ABR

Species: Human
Alias: ABR
External Links:
Annotation:

Classification

Group: Atypical
Family: BCR

Sequence

Name Sequence Type Origin Length Description Download
ABR.AA Protein None 1118 None Fasta, JSON
ABR.NA RNA None 3354 None Fasta, JSON

Protein domain

Protein domains of ABR.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RhoGEF ABR.AA RhoGEF 354-542 29 9.4e-59 202.42 SMART 1-211 (211) Show / Hide
Range on Protein: 354-542
Range on HMM: 1-211/211
Sequence Identity: 29% (63 aa)

VLSGFLASEEIYINQLEALLL-PMKPLKATATTSQ-PVLTIQQIETIFY-KIQDIYEIHKEFYDNLCPKVQQW---------------DSQVTMGHLFQK
|.  ....|. |...|. ..   |||.. ...... |.|. .....||.  |..|||.|..|.| |   ...|               |.. ..|..|.|
VIQELMQTERNYVRDLHIIVQHYMKPMQKEEKCHKLPFLSPDEVNHIFGPNIEEIYEFHRRFLDELEERIEEWDCSMDWKSFRNFQIRDICDRIGDCFMK

L---ASQLGVYKAFVDNYKVALETAEK--CSQSNNQFQKISEELKVKGPKDSKDS-HTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDA
.   .... .|.....|.. ||.. .|  |...|..|||  .|.  . . .|. | | . |.| .| ||. |.|.  | |...||||| |||||  ||.|
WFHAEEMFKMYSEYCNNHPYALKHLKKWMCCKKNPRFQKFCKECESHPNCRSN-SEH-RLTLEDFLIKPMQRITKYPLLLKEILKHTPPDHPDYEDLQKA

LRISQNFLSSINE
|..........||
LDCMKDVAQHCNE

RhoGEF ABR.AA RhoGEF 354-542 29 1.2e-50 175.77 Pfam 1-196 (196) Show / Hide
Range on Protein: 354-542
Range on HMM: 1-196/196
Sequence Identity: 29% (60 aa)

VLSGFLASEEIYINQLEALLLPM-KPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCP--KVQQW--DSQVT--MGHLF--QK-LASQLGVY
|.  .. .|. |...|. ..    |||.  |  ..|.|. ..|.|||  |..|||.|..|.. |    ....|  .....  .|..|   | ... . .|
VIQEIIQTERSYVRDLNIIIEHYMKPLRNCA--NPPILSPDEIHTIFSNIEEIYEFHQRFLEDLEERDRMECWNPPDYQCQTIGDCFMFLKHMFPFFKMY

KAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVT-MEALLYKPIDRVTRSTLVLHDLLKHTPV-DHP-DYPLLQDALRISQNFLSSI
  .. ||  |... .||...| .||.. .... .    ..  . . .  . .| ||. |..|  | | .||||||  ||| ||. || ||   ....|.|
SEYCNNYPKAMKLLKKCRKKNPKFQQFLKWCEKE----NDPCCRRLDLLQSFLIKPVQRIPRYPLLLKELLKHTPPCDHPKDYEDLQKALEAMKEVASHI

NE
||
NE

PH ABR.AA PH 561-720 18 1.8e-13 51.97 SMART 1-82 (82) Show / Hide
Range on Protein: 561-720
Range on HMM: 1-82/82
Sequence Identity: 18% (30 aa)

LVKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQS
..| |.|   |  ..| |...||.|.|.. | |          ..|  ||| |.   .. .                                       
VIKEGWLYKKSK-RWKKRWFVLFNDCLYYYKDK----------KPKGSIPLSDC-TVRE-P---------------------------------------

RAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKD
                         |.||. .. .|.|  .|. |. || .||||.... 
------------------------CFEIHH-DR-TYYFQCESEEEMQEWMQAIQKAIHNN

PH ABR.AA PH 561-718 15 8.9e-11 41.51 Pfam 1-92 (92) Show / Hide
Range on Protein: 561-718
Range on HMM: 1-92/92
Sequence Identity: 15% (25 aa)

LVKDGFLVEVS-ESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQ
..| |.|   .  .|.| |...||...|.. | .|                                          .. |..|.  . .. | . |   
VIKEGWLHKKGKRKSWKKRWFVLFNNCLYYYKDDK------------------------------------------YRPKGSIPLSDCQVTKVPDN---

SRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQK
                          |.|.. ....|.|  .|. |. .| .|||....
---------------------KRPHCFQIRT-DRRTYYFQAESEEEMNDWMQAIQSACR

C2 ABR.AA C2 765-854 19 7.2e-14 49.77 Pfam 1-90 (90) Show / Hide
Range on Protein: 765-854
Range on HMM: 1-90/90
Sequence Identity: 19% (19 aa)

LHVIVHSAKGFKQ-------SANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEEFEIE--LEGSQS-LRILCYEKCYDKTKVNKDNNEIVDKIMGKGQ
|.| |..|.. .        ... |......  .  ..| ||.| ..|  |.|.|.|...  ..  |. ||. .. .. ..           |...|. .
LRVHVIEARNLPPMDWDKNGKSDPYVKVYLGGDPKDTQKYKTKVIKNTLNPVWNETFTFDVPPPDLQHTLRFTVWDWDRFGR----------DDFIGQCC





C2 ABR.AA C2 764-871 14 1e-13 52.83 SMART 1-92 (92) Show / Hide
Range on Protein: 764-871
Range on HMM: 1-92/92
Sequence Identity: 14% (18 aa)

FLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTA---EPKWDE---EFEIELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQL
 |.| ...|.. .   . |....           ||.| ..|     |.|.|   .|....   | ||. ....                ...|. .|  
TLTVHIIEARNLP---DPYVKVY-----------KTKVVKNTLSGFNPVWNEWMETFYFDVHP-Q-LRFEVWDH----------------DFIGHCCIPP

D------------PQTVETKNWHTDV
.             ....  ..|   
NNPHWHQWDGCIHLSDIL-GYRH-WW

RhoGAP ABR.AA RhoGAP 917-1096 32 3.8e-69 236.95 SMART 1-193 (193) Show / Hide
Range on Protein: 917-1096
Range on HMM: 1-193/193
Sequence Identity: 32% (66 aa)

SKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDI-----------LLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIA
| .| |||.|.|..||.|....||||..|... ||.|.. || ...             ...... |....|| ||.|||||||||.|..||. |.| . 
SHIPIIVRKCIEYIEKHGMDTEGIYRKCGNQSRIQELRNAFDRGPD-DLCSTDNYITHEFNDWEEWDVHDVAGVLKQYFRELPEPLITFELYEEFIEAMK

L--------------SDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQVQ
.              .|. ..  ... |...||.... |. .|. ||.||||... |||..||||..|||||..|.          ..|.  .... ...
CYQIEQTSRKQWNHSEDEEERIHALHQLISQLPPCHRNTLRYLM-HLNRVAEHSDVNKMNAHNLAICFGPTLFWPP----------MMDMRHQNKCVEFL

VLLYY
.  |.
IEHYD

RhoGAP ABR.AA RhoGAP 920-1073 41 6.4e-69 235.83 Pfam 1-156 (156) Show / Hide
Range on Protein: 920-1073
Range on HMM: 1-156/156
Sequence Identity: 41% (65 aa)

PYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFME--GIALSDPAAKENCMM
| |||.|.|..|..|....||||.|| .. |..|.. || .  . |. ... |....|. ||.|||||||||.|..||..|.|     . |.  . ..| 
PMIVRKCIEYIEQHGLDTEGIYRVSGNKSRIKELREAFDRGPDVDLNDWEWHDVHDVASVLKQYFRELPEPLFTFELYEEFIEAMAAKIEDEEERIEAMR

HLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKA
 |.|.||.||. |. .|..||.|||. . .|||. ||||..|||.|..|.. .|. 
ELIRKLPPPNYDTLRYLMRHLHRVAQHSDVNKMNAHNLAICFGPNLFWPPDDDSMD