Gene DhkM (Slime mold)
DhkM
Sequence
Protein domains of DhkM.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| HATPase_c | DhkM.AA | HATPase_c | 1194-1498 | 11 | 1.9e-21 | 76.85 | Pfam | 1-120 (120) | Show / Hide |
Range on Protein: 1194-1498
Range on HMM: 1-120/120
Sequence Identity: 11% (36 aa)
GDSQKIKQILLKLITNSIKATYE-GEVYIRVSLSSNLGVLKQQPIHHHRHHHRHHHHHHHHHHHHIIDDDDYDDDNDDDNNTEDSSSCCNIDELSDKIKD
|| ..|... |..|.||.|.| |.. .||.
GDPDRLHQVVWNLVDNAIKHTPEGGHITVRVHRDD-----------------------------------------------------------------
NQDENLELKKSNNDKIIENKENQENNNNNNNNNNNNNNNNNNNNNNSNNNTNININTNNNNDSNNNNCINNDLKNNNNNSNNNVNNNNNNINDSNNNNNS
----------------------------------------------------------------------------------------------------
NNNNINNNINNNINNNNNIKKKKKKNEFTVYFSVIDSGSGIDP------YSTNLLFQPFSLSS-YNVNSTNTDGE--FGLGLAICKQLSNLMNGEIKYET
| ..|.|.| ||.| . .|.|| .. . . | .||||.||.... ...|.| .|.
---------------------------DHVRITVEDNGPGIPPEMHSIAEDIPRIFEPFYRTDPD--SR-RKYGGGLTGLGLYICRRIVEQHGGTIWVES
EMEKGSVFELQVPMK
| ..|..|.. .|..
EPGGGTTFTFTLPLE
|
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| HATPase_c | DhkM.AA | HATPase_c | 1194-1499 | 10 | 1.2e-19 | 72.49 | SMART | 1-130 (130) | Show / Hide |
Range on Protein: 1194-1499
Range on HMM: 1-130/130
Sequence Identity: 10% (36 aa)
GDSQKIKQILLKLITNSIKATYE------------GEVYIRVSLSSNLGVLKQQPIHHHRHHHRHHHHHHHHHHHHIIDDDDYDDDNDDDNNTEDSSSCC
|| ..|.|. |..|.||.| | |. |.|...
GDPDRLRQVLWNLLDNAIKHTPEGHADPDLHDGKPGGGRITVRVH-------------------------------------------------------
NIDELSDKIKDNQDENLELKKSNNDKIIENKENQENNNNNNNNNNNNNNNNNNNNNNSNNNTNININTNNNNDSNNNNCINNDLKNNNNNSNNNVNNNNN
----------------------------------------------------------------------------------------------------
NINDSNNNNNSNNNNINNNINNNINNNNNIKKKKKKNEFTVYFSVIDSGSGIDP------YSTNLLFQPFSLSSY-------NVNSTNTDGE-FGLGLAI
...|.|.| ||.| . .|.|| . . .|... | .||||.|
-----------------------------------------RITVEDNGPGIPPEMHKSIEDIPRIFEPFYRTDDSPSRMCPDSRSRKYGGGLTGLGLSI
CKQLSNLMNGEIKYETEMEKGSVFELQVPMKC
||.......|.|..| ..|.. .|..
CKRIVEQHGGTIWVE------TTFTFTLPLER
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| Kinase | DhkM.AA | HisK | 1194-1491 | 12 | 8.8e-07 | 21.1 | In-house | 1-157 (164) | Show / Hide |
Range on Protein: 1194-1491
Range on HMM: 1-157/164
Sequence Identity: 12% (39 aa)
GDSQKIKQILLKLITNSIKAT------YEGEVYIRVSLSSNLGVLKQQPIHHHRHHHRHHHHHHHHHHHHIIDDDDYDDDNDDDNNTEDSSSCCNIDELS
| ..|||||. ||.|..| | ..| . | |..... ..
SDPNRIKQILINLISNALKFTQKGGIPFQGYIKIKVEQINTQNNI-------------------------------------------------------
DKIKDNQDENLELKKSNNDKIIENKENQENNNNNNNNNNNNNNNNNNNNNNSNNNTNININTNNNNDSNNNNCINNDLKNNNNNSNNNVNNNNNNINDSN
.. | .
------KY-N-S----------------------------------------------------------------------------------------
NNNNSNNNNINNNINNNINNNNNIKKKKKKNEFTVYFSVIDSGSGIDPYSTNLLFQPFS-----------LSSYNVNSTNTDGEFGLGLAICKQLSNLMN
. ...|..|. . . . ... . .||.|.| |... . .|..|. . . . |. | ||||.||..| ..
--------IFIQKIQENM-V-Q---E-QLQQKNLIQISVQDTGCGMPEEQQKKIFKMFGNIDDQHQMIKKTFNHQNKKNNQHG-CGLGLTICNNLAKGLG
--------GEIKYETEMEKGSVF
..|. . | ||| |
PEHNQNGNRGIQVQSEVGKGSTF
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| REC | DhkM.AA | REC | 1540-1652 | 16 | 1.3e-05 | 22.27 | SMART | 1-150 (150) | Show / Hide |
Range on Protein: 1540-1652
Range on HMM: 1-150/150
Sequence Identity: 16% (27 aa)
LKILVIDDN----PNIGKVIA------MHLEPFGFK--------VFQRTTFQ-------SAIYFFNERN-----------GDFNLILLDPLIP-------
..||..||. | | .... . || |. | . . . |. ..| . ... ||..| |
MRILIVDDDPAMAPVIREMLRNYTVIQRLLEKEGYENKMWMVEVVDEA-DGETLMNEIWEALELLQEHRDKKEDATTDQSEPPDLIIMDIMMPGDPFEDG
-SLVIDEIKQMKQDSSNIIKNPPLVIMCTAKLR-----KSLNVDNVHYLYKPIKREQLTVLS
|. ..... .||.||. . | . . |. ||...|.|
GMDGIELCRRIR-----------PIIMLTAHDDEEDRVRALEAGADDYITKPFDPEELLARI
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| Response_reg | DhkM.AA | Response_reg | 1542-1592 | 24 | 1.723011 | 4.32 | Pfam | 1-51 (115) | Show / Hide |
Range on Protein: 1542-1592 Range on HMM: 1-51/115 Sequence Identity: 24% (13 aa) ILVIDDNPNIGKVIAMHLE-PFGF-KVFQRTTFQSAIYFFNERNGDFNLILLD .|..||.| . .... || |. .| .. ..|. . |. . ||..| VLIVDDHPLMREGLRQILEQKEGYEVVAEADDGEEALEWWQEHH--PDLIIMD |
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| REC | DhkM.AA | REC | 2261-2379 | 23 | 6.7e-29 | 103.25 | SMART | 1-150 (150) | Show / Hide |
Range on Protein: 2261-2379 Range on HMM: 1-150/150 Sequence Identity: 23% (38 aa) VNILLVEDN----LVNAKIAM------TVLRKHNFR--------VELSKNGQ-------LAMERIKQSH-----------SSFDLILMDIHMP------- .||.|.|. |.... |.|.... |. .|. |.|.... . . .|||.||| || MRILIVDDDPAMAPVIREMLRNYTVIQRLLEKEGYENKMWMVEVVDEA-DGETLMNEIWEALELLQEHRDKKEDATTDQSEPPDLIIMDIMMPGDPFEDG VMDGITCSKLTRKFETEHGLKHLPIIALTADATTGHKNLCLEAGCNEFMSKPLDYALLISLL ||||. . | |||.||| .. .. .||||.. ...|| | |. . GMDGIELCRRIR-----------PIIMLTAHDDEEDRVRALEAGADDYITKPFDPEELLARI |
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| Response_reg | DhkM.AA | Response_reg | 2263-2380 | 29 | 5.6e-21 | 77.7 | Pfam | 1-115 (115) | Show / Hide |
Range on Protein: 2263-2380 Range on HMM: 1-115/115 Sequence Identity: 29% (36 aa) ILLVEDNLVNAKIAMTVLR-KHNF-RVELSKNGQLAMERIKQSHSSFDLILMDIHMPVMDGITCSKLTRKF-ETEHGLKHLPIIALTADATTGHKNLCLE .|.|.|. ..... . |. |. . .|.. .|. |.|.... | .|||.||| || |||.. |.|. ... ..|||..|| .. . .|. VLIVDDHPLMREGLRQILEQKEGYEVVAEADDGEEALEWWQEHH--PDLIIMDINMPGMDGLE---LCRRIRRQHP-HPQTPIIMCTAHGDEDDAVEALQ AGCNEFMSKPLDYALLISLLK || | . .|| | . |. .. AGANDYITKPFDPDELHAAIR |
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