9395

Species: Tetrahymena
Alias: 9395, 3699.m00124, 1077, TTHERM_00128310, 9.m00416, PreTt09395
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E6

Sequence

Name Sequence Type Origin Length Description Download
9395.AA Protein None 622 None Fasta, JSON
9395.kin_dom Protein Kinase Domain None 159 None Fasta, JSON
9395.NA RNA None 1869 None Fasta, JSON

Protein domain

Protein domains of 9395.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 9395.AA Ciliate-E6 68-220 50 1.3e-99 317.1 In-house 1-154 (154) Show / Hide
Range on Protein: 68-220
Range on HMM: 1-154/154
Sequence Identity: 50% (78 aa)

AKLLQECNHENIPKYIDQFQIKQFYLILMESFDTTLFNWSQQVENFYYIKND-LFIKFSQELFSIVEYIHSKNYLLQNLTLQNIYIDKNMKLKILDFGEG
.. |..|||.||.||.|.|||...|.|.||.....|..|..|..|...|... .|.||...||..|||.|||||.|||.||.||..||||..||.|||..
IQNLKNCNHPNILKYMDSFQIENYYFIVMERCEMNLQDWIHQHKNKKQINQNDQFFKFCCQLFHAVEYLHSKNYVLQNITLKNIFLDKNMNIKICDFGFQ

QSIIPSIETKKFLAQQPGNEYIYLPPEFFDYSKKHDQKNEQVKWTQCADIWMLG
|.|||...||.|.||...|.|.|.|||.|||||....|...|.|||..|||...
QCIIPNQQTKEFMAQKNQNKYHYCPPEQFDYSKDQQSKHYKVNWTQEGDIWSVC

Kinase 9395.AA Ciliate-A2 29-281 31 5.8e-36 122.37 In-house 8-272 (272) Show / Hide
Range on Protein: 29-281
Range on HMM: 8-272/272
Sequence Identity: 31% (85 aa)

ILFVQN---ENQEEYVMRIFNLQSDDDQSKICDQKLNQAQNFAKLLQECNHENIPKYIDQFQIKQFYLILMESF-DTTLFNWSQQVEN-FYYIKNDLFIK
..||.    .| |.|   |.... |   .||. ||| ...  |..|..|||.|| || | |||. .| | ||   .  |  | .  .|    |   .|..
VIFVEHMDNHNNEKYAIKIQSII-DGIDQKISQQKLQECKHEAQFLKNCNHPNIVKYHDEFQIGFYYFIQMEKCPECSLQDWIDKFQNQQKFIPDHQFVH

FSQELFSIVEYIHSKNYLLQNLTLQNIYIDKNMK-LKILDFGEGQSIIPSIETKKFLAQQPGNEYIYLPPEFFDY---SKKHDQKNEQVKWTQCADIWML
| . . . .||.|.||| | .| |.|| ||..   .|  |||    . |.|... |....|  . .| ||| .     .    .|..|.| |  .||| .
FACQILDAIEYLHNKNYVLRDLSLRNILIDQDNQIIKLCDFGLAKKYQPEINSQMFYTSCPKGVFFYYPPECHFQCFEMNGEQNKKQQIKQTFMGDIWAF

GICLYALAGADLFQIQQFT---QGKDFFQYNLNKVDLELRKFVMNILCFNTNQRP-QASQLIERLS
|||||.|.|||. .  ..|   |.|..    ....| .. .   .||    ..||    |... . 
GICLYQLGGADQQHCYKLTQCNQKKWWQYQDYPNLDEKCNQIIQQILNCDPKKRPSSIQQIRHHWH

S_TKc 9395.AA S_TKc 24-281 15 4.2e-11 -14.07 SMART 1-231 (231) Show / Hide
Range on Protein: 24-281
Range on HMM: 1-231/231
Sequence Identity: 15% (44 aa)

INREDIL----------FVQNENQEEYVMRIFNLQSDDDQSKICDQKLNQAQNFAKLLQECNHENIPKYIDQFQIKQFYLILMESFDT---TLFNWSQQV
    ...           . .. .... . | .               .....  ..|.. .|.|| |..| ||  ... . ||  |.   .||   .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR

ENF---YYIKNDLFIKFSQELFSIVEYIHSKNYLLQNLTLQNIYIDKNMKLKILDFGEGQSIIPSIETKKFLAQQPGNEYI----YLPPEFFDYSKKHDQ
      ...      .. ..... .||.||.. .   |  .|| .|.   .|| |||    .               . ..    |..|| .        
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------------TTFCGTPWYMAPEVL--------

KNEQVKWTQ-CADIWMLGICLYALAGADL-FQIQQFTQGKDFFQYNLNKVDLELRKFVMNILCFNTNQRPQASQLIE--------RLS
     ...   .|.| .|..|| ..     |.     | .  |.  .   . |.. |....|... ..|| | .. .           
-----GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 9395.AA Ciliate-E2 69-278 17 2.2e-10 31.86 In-house 84-361 (365) Show / Hide
Range on Protein: 69-278
Range on HMM: 84-361/365
Sequence Identity: 17% (51 aa)

KLLQECNHENIPKYIDQFQ--IKQFYLILMESFDT-TLFNWSQQVENFY--------YIKNDLFIKFSQELFS---------------IVEYIHSKN-YL
..|.. || || |... ||   .. . . || ..  .|| . ..   .         |..    .........                .||.||||  .
NILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNII

LQNLTLQNIYIDKNMKLKILDFGEGQSIIPSIETKK-----FLAQQPGN-----------------------EYIYLPPEFFDYSKKHDQKNEQVKWTQC
  .. ..|| .     .|| |||  . . .. . .       . .. .|                        . |..|| . . |   | ..|  ..  
HRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ-QKQKGYDYK

ADIWMLGICLYALAGADL-FQIQQFTQGKDFFQYNL---------------NKVDLELRKFVMN----ILCFNTNQRPQ-ASQLIE
.||| ||..|| .    . | .||  |.|  |. .                .|...|   .  .    .|. . ..|.. ..|...
CDIWSLGVILYEMLFGKPPF-QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN

Kinase 9395.AA Kin4 124-164 43 9.5e-07 16.09 In-house 116-155 (273) Show / Hide
Range on Protein: 124-164
Range on HMM: 116-155/273
Sequence Identity: 43% (18 aa)

FSQELFSIVEYIHSKNYLLQNLTLQNIYIDKNMKLKILDFG
|.| | | |.|.|.|      | | |. .||.  | | |||
FAQ-LISGVHYMHYKGLVHRDLKLENLLLDKHENLVITDFG

Kinase 9395.AA TKL 132-227 15 4e-06 17.98 In-house 145-283 (364) Show / Hide
Range on Protein: 132-227
Range on HMM: 145-283/364
Sequence Identity: 15% (21 aa)

VEYIHS--------KNYLLQNLTLQNIYIDKNMK--------------LKILDFGEGQSIIPSIE---------------TKKFLAQQPGNEYIYLPPEF
..| ||        .. .  .|. .|| .|.|..              .|| |||  ... .| .               . .     ..  . ...|| 
MNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEV

FDYSKKHDQKN------EQVKWTQCADIWMLGICLYALA
.. . . ..|.      .. . .. .|..  ||.|. ..
LRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEIL

Kinase 9395.AA SAK 134-164 45 5e-06 16.27 In-house 115-145 (254) Show / Hide
Range on Protein: 134-164
Range on HMM: 115-145/254
Sequence Identity: 45% (14 aa)

YIHSKNYLLQNLTLQNIYIDKNMKLKILDFG
|.|| . .   ||| || . ..|..|| |||
YLHSHGIMHRDLTLSNILLTRDMHCKIADFG

Kinase 9395.AA TKL-ciliate1 254-280 29 7e-06 16.15 In-house 253-279 (279) Show / Hide
Range on Protein: 254-280
Range on HMM: 253-279/279
Sequence Identity: 29% (8 aa)

ELRKFVMNILCFNTNQRPQASQLIERL
.. .. |  .| | |.|| ....|..|
NFHNLMMRCWCQNPNKRPNFNEIIQIL

Kinase 9395.AA PHK 128-164 45 2.4e-05 13.92 In-house 118-154 (273) Show / Hide
Range on Protein: 128-164
Range on HMM: 118-154/273
Sequence Identity: 45% (17 aa)

LFSIVEYIHSKNYLLQNLTLQNIYIDKNMKLKILDFG
||. |.|.|..|     | . ||  | ||. || |||
LFEGVCYMHAHNIVHRDLKPENILCDDNMNIKISDFG

Kinase 9395.AA MELK 123-164 33 6.4e-05 12.41 In-house 101-142 (254) Show / Hide
Range on Protein: 123-164
Range on HMM: 101-142/254
Sequence Identity: 33% (14 aa)

KFSQELFSIVEYIHSKNYLLQNLTLQNIYIDKNMKLKILDFG
.| ... | . |.||. |  ..|  .|. .| ...||..|||
HFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFG

Kinase 9395.AA CAMK 70-172 15 0.000129 10.01 In-house 84-249 (425) Show / Hide
Range on Protein: 70-172
Range on HMM: 84-249/425
Sequence Identity: 15% (26 aa)

LLQECN-------HENIPKYIDQFQIKQ--------------------FYLIL--MESFDTT-----LFNWSQQVENF------------YYIKNDLFIK
... ..       |.|| | .. .. ..                    .|...  ||  .       ||.. .. ...             ... .   .
IMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARR

FSQELFSIVEYIHSKNYLLQNLTLQNIYIDKNM-----------------KLKILDFGEGQSIIPS
. . . | |.|.||.|     | . || .|.|.                 ..|| |||  . ..|.
YFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPG

Kinase 9395.AA TKL 268-280 30 0.216945 0.78 In-house 352-364 (364) Show / Hide
Range on Protein: 268-280
Range on HMM: 352-364/364
Sequence Identity: 30% (4 aa)

NQRPQASQLIERL
..|| ......||
EKRPSFQEILKRL

Kinase 9395.AA MELK 214-226 61 0.220737 0.12 In-house 181-193 (254) Show / Hide
Range on Protein: 214-226
Range on HMM: 181-193/254
Sequence Identity: 61% (8 aa)

ADIWMLGICLYAL
||.| .|| ||.|
ADVWSMGILLYVL

TPR 9395.AA TPR 339-372 20 5.5e-08 33.77 SMART 1-34 (34) Show / Hide
Range on Protein: 339-372
Range on HMM: 1-34/34
Sequence Identity: 20% (7 aa)

YEVLNLIAQIYLQKNQFEQAEIILNQALKINPEN
.|... ....|........|.  ...||...|.|
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN

TPR_2 9395.AA TPR_2 339-372 26 2.6e-07 29.93 Pfam 1-34 (34) Show / Hide
Range on Protein: 339-372
Range on HMM: 1-34/34
Sequence Identity: 26% (9 aa)

YEVLNLIAQIYLQKNQFEQAEIILNQALKINPEN
 |......|.|........|.  ...|||..|.|
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN

TPR_1 9395.AA TPR_1 339-372 23 4e-07 28.85 Pfam 1-34 (34) Show / Hide
Range on Protein: 339-372
Range on HMM: 1-34/34
Sequence Identity: 23% (8 aa)

YEVLNLIAQIYLQKNQFEQAEIILNQALKINPEN
.|... ....|........|.  ...||..||.|
AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN

TPR_2 9395.AA TPR_2 305-338 11 0.008572 13.97 Pfam 1-34 (34) Show / Hide
Range on Protein: 305-338
Range on HMM: 1-34/34
Sequence Identity: 11% (4 aa)

LITQIQEGKKCLHNKQYEEALQKFNQVIEKNSED
     . |. ......|.||.. ...... . ..
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN

TPR 9395.AA TPR 305-338 14 0.028984 14.1 SMART 1-34 (34) Show / Hide
Range on Protein: 305-338
Range on HMM: 1-34/34
Sequence Identity: 14% (5 aa)

LITQIQEGKKCLHNKQYEEALQKFNQVIEKNSED
  .  . |  ......|.||.. .....| . ..
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN

TPR_1 9395.AA TPR_1 312-338 22 0.107793 9.9 Pfam 8-34 (34) Show / Hide
Range on Protein: 312-338
Range on HMM: 8-34/34
Sequence Identity: 22% (6 aa)

GKKCLHNKQYEEALQKFNQVIEKNSED
|  ... ..|.||.. .....| | ..
GNCYYKMGNYDEAIECYQKALELNPNN

TPR_1 9395.AA TPR_1 394-407 21 12.12424 2.74 Pfam 21-34 (34) Show / Hide
Range on Protein: 394-407
Range on HMM: 21-34/34
Sequence Identity: 21% (3 aa)

INHYERCIKNHPEY
| .|.....  |..
IECYQKALELNPNN

TPR_2 9395.AA TPR_2 394-407 35 66.166769 0.21 Pfam 21-34 (34) Show / Hide
Range on Protein: 394-407
Range on HMM: 21-34/34
Sequence Identity: 35% (5 aa)

INHYERCIKNHPEY
|..||...|  |..
IEYYEKALKLDPNN

TPR_1 9395.AA TPR_1 443-473 29 0.000109 20.35 Pfam 4-34 (34) Show / Hide
Range on Protein: 443-473
Range on HMM: 4-34/34
Sequence Identity: 29% (9 aa)

LKKLGMIYATQKKEQKALNQFKKAIALNPFD
.. ||..|  ... ..|.  ..||..||| .
WYNLGNCYYKMGNYDEAIECYQKALELNPNN

TPR_2 9395.AA TPR_2 440-473 26 0.000134 20.36 Pfam 1-34 (34) Show / Hide
Range on Protein: 440-473
Range on HMM: 1-34/34
Sequence Identity: 26% (9 aa)

NMGLKKLGMIYATQKKEQKALNQFKKAIALNPFD
  ..  ||..|. |.. ..|.. ..||..|.| .
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN

TPR 9395.AA TPR 440-473 23 0.000233 21.73 SMART 1-34 (34) Show / Hide
Range on Protein: 440-473
Range on HMM: 1-34/34
Sequence Identity: 23% (8 aa)

NMGLKKLGMIYATQKKEQKALNQFKKAIALNPFD
   .. ||..|  ... ..|.. ..||..|.| .
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN

TPR 9395.AA TPR 474-507 23 0.000303 21.35 SMART 1-34 (34) Show / Hide
Range on Protein: 474-507
Range on HMM: 1-34/34
Sequence Identity: 23% (8 aa)

FECQNLIGKINYVLQNKDQAINDFNLSLTINPDQ
 |. . .| . | . . |.||.... .|...|. 
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN

TPR_1 9395.AA TPR_1 474-507 29 0.000569 17.85 Pfam 1-34 (34) Show / Hide
Range on Protein: 474-507
Range on HMM: 1-34/34
Sequence Identity: 29% (10 aa)

FECQNLIGKINYVLQNKDQAINDFNLSLTINPDQ
 |  . .| . | ..| |.|| ...  | .||. 
AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN

TPR_2 9395.AA TPR_2 474-507 23 0.001931 16.26 Pfam 1-34 (34) Show / Hide
Range on Protein: 474-507
Range on HMM: 1-34/34
Sequence Identity: 23% (8 aa)

FECQNLIGKINYVLQNKDQAINDFNLSLTINPDQ
.|. ...|.. | ... |.||.... .| ..|. 
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN

TPR_1 9395.AA TPR_1 539-572 29 0.002771 15.45 Pfam 1-34 (34) Show / Hide
Range on Protein: 539-572
Range on HMM: 1-34/34
Sequence Identity: 29% (10 aa)

YEAFEQIGNELNFDQKFLSAIQYYKKTIQIKPNI
.||. ..|| .   ...  ||..|.| ... || 
AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN

TPR 9395.AA TPR 539-572 29 0.015092 15.71 SMART 1-34 (34) Show / Hide
Range on Protein: 539-572
Range on HMM: 1-34/34
Sequence Identity: 29% (10 aa)

YEAFEQIGNELNFDQKFLSAIQYYKKTIQIKPNI
.||. ..|| .    ..  ||..|.| ... || 
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN

TPR_2 9395.AA TPR_2 539-572 29 1.18924 6.39 Pfam 1-34 (34) Show / Hide
Range on Protein: 539-572
Range on HMM: 1-34/34
Sequence Identity: 29% (10 aa)

YEAFEQIGNELNFDQKFLSAIQYYKKTIQIKPNI
 ||  ..|. .   ...  ||.||.| ... || 
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN

TPR_1 9395.AA TPR_1 525-538 35 1.925432 5.53 Pfam 21-34 (34) Show / Hide
Range on Protein: 525-538
Range on HMM: 21-34/34
Sequence Identity: 35% (5 aa)

ISYFKKACLIDPNY
| ...||  ..||.
IECYQKALELNPNN

TPR_2 9395.AA TPR_2 525-538 50 6.414248 3.8 Pfam 21-34 (34) Show / Hide
Range on Protein: 525-538
Range on HMM: 21-34/34
Sequence Identity: 50% (7 aa)

ISYFKKACLIDPNY
| |..||  .|||.
IEYYEKALKLDPNN