Gene 14530 (Tetrahymena)

14530

Species: Tetrahymena
Alias: PreTt14530, 14530, 3825.m02898, 2.m02237, TTHERM_00038950, 161
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-A2

Sequence

Name Sequence Type Origin Length Description Download
14530.AA Protein None 273 None Fasta, JSON
14530.kin_dom Protein Kinase Domain None 240 None Fasta, JSON
14530.NA RNA None 822 None Fasta, JSON

Protein domain

Protein domains of 14530.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 14530.AA Ciliate-A2 34-273 45 1.1e-140 473.64 In-house 1-271 (272) Show / Hide 
Range on Protein: 34-273
Range on HMM: 1-271/272
Sequence Identity: 45% (123 aa)

GSGSFGKCIFVEDRQDANKIKKYAIKAQIVIDPHLQIIDNEKLQSCQDEAKILREIKHKNVVKVYEDYQIKNYHFIEMEQC-DSSLQKWVE--SQQGTFI
|.|.||..||||... .....|||||.|..||.. |.|...|||.|..||..|....|.|.||.....||..|.||.||.| ..|||.|..  ..|..||
GQGCFGCVIFVEHMD-NHNNEKYAIKIQSIIDGIDQKISQQKLQECKHEAQFLKNCNHPNIVKYHDEFQIGFYYFIQMEKCPECSLQDWIDKFQNQQKFI

PQKQFIHFANQLLDGVEYIHNLNYVLRDLSLGNILICQDGT-LKLCDFGLAKKFKPEIEEQMLLTKCLKGAAFYYPPEILN-------------------
|..||.|||.|.||..||.|| |||||||||.||||.||.. .||||||||||..|||..||..|.|.||..||||||...                   
PDHQFVHFACQILDAIEYLHNKNYVLRDLSLRNILIDQDNQIIKLCDFGLAKKYQPEINSQMFYTSCPKGVFFYYPPECHFQCFEMNGEQNKKQQIKQTF

-RDIWAIGVRLQMIGGIDFSQSYLIT-------RKVNTAPKVDDECNKLIQFILNEDKDKRP-TYQNILKTL
 .||||.|..|...||.|....| .|       ......|..|..||..||.|||.|..||| ..|.|....
MGDIWAFGICLYQLGGADQQHCYKLTQCNQKKWWQYQDYPNLDEKCNQIIQQILNCDPKKRPSSIQQIRHHW
Kinase 14530.AA Ciliate-E6 83-210 33 8.7e-31 95.33 In-house 1-130 (154) Show / Hide 
Range on Protein: 83-210
Range on HMM: 1-130/154
Sequence Identity: 33% (44 aa)

AKILREIKHKNVVKVYEDYQIKNYHFIEMEQCDSSLQKWVE-SQQGTFIPQK-QFIHFANQLLDGVEYIHNLNYVLRDLSLGNILICQDGTLKLCDFGLA
.. |..  |.| .| ..  ||.||.|| || |. .|| |..  .    | |. ||. |. ||. .|||.|  ||||  ..| || . ..  .|.||||. 
IQNLKNCNHPNILKYMDSFQIENYYFIVMERCEMNLQDWIHQHKNKKQINQNDQFFKFCCQLFHAVEYLHSKNYVLQNITLKNIFLDKNMNIKICDFGFQ

KKFKPEIEEQMLLTKCLKGAAFYYPPEILN
.   | .. .  . .      .| ||| ..
QCIIPNQQTKEFMAQKNQNKYHYCPPEQFD
Kinase 14530.AA CAMK 70-218 16 1e-26 82.49 In-house 38-322 (425) Show / Hide 
Range on Protein: 70-218
Range on HMM: 38-322/425
Sequence Identity: 16% (47 aa)

IIDNE-------------------------------KLQSCQDEAKILRE-------IKHKNVVKVYEDYQ------------IKNY--------HFIEM
||| .                               .... . | .|..        ..|.|..| || |.              ..         .. |
IIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVM

---EQCDS-----SLQKWVESQQG-------------TFIPQKQFIHFANQLLDGVEYIHNLNYVLRDLSLGNILICQD-----------------GTLK
   | |.       |  .. .. .               .. ..  ..  |....|.|.|..| | ||| . |||....                 ...|
EIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIK

LCDFGLAKKFKPEIEEQML-------------------LTKCLKGAAFYYP-PEILNR---------------------DIWAIGV
..|||.|.||.|  .. |.                   . |   |   | . ||.||.                     |.|..||
IIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGV
Kinase 14530.AA ULK 34-218 25 8.3e-26 87.12 In-house 8-244 (329) Show / Hide 
Range on Protein: 34-218
Range on HMM: 8-244/329
Sequence Identity: 25% (63 aa)

GSGSFGKCIFVEDRQDANK---IKKYAIKAQI----VIDPHL---QIIDNEKLQSCQDEAKILREIK----HKN----VVKVYEDYQIK--NYHFIEMEQ
|.||||     . |   .|    .|.|.|        .....   |..    .|. . | ||....|    |||    .|| |. .. .  |...| || 
GKGSFG--KVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYM----WQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEY

CDS-SLQKWVESQQG--------TFIPQKQFIHFANQLLDGVEYIHNLNYVLRDLSLGNILICQD------------GTLKLCDFGLAKKFKPE-IEEQM
|.   |..  . ...         ...... |.|  |.| |  ..|  |.. ||. . ||||  .            |.||..|||.||..  .  |.||
CNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQM

LLTKC----LKGAAFYYPPEILN----------R--DIWAIGV
..|      |.|   |  |.||.             ||| .|.
MMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGC
Kinase 14530.AA CAMKL 70-218 23 2.6e-25 77.58 In-house 32-224 (297) Show / Hide 
Range on Protein: 70-218
Range on HMM: 32-224/297
Sequence Identity: 23% (46 aa)

IIDNEKLQS------------------CQDEAKILREIK---HKNVVKVYEDYQIKNY------HFIEMEQCDSS---LQKWVESQQGTF--IPQKQFIH
||| .|..                    . |..|.. ..   |.|..| || .. ...       .. || |..    |. ..... .    .| ..  .
IIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARR

FANQLLDGVEYIHNLNYVLRDLSLGNILICQDG--TLKLCDFGLAKKFKP--EIEEQMLLTKCLKGAAFYYPPEILNR----------DIWAIGV
.  |....|.|.|... | ||. . |||. ..|  ..|..|||.. ...|   ...|.| | |  |   | .|||...          |||..||
YFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFC--GSPPYMAPEIFQGNNKPYDGPKVDIWSCGV
Kinase 14530.AA Ciliate-E2 27-218 19 2e-24 80.76 In-house 1-284 (365) Show / Hide 
Range on Protein: 27-218
Range on HMM: 1-284/365
Sequence Identity: 19% (57 aa)

VITNLNAGSGSFG---KCIFVEDRQDA-----------------NKIKKYAIKAQIVIDPHLQIIDNEKLQSCQ------DEAKILREIKHKNVVKVYED
 . .   |.|.||   ||   .....                  .|||.||.| ..  .   .   .  ..  .       | .||....|.|..| || 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YQ--IKNYHFIEMEQCDS-SLQKWVE--SQQGTFIPQ-------KQFIHFANQLLD---------------GVEYIHNLN-YVLRDLSLGNILICQDGTL
.|   .|. .. || |.  .|... .  ... .....       |. ...  |.|.               ..||.|. |  . ||. . |||.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLCDFGLAKKFKPEIEE------QMLLTKCL----------------------KGAAFYYPPEILNR----------------DIWAIGV
|..||||.||.... ..      . ...                          | . | .|||||.                |||..||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGV
Kinase 14530.AA CMGC 77-186 19 2.1e-24 76.29 In-house 66-257 (513) Show / Hide 
Range on Protein: 77-186
Range on HMM: 66-257/513
Sequence Identity: 19% (37 aa)

QSCQDEAKILREIK-----------------HKNVVKVYEDYQIKN-----------------YHFIEMEQCDSSLQKWVESQQ----------------
.....| |||....                 |.|.|| |. .. ||                 . .. .| .| .| .  ...|                
IRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHEN

----------GTFIPQKQFIHFANQLLDGVE--YIHNLN--YVLRDLSLGNILICQD--------------------GTLKLCDFGLAKKFKPE
            ...  .   .. |.| |..  |.|  .   . |||   ||||...                    |.||.||||||... |.
KHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPH
Kinase 14530.AA ULK 34-218 24 5.6e-24 82.0 In-house 8-240 (324) Show / Hide 
Range on Protein: 34-218
Range on HMM: 8-240/324
Sequence Identity: 24% (59 aa)

GSGSFGKCIFVEDRQDANK--IKKYAIKAQIVIDPHLQIIDNEK------LQSCQDEAKILREIK---HKN--VVKVYEDYQIK--NYHFIEMEQCDS-S
|.||||     . |   ..   ...|.|   .||   ..... .      .|. . | .|....|   |.|  .|| |. .. .  |...| || |.   
GKGSFG-VKVYKGRNKKTNTQNQYVACK---MIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGD

LQKWVESQQG-------TFIPQKQFIHFANQLLDGVEYIHNLNYVLRDLSLGNILICQD------------GTLKLCDFGLAKK-FKPEIEEQMLLTKC-
|..  . ...        ...... |.|  |.. |  ..|. |.. ||. . ||||  .            |.||..|||.||. .... |.||. | . 
LEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVN

---LKGAAFYYPPEILN----------R--DIWAIGV
   .||   |  |.||.             ||| .|.
EKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGC
Kinase 14530.AA Ciliate-E2-Unclassified 28-218 21 1e-19 65.11 In-house 2-258 (352) Show / Hide 
Range on Protein: 28-218
Range on HMM: 2-258/352
Sequence Identity: 21% (55 aa)

ITNLNAGSGSFGKCIFVEDRQDANKI--KKYAIKAQIVIDPHLQIIDNEKLQSCQDEAK---------------ILREIKHKNVVKVYEDYQIKNYHFIE
. .   |.|.|||   ......  ..  .||..|.||. .   .  | |.... . . .               ||. ..| ..|| ..  | |.. .| 
KIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MEQC-DSSLQKWVES---------------QQGTFIPQKQFI-----HFANQLLDGVEYIHNLN-YVLRDLSLGNILICQDG---TLKLCDFGLAK----
||.| . .|... ..               .|.  .. .| .     ... |.|.| ||.|  |  . ||. . |||. ..|    .|..|||..|    
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

-------------KFKPEIEEQMLLTKCLKGAAFYYPPEILNR-----------DIWAIGV
              .|...  ..  | . .    | .||.| .           |||. ||
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMP-Q-YTAPEVLQGQNYDHSKAYKCDIWSLGV
Kinase 14530.AA STE 34-271 18 7.3e-18 59.75 In-house 8-353 (359) Show / Hide 
Range on Protein: 34-271
Range on HMM: 8-353/359
Sequence Identity: 18% (64 aa)

GSGSFGKCIFVEDR-----------------QDANKIKKYAIKAQIVIDPH------LQIIDNEKLQSCQDEAKILREIK--HKNVVKVYEDYQIK----
|.|.||.     ..                 ..   ||.  .. .   | .      |.....|..|. . | ||... .  |.|.|| |  |  .    
GKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNH

---NYHFIEMEQCD-SSLQKWVESQQGTFIP------------QKQFIHFANQLLDG-VEYIHNLNYVLRDLSLGNILICQDGTLKLCDFGLAKKFKPEI
   .. .| || .|  || . ...  |.. |             .| .... |.| |  .|.|..... ||.  .|||.      ||||||..... ...
KNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSM

EEQMLLT------------KC--LKGAAFYYPPEILNR-------------DIWAIGVRL--------QMIGGIDFSQSYLITRKV-------------N
 .. . .            |.  . |   .  ||....             ||| .|  .         .  . ...  ..|...              .
ANI-Q-SNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNG

TAPKVD-----------------------DECNKLIQFILNEDKDKRPTYQNILK
. |.                         .|..  |.  |. | .||||..  ||
PPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLK
S_TKc 14530.AA S_TKc 26-271 23 1.9e-17 65.22 SMART 1-220 (231) Show / Hide 
Range on Protein: 26-271
Range on HMM: 1-220/231
Sequence Identity: 23% (62 aa)

YVITNLNAGSGSFGKCIFVEDRQDANKIKKYAIKAQIVIDPHLQIIDNEKLQSCQDEAKILREIKHKNVVKVYEDYQIKNYHFIEMEQCDS---SLQKWV
| | ..  |.|.|||.  . ..      ...|||                 .. . | .||.. .|.|.|| |. .|  .. .. || ||    .| .  
YEILRK-IGKGAFGKVYKCRHKK---TGRIVAIKIIK--------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYI

ESQQGTF----IPQKQFIHFANQLLDGVEYIHNLNYVLRDLSLGNILICQDGTLKLCDFGLAKKFKPEIEEQMLLTKCLKGAAFYYPPEIL--NR---DI
.....      .|  .  ... |.....||.|... . |||   |||...  ..|.||||||...           . . |  .| .||.|  ..   |.
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVLGYGKCKCDW

WAIGVRLQMIGG----IDFSQSYLITRKVNTAPKVDDECNKLIQFILNEDKDKRPTYQNILK
|..|. |          .  | ... .|.      ..|.  .|. .|. | .||||   .|.
WSCGCILYEMLCGYPPFP--QMQMMFKKIG-----SPEAKDFIRKCLQKDPEKRPTA-EALQ
Kinase 14530.AA Pkinase 70-183 30 9.5e-17 60.31 Pfam 31-162 (293) Show / Hide 
Range on Protein: 70-183
Range on HMM: 31-162/293
Sequence Identity: 30% (40 aa)

IIDNEKLQSCQD-------EAKILREIKHKNVVKVYEDYQIKNYHFIEMEQCDS-----SLQKWVE-SQQGTF-IPQKQFIHFANQLLDGVEYIHNLNYV
||. ..  |..|       |..|.....|.|.|. |. .. |..  . || |.      .|  ... ...|.|  . .. .... |.| |.||.|. . .
IIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGII

LRDLSLGNILICQDGTL----KLCDFGLAKKF
 ||| . |||| ..|..    |.|||||||.|
HRDLKPENILIDNNGHIDACVKICDFGLAKQF
Kinase 14530.AA TyrKc 27-273 18 4.5e-12 -27.5 SMART 1-280 (280) Show / Hide 
Range on Protein: 27-273
Range on HMM: 1-280/280
Sequence Identity: 18% (56 aa)

VITNLNAGSGSFG---KCIFVEDRQDANKIKKYAIKAQIVIDPHLQIIDNEKLQSCQDEAKILREI--KHKNVVKVYEDYQIK-------NYHFIEMEQC
.  .   |.| ||   |..            . |.|                ..   .||.|....  .|.|.|. |     .         ..| || .
ITLGKKLGEGAFGEVYKGTWK---------IQVAVKMLKEDA----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYM

DS-SLQKWVESQQGTFIPQKQFIHFANQLLDGVEYIHNLNYVLRDLSLGNILICQDGTLKLCDFGLAKKFKPE----IEEQMLLTK---CLK--GAAFYY
.  .|..   . ... .. |....|. |  .| ||.|  |.. |||   |.|.  ..| | .||||... . .     ....  .|   . |       .
PHGDLKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM

PPEIL-NR------DIWAIGVRL---QMIGGIDFSQ------------SYLITRKVNTAPKV---------DDECNKLIQFILNEDKDKRPTYQNILKTL
.|| .  .      |.|. || .      |.   .              |. ...    |.           ||  ....   .|| ..||| ..| . .
APECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 14530.AA Pkinase_Tyr 130-181 34 4.6e-07 24.54 Pfam 108-159 (270) Show / Hide 
Range on Protein: 130-181
Range on HMM: 108-159/270
Sequence Identity: 34% (18 aa)

IPQKQFIHFANQLLDGVEYIHNLNYVLRDLSLGNILICQDGTLKLCDFGLAK
.. |. .... |  .| || .. |.. |||   |.|.  ... | ||||||.
LTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase 14530.AA CAMKL 242-271 33 0.003372 5.89 In-house 265-293 (297) Show / Hide 
Range on Protein: 242-271
Range on HMM: 265-293/297
Sequence Identity: 33% (10 aa)

PKVDDECNKLIQFILNEDKDKRPTYQNILK
..|. .|  ||. .|. . .|||| ..|..
YHVS-DCRDLIRKMLQVNPEKRPTIHQIMN
Kinase 14530.AA CAMK 243-271 37 0.019751 2.84 In-house 393-421 (425) Show / Hide 
Range on Protein: 243-271
Range on HMM: 393-421/425
Sequence Identity: 37% (11 aa)

KVDDECNKLIQFILNEDKDKRPTYQNILK
.|..||  ||. .|. | .||.| . .|.
FVSQECKDLIRKMLQVDPEKRMTIEQCLN
Kinase 14530.AA Ciliate-E2 243-271 35 0.07387 2.14 In-house 328-361 (365) Show / Hide 
Range on Protein: 243-271
Range on HMM: 328-361/365
Sequence Identity: 35% (12 aa)

KVDDECNKLIQF----ILNEDKDKRPT-YQNILK
|...||  ||.     .|. | .||.| .. ||.
KWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase 14530.AA Ciliate-E2-Unclassified 243-271 24 0.192684 0.79 In-house 316-348 (352) Show / Hide 
Range on Protein: 243-271
Range on HMM: 316-348/352
Sequence Identity: 24% (8 aa)

KVDDECNKLIQ----FILNEDKDKRPTYQNILK
....|.  .|.     .|. . .||.|.. ||.
HWSPEAKDFINDLLQKMLKKNPNKRITFEQILN
Kinase 14530.AA Pkinase 242-273 32 0.330583 5.35 Pfam 260-293 (293) Show / Hide 
Range on Protein: 242-273
Range on HMM: 260-293/293
Sequence Identity: 32% (11 aa)

PKVDDECNKLIQFILNEDKDKRPTYQNILKT--L
.....|| ..|  .|. |  |||| . ||.   .
HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 14530.AA Pkinase_Tyr 82-98 44 0.52914 4.02 Pfam 53-70 (270) Show / Hide 
Range on Protein: 82-98
Range on HMM: 53-70/270
Sequence Identity: 44% (8 aa)

EAKILREI-KHKNVVKVY
||||.... .|.|.|. |
EAKIMKQLGHHPNIVRLY