Gene 7504 (Tetrahymena)
7504
Group:
Other
Family:
Ciliate-D1
Sequence
Protein domains of 7504.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 7504.AA | Ciliate-A5 | 54-279 | 21 | 2.6e-15 | 49.61 | In-house | 38-275 (275) | Show / Hide |
Range on Protein: 54-279 Range on HMM: 38-275/275 Sequence Identity: 21% (51 aa) QKRIDLRHPNLLNALAFEHQFMEVFGLSSNNLIYFFEHVEIQLAQVLHQRISLN--SRFPEGDIIRIATEVLNCLVYLQKYDIVMGNIEPCTIFHDTNEN ..| | |||... . |. . | | .. .. ..| . . | | . .| . .. |... |. ... . |||. .|. |.| | .|. | .. EQRMQLQHPNIVKLIDFHTHKKEEFCSQFYKVNCYYEYHDNNLEQEMQMRKQCQKDIFYNEQELWYIMDCLISVCMYLQQNNICHGDIRPQNICL-TQDG CIKMYDAT-----LI-LGEHPVYKMAKSQFQGRKPYYTPEVIYALTFHQEEVLSKYK---FQSDIFQLGLTLLELCSFQDSTQLFDTDKKKINTQE--MD .| | .. . . .. . . |.| |. |.. |... .. . ||.|.||...||.|. .| || .. .. .. . . QVKLMDMNESKDFFYQINWSSYKQYQHHMSTENKQYLSPMQWYQMMHRDEQNIQRPEHNWYKSDVFCLGMICLEMCTMRDCTQFYYDYETFQIQNNQLIK LRLQNICPTYSHKLQQVIKSMLNLDPRKRPSAQDLLIQM . .| || . .|| ||.... |||. .. .. QLIQMKEKKYSEQFINFIKQMLQFEENKRPDFHQIYQYL |
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| Kinase | 7504.AA | NEK-Unclassified | 196-281 | 29 | 8.5e-11 | 31.67 | In-house | 167-258 (258) | Show / Hide |
Range on Protein: 196-281 Range on HMM: 167-258/258 Sequence Identity: 29% (27 aa) EVLSK--YKFQSDIFQLGLTLLELCSFQ---DSTQLFDTDKKKINTQE-MDLRLQNICPTYSHKLQQVIKSMLNLDPRKRPSAQDLLIQMHS ||. . | .||. || ..|.| . | . . | .. | . ||| |||||. || .. .|||| ... | EVCQDQPYNNRSDVWSLGCIIYEMCTCEPFFDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI |
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| Kinase | 7504.AA | NAK | 248-279 | 34 | 7.3e-10 | 29.03 | In-house | 268-299 (299) | Show / Hide |
Range on Protein: 248-279 Range on HMM: 268-299/299 Sequence Identity: 34% (11 aa) PTYSHKLQQVIKSMLNLDPRKRPSAQDLLIQM ..|| .....|. ||. ||..||. ..| |. SRYSQQMHDLIRYMLTPDPEQRPNIYQVLNQL |
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| S_TKc | 7504.AA | S_TKc | 17-283 | 17 | 6.4e-09 | -46.09 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 17-283
Range on HMM: 1-231/231
Sequence Identity: 17% (51 aa)
FLRDKYMKSFGNVKIYEVKHFN-------KQVVGIPCLLPVSDPQKRIDL-------RHPNLLNALAFEHQFMEVFGLSSNNLIYFFEHVEI---QLAQV
. . . . | | ..| . |.. ..| .|||. . . . . ..| ..|... | ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKKHHPNIVKLYDVFQD---------DHLYMVMEYCDGDLGDLFDY
LHQRIS--LNSRFPEGDIIRIATEVLNCLVYLQKYDIVMGNIEPCTIFHDTNENCIKMYD---ATLILGEHPVYKMAKSQFQGRKPYYTPEVIYALTFHQ
...| . |...||| .. ... .... | |. . |. . | |. |. .|| | |... . | | | |||.
IKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-----------TTFCGTPWYMAPEVL-------
EEVLSKYKF-QSDIFQLGLTLLELCS----FQDSTQLFDTDKKKINTQEMDLRLQNICPTYSHKLQQVIKSMLNLDPRKRPSAQDLLI-----QMHSST
.| . .|. .| .| |... |. .|.. ...|. |. . . |. .|. ||.|||.| ..| .|
-----GYGKCKCDWWSCGCILYEMLCGYPPFP----------------QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
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| Kinase | 7504.AA | NEK | 248-276 | 41 | 1.6e-08 | 26.52 | In-house | 251-281 (286) | Show / Hide |
Range on Protein: 248-276 Range on HMM: 251-281/286 Sequence Identity: 41% (13 aa) PT--YSHKLQQVIKSMLNLDPRKRPSAQDLL .. || .||..| .||. || .|||....| SHRMYSQDLQNLISQMLQKDPEQRPSCNQIL |
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| Kinase | 7504.AA | NEK1 | 246-281 | 36 | 2.1e-08 | 25.41 | In-house | 241-276 (276) | Show / Hide |
Range on Protein: 246-281 Range on HMM: 241-276/276 Sequence Identity: 36% (13 aa) ICPTYSHKLQQVIKSMLNLDPRKRPSAQDLLIQMHS | |.|| .|| ...|.. .|| |||....| . IPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI |
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| Kinase | 7504.AA | Ciliate-E4 | 55-157 | 30 | 8.9e-08 | 22.51 | In-house | 49-150 (150) | Show / Hide |
Range on Protein: 55-157 Range on HMM: 49-150/150 Sequence Identity: 30% (31 aa) KRIDLRHPNLLNALAFEHQFMEVFGLSSNNLIYFFEHVEIQLAQVLHQRISLNSRFPEGDIIRIATEVLNCLVYLQKYDIVMGNIEPCTIFHDTNENCIK .|.|| |.|. . . |. . | | |. |.| . |.| . |. . .| | | || | . |||. | |.. | || | . .| RRQDLNHENIIMVYEYFHKKEDQFCSSIYRLYWFMEYLQKDLQQHIKQHKQQGQHFDESEIWQIAFCCINAMYYLQQVNITHGDLKPSNIFFD-QYFMVK MYD . | IAD |
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| Kinase | 7504.AA | WEE | 250-276 | 48 | 1.1e-07 | 21.99 | In-house | 266-292 (297) | Show / Hide |
Range on Protein: 250-276 Range on HMM: 266-292/297 Sequence Identity: 48% (13 aa) YSHKLQQVIKSMLNLDPRKRPSAQDLL .| |.|.||.|.. ||..||..|.|| ISQELKQLIKWMMHPDPEQRPTCQQLL |
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| Kinase | 7504.AA | NAK-Unclassified | 248-281 | 38 | 1.2e-07 | 22.52 | In-house | 372-405 (405) | Show / Hide |
Range on Protein: 248-281 Range on HMM: 372-405/405 Sequence Identity: 38% (13 aa) PTYSHKLQQVIKSMLNLDPRKRPSAQDLLIQMHS ..|| .| ..|| |||.||. ||. .| . HNYSNQLHNLIKIMLNEDPIQRPNIYQVLNHICQ |
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| Kinase | 7504.AA | NEK2 | 250-281 | 34 | 1.2e-07 | 21.64 | In-house | 288-319 (319) | Show / Hide |
Range on Protein: 250-281 Range on HMM: 288-319/319 Sequence Identity: 34% (11 aa) YSHKLQQVIKSMLNLDPRKRPSAQDLLIQMHS || |. .| .|.|.|...||| .| . YSRHLNEIIHFMINVDHYHRPSIEEILQHPQI |
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| Kinase | 7504.AA | Ciliate-A2 | 251-280 | 41 | 1.7e-07 | 22.41 | In-house | 242-272 (272) | Show / Hide |
Range on Protein: 251-280 Range on HMM: 242-272/272 Sequence Identity: 41% (13 aa) SHKLQQVIKSMLNLDPRKRP-SAQDLLIQMH . |..| |. ||.|| ||| | | .. ..| DEKCNQIIQQILNCDPKKRPSSIQQIRHHWH |
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| Kinase | 7504.AA | Pkinase | 254-279 | 35 | 0.000601 | 15.04 | Pfam | 266-293 (293) | Show / Hide |
Range on Protein: 254-279 Range on HMM: 266-293/293 Sequence Identity: 35% (10 aa) LQQVIKSMLNLDPRKRPSAQDLLIQ--M ....||..|..|| |||.|...| . CKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | 7504.AA | WEE | 205-217 | 61 | 0.073942 | 2.1 | In-house | 217-229 (297) | Show / Hide |
Range on Protein: 205-217 Range on HMM: 217-229/297 Sequence Identity: 61% (8 aa) SDIFQLGLTLLEL .||| ||.|..|| ADIFSLGITIYEL |
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