26506

Species: Tetrahymena
Alias: 48.m00269, TTHERM_00433650, PreTt26506, 3831.m01605, 26506, 1012
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E6

Sequence

Name Sequence Type Origin Length Description Download
26506.AA Protein None 541 None Fasta, JSON
26506.kin_dom Protein Kinase Domain None 117 None Fasta, JSON
26506.NA RNA None 1626 None Fasta, JSON

Protein domain

Protein domains of 26506.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 26506.AA Ciliate-E6 74-196 44 4.3e-60 189.75 In-house 1-125 (154) Show / Hide
Range on Protein: 74-196
Range on HMM: 1-125/154
Sequence Identity: 44% (56 aa)

VNRLKQCSHKNILRYYDSFQIEDSFFIVMEKVEFSLQQWIN--DNRRNLIQKEQFLKFAQQMVEVADYLHHQKYILSNISLKNIFLDRDLNIKLSTFTVQ
...||.|.|.|||.|.||||||...|||||..|..||.||.  .|.....|..||.||..|......|||...|.|.||.|||||||...|||.. |  |
IQNLKNCNHPNILKYMDSFQIENYYFIVMERCEMNLQDWIHQHKNKKQINQNDQFFKFCCQLFHAVEYLHSKNYVLQNITLKNIFLDKNMNIKICDFGFQ

QEVSVKYLLDKQIYA-LENNQLIYFP
|.. ..  . |.. |  . |...|.|
QCI-IPNQQTKEFMAQKNQNKYHYCP

Kinase 26506.AA Ciliate-A2 34-165 40 3.4e-32 109.12 In-house 4-144 (272) Show / Hide
Range on Protein: 34-165
Range on HMM: 4-144/272
Sequence Identity: 40% (57 aa)

GFGKYLFAKYQ--QNSC--MIKIISIQSDEQLS--QQKKLQKAMEKVNRLKQCSHKNILRYYDSFQIEDSFFIVMEKV-EFSLQQWIN--DNRRNLIQKE
.||. .|..    .|.    |||.||. |.  .   |.||| . ..   || |.|.|| .|.|.|||    ||.|||  |.|||.||    | .. |...
CFGCVIFVEHMDNHNNEKYAIKIQSII-DGIDQKISQQKLQECKHEAQFLKNCNHPNIVKYHDEFQIGFYYFIQMEKCPECSLQDWIDKFQNQQKFIPDH

QFLKFAQQMVEVADYLHHQKYILSNISLKNIFLDRDLN-IKL
||..||.|. .  .||| . |.| ..||.|| .| | . |||
QFVHFACQILDAIEYLHNKNYVLRDLSLRNILIDQDNQIIKL

Kinase 26506.AA STE 48-146 17 1.7e-09 29.84 In-house 42-174 (359) Show / Hide
Range on Protein: 48-146
Range on HMM: 42-174/359
Sequence Identity: 17% (24 aa)

CMIKIISIQSDEQLSQQ------------KKLQKAMEKVNRLKQCS--HKNILRYYDSFQIE-------DSFFIVMEKVEF-SLQQWINDN-RRNLIQK-
. ||......... . .            ...|. .. .. .|.|.  |.|| .||...  |       |. .|.|| ..  || . |. .  ..  .. 
MAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNH

---------EQFL-KFAQQMVEV-ADYLHHQKYI
         |. . ....| ..   .||| ...|
NRQHQHRFPESQIAYICRQILKGLLYYLHSHHII

Kinase 26506.AA STE20 50-103 28 2.2e-08 27.07 In-house 33-88 (288) Show / Hide
Range on Protein: 50-103
Range on HMM: 33-88/288
Sequence Identity: 28% (17 aa)

IKIISIQSDE--QLSQQKKLQKAMEKVNRLKQCSHKNILRYYDSFQIE----DSFFIVME
||.... ...  |    ....  .  .. .||| |.|| .||.|.. .    |. .||||
IKKMNLEKCDNEQ----DEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVME

S_TKc 26506.AA S_TKc 28-275 14 6.5e-08 -60.89 SMART 1-231 (231) Show / Hide
Range on Protein: 28-275
Range on HMM: 1-231/231
Sequence Identity: 14% (41 aa)

IRKDKE----GFGKYLFAKYQQ--NSCMIKIISIQSDEQLSQQKKLQKAMEKVNRLKQCSHKNILRYYDSFQIEDSFFIVMEKVEF---SLQQWINDNRR
 .. ..    .|||   ..       . ||||.             ....  .. ||.  |.|| ..||.||  |....||| ..    .| . | ...|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

NL----IQKEQFLKFAQQMVEVADYLHHQKYILSNISLKNIFLDRDLNIKL-----STFTVQQEVSVKYLLDKQIYALENNQLIYFPIC---------LI
.     .   .  ....|...  .|.| .. |   .   ||.||.  .||.     ...                            .|         ..
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------------TTFCGTPWYMAPEVL

EEGGNQNMVALSN-KQDMYTIGLCLYCLTG----VSYMEVLNYIQGGKFQVNISLGVDINQLLQLMLFRNTY-----SSVP-------SPCY
           .  | |.. .| .|| .       .  ..   ..  .         .  .... .| ..                   |  
---------GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF

Kinase 26506.AA SLK 60-170 20 1.3e-07 21.64 In-house 33-143 (259) Show / Hide
Range on Protein: 60-170
Range on HMM: 33-143/259
Sequence Identity: 20% (23 aa)

QLSQQKKLQKAMEKVNRLKQCSHKNILRYYDSFQIEDSFFIVMEKVEFSLQQWINDNRRNLIQKEQFLKFAQQMVEVADYLHHQKYILSNISLKNIFLDR
.. .. .|.  |  .. | .| | ||.. |... ...  ....|  .      |  .    .. .|    ...|.|  ..||..| |  ..   || .  
EIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQYVCKHMCEALNWLHSNKVIHRDLKAGNILMTM

DLNIKLSTFTV
| ...|  | |
DGDVRLADFGV

Kinase 26506.AA Ciliate-E2-Unclassified 49-168 20 2.3e-07 21.61 In-house 29-191 (352) Show / Hide
Range on Protein: 49-168
Range on HMM: 29-191/352
Sequence Identity: 20% (34 aa)

MIKIISIQSDEQLSQQK-----KLQKAMEKVN-------------RLKQCSHKNILRYYDSFQIEDSFFIVMEKVE-FSLQQWIND--------------
|  ...||.. |.....       .|.|.. .              |... | .|..... || .. ..||||..|  .|.|.|..              
MKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHN

-NRRNLIQKEQFL-----KFAQQMVEVADYLHHQK-YILSNISLKNIFLDRDL---NIKLSTF
 ..|. .. .| .     ... | ..  .||||..  |  .| . ||..| .    .||.. |
MKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDF

Kinase 26506.AA Jak 72-160 22 3e-07 21.76 In-house 58-154 (299) Show / Hide
Range on Protein: 72-160
Range on HMM: 58-154/299
Sequence Identity: 22% (22 aa)

EKVNRLKQCSHKNILRYYDSF--QIEDSFFIVMEKVEF-SLQQWIN---DNRRNLIQK--EQFLKFAQQMVEVADYLHHQKYILSNISLKNIFLDRD
. . ...|.|||.|..|.     ...|.  .||| ... .|  . .   ..... .     . ..||.| .....||. ..||  ... .|| .||.
REISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGPLDDYLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDRE

Kinase 26506.AA Ciliate-E2 49-166 19 1e-06 18.58 In-house 48-198 (365) Show / Hide
Range on Protein: 49-166
Range on HMM: 48-198/365
Sequence Identity: 19% (31 aa)

MIKIISIQSDEQLSQQKKLQKAMEKVN----------RLKQCSHKNILRYYDSFQ--IEDSFFIVMEKVEF-SLQQWINDNRRNL---------IQKEQF
.|. . |..  |. |.|. .. | ..|           |.| .|.||...|..||   ......||| ..  .|...|..|. .          .  .. 
KIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEI

LKFAQQMVEVA---------------DYLHHQK-YILSNISLKNIFLDRDLNIKLS
... .| ...                 ||| ..  |  .| . ||..     ||..
KYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKII

Kinase 26506.AA PAKA 60-103 34 3e-06 17.97 In-house 35-78 (260) Show / Hide
Range on Protein: 60-103
Range on HMM: 35-78/260
Sequence Identity: 34% (15 aa)

QLSQQKKLQKAMEKVNRLKQCSHKNILRYYDSFQIEDSFFIVME
....| | .. .     .|.| |||| .|.||. ..|  ..|||
NMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVME

Kinase 26506.AA NEK1 60-103 29 5e-06 17.04 In-house 33-80 (276) Show / Hide
Range on Protein: 60-103
Range on HMM: 33-80/276
Sequence Identity: 29% (14 aa)

QLSQQ--KKLQKAMEKVNRLKQCSHKNILRYYDSFQIEDS--FFIVME
.....  |  ...|. |. |.   | || .|..||. . .   .||||
NVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVME

Kinase 26506.AA Pkinase 77-166 23 3.5e-05 19.39 Pfam 54-154 (293) Show / Hide
Range on Protein: 77-166
Range on HMM: 54-154/293
Sequence Identity: 23% (25 aa)

LKQCSHKNILRYYDSFQIEDSFFIVMEKVEF-----SLQQWINDNRRNLI--QKEQFLKFAQQMVEVADYLHHQKYILSNIS-----LKNIFLDRDLNI-
.| ..|.||.|.||.|. .|.  .||| .|      .|  .|   |.. .  . ..  ... |...  .|.| .     .|      . ||..|.. .| 
MKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM-----GIIHRDLKPENILIDNNGHID

---KLS
   |..
ACVKIC

TPR_1 26506.AA TPR_1 427-460 26 1e-06 27.41 Pfam 1-34 (34) Show / Hide
Range on Protein: 427-460
Range on HMM: 1-34/34
Sequence Identity: 26% (9 aa)

DEVYNNIGDIYLKQNDFNTSKSYFEKSIEFNPRQ
 |...|.| .|.|.....    ...| .| ||  
AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN

TPR 26506.AA TPR 427-460 26 1.1e-05 26.19 SMART 1-34 (34) Show / Hide
Range on Protein: 427-460
Range on HMM: 1-34/34
Sequence Identity: 26% (9 aa)

DEVYNNIGDIYLKQNDFNTSKSYFEKSIEFNPRQ
 |...|.| .|.|..|..    ...|..| .|  
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN

TPR_2 26506.AA TPR_2 427-460 32 2.1e-05 23.23 Pfam 1-34 (34) Show / Hide
Range on Protein: 427-460
Range on HMM: 1-34/34
Sequence Identity: 32% (11 aa)

DEVYNNIGDIYLKQNDFNTSKSYFEKSIEFNPRQ
 |...|.|..|.||.|.   . |.||... .|. 
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN

TPR_1 26506.AA TPR_1 461-494 20 8.3e-05 20.77 Pfam 1-34 (34) Show / Hide
Range on Protein: 461-494
Range on HMM: 1-34/34
Sequence Identity: 20% (7 aa)

YIAYYNLAQVYFEQKMFQKGSYYLKKAKKIEQDD
. |.|||...|.... ...   ...|| ... ..
AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN

TPR_2 26506.AA TPR_2 461-494 32 0.000123 20.49 Pfam 1-34 (34) Show / Hide
Range on Protein: 461-494
Range on HMM: 1-34/34
Sequence Identity: 32% (11 aa)

YIAYYNLAQVYFEQKMFQKGSYYLKKAKKIEQDD
  |.|||.|.|..|. ...   |..|| |.. ..
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN

TPR 26506.AA TPR 461-494 20 0.000311 21.31 SMART 1-34 (34) Show / Hide
Range on Protein: 461-494
Range on HMM: 1-34/34
Sequence Identity: 20% (7 aa)

YIAYYNLAQVYFEQKMFQKGSYYLKKAKKIEQDD
. |.|||...|. .. ...   ...|| ... ..
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN

TPR_2 26506.AA TPR_2 393-426 26 0.115001 9.98 Pfam 1-34 (34) Show / Hide
Range on Protein: 393-426
Range on HMM: 1-34/34
Sequence Identity: 26% (9 aa)

DVAMFGLGSAYEDLGFIQESLSCYDKYINLNSFD
  | . || .|. .|  .| . .|.| . |.  .
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN

TPR 26506.AA TPR 393-426 29 0.252432 5.84 SMART 1-34 (34) Show / Hide
Range on Protein: 393-426
Range on HMM: 1-34/34
Sequence Identity: 29% (10 aa)

DVAMFGLGSAYEDLGFIQESLSCYDKYINLNSFD
  | . || .|. .| ..| . ||.| . |.  .
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN

TPR 26506.AA TPR 495-527 24 0.40242 4.06 SMART 2-34 (34) Show / Hide
Range on Protein: 495-527
Range on HMM: 2-34/34
Sequence Identity: 24% (8 aa)

DSYELLGYFYEQKQEYEKSLKCYEKLSMNIQNH
. .  ||  |... .|.. ..||.|      |.
EAWYNLGNCYYKMGDYDEAIECYQKALELDPNN

TPR_1 26506.AA TPR_1 393-426 32 0.481861 7.63 Pfam 1-34 (34) Show / Hide
Range on Protein: 393-426
Range on HMM: 1-34/34
Sequence Identity: 32% (11 aa)

DVAMFGLGSAYEDLGFIQESLSCYDKYINLNSFD
  | . || .|. .|  .| . ||.| . ||  .
AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN

TPR_2 26506.AA TPR_2 495-527 24 0.494029 7.74 Pfam 2-34 (34) Show / Hide
Range on Protein: 495-527
Range on HMM: 2-34/34
Sequence Identity: 24% (8 aa)

DSYELLGYFYEQKQEYEKSLKCYEKLSMNIQNH
. . .||  |.....|.. ...|||.     |.
EAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN

TPR_1 26506.AA TPR_1 495-519 28 0.711127 7.04 Pfam 2-26 (34) Show / Hide
Range on Protein: 495-519
Range on HMM: 2-26/34
Sequence Identity: 28% (7 aa)

DSYELLGYFYEQKQEYEKSLKCYEK
. .  ||. |.....|.. ..||.|
EAWYNLGNCYYKMGNYDEAIECYQK

TPR_2 26506.AA TPR_2 377-392 37 55.530135 0.48 Pfam 19-34 (34) Show / Hide
Range on Protein: 377-392
Range on HMM: 19-34/34
Sequence Identity: 37% (6 aa)

QAFYSYKKAFELNDKN
.|   |.|| .|. .|
EAIEYYEKALKLDPNN

TPR_1 26506.AA TPR_1 382-392 63 57.028244 0.39 Pfam 24-34 (34) Show / Hide
Range on Protein: 382-392
Range on HMM: 24-34/34
Sequence Identity: 63% (7 aa)

YKKAFELNDKN
|.|| ||| .|
YQKALELNPNN