Gene 10885 (Tetrahymena)
10885
Sequence
Protein domains of 10885.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 10885.AA | Ciliate-C8 | 127-318 | 26 | 2.1e-41 | 143.88 | In-house | 1-238 (238) | Show / Hide |
Range on Protein: 127-318 Range on HMM: 1-238/238 Sequence Identity: 26% (63 aa) GSFSMVYSAKKIKNNQNIALRIQEVHDQDQDDF-----NNYISICKQIQMPLIAELYDVYYID--IEKSK-----------------FAIFELELAQ--C |.|.|| .|. .|.|. .|| . |. .. | . .|..| .. |||.. ..|| .|.. ..| . | .|.|. | | GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC DLNQLLKG-QEQNGQLNEEDKMIIAKQLIEVINYVHNFNIILRDIKPSKIGLKLSDSNQISIKLFI------SYWTIRLKDGSN------AIKTKQP--- .|.|... ...........|.||| | |...|| | |||. |||||. . . .....| .||| . |.. . .| |. NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM --VGALVFSAPENNKE--NQDDFVYSKESDIFSLGATL .| . ..||| |. . ..||.||..|.| | YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL |
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| Kinase | 10885.AA | C8 | 118-318 | 27 | 2.3e-38 | 130.75 | In-house | 1-226 (226) | Show / Hide |
Range on Protein: 118-318
Range on HMM: 1-226/226
Sequence Identity: 27% (63 aa)
SDSFQFIGAGSFSMVYSAKKIKNNQNIALRIQEVHDQDQDDFNNYISICKQIQMPLIAELYDVYYID--IEKSKFAIFELELAQ-----------CDLNQ
...||.. |...|| .||..|.|..|.| .|.. |...| .| .|| |...||.. ..|| |... . . .. ||.| . |....
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKC--QNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVME
-----------LLKGQEQNGQLNEEDKMIIAKQLIEVINYVHNFNIILRDIKPSKIGLKLSDSNQISIKLFISYWTIRLKDGSNAIKTKQP--VGALVFS
.. .....|...|.| ||| |.|. .||.| .||. |||||. . ..|. .. .||| ... . | .|. .| . ..
MELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYF
APENNKE-NQDDFVYSKESDIFSLGATL
||| |. ... |...||.||.| |
APEIEKKQDNQYKQYRIQSDLFSVGLVL
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| Kinase | 10885.AA | Ciliate-E1 | 124-249 | 29 | 2.1e-31 | 99.62 | In-house | 1-140 (202) | Show / Hide |
Range on Protein: 124-249 Range on HMM: 1-140/202 Sequence Identity: 29% (41 aa) IGAGSFSMVYSAKKIKNN-QNIALRIQEVHDQ-DQDDFNNYISICKQIQMPLIAELYDVYYIDIEKSKFAIFELELAQCDLNQLLKGQE----------- ||.||||.|. ||...|| ...|. |...... .|..|...| ...|.. .. | | ...||. |.......... .| .|.. .. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC --QNGQLNEEDKMIIAKQLIEVINYVHNFNIILRDIKPSKI ...|.... || |..|||. ....|..||| |||||..| QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNI |
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| Kinase | 10885.AA | C2 | 127-331 | 26 | 8.6e-25 | 81.7 | In-house | 1-245 (245) | Show / Hide |
Range on Protein: 127-331 Range on HMM: 1-245/245 Sequence Identity: 26% (65 aa) GSFSMVYSAKKIKNNQNIALRIQEVHD---QDQDDFNNYISICKQIQ-MPLIAELYDVYYIDIE-KSK------------------------FAIFELEL |.|..| | | |. .|| |||. . . . ..| .|.| ||.| ..|. .| . . |. | .|.| GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF AQCDLNQ-LLKGQEQNGQLNEEDKMIIAKQLIEVINYVHNFNIILRDIKPSKIGLKLSDSNQISIKLFI----------SYWTIRLKDGSNAIKTKQPVG |..| | . . ..|| ..... |||.| | . .||| | |.|. |||||| . . ..... ||| . || . | ... .. CQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKW ALVF----SAPENNKENQDDFVYSKESDIFS-LGATLCVLDNYEILKNKL . .|||.... .| |.||.|| .| | ||| .. . TQQYYQHIFAPEVYQN-----IYKKNSDLFSTVGYVLLELDNMQQYTICC |
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| Kinase | 10885.AA | CAMK | 123-246 | 16 | 4.7e-13 | 37.68 | In-house | 1-207 (425) | Show / Hide |
Range on Protein: 123-246 Range on HMM: 1-207/425 Sequence Identity: 16% (34 aa) FIGAGSFSMVYSAKKIKNN------------QNIALRI-----------------------------QEVHDQDQDDFNNYISICKQ-------IQMPLI .| |||. |. .. .... | | | ... ..|.. . . |.|.|. .. | | TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI AELYDVYY----------------IDIEKSKFAIFEL---ELAQC-----DLNQLLKGQEQN------------GQLNEEDKMIIAKQLIEVINYVHNFN ||.|| . .| |. .. . |... || . .. .... | ..|.. . .|... ..| |. | IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN IILRDIKP |. ||.|| IVHRDLKP |
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| Kinase | 10885.AA | S_TKc | 118-388 | 16 | 8.2e-12 | -3.69 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 118-388 Range on HMM: 1-231/231 Sequence Identity: 16% (49 aa) SDSFQFIGAGSFSMVYSAKKIKNNQNIALRIQEVHDQDQDDFNNYISICKQIQMPLIAELYDVYYIDIEKSKFAIFELELAQC---DLNQLLKGQEQNGQ . . || |.|. || ....| .. |. | ... . |.|.|. . | | ||||.. .. . .|.. || ...| . .| YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGL ---LNEEDKMIIAKQLIEVINYVHNFNIILRDIKPS-----KIGLKLSD---SNQISIKLFISYWTIRLKDGSNAIKTKQPVGALVFSAPENNKENQDDF ..| . ...|... ..| |. .|| ||.||. . .|..| . |. . .| . . ||| RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL----------------------TTFCGTPWYMAPEVL------- VYSK-ESDIFSLGATLCVLDN----YEILKNKLRQLVLSSLEPHFKQPFEKLQINRQSQIYKFIEQFCKYEIKQRKPLQSIID----QNQKELL |.| ..|. |.| .| . .. ... .... .. ||.. .... ..| . .. . . GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 10885.AA | CMGC | 118-249 | 15 | 3.6e-10 | 28.68 | In-house | 1-215 (513) | Show / Hide |
Range on Protein: 118-249 Range on HMM: 1-215/513 Sequence Identity: 15% (34 aa) SDSFQFIGAGSFSMVYSAKKIKNNQN--------------IALRIQEVHDQDQDDFN-------------NYISICKQIQ-----------------MPL . . || |....||... ..||. .|. . .... |.| |... . YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN IAELYDVYYIDIEKSKFA-------------IFELELAQCDLNQLLKGQE--QNG----QLNEED------------KMIIA------KQLIEVIN--YV | |||..| . .... . . |. ..|| |..| . ..| |.| . . .|... .. | IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC HNFN--IILRDIKPSKI | . || ||.||. | HSHWGNIIHRDLKPENI |
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| Kinase | 10885.AA | CK1-Unclassified | 223-246 | 62 | 1.4e-07 | 18.43 | In-house | 109-132 (244) | Show / Hide |
Range on Protein: 223-246 Range on HMM: 109-132/244 Sequence Identity: 62% (15 aa) IAKQLIEVINYVHNFNIILRDIKP || |.|. | |.|| |.| ||||| IADQMIQRIEYLHNKNFIHRDIKP |
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| Kinase | 10885.AA | PLK1 | 119-245 | 21 | 2.6e-07 | 19.82 | In-house | 2-126 (253) | Show / Hide |
Range on Protein: 119-245 Range on HMM: 2-126/253 Sequence Identity: 21% (28 aa) DSFQFIGAGSFSMVYSAKKIKNNQNIALRIQE----VHDQDQDDFNNYISICKQIQMPLIAELYDVYYIDIEKSKFAIFELELAQCDLNQLLKGQEQNGQ . .|.| | | | .. . .. .| .. . .. .| |.| .|.. . | .... . | ... . ||| | . |. . . . EKGRFLGKGGFAHCYEIRDKDTKEVFAGKVVPKSLLIKQHQRDKMTQEIQIHRQLHHRHIVKFHHFF----EDKQNVYIVLEL--CRRRSLMELHKRRKA LNEEDKMIIAKQLIEVINYVHNFNIILRDIK . | . .|..| . |.|| .|| ||.| ITEPECRYYMYQIVEGCQYLHNNKIIHRDLK |
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| Kinase | 10885.AA | Ciliate-E2a | 211-246 | 35 | 3.1e-07 | 17.39 | In-house | 92-130 (275) | Show / Hide |
Range on Protein: 211-246 Range on HMM: 92-130/275 Sequence Identity: 35% (14 aa) QNGQLNEE--DKMIIAKQLI-EVINYVHNFNIILRDIKP |.....|| . . | .||. . ..|.|. ||. ||.|| QCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKP |
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| Kinase | 10885.AA | Pkinase | 118-247 | 21 | 3.7e-07 | 26.39 | Pfam | 1-137 (293) | Show / Hide |
Range on Protein: 118-247
Range on HMM: 1-137/293
Sequence Identity: 21% (31 aa)
SDSFQFIGAGSFSMVYSAKKIKNNQNIALRIQEVHDQDQDDFNN-----YISICKQIQMPLIAELYDVYYIDIEKSKFAIFELELAQC-----DLNQLLK
. ||.|||. || ........ |. | ...... . . |.| | .. | | .|||... .. . .|.... || ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIS
GQEQNGQL--NEEDKMIIAKQLIEVINYVHNFNIILRDIKPS
. ...| . |.. ...|... ..| |. .|| ||.||.
T-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPE
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| Kinase | 10885.AA | Ciliate-A2 | 196-246 | 28 | 0.000111 | 12.52 | In-house | 78-130 (272) | Show / Hide |
Range on Protein: 196-246 Range on HMM: 78-130/272 Sequence Identity: 28% (15 aa) ELA-QCDLNQLLKG-QEQNGQLNEEDKMIIAKQLIEVINYVHNFNIILRDIKP |. .|.|.. . | | . .... .|.|... |.| || |..|||... EKCPECSLQDWIDKFQNQQKFIPDHQFVHFACQILDAIEYLHNKNYVLRDLSL |
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| Kinase | 10885.AA | Ciliate-A2 | 125-153 | 32 | 0.000645 | 9.83 | In-house | 1-31 (272) | Show / Hide |
Range on Protein: 125-153 Range on HMM: 1-31/272 Sequence Identity: 32% (10 aa) GAGSFSMVYSAKKI--KNNQNIALRIQEVHD | |.|. |. .. . ||. |. || . | GQGCFGCVIFVEHMDNHNNEKYAIKIQSIID |
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| Kinase | 10885.AA | TyrKc | 122-388 | 14 | 0.000661 | -159.47 | SMART | 5-280 (280) | Show / Hide |
Range on Protein: 122-388 Range on HMM: 5-280/280 Sequence Identity: 14% (46 aa) QFIGAGSFSMVYSA--------KKIKNNQNIALRIQEVHDQDQDDFNNYISICKQI--QMPLIAELYDVYYIDIE-----KSKFAIFELELAQCDLNQLL . .| | | || . |..|.. . || . ..| ... . | | || | . . . . ..|. . ||.. | KKLGEGAFGEVYKGTWKIQVAVKMLKEDA-------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEY-MPHGDLKDYL KGQEQNGQLNEEDKMIIAKQLIEVINYVHNFNIILRDIKPSKIGLKLSDSNQISIKLFISYWTIRL------KDGSNA--------IKTK----QPV--G . . . |. .|. .. | . .| | |.| ||. . .. |.. .|. . ..| . RKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTML ALVFSAPENNKENQDDFVYSKESDIFSLG------ATLCVLDNYE-----ILKNKLRQLVLSSLEPHFKQP-----FEKLQINRQSQIYKFIEQFCKYEI . ||| .. ... .||..| | |.. .. . ....| . . . | . .|. ..| .... PIRWMAPECI----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF----VCCPDEMYQIMKQCWHEDP KQRKPLQSIIDQNQKELL ..| . | .|.. EDRPTFSEI-----HECF |
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| Kinase | 10885.AA | CK1-Unclassified | 124-146 | 34 | 0.014723 | 3.39 | In-house | 7-29 (244) | Show / Hide |
Range on Protein: 124-146 Range on HMM: 7-29/244 Sequence Identity: 34% (8 aa) IGAGSFSMVYSAKKIKNNQNIAL ||.||| ..| .. ...|.. |. IGQGSFGEIYKCINMQTNEEVAI |
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| Kinase | 10885.AA | Ciliate-E2a | 305-318 | 28 | 0.154533 | 0.32 | In-house | 193-206 (275) | Show / Hide |
Range on Protein: 305-318 Range on HMM: 193-206/275 Sequence Identity: 28% (4 aa) YSKESDIFSLGATL |.. |..|.|. . YDTKCDMWSCGVIF |
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