22236

Species: Tetrahymena
Alias: TTHERM_00216110, 22236, PreTt22236, 18.m00262, 515, 3701.m00024
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Atypical
Family: HisK

Sequence

Name Sequence Type Origin Length Description Download
22236.AA Protein None 1127 None Fasta, JSON
22236.kin_dom Protein Kinase Domain None 115 None Fasta, JSON
22236.NA RNA None 3384 None Fasta, JSON

Protein domain

Protein domains of 22236.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
HisKA 22236.AA HisKA 402-470 19 7.4e-09 33.86 Pfam 1-69 (69) Show / Hide
Range on Protein: 402-470
Range on HMM: 1-69/69
Sequence Identity: 19% (14 aa)

YKDKLLASVCHDIKTPVCQLIQFLNFALEKGVNKIPEDS--RNFIEISLKTTGLLMYLISDILDYSQMKKK
 | ..||.. |...||.  .. ..  ...  . . ...   | ..|. .. .  .  ||.|.||.|..   
AKRQFLANMSHELRTPLTAIRGYAELLQD--YTDLDPEQMRREYLETIQREAQRMQRLINDLLDFSRIEAG

HisKA 22236.AA HisKA 402-470 15 1.4e-07 32.41 SMART 1-89 (89) Show / Hide
Range on Protein: 402-470
Range on HMM: 1-89/89
Sequence Identity: 15% (14 aa)

YKDKLLASVCHDIKTPVCQLIQFLNFALEKG-------VNKIPEDS-------------RNFIEISLKTTGLLMYLISDILDYSQMKKK
 |...||.. |...||.  .. ..  .....         . ...              | ..|. .. .  .  ||.|.||.|..   
AKRQFLANMSHELRTPLTAIRGYAELLQDWYYKQRYHHWTDLDPEQRLPMLRREFNCEYREYLETIQREADRMQRLINDLLDLSRIEAG

Kinase 22236.AA HisK 522-636 39 1.1e-56 194.61 In-house 1-164 (164) Show / Hide
Range on Protein: 522-636
Range on HMM: 1-164/164
Sequence Identity: 39% (64 aa)

NDSNRIKQVLINLISNALKFTQQG------RIIISIS----------------TIGEN--------SNLISISVQDTGIGMSEEIKAKLFQQYS------
.| |||||.|||||||||||||.|       | |...                .| ||        .||| |||||||.||.||.. |.|....      
SDPNRIKQILINLISNALKFTQKGGIPFQGYIKIKVEQINTQNNIKYNSIFIQKIQENMVQEQLQQKNLIQISVQDTGCGMPEEQQKKIFKMFGNIDDQH

-----TFNQEGL--NKNGIGLGLNNCKTIVGELGPT------SQFQVESVQNEGSIFTFQIYQN
     |||..    |..|.||||. |. ... |||.       ..||.| ...||.|.|.||.|
QMIKKTFNHQNKKNNQHGCGLGLTICNNLAKGLGPEHNQNGNRGIQVQSEVGKGSTFSFYIYNN

Kinase 22236.AA HATPase_c 522-636 28 1.2e-24 88.03 Pfam 1-120 (120) Show / Hide
Range on Protein: 522-636
Range on HMM: 1-120/120
Sequence Identity: 28% (36 aa)

NDSNRIKQVLINLISNALKFTQQ-GRIIISISTIGENSNLISISVQDTGIGMSE------EIKAKLFQQYSTFNQ--EGLNKNG--IGLGLNNCKTIVGE
.| .|..||. ||..||.|.|.. |.| ..... .   . ..|.|.|.|.|...      |  ...|. . .. .     .  |   |||| .|. || .
GDPDRLHQVVWNLVDNAIKHTPEGGHITVRVHRDD---DHVRITVEDNGPGIPPEMHSIAEDIPRIFEPFYRTDPDSR-RKYGGGLTGLGLYICRRIVEQ

LGPTSQFQVESVQNEGSIFTFQIYQN
.| |   .|||  ..|. ||| .   
HGGT--IWVESEPGGGTTFTFTLPLE

Kinase 22236.AA HATPase_c 522-637 23 2.7e-23 84.61 SMART 1-130 (130) Show / Hide
Range on Protein: 522-637
Range on HMM: 1-130/130
Sequence Identity: 23% (35 aa)

NDSNRIKQVLINLISNALKFTQQ--------------GRIIISISTIGENSNLISISVQDTGIGMSE------EIKAKLFQQYSTFNQ---------EGL
.| .|..|||.||..||.|.|..              ||| ....         .|.|.|.|.|...      |.  ..|. . .. .            
GDPDRLRQVLWNLLDNAIKHTPEGHADPDLHDGKPGGGRITVRVH---------RITVEDNGPGIPPEMHKSIEDIPRIFEPFYRTDDSPSRMCPDSRSR

NKNG--IGLGLNNCKTIVGELGPTSQFQVESVQNEGSIFTFQIYQNN
.  |   ||||  || || ..| | ...        . ||| .    
KYGGGLTGLGLSICKRIVEQHGGTIWVE--------TTFTFTLPLER

REC 22236.AA REC 1009-1121 21 8.5e-19 69.69 SMART 1-150 (150) Show / Hide
Range on Protein: 1009-1121
Range on HMM: 1-150/150
Sequence Identity: 21% (34 aa)

HNILIVDDN----QFNILALK-----LLISENENII--------VYQAENGE-------QAVQKAKQM-------------NFKLIFMDMQMP-------
..||||||.    . .  .|.      .. | |..         | .| .||       .|......              .. ||.||..||       
MRILIVDDDPAMAPVIREMLRNYTVIQRLLEKEGYENKMWMVEVVDEA-DGETLMNEIWEALELLQEHRDKKEDATTDQSEPPDLIIMDIMMPGDPFEDG

IMDGQTASQIIKQDLKIATPIISLTANEYTNEEKKQL-TMFEDFLNKPIQKQKVHEIL
 ||| .. . |.       ||| |||.       . |     |.. ||.. . . . .
GMDGIELCRRIR-------PIIMLTAHDDEEDRVRALEAGADDYITKPFDPEELLARI

Response_reg 22236.AA Response_reg 1011-1122 27 1e-17 66.03 Pfam 1-115 (115) Show / Hide
Range on Protein: 1011-1122
Range on HMM: 1-115/115
Sequence Identity: 27% (32 aa)

ILIVDDNQFNILALKLLISENENI-IVYQAENGEQAVQKAKQMNFKLIFMDMQMPIMDGQTASQIIKQDLK-IATPIISLTANEYTNEEKKQLTMF--ED
.|||||.. .  .|. .. . | . .|  |..||.|....... . ||.||..|| ||| .. . | . ..   |||| .||..   . . .       |
VLIVDDHPLMREGLRQILEQKEGYEVVAEADDGEEALEWWQEHHPDLIIMDINMPGMDGLELCRRIRRQHPHPQTPIIMCTAHGD-EDDAVEALQAGAND

FLNKPIQKQKVHEILQ
.. ||. ... |....
YITKPFDPDELHAAIR