Gene 1573 (Tetrahymena)

1573

Species: Tetrahymena
Alias: 1573, TTHERM_01298610, PreTt01573, 744, 314.m00034
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-D1

Sequence

Name Sequence Type Origin Length Description Download
1573.AA Protein None 1321 None Fasta, JSON
1573.kin_dom Protein Kinase Domain None 145 None Fasta, JSON
1573.NA RNA None 3966 None Fasta, JSON

Protein domain

Protein domains of 1573.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Pkinase 1573.AA Pkinase 22-321 16 1.8e-13 48.68 Pfam 1-200 (293) Show / Hide 
Range on Protein: 22-321
Range on HMM: 1-200/293
Sequence Identity: 16% (53 aa)

VQFLNVIGQGN-SVVYEVYHQVQNKNMALKEIILQSQEDEQYIKD----EQQMLKFLSVEQQNSYFIKYEDFCFVKVIVNEYIEHNVAYLLMEKASISLS
 ... .||.|. ..||. .|.  .|  |.|.| ........ . .    | |..| |.      . ... |..           ..  |. || .   |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN----HPNIVRLYDWFED---------KDHIYMVMEYCEGGLY

SFVDLR--IK--KNIPF--SIEEIVFISEECINAFTCLQEYKIAHSDIKPENILLD--FFPQEQNFQNSLNHIGEKLSEGTIIDQKFQNTKNTYVNQNIN
   ||   |.  .. .|  | .|. |.  . . .   . . .| | |.||||||.|    . .                                     
-VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-------------------------------------

DKKYQKVDLNQQLAQKNQISNQSIQQKSIAIIDDSNKELSPNITLSSFTCRIKICDIGSAIKNNSSGEGNSVQLHRIEGTIPFLAPELFKKYIKKEVTAL
                                                  ..|||| |.| . .   . |.. .. . ||....|||. .       .. 
--------------------------------------------------CVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIR-------GGQ

YNPYKSDVFSLGL
| ..|.|..|.|.
YYGPKVDMWSCGC
Kinase 1573.AA S_TKc 22-381 16 6.8e-12 -2.52 SMART 1-231 (231) Show / Hide 
Range on Protein: 22-381
Range on HMM: 1-231/231
Sequence Identity: 16% (61 aa)

VQFLNVIGQGN-SVVYEVYHQVQNKNMALKEIILQSQEDEQYIKDEQQMLKFLSVEQQNSYFIKYEDFCFVKVIVNEYIEHNVAYLLMEKASI---SLSS
 ..|..||.|  ..|| ..|   .. .|.|.|        . |. | |.||      .  . .|. |..            .  |. || ..    .| .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-----HHPNIVKLYDVFQD----------DHLYMVMEYCDGDLGDLFD

FVDLRIK--KNIPFSIEEIVFISEECINAFTCLQEYKIAHSDIKPENILLDFFPQEQNFQNSLNHIGEKLSEGTIIDQKFQNTKNTYVNQNINDKKYQKV
. . | .  .. ||.  .. |.  . ..|   . . .| | |.||||||||                                                 
YIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------------------------------------------------

DLNQQLAQKNQISNQSIQQKSIAIIDDSNKELSPNITLSSFTCRIKICDIGSAIKNNSSGEGNSVQLHRIEGTIPFLAPELFKKYIKKEVTALYNPYKSD
                                           .||||| |.| .            . . ||  ..|||..           |.. |.|
-------------------------------------------HIKICDFGLARQL-----------TTFCGTPWYMAPEVL----------GYGKCKCD

VFSLGLCILFLIIQQRFYKQNRIYMEDTAYSEIIQEWIILISDVLDNTLQIQYENRPDFLQLNK---------LF
. |.| ..  ..  .  .       .. .  ..|     ...  ... ||   |.||   .. .          |
WWSCGCILYEMLCGYPPFP------QMQMMFKKIG-SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 1573.AA Ciliate-E4 121-166 39 1.8e-10 31.53 In-house 96-141 (150) Show / Hide 
Range on Protein: 121-166
Range on HMM: 96-141/150
Sequence Identity: 39% (18 aa)

LRIKKNIPFSIEEIVFISEECINAFTCLQEYKIAHSDIKPENILLD
.. .....|.  ||  |   ||||.  ||   |.| |.|| ||..|
QHKQQGQHFDESEIWQIAFCCINAMYYLQQVNITHGDLKPSNIFFD
Kinase 1573.AA Ciliate-E1 28-166 24 1.9e-10 30.67 In-house 1-143 (202) Show / Hide 
Range on Protein: 28-166
Range on HMM: 1-143/202
Sequence Identity: 24% (36 aa)

IGQGN-SVVYEVYHQVQN-KNMALKEIILQ---SQEDEQYIKDEQQ-MLKFLSVEQQNSYFIKYE--DFCFVKVIVNEYIEHNVAYLLMEKASISLSSFV
||.|  |.|.. . | .| ...|.| | ..   .|...|... |.. ..| .  |..  ..|.|   |.. ...|..|. ...    | ..    |   .
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNH--NRL-EYW

DLRIKKNIPFSIEEIVFISEECINAFTCLQEYKIAHSDIKPENILLD
..  .... |...... |    | ..  |. |.| |.||||.||| .
QQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILIN
Kinase 1573.AA Ciliate-E2 22-377 14 1.3e-07 22.21 In-house 1-359 (365) Show / Hide 
Range on Protein: 22-377
Range on HMM: 1-359/365
Sequence Identity: 14% (67 aa)

VQFLNVIGQG-NSVVYEVYH-QVQN-------------------KNMALKEIILQSQEDEQYIKDEQQMLK-------FLSVEQQ------NSYFIKYED
  |...||||  ..||.. . .||.                    .. ....  ... . ..|| |.....       ..  |..      . . ||. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKI-NEKNILEQLNHPNIIKMYE

FCFVKVIVNEYI--EHNVAYLLMEKASI-SLSSFVDLR---IKKNIP----FSIEEIVFISEECIN---------------AFTCLQEYK-IAHSDIKPE
.         ..    |  || || ..  .| ..   .    ...|.    |...|| .|... ..               |.  | . . | | |||||
C---------FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPE

NILLDFFPQEQNFQNSLNHIGEKLSEGTIIDQKFQNTKNTYVNQNINDKKYQKVDLNQQLAQKNQISNQSIQQKSIAIIDDSNKELSPNITLSSFTCRIK
|||.                                                                                              ||
NILF----------------------------------------------------------------------------------------------IK

ICDIGSAIKNNSSGEGNS---------------------------VQLHRIEGTIPFLAPELFK-KYIKKEVTALYNPYKSDVFSLGLCILFLIIQQRFY
|.| | . |.. . . ..                            . ..| || ...||| .. | . .. .  .  ||.|..||| .||.  .  .. 
IIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLG-VILYEMLFGKPP

KQNRIYMEDTAYSEIIQEWIILIS--------------------------DVLDN----TLQIQYENRPD-FLQL
             ..|..  | ..                          | . .     || . |.|.. . |.
F-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQI
Kinase 1573.AA YANK 148-166 73 1.3e-07 22.2 In-house 115-133 (261) Show / Hide 
Range on Protein: 148-166
Range on HMM: 115-133/261
Sequence Identity: 73% (14 aa)

LQEYKIAHSDIKPENILLD
|||..| | ||||.|||||
LQEMHIIHRDIKPDNILLD
Kinase 1573.AA Ciliate-B2 91-165 30 7.2e-07 12.08 In-house 63-137 (197) Show / Hide 
Range on Protein: 91-165
Range on HMM: 63-137/197
Sequence Identity: 30% (23 aa)

VKVIVNEYIEHNVAYLLMEKASISLSSFVDLRIKKNIPFSIEEIVFISEECINAFTCLQEYKIAHSDIKPENILL
||.|    |. ..  | |||   || . ...  |. . |  . .. .  . |.. . .  | | | ||||.|||.
VKYIDHIQINETIDVLIMEKCECSLKQELQKIQKQQKCFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILF
Kinase 1573.AA TKL 248-381 15 2e-06 18.89 In-house 168-364 (364) Show / Hide 
Range on Protein: 248-381
Range on HMM: 168-364/364
Sequence Identity: 15% (31 aa)

SPNITLSSF-------------TCRIKICDIGSAIKNNSSGEGNSV---------------QLHRIEGTIPFLAPELFKKYIKKEVTA---------LYN
|.|| . .              ....|||| | .  .. ||. |                 ..... ||. ..|||.... .. .  .          |.
SKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYS

PYKSDVFSLGLCILFLIIQQRFYKQNR---IYMEDTAYSEIIQEWIIL--------------------------ISDVLDNTLQIQYENRPDFLQLNKLF
. |.||.| |...  ..  .| |...    ... |   .|........                          ... .    .   |.|| |... | .
E-KCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 1573.AA Ciliate-E2-Unclassified 259-367 19 3e-06 17.49 In-house 185-306 (352) Show / Hide 
Range on Protein: 259-367
Range on HMM: 185-306/352
Sequence Identity: 19% (25 aa)

RIKICDIGSAI---KNNSSGEGNS--------VQLHRIE-GTIPFL----APELFKKYIKKEVTALYNPYKSDVFSLGLCILFLIIQQRFYKQNRIYMED
.|||.| |...   .|| .  .|.         |.     ||. ..    |||....    . .|    ||.|..||| .. ... ... ...|  . ..
YIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA----YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQ

TAYSEIIQEWI----ILISDVLDNTLQIQ
.  ...|   .    .|... ... .|..
QLITQWI-N-NAYRKQLYQNIKQKNIQFP
Kinase 1573.AA CAMK 257-320 19 4e-06 14.81 In-house 232-321 (425) Show / Hide 
Range on Protein: 257-320
Range on HMM: 232-321/425
Sequence Identity: 19% (18 aa)

TCRIKICDIGSA--IKN---------NSSGEGNSVQ----------LHRIEGTIPFLA-PELFKKYIKKEVT------ALYNPYKSDVFSLG
.. |||.| | |  ..          . .||    .          ..   || .. | ||....  ... .        | ..|.|. |.|
NNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCG
Kinase 1573.AA Ciliate-A5 259-324 25 6e-06 16.64 In-house 137-209 (275) Show / Hide 
Range on Protein: 259-324
Range on HMM: 137-209/275
Sequence Identity: 25% (19 aa)

RIKICDIG----SAI-KNNSSGEGNSVQLHRIEGTIPFLAPELFKKYIKKE----VTALYNPYKSDVFSLGLCIL
..|. |..    . .  |.||   .  |.| . .. . |.|....    ..      . .| ||||||.||. .|
QVKLMDMNESKDFFYQINWSS--YKQYQHHMSTENKQYLSPMQWYQMMHRDEQNIQRPEHNWYKSDVFCLGMICL
Kinase 1573.AA TKL 28-166 12 9e-06 16.76 In-house 1-174 (364) Show / Hide 
Range on Protein: 28-166
Range on HMM: 1-174/364
Sequence Identity: 12% (25 aa)

IGQGN-SVVYEVYHQVQN--------KNMALKEIILQS-QEDEQ----------------YIKDEQQMLKFLSVEQQNSY------------FIKYEDF-
||.|  ..||  ... ..        | .| | .  .. .|..                 . .. ... .|. .|                 . ..... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-CFVK--------VIVNEYIEHNV-AYLLMEKASISLSSFVDLRIKKNIPFSIEEIVFISEECINAFTCLQEYK--------IAHSDIKPENILLD
 . ..         || ||...    ..|                       .. .. .. ..  .   |   .        |.| |.|..|||.|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVD
Kinase 1573.AA C8 260-323 29 9e-06 16.18 In-house 166-226 (226) Show / Hide 
Range on Protein: 260-323
Range on HMM: 166-226/226
Sequence Identity: 29% (19 aa)

IKICDIGSAIKNNSSGEGNSVQLHRIEGTIPFLAPELFKKYIKKEVTALYNPYKSDVFSLGLCI
||.||.| | .  .. .    . .   ||  ..|||  ||   ..     .  .||.||.||  
IKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKK---QDNQYKQYRIQSDLFSVGLVL
Kinase 1573.AA Ciliate-B2 312-320 44 4.1e-05 7.86 In-house 189-197 (197) Show / Hide 
Range on Protein: 312-320
Range on HMM: 189-197/197
Sequence Identity: 44% (4 aa)

YKSDVFSLG
..||..|.|
FQSDIYSMG
Kinase 1573.AA CAMK 152-166 73 7.6e-05 10.76 In-house 199-213 (425) Show / Hide 
Range on Protein: 152-166
Range on HMM: 199-213/425
Sequence Identity: 73% (11 aa)

KIAHSDIKPENILLD
.|.| |.||||||||
NIVHRDLKPENILLD
Kinase 1573.AA Ciliate-A5 122-165 32 0.000125 12.08 In-house 87-132 (275) Show / Hide 
Range on Protein: 122-165
Range on HMM: 87-132/275
Sequence Identity: 32% (15 aa)

RIKKN--IPFSIEEIVFISEECINAFTCLQEYKIAHSDIKPENILL
| ..   |...  |...|    |..  .||. .| | ||.| ||.|
RKQCQKDIFYNEQELWYIMDCLISVCMYLQQNNICHGDIRPQNICL
Kinase 1573.AA Ciliate-E2-Unclassified 24-166 17 0.000217 11.16 In-house 3-178 (352) Show / Hide 
Range on Protein: 24-166
Range on HMM: 3-178/352
Sequence Identity: 17% (31 aa)

FLNVIGQGN-SVVYEVYHQVQNKNMALKEIILQSQEDEQYIK---DEQQMLKFLSVEQQNSYFIKY----------EDFCFVKVIVNEYIEH--NVAYLL
.. .||||. ..||...|  |.   . .... ..|.. | ..   | . |.. . ...... ..             ..    ... .|..   .  |. 
IIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MEKA-SISLSSFVDL-------------RIKKNIPFSIEEIV-----FISEECINAF-TCLQEYKIAHSDIKPENILLD
||..   .|. .                ..|..  |. ....     |.  . ....  . .. .| | ||||||||.|
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFD
Kinase 1573.AA CAMK 27-74 12 0.001601 6.42 In-house 1-89 (425) Show / Hide 
Range on Protein: 27-74
Range on HMM: 1-89/425
Sequence Identity: 12% (11 aa)

VIGQGN-SVVYEVYHQVQN------------KNMALKEIILQ----------------------------SQEDEQYIKDEQQMLKFLS
..|.|. ..|....|   .            .  | | |  .                            ...|.. .. | ...| |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQ
Kinase 1573.AA Ciliate-A5 364-381 38 0.004532 6.6 In-house 258-275 (275) Show / Hide 
Range on Protein: 364-381
Range on HMM: 258-275/275
Sequence Identity: 38% (7 aa)

LQIQYENRPDFLQLNKLF
||. ...|||| |.  ..
LQFEENKRPDFHQIYQYL
Kinase 1573.AA C8 22-165 21 0.004918 6.51 In-house 1-156 (226) Show / Hide 
Range on Protein: 22-165
Range on HMM: 1-156/226
Sequence Identity: 21% (33 aa)

VQFLNVIGQGN-SVVYEVYHQVQNKNMALKEIILQSQEDEQYIKDEQQMLKFLS-VEQQNSYFIKYEDFCFVKVIVNEYIEHNVAYLLMEKASISLSS--
..  ... .|. ..| . .   .|.. .||  . |...| | |   .. .. .  ..| ..| ..|. |   .. ..|  ..|   .. |. | .. .  
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME

--------FVDLRIKKNIPFSIEEIVFISEECINAFTCLQEYKIAHSDIKPENILL
        . | | .|. .|| |.   |    |     ..  .| | ||||.|.|.
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLV
Kinase 1573.AA Ciliate-E4 476-492 23 0.29389 0.64 In-house 83-99 (150) Show / Hide 
Range on Protein: 476-492
Range on HMM: 83-99/150
Sequence Identity: 23% (4 aa)

IDYINSTIDTDIKSRQQ
..|..  . ..|| ..|
MEYLQKDLQQHIKQHKQ