13030

Species: Tetrahymena
Alias: 458, TTHERM_00058450, PreTt13030, 4.m00429, 3707.m00074, 13030
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E5

Sequence

Name Sequence Type Origin Length Description Download
13030.AA Protein None 466 None Fasta, JSON
13030.kin_dom Protein Kinase Domain None 184 None Fasta, JSON
13030.NA RNA None 1401 None Fasta, JSON

Protein domain

Protein domains of 13030.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 13030.AA Ciliate-E5 77-274 38 3.3e-113 369.89 In-house 3-271 (271) Show / Hide
Range on Protein: 77-274
Range on HMM: 3-271/271
Sequence Identity: 38% (103 aa)

SNRLLGKTPSTKILRALNKQ-GKSVAIKILKCNSMKDYEKNQNEFKLMKLFNSDYIIKVQELLEYRTQDKLLHFLIMERCLYDLHSQL----MLMTVNQS
.|..|||  |  ....  ..  |..||||.||...|..|.||.||...| |||..||||.....|..... ..|.|||||..|||..|    . |. .|.
ENQILGKGGSGMVMKGCSEWNDKPIAIKIMKCKNQKQCEDNQREFNILKQFNSPHIIKVYQIYQYQYENMNYQFIIMERCKCDLHTYLNKIIYQMK-WQK

HPDIYKICLDLIRGLQDIHNKNTVHLDIKPHNIVLGADNKWKFIDMGIS---------NQLSTNDG----------------------------------
|.|||.|||.|..||||||.||..||||||.||.||.|||||.||||||         .|.|....                                  
HQDIYQICLQLVKGLQDIHQKNIIHLDIKPANILLGYDNKWKYIDMGISRKFKHVVRDKQVSEQRQNSSETIEENMIKFIKIIPYFFQREYPKLHNKNRK

-------YVSKLKGLTLNYCSPEQYQQFYGIN-----------------KVKATKSSDTFSLGLVFLKLT
       ....|||.| .|.||||||......                 |.|.||.||..|||.|||.||
KLRYQIPHTCNLKGFTQCYSSPEQYQCYHNQMFYILIRNLPDIKYIQSFKKKITKQSDIYSLGIVFLELT

Kinase 13030.AA Ciliate-A1 75-332 27 1.6e-71 242.77 In-house 1-301 (301) Show / Hide
Range on Protein: 75-332
Range on HMM: 1-301/301
Sequence Identity: 27% (84 aa)

TFSNRLLGKTPSTKILRALNKQGKS--VAIKILKCNSMKDYEKNQNEFKLMKLFNSDYIIKVQELLEYRTQDKLLHFLIMERCLYDLHSQLMLMTVNQSH
.    |..|     ..|| . |..   ...||..|   . |  | .|....|. |. . ||. ..|.|.|..|.  |.||| |.| . ....      . 
YHVVQLIDKGSFGVVMRAYDIQNQKKYLCCKIIICTNFEQYKNNIQEYRKCKQINHNNVIKNYQQLYYNTNNKECMFIIMEYCQYGNLFNYCYQNDYMKK

PDIYKICLDLIRGLQDIHNKNTVHLDIKPHNIVLGADNKWKFIDMGISNQLSTND-----------------GYVSKLKGLTLNYCSPEQYQQFY---GI
 .|| ||. .| |. ||| .| .|.|.|| ||... |.|||..|.|.| ||  |                   | .  ||..| |.|||||| .|    .
EEIYEICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKWKICDLGMSKQLEQNQDCCDDVNGCSFSKQVNKHYHTCKKGGNLYYMSPEQYQMHYRDQMF

NKVKATKSSDTFSLGLVFLKLTG-----------VTIPKSDVEK------------SKQESYNYVSFFNPKFPELNIIINQMLSQIPDQRPQLIEIEENL
 . |  | || .|||.... |..           | |.                  .|.   .. ....|.| ||...|..|..  | .| .| .. . |
IENKIYKQSDMYSLGCIICFLCYKEDSHPYVGTIVNIFGNNMQNDQSIHFCKSVNAIKK--IIFPPMQEPRFEELQNLIFKMMQYEPNNRCSLQQCIDCL

