Gene HisK_o (S.moellendorffii)
HisK_o
Species: S.moellendorffii
Alias: HisK_o
External Links:
Annotation:
Sequence
Protein domains of HisK_o.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| TOP2c | HisK_o.AA | TOP2c | 115-730 | 43 | 4.90000000001e-276 | 924.22 | SMART | 1-639 (639) | Show / Hide |
Range on Protein: 115-730 Range on HMM: 1-639/639 Sequence Identity: 43% (285 aa) GLHHLIYEVLDNAIDEVQAGF-ATQVDVVLHSDG-SVSITDNGRGIPTDVHPATGKSTLETVLTVLHAGGKFGGDESGYTVSGGLHGVGVSVVNALSKRL |||||..|..||||||..||. .....|..| |. |.|..|||||||.|.|| ....|.|...|.|||||||..|| | |||||||||.||.||||... GLHHLFWEIVDNAIDEAMAGYKMNHIKVTIHKDNNSISVWDNGRGIPVDMHPKEKMYTPEMIFTHLHAGGKFDDDE--YKVSGGLHGVGASVCNALSTWF EATVWRN--GQEYRQVFQR-GKAVGSLTTRSLPRESSSRTGTCVKFLPDDEVFTTTT--AFDPNIVSSRLREVAFLNPEVTINLKEESATTDEVFHFGGG | .|.|. | .|.|.... .| .. . . . ..|| | |.||.|.|..|| .|. . . ||.|.||||. |.|.. | . . ..||. || EVEVHRDKYGKKYKQTWHNNMKPCSPPKIIGCTKK---KHGTKVTFWPDPEIFKMTTLDDYDFDTMKRRLYEMAFLNKGVKIYWNDERTDEEKQFHYEGG LVEYVEWLNQDKTKIHD-------PISFSVEKDD--------ISVNVSMQWCSDAY--SDTLLGYANSIRTADGGTHLDGLKMGLTRTLNILGRRSKAIR ...||| .| .|..||. .. .... | |.. . .|| .| | |.. ....|.|.| .||||..|.| ..||..| .. | .. FKDYVEYYNKNKETIHPMDTNETMEPFYIEHEKDNKMPRHEDIRWEWAFQW-NDGYFHSFNIVSFCNNINTHEGGTHENGFKDAITRVINDYAKKKKKLK EK--GDNLSGEHAREGLTCVISVKVPEP--EFEGQTKTRLGNVEVRKIVEQAVIEQVTEYLEFRPDTLEAILSKALQAYKAAEAAKKARELVRR--KNVL || .|..... ||.|. .||.|.|.| .||||||..||| |||.|||. | |... .|. |.. ..|. |.....|| ||||||||. |. |. . EKDNDKNIKPDDIREHLWAFISCKIPNPIIQFEGQTKEKLGNSEVRFIVEKIVSECFLHWLFENPQEAKKIIEKVIEWAKAREAAKKAREKTRKSKKSKT KTSTLPGKLADCTSSDPR--VSEIFIVEGESAGGSAKQGRD---RAFQAILPLKGKILNIERKDDAAIYKNQEIQDLIVALGLGTRGEEFHKDTLRYHKI . ..||||||||.. || .|.||||| |||||||.||| | ||||.||.||||| | . . |.||.|||..| |||.| . | ..|||||| ERISLPGKLADCQWKDPKSHKCELFIVEGDSAGGSAKMGRDVVGRDFQAIFPLRGKILNVEKARHDQILKNEEIQNIITALGCGIGKDYFDIEKLRYHKI IILTDADVDGAHIRTLLLTFFFRYQRALFDGG-YIYVGVPPLYKVCLKLVWFLDSKHNSQVERGKHAHYCYSENELQGLLGTFA---ANAPYNIQRFKGL .| ||||||||||||||||||.|| . | . | ..| .|||||| ....| . | ... |.. | ... . | ..|||.||| MIMTDADVDGAHIRTLLLTFFHRYMPPLIEHGGHVYIFQPPLYKV----------TWGKQ-KGQKYVYSFYWDDEYEEWKEKKHGKKNNKKWEIQRYKGL GEMMPLQLWDTTLDPSKRMLKKLTLEDAVEAS-FTFSRLMGDKVEPRKELILKSAA |||.| |||..| || ...... ...|| || .|. .|||||||||| | ..|. GEMNPDQLWEYTMDPERHTMRFVWIDDADEADDRIFMAFMGDKVEPRKEWIQENAP |
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| DNA_gyraseB | HisK_o.AA | DNA_gyraseB | 307-477 | 41 | 8.4e-71 | 246.32 | Pfam | 1-191 (191) | Show / Hide |
Range on Protein: 307-477 Range on HMM: 1-191/191 Sequence Identity: 41% (79 aa) GLVEYVEWLNQDKTKI--HD---PISFSVEK--------DD---ISVNVSMQWCSDAYSD-TLLGYANSIRTADGGTHLDGLKMGLTRTLNILGRRSKAI |...||...| ||. . |. ||.|. |. .| . | ...||..| |.. ... ..|.|.| |||||.||.. .|||..| .. . . GIKDYVKYYNKDKKPLCKHSETPPIYFEGEYAFTVIEKTNDRRDWEVEWAFQWNEDSYNEFNIVSFVNNIPTPDGGTHVDGFRDALTRAINEYAKKKNKL REKGDNLSGEHAREGLTCVISVKVPEP-EFEGQTKTRLGNVEVR--KIVEQAVIEQVTEYLEFRPDTLEAILSKALQAYKAAEAAKKAREL .| .|..|. |||||.|.|.|.|.| .||||||..||| ||| .|||..| |. ...|| |. ...|..||.||.||.|||.||||| KKKDENITGDDIREGLTAVVSCKIPNPIQFEGQTKEKLGNPEVRFGSIVEKIVYEKFEKWLEKNPEIAKKIIEKAIQAAKAREAARKAREL |
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| DNA_gyraseB_C | HisK_o.AA | DNA_gyraseB_C | 662-726 | 58 | 3.8e-36 | 131.21 | Pfam | 1-67 (67) | Show / Hide |
Range on Protein: 662-726 Range on HMM: 1-67/67 Sequence Identity: 58% (39 aa) AANAPYNIQRFKGLGEMMPLQLWDTTLDPSKRMLKKLTLEDAVE-ASFTFSRLMGD-KVEPRKELIL .|. |.|||.||||||.| |||.||.||..|.|...|.|||.| |. .||.|||| .||||.| | KKNKKYEIQRYKGLGEMNPEQLWETTMDPETRRLLQVTIEDAEEQADEMFSMLMGDKDVEPRREWIE |
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| HATPase_c | HisK_o.AA | HATPase_c | 111-260 | 20 | 4.2e-29 | 103.51 | Pfam | 1-120 (120) | Show / Hide |
Range on Protein: 111-260 Range on HMM: 1-120/120 Sequence Identity: 20% (31 aa) TGPRGLHHLIYEVLDNAIDEVQAGFATQVDVVLHS---DGSVSITDNGRGIPTDVHPATGKSTLETVLTVLHAGGKFGGDESGYTVSGGLHGVGVSVVNA . |..||... ...||||.. ..| ....| .| . .....|||.||| . | |..| . ...........| . . ..|||.|.| ..... GDPDRLHQVVWNLVDNAIKHTPEG--GHITVRVHRDDDHVRITVEDNGPGIPPEMH-----SIAEDIPRIFEPFYRTDPDSR-RKYGGGLTGLGLYICRR LSKRLEATVWRNGQEYRQVFQRGKAVGSLTTRSLPRESSSRTGTCVKFLPDDE ...... |.|..... ||.. | .. | IVEQHGGTIWVESEP-------------------------GGGTTFTFTLPLE |
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| HATPase_c | HisK_o.AA | HATPase_c | 111-261 | 18 | 1e-27 | 