Gene TIF1 (Sea Urchin)
TIF1
Sequence
Protein domains of TIF1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| CLECT | TIF1.AA | CLECT | 37-183 | 26 | 3.3e-26 | 94.32 | SMART | 1-141 (141) | Show / Hide |
Range on Protein: 37-183 Range on HMM: 1-141/141 Sequence Identity: 26% (47 aa) C---PPLWTGF-------NDNCYRFFVSGNLSWFDAELACRTFSTPCGEESSSSSMGHLVSIHSQEEMDFITAMYDSLRSKRPTIDTRTWIGLHDRTAEQ | || |. . ...||.|| | ||. .|. . .. . . |||.|||||||.||.. . ||||| CPHCPPGWNWYPRPNKYFGGHCYKFFT-----WHDAQQFCQSMGPW--THR--VQGGHLASIHSQEENDFVQSL--------------YWIGLH-----G SAEWTDSS--------DFDYASWAPSQPND---------QNGASDCVFFSRNTLYKWNDIPCT--PGSRVESFVSD .|.| | .|| |||..||. .| .||... |||..|. . .|. -WQWSDGSGWIPPTNPWVDYTNWAPGYPNNQPNNWWRHGNGGNGNCVYMW------WNDVNCNSNDPYHKHPFICK |
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| Lectin_C | TIF1.AA | Lectin_C | 55-171 | 32 | 7.4e-20 | 77.1 | Pfam | 1-112 (122) | Show / Hide |
Range on Protein: 55-171 Range on HMM: 1-112/122 Sequence Identity: 32% (40 aa) GNLSWFDAELACRTFSTPCGEESSSSSMGHLVSIHSQEEMDFITAMYDSLRSKRPTIDTRTWIGLHDRTAEQSAEW---TDSSDFDYA-SWAPSQPNDQN .|..|...|.. . | ||||||||||..|| . .. .. ...||||||.. | . .| .| .. .|. ||| .||. . ERMTWHEAQAYCQKMGGHC----------HLVSIHSQEEQMFIWDFITQHTKY---YNHYFWIGLHDCNTEWQWVWWWEWDGTPVNYTENWAPGEPNNWQ G---ASDCVFFSRNTL-YKWNDIPC . ||| ....| .||||..| NHGGNEDCVHMWTDTNWGKWNDEHC |
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| Zf-C3HC4 | TIF1.AA | zf-C3HC4 | 208-265 | 25 | 8.4e-10 | 29.39 | Pfam | 1-48 (48) | Show / Hide |
Range on Protein: 208-265 Range on HMM: 1-48/48 Sequence Identity: 25% (16 aa) CKVCEREFSADVQPRMLPCLHT-----VCAQCLANVTNNTALASGQQGILAGSGVVIAKCPIC | .| |.. .. | ..||.|. .| |. . |. || . |||| CWICHCEWKDPNNPLIHPCGHRGSLKWFCHSCIKRWWNH-------------SGNTQ--CPIC |
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| RING | TIF1.AA | RING | 208-265 | 22 | 1.1e-08 | 36.05 | SMART | 1-23 (23) | Show / Hide |
Range on Protein: 208-265 Range on HMM: 1-23/23 Sequence Identity: 22% (13 aa) CKVCEREFSADVQPRMLPCLHTVCAQCLANVTNNTALASGQQGILAGSGVVIAKCPIC | .| |..||| | | |. |||| CPICLE-------PVVLPCGH-FCY-CI--------------------------CPIC |
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| BBOX | TIF1.AA | BBOX | 292-339 | 29 | 0.000105 | 21.32 | SMART | 1-51 (51) | Show / Hide |
Range on Protein: 292-339 Range on HMM: 1-51/51 Sequence Identity: 29% (15 aa) GGEMLCHNCDANAPATNFC-VDCPGGLCDPCVLL--HGKVRFLRDHVIQPR . . .| |.. ..||. || .|| ||..| . | ... |.| ..| HRPPMCDNHQQHEPAHFFCVEDCQQCLCWDCDESGEHQANKLFRGHQVVPL |
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| Zf-B_box | TIF1.AA | zf-B_box | 293-339 | 20 | 1.838617 | 6.48 | Pfam | 1-45 (45) | Show / Hide |
Range on Protein: 293-339 Range on HMM: 1-45/45 Sequence Identity: 20% (10 aa) GEMLCHNCDANAPATNFCVDCPGGLCDPCVLL-HGKVRFLRDHVIQPR . .| ... |.. .| || .|. |.. | . ...| ..| QM-YCPEHPE-EPLEYYCQDCQQCICEDCAVHGHKGNG-FKKHTVVPI |
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| BBOX | TIF1.AA | BBOX | 349-390 | 27 | 7.1e-10 | 40.05 | SMART | 1-51 (51) | Show / Hide |
Range on Protein: 349-390 Range on HMM: 1-51/51 Sequence Identity: 27% (14 aa) VQPPFCTIHP-KERLQLYC-EKCVRLTCRDCQLV-SH------KDHSYQFL .|| |..| .|.....| | | . |.|| .. | ..| ...| HRPPMCDNHQQHEPAHFFCVEDCQQCLCWDCDESGEHQANKLFRGHQVVPL |
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| Zf-B_box | TIF1.AA | zf-B_box | 350-390 | 32 | 4.7e-09 | 40.49 | Pfam | 1-45 (45) | Show / Hide |
Range on Protein: 350-390 Range on HMM: 1-45/45 Sequence Identity: 32% (15 aa) QPPFCTIHPKERLQLYCEKCVRLTCRDCQLVSHKD-----HSYQFL |. | .||.|.|..||..| .. |.|| . .||. |... . QM-YCPEHPEEPLEYYCQDCQQCICEDCAVHGHKGNGFKKHTVVPI |
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| PHD | TIF1.AA | PHD | 1307-1350 | 36 | 2.1e-10 | 34.06 | Pfam | 1-51 (54) | Show / Hide |
Range on Protein: 1307-1350 Range on HMM: 1-51/54 Sequence Identity: 36% (19 aa) WCAVCNN-----GGNLVCCD-RCPRVYHHECHVPLIS--EVPEDDDFDCTLC .|.||. .|...||| ||| .| .|| | .. |.||. .. |. | YCCVCQKCDWDDDGDMICCDNGCPRWFHQYCHGPPLEPEEIPEG-EWYCPRC |
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| PHD | TIF1.AA | PHD | 1307-1351 | 34 | 1e-07 | 32.91 | SMART | 1-39 (39) | Show / Hide |
Range on Protein: 1307-1351 Range on HMM: 1-39/39 Sequence Identity: 34% (16 aa) WCAVCNNGGNLVCCD-RCPRVYHHECHVPLISEVPEDDDFDCTLCF .| ||. | ...|| .|.| || |. | . |.|. . | | YC-VCGK-G-MIQCDPGCDRWYHQ-CLGPPLE--PPDG-WYCPRCR |
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| BROMO | TIF1.AA | BROMO | 1373-1479 | 31 | 5.7e-24 | 86.87 | SMART | 1-118 (118) | Show / Hide |
Range on Protein: 1373-1479 Range on HMM: 1-118/118 Sequence Identity: 31% (39 aa) TAREFKLCQRLLLEMYCLEDSQ------------PFLEPVGPE---VTGYLEIIPIPMDLSTIKSKLSLTSPNKYFSPRQMVEDLRVMFTNCYQYNGETS . . .| ||.|| |..|..... ||..|| . . .| .|| ||||.||| || ..| |. ..|.|.. ||.||..||.. | DPK-QKKCQELLKEVMCHKHDHGDPMNRGRPYAWPFMQPVDRKELNYPDYYDIIKNPMDLKTIKKKLEN---HQYQSMEEFVDDFMLMFNNCMTYNEPDS DLGKIAQHLQRYASRFMKRYLP . | |. ||.. . .. . | EVYKMAKKLQKFFEEKWREFPP |
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| Bromodomain | TIF1.AA | Bromodomain | 1380-1465 | 33 | 5.4e-22 | 74.02 | Pfam | 1-89 (89) | Show / Hide |
Range on Protein: 1380-1465 Range on HMM: 1-89/89 Sequence Identity: 33% (31 aa) CQRLLL--EMYCLEDSQPFLEPV---GPEVTGYLEIIPIPMDLSTIKSKLSLTSPNKYF-SPRQMVEDLRVMFTNCYQYNGETSDLGKIAQH |.... ... ....||..|| |...| .||. |||||||. || ||| .. . .|.. |..||. |||. |.. |.|.. CDQIMDMKYIMEHPICEPFWHPVDPDRDEYPDYYDIIKHPMDLSTIQQKL---KNNKYRNNIAEFWHDMELMWHNCMTYNGPDSPIYKDARK |
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