KKI
. .
YIF

Kinase 13030.AA Ciliate-B2 94-267 29 1e-37 86.21 In-house 24-197 (197) Show / Hide
Range on Protein: 94-267
Range on HMM: 24-197/197
Sequence Identity: 29% (53 aa)

NKQGKSVAIKILKCNSMKDYEKNQNEFKLMKLFNSDYIIKVQELLEYRTQDKLLHFLIMERCLYDLHSQLM---LMTVNQSHPDIYKICLDLIRGLQDIH
... . .|.||.      | |  |.| | ||.|  .| |.| .....   ..  . ||||.| ..| . |    ..  .     .|..  .|| ||  ..
IREYQDLAFKIYFNKQDCDKEEIQHEIKIMKMF--EYNINVVKYIDHIQINETIDVLIMEKCECSLKQELQKIQKQQKCFNNQKLYQMIFQLIDGLIQFR

NKNTVHLDIKPHNIVLGADNKWKFIDMGISNQLSTNDGYVSKLKGLTLNYCSPEQYQQF-YGINKVKATKSSDTFSLG
 .| .|||||| || .   .. .. | |||   .  |    | ||.|  | |||| ...       .    || .|.|
MYNILHLDIKPQNILFMQNGNYVYCDFGISSIKK--DNQQIKIKGFTKKYASPEQMECDHNQTFVTNIDFQSDIYSMG

Kinase 13030.AA Ciliate-E1 81-264 25 1.2e-27 87.2 In-house 1-202 (202) Show / Hide
Range on Protein: 81-264
Range on HMM: 1-202/202
Sequence Identity: 25% (52 aa)

LGKTPSTKILRA--LNKQGKSVAIKILKCN---SMKDYEKNQNEFK-LMKLFN-SDYIIKVQELLEYRTQDKLLHFLIMERCLYDLHSQL----------
.|.  .  ...|   | . ..||.|| .|.   .. .......| . .|| |.  .|||.... ..   .. ... .|.| | . |. .|          
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKI--DQNYICIIIFECCCCSLKDYLQNHNRLEYWQ

MLMTVNQSHPDI--YKICLDLIRGLQDIHNKNTVHLDIKPHNIVLGADNKWKFIDMGISNQLSTNDGYVSKLKGLTLNYCSPEQYQ---QFYGINKVKAT
.... .... .    .|  .|| ||...|..|  |.||||.||.   ... .. | ||| .|  |. . .. || | .|..||||.   | . ... | .
QCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNKNQKIN

KSSDTF
. || .
YKSDIY

Kinase 13030.AA Ciliate-E3 100-274 32 5.7e-25 75.01 In-house 27-202 (202) Show / Hide
Range on Protein: 100-274
Range on HMM: 27-202/202
Sequence Identity: 32% (60 aa)

VAIKILKCNSMKD------YEKNQNEFKLMKLFNSDYIIKVQELLEYRTQDKLLHFLIMERCLYDLHSQLMLMTVNQSHPDIYKICLDLIRGLQDIHNKN
|||| . |   ..        | |.||.. . .|| .. |... . |  | |.. |...| |     .  .    |..   ||.||  .|.|. .|| ||
VAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQINSQNVVKCHDQY-YDQQNKMI-FIVQEYCSNGDLYHYIK-QQNKTQNIIYDICIQIIQGMIAIHEKN

TVHLDIKPHNIVLGADN---KWKFIDMGISNQLSTNDGYVSKL-KGLTLNYCSPEQYQQFYGINKVKATKSSDTFSLGLVFLKLT
  | |||| || ..  |     |. | | | ||. | |. . .  |.|  | .||| .|       .  | ||  |.| ||. | 
IIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQNDQ------QQISKESDYYSVGAVFCQLC

Kinase 13030.AA TKL 156-329 15 4.4e-17 58.05 In-house 126-364 (364) Show / Hide
Range on Protein: 156-329
Range on HMM: 126-364/364
Sequence Identity: 15% (39 aa)

LYDLHSQLMLMTVNQSHPDIYKICLDLIRGLQDIHN--------KNTVHLDIKPHNIVLGADNK--------------WKFIDMGIS--NQLSTNDGYV-
|..||           .. . ...||  ||..  |.        .. .| |.|..|| .  ...               |  |.|.|  .. |.|.    
LHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTM

---------------SKLKGLTLNYCSPEQ------YQQFYGI----NKVKATKSSDTFSLGLVFLKLTGVTIPKSDVEKSKQE---------SYNYVSF
               .  .. |.....||       |.. .||    .. ......| .| |.|.  .    .| .|   . ..         ..... .
TTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKG

FNPKFP-----------------ELNIIINQMLSQIPDQRPQLIEIEENL
  |  |                 ..  .. .  .. |..||   || . |
LRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase 13030.AA Pkinase 97-320 19 1.4e-15 56.12 Pfam 24-282 (293) Show / Hide
Range on Protein: 97-320
Range on HMM: 24-282/293
Sequence Identity: 19% (53 aa)

GKSVAIKILKCNSMKDYEKNQN----EFKLMKLFNSDYIIKVQELLEYRTQDKLLHFLIMERCLY-----DLHSQLM-LMTVNQ--SHPDIYKICLDLIR
|| ||.||.|  . |. .. ..    | ..|| .|...|..  .  |.   .. .. ..|| |       ||.. ..  .  .   |  .. .... ..|
GKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED---KDHIY-MVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILR

GLQDIHNKNTVHLDIKPHNIVLGADNKW----KFIDMGISNQL-STNDGYVSKLKGLTLNYCSPEQYQQFYGIN-KVKATKSSDTFSLGLVFLKLTGVTI
||. .|... .| |.|| || .  ..      | .| |.. |.   |..  . . | |..|..||       |.   . ....| .|.|...  .     
GLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCG-TPWYMAPEV------IRGGQYYGPKVDMWSCGCILYEMLCGRP

PKSDV---------EKSKQESYNYVSFFNPKF---------------------PELNIIINQMLSQIPDQRP
| ..          .. ..  .  ..|  |.                      .|.  .|. .| . | .||
PFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP

Kinase 13030.AA S_TKc 75-333 19 7.6e-15 40.77 SMART 1-231 (231) Show / Hide
Range on Protein: 75-333
Range on HMM: 1-231/231
Sequence Identity: 19% (54 aa)

TFSNRLLGKTPSTKILRALNKQ-GKSVAIKILKCNSMKDYEKNQNEFKLMKLFNSDYIIKVQELLEYRTQDKLLHFLIMERCLY---DLHSQLMLMTVN-
    |..||    |  .. .|  |. |||||.|       |. ..| ...|  . ..|.|  .  .         ...|| |     ||.. .  .  . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----QSHPDIYKICLDLIRGLQDIHNKNTVHLDIKPHNIVLGADNKWKFIDMGISNQLSTNDGYVSKLKGLTLNYCSPEQYQQFYGINKVKATK-SSDTF
     .  .. ...  ....|. .|... .| |.|| || |      | .| |.. ||        .    |..|..||           . .| ..|  
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---------GYGKCKCDWW

SLGLVFLKLTGVTIPKSDVEKSKQESYNYVSFFNPKFPELNIIINQMLSQIPDQRPQLIEIEE-----NLKKII
|.| ..  .     | .      |. .. .       ||.  .|...|   |..||   |. .     ..   .
SCGCILYEMLCGYPPFP----QMQMMFKKIG-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 13030.AA C8 89-270 24 3e-12 38.92 In-house 15-226 (226) Show / Hide
Range on Protein: 89-270
Range on HMM: 15-226/226
Sequence Identity: 24% (53 aa)

ILRALN-KQGKSVAIKILKCNSMKDYEKNQNEFKLMKLFNSDYIIKVQELL--EYRTQDKLLHFLIMERCL-----------YDLHS---------QLML
.|.| | |. . ...|..||   .. ...||. ..|| .  . ...  . .  || .. .  .    | |            .....         || .
VLKAKNVKDNREIVLKFQKC---QNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMELCEQNLKQLYD

MTVNQSHP----DIYKICLDLIRGLQDIHNKNTVHLDIKPHNIVLGADNKW----KFIDMGISNQLSTNDGYVSKLK----GLTLNYCSPEQYQQFYGIN
   |.  .    .  .| . .| |.  || || .| ||||||. . .|..     |  |.|.. |.| |       |    | |. |  ||. ..    .
ERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCG-TWAYFAPEIEKKQDNQY

KVKATKSSDTFSLGLVF
| . .. || ||.||| 
K-QYRIQSDLFSVGLVL

Kinase 13030.AA STE 177-248 26 2.1e-10 33.07 In-house 155-236 (359) Show / Hide
Range on Protein: 177-248
Range on HMM: 155-236/359
Sequence Identity: 26% (24 aa)

KICLDLIRG-LQDIHNKNTVHLDIKPHNIVLGADNKWKFIDMGISNQLS----------------TNDGYVSKLKGLTLNYCSPEQYQQ
.|| ....| |. .|... .| |||| || |      | .| |.. ||.                |...    . |    . .||  ||
YICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP--WMAPEVIQQ

Kinase 13030.AA MSN 149-228 34 6.4e-10 28.7 In-house 78-159 (265) Show / Hide
Range on Protein: 149-228
Range on HMM: 78-159/265
Sequence Identity: 34% (28 aa)

FLIMERCLYDLHSQLMLMTVNQSHPD--IYKICLDLIRGLQDIHNKNTVHLDIKPHNIVLGADNKWKFIDMGISNQLSTNDG
...|| |       |. || .||  .  |  || ...|||. .| .  .| |||  |..|  . . | .| |.| ||.   |
WMVMEFCGAGSVTDLVKMTKGQSLKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVG

Kinase 13030.AA Ciliate-E6 177-267 26 1.1e-09 27.32 In-house 57-154 (154) Show / Hide
Range on Protein: 177-267
Range on HMM: 57-154/154
Sequence Identity: 26% (26 aa)

KICLDLIRGLQDIHNKNTVHLDIKPHNIVLGADNKWKFIDMGISNQLSTNDGY---VSKLKGLTLNYCSPEQYQ----QFYGINKVKATKSSDTFSLG
|.|..|  ... .| || |.  |.. || |  . . |. | |..    .|  .    .. ..  . ||.|||.     |     ||. |...| .|..
KFCCQLFHAVEYLHSKNYVLQNITLKNIFLDKNMNIKICDFGFQQCIIPNQQTKEFMAQKNQNKYHYCPPEQFDYSKDQQSKHYKVNWTQEGDIWSVC

Kinase 13030.AA TyrKc 75-329 19 1.1e-07 -98.67 SMART 1-280 (280) Show / Hide
Range on Protein: 75-329
Range on HMM: 1-280/280
Sequence Identity: 19% (57 aa)

TFSNRLLGKTPSTKILRALNKQGKSVAIKILKCNSMKDYEKNQNEFKLMKLF--NSDYIIKVQELLEYRTQDK------LLHFLIMERCLY-DLHSQLML
   .. ||     .. ..  |    ||.| || ..    |   .| ..|. .  . . |..   |. . ||..        ....|| . . ||.. |  
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVR---LYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

MTVNQSHPDIYKICLDLIRGLQDIHNKNTVHLDIKPHNIVLGADNKWKFIDMGISNQLSTN-------DGYVS----KLKG-LTLNYCSPEQYQQFYGIN
   . ...|  ..|..  .| . .| || .| |.   |. .|...  |  | | |  .          | |..      |. | .  ..||        |
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI------N

KVKATKSSDTFSLGLV-----------FLK-----LTGVTIPKSDVEKSKQESYNYVSFFNP-----KFPELNIIINQMLSQIPDQRPQLIEIEENL
. | |  || .| | .                   ..   . .   .    .   ..    |       .|.  |. |     |..||   || | .
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase 13030.AA STE 91-133 16 0.000557 10.09 In-house 17-94 (359) Show / Hide
Range on Protein: 91-133
Range on HMM: 17-94/359
Sequence Identity: 16% (13 aa)

RALNK----------------QGKSVAIKILKCNSM-----------------KDYEKNQNEFKLMKLFN--SDYIIK
.|.|.                .|. .|||... ..                  .. .. ..| |.|| .|  ...|.|
KAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVK

Kinase 13030.AA TKL 81-133 11 0.087482 2.22 In-house 1-89 (364) Show / Hide
Range on Protein: 81-133
Range on HMM: 1-89/364
Sequence Identity: 11% (10 aa)

LGKTPSTKILRALNKQ---------GKSVAIKILKCNS---------------------------MKDYEKNQNEFKLMKLFNSDYIIK
.|.  . .. ..  ..         || ||.|..| ..                           ..  ..  .| ..|. .. . |..
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQