Gene 4594 (Tetrahymena)

4594

Species: Tetrahymena
Alias: 3748.m00304, 197.m00068, 1071, TTHERM_01014640, 4594, PreTt04594
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Atypical
Family: HisK

Sequence

Name Sequence Type Origin Length Description Download
4594.AA Protein None 1515 None Fasta, JSON
4594.kin_dom Protein Kinase Domain None 117 None Fasta, JSON
4594.NA RNA None 4548 None Fasta, JSON

Protein domain

Protein domains of 4594.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
HisKA 4594.AA HisKA 211-239 27 1e-06 25.99 Pfam 1-29 (69) Show / Hide 
Range on Protein: 211-239
Range on HMM: 1-29/69
Sequence Identity: 27% (8 aa)

YKHKMINSISHDLKTPLNGMILLLDILKE
 | ... ..||.|.|||.........|..
AKRQFLANMSHELRTPLTAIRGYAELLQD
HisKA 4594.AA HisKA 211-293 13 0.000766 11.01 SMART 1-89 (89) Show / Hide 
Range on Protein: 211-293
Range on HMM: 1-89/89
Sequence Identity: 13% (13 aa)

YKHKMINSISHDLKTPLNGMILLLDILKE---QIKNNFLKPSDQKFPSFLSVSPLS-------------ANVKIQSNEQNASSSHQINLILVNKQNSQQ
 | ... ..||.|.|||.........|..   .          | ...    .|               . .  .  ..  . ...|| .|   .  ..
AKRQFLANMSHELRTPLTAIRGYAELLQDWYYK----------QRYHHWTDLDPEQRLPMLRREFNCEYREYLETIQREADRMQRLINDLLDLSRIEAG
Kinase 4594.AA HisK 1162-1278 34 1.5e-53 184.26 In-house 1-164 (164) Show / Hide 
Range on Protein: 1162-1278
Range on HMM: 1-164/164
Sequence Identity: 34% (57 aa)

NDKPRIKQILINIIGNAIKFTFEG------FVRIIVQ--------------NCESPSN----------LIQIIVQDTGIGIPDSIKKNILNFAA------
.|. ||||||||.|.||.|||..|      ...|.|.              ......|          |||| |||||.|.|....|.| ..        
SDPNRIKQILINLISNALKFTQKGGIPFQGYIKIKVEQINTQNNIKYNSIFIQKIQENMVQEQLQQKNLIQISVQDTGCGMPEEQQKKIFKMFGNIDDQH

------HIQQVKDDNRQGVGIGLEICSRLCQIIGPLD-----QEIQVESKVNIGSSFSFLIYLN
      ...| | .|..|.|.|| || .| ...|| .     ..|||.|.|..||.|||.|| |
QMIKKTFNHQNKKNNQHGCGLGLTICNNLAKGLGPEHNQNGNRGIQVQSEVGKGSTFSFYIYNN
Kinase 4594.AA HATPase_c 1162-1278 28 9.4e-18 64.02 Pfam 1-120 (120) Show / Hide 
Range on Protein: 1162-1278
Range on HMM: 1-120/120
Sequence Identity: 28% (36 aa)

NDKPRIKQILINIIGNAIKFTFE-GFVRIIVQNCESPSNLIQIIVQDTGIGIPD------SIKKNILNFAAHIQQ-VKDDNRQG--VGIGLEICSRLCQI
.|  |..|.. |...||||.| | | ... |  ..   . ..| |.|.|.|||.          .|.       .    ....|   |.|| || |... 
GDPDRLHQVVWNLVDNAIKHTPEGGHITVRVHRDD---DHVRITVEDNGPGIPPEMHSIAEDIPRIFEPFYRTDPDSR-RKYGGGLTGLGLYICRRIVEQ

IGPLDQEIQVESKVNIGSSFSFLIYLN
 |  .  |.|||... |. |.| . | 
HG-GT--IWVESEPGGGTTFTFTLPLE
Kinase 4594.AA HATPase_c 1162-1279 23 1.3e-16 62.46 SMART 1-130 (130) Show / Hide 
Range on Protein: 1162-1279
Range on HMM: 1-130/130
Sequence Identity: 23% (35 aa)

NDKPRIKQILINIIGNAIKFTFE--------------GFVRIIVQNCESPSNLIQIIVQDTGIGIPD------SIKKNILNFAAHIQQ--------VKDD
.|  |..|.|.|...||||.| |              | ... |          .| |.|.|.|||.       . ..|.       .         .  
GDPDRLRQVLWNLLDNAIKHTPEGHADPDLHDGKPGGGRITVRVH---------RITVEDNGPGIPPEMHKSIEDIPRIFEPFYRTDDSPSRMCPDSRSR

NRQG--VGIGLEICSRLCQIIGPLDQEIQVESKVNIGSSFSFLIYLNH
...|   |.|| || |...  |     |.||      . |.| . | .
KYGGGLTGLGLSICKRIVEQHGGT---IWVE------TTFTFTLPLER
REC 4594.AA REC 1384-1504 25 5.6e-31 110.15 SMART 1-150 (150) Show / Hide 
Range on Protein: 1384-1504
Range on HMM: 1-150/150
Sequence Identity: 25% (42 aa)

DTILIVDDV----AFNLIALR------NTLKLIYPN------LNILEAQNGK-------QAVEIVHEYN-----------GKIDLIIMDINMP-------
 .||||||     . .. .||      ..|.           ... || .|.       .|.|.. | .           ...|||||||.||       
MRILIVDDDPAMAPVIREMLRNYTVIQRLLEKEGYENKMWMVEVVDEA-DGETLMNEIWEALELLQEHRDKKEDATTDQSEPPDLIIMDIMMPGDPFEDG

IMDGFQAISIINQEIKDQVLEYVPIIAHTAFDNNEDKQKCFQLGAKGFLPKPVKKIELEKSV
 |||....  |            |||. ||.|. ||.......|| ....||..  || . .
GMDGIELCRRIR-----------PIIMLTAHDDEEDRVRALEAGADDYITKPFDPEELLARI
Response_reg 4594.AA Response_reg 1386-1505 34 1.8e-29 108.13 Pfam 1-115 (115) Show / Hide 
Range on Protein: 1386-1505
Range on HMM: 1-115/115
Sequence Identity: 34% (43 aa)

ILIVDDVAFNLIALRNTLKLIYPNL-NILEAQNGKQAVEIVHEYNGKIDLIIMDINMPIMDGFQAISII-NQEI-KDQVLEYVPIIAHTAFDNNEDKQKC
.|||||   .. .||. |..    . .. ||..|..|.|...|.   .|||||||||| |||..... |  |.   .     .|||. ||... .|....
VLIVDDHPLMREGLRQILEQK-EGYEVVAEADDGEEALEWWQEHH--PDLIIMDINMPGMDGLELCRRIRRQHPHPQ-----TPIIMCTAHGDEDDAVEA

FQLGAKGFLPKPVKKIELEKSVR
.|.|| ....||... || . .|
LQAGANDYITKPFDPDELHAAIR