Gene n1188 (Tetrahymena)
n1188
Species: Tetrahymena
Alias: 616.m00002, n1188, 1188
External Links:
Annotation:
Sequence
Protein domains of n1188.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | n1188.AA | C8 | 81-192 | 42 | 1.6e-38 | 131.32 | In-house | 110-216 (226) | Show / Hide |
Range on Protein: 81-192 Range on HMM: 110-216/226 Sequence Identity: 42% (48 aa) YLDRQNKDEQQTEGDKFQITIQIIDSVNYIHQFNIIHRDIKPEKFLVYLDGKQISRSQLCKSFLFINDFGLSTQIPVNKDSIQTIEH--IGNLGYSAPEM |..|.||. | .. .|..|.||.||.|||||..||.||||||. |||.||.... || |||...|.. ||..||.... .|...|.|||. YDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLC-------DFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEI LNKNDNELIFYTKK ..|.||.. .|... EKKQDNQYKQYRIQ |
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| Kinase | n1188.AA | Ciliate-C8 | 79-219 | 38 | 4.8e-38 | 132.72 | In-house | 103-238 (238) | Show / Hide |
Range on Protein: 79-219 Range on HMM: 103-238/238 Sequence Identity: 38% (59 aa) DEYLDR-QNKDEQQTEGDKFQITIQIIDSVNYIHQFNIIHRDIKPEKFLVYLDGKQISRSQLCKSFLFINDFGLSTQIPVNKD---------SIQTIEH- ..|.|| ..|. . .. .|..|.||.||||||.|.|||.||||||. |||..| ... ||. |. . |||...|.| ||. ..|.||. KQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCD-FKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEMY -IGNLGYSAPEMLNK-NDNELIFYTKKVFFFQNFNFKLIFILFYFDSYSVGLLL .||.||.|||...| ..... ...|| |||||||.| FCGNWGYFAPEVEKKQSRIQSDIFSKK-----------------SDSYSVGLVL |
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| Kinase | n1188.AA | C2 | 81-134 | 41 | 3.2e-17 | 55.49 | In-house | 108-162 (245) | Show / Hide |
Range on Protein: 81-134 Range on HMM: 108-162/245 Sequence Identity: 41% (23 aa) YLDRQNKDE-QQTEGDKFQITIQIIDSVNYIHQFNIIHRDIKPEKFLVYLDGKQI |..|. |.. . .. | ...||..||.||.|.|.|.||||||. ||. .| ..| YFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGI |
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| Kinase | n1188.AA | CAMK | 102-193 | 22 | 3.1e-15 | 44.86 | In-house | 187-315 (425) | Show / Hide |
Range on Protein: 102-193 Range on HMM: 187-315/425 Sequence Identity: 22% (29 aa) QIIDSVNYIHQFNIIHRDIKPEKFLVYLDGKQISRSQ-------LCKSFLFINDFGLSTQIPVNKDSI---------------------QTIEHIGNLGY ||.. |.|.|. ||.|||.||| |. ... .. . . . | |||...... .... . | ..| QICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDP-VEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEY SA-PEMLNKN---------DNELIFYTKKV | ||.||.. |.| |..|. MAAPEVLNGKGHCNMQNATDEEKPYYGPKC |
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| Kinase | n1188.AA | Ciliate-E2 | 98-193 | 21 | 8.3e-14 | 43.76 | In-house | 149-277 (365) | Show / Hide |
Range on Protein: 98-193
Range on HMM: 149-277/365
Sequence Identity: 21% (32 aa)
QITIQIID---------------SVNYIHQFN-IIHRDIKPEKFLVYLDGKQISRSQLCKSFLFINDFGLSTQIPVNKD--------SIQTIEH------
.|. ||.. ..|.|. | ||||||||| |. ..| |||||... . . . . .
YIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRT
----------------IGNLGYSAPEMLNKNDNE----LIFYTKKV
.|..|| |||.||. ... |..|.
PGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKC
|
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| Kinase | n1188.AA | CAMKL | 102-183 | 31 | 3.2e-13 | 38.41 | In-house | 135-210 (297) | Show / Hide |
Range on Protein: 102-183 Range on HMM: 135-210/297 Sequence Identity: 31% (27 aa) QIIDSVNYIHQFNIIHRDIKPEKFLVYLDGKQISRSQLCKSFLFINDFGLSTQIP-V-NKDSIQTIEHIGNLGYSAPEMLNK-ND ||.. |||.|. .|.||||||| |. .|.. . | |||.|... . ... .. | . | |||.... |. QIVSAVNYCHSHGIVHRDIKPENILLDENGNN---------NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNK |
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| Kinase | n1188.AA | CAMK-Unique | 98-180 | 25 | 2.5e-11 | 33.45 | In-house | 161-262 (363) | Show / Hide |
Range on Protein: 98-180 Range on HMM: 161-262/363 Sequence Identity: 25% (26 aa) QITIQIIDSVNYIHQFNIIHRDIKPEKFLVYLDGK-----QISRSQLCKSFLFINDFGLSTQIPVNKDS--IQTIEHIGNLGYSAP-------------- .| .. |.| |. .|.|||.|.| .|. .| . . . ..... ||||.... || . .||. .| . | || FIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTM--CGTPCYMAPEIVFCKNYQEMTRD EMLN |..| EVIN |
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| Kinase | n1188.AA | RAD53 | 102-123 | 54 | 4.7e-11 | 28.63 | In-house | 117-138 (305) | Show / Hide |
Range on Protein: 102-123 Range on HMM: 117-138/305 Sequence Identity: 54% (12 aa) QIIDSVNYIHQFNIIHRDIKPE |..|.|.|.| .|.|||.||| QMCDAVKYLHDNGICHRDLKPE |
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| Kinase | n1188.AA | Aur | 97-123 | 51 | 5.6e-11 | 24.68 | In-house | 104-130 (257) | Show / Hide |
Range on Protein: 97-123 Range on HMM: 104-130/257 Sequence Identity: 51% (14 aa) FQITIQIIDSVNYIHQFNIIHRDIKPE . .. ||.. ..| | |||||||||| AKYMYQICNALDYCHSKNIIHRDIKPE |
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| Kinase | n1188.AA | Ciliate-C1 | 101-123 | 60 | 9.2e-11 | 23.61 | In-house | 136-158 (328) | Show / Hide |
Range on Protein: 101-123 Range on HMM: 136-158/328 Sequence Identity: 60% (14 aa) IQIIDSVNYIHQFNIIHRDIKPE .| |... |||| || |||.||| HQLINVIQYIHQNNICHRDLKPE |
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| S_TKc | n1188.AA | S_TKc | 5-236 | 15 | 1e-06 | -78.51 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 5-236
Range on HMM: 1-231/231
Sequence Identity: 15% (42 aa)
FGNEEEIVLFSFCLTLQNTNKKILEKDKKAQLKKVEVFIIQSAEISLQKQKILEQFSNSKLWNGVSYQKSKAFIDEYLDR---------QNKDEQ-----
. ..| .| . ..|| ... .|.. . ||.. |. || .. .. ||.| ... .
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--EHIRREIQILKK---HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP
QTEGDKFQITIQIIDSVNYIHQFNIIHRDIKPEKFLVYLDGKQISRSQLCKSFLFINDFGLSTQIPVNKDSIQTIEHIGNLGYSAPEMLNKNDNE-----
.| . .. ||.. ..|.|. .|||||.||| |. . | ||||..|. .| . | |||.| .
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------------HIKICDFGLARQL---------TTFCGTPWYMAPEVL--GYGKCKCDW
-------LIFYTKKVFFFQNFNFKLIFILFYFDSYSVGLLLALLG-NYQ-----DLKE-----NKVSMF
.... . | .... .. .. .. .| . . .. . .. |
WSCGCILYEMLCGYPPFP--QMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
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| Kinase | n1188.AA | Pkinase | 102-123 | 54 | 2e-06 | 23.87 | Pfam | 116-137 (293) | Show / Hide |
Range on Protein: 102-123 Range on HMM: 116-137/293 Sequence Identity: 54% (12 aa) QIIDSVNYIHQFNIIHRDIKPE ||. ..|.|. .|||||.||| QILRGLEYCHSMGIIHRDLKPE |
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| Kinase | n1188.AA | C8 | 211-219 | 66 | 0.017284 | 4.59 | In-house | 218-226 (226) | Show / Hide |
Range on Protein: 211-219 Range on HMM: 218-226/226 Sequence Identity: 66% (6 aa) DSYSVGLLL |..||||.| DLFSVGLVL |
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