMPILDGFETTKLL-RLRELENNWKPLNIVALSADSSSSFGQVCFDC
 ||||| .|.|..|.|.|. ...  .|  |..| |||. .  .. .|.|.||..|| .||.|... . | .. . .   . |....| .. .  . ... 
VLIVDDHPLMREGLRQILEQKEGYEVVAEADDGEEALEWWQEHH-PDLIIMDINMPGMDGLELCRRIRRQHP-HPQ---TPIIMCTAHGDEDDAVEALQA

GMNGYLGKPITLITLKDTLL
|.|.|. ||. .  |.. . 
GANDYITKPFDPDELHAAIR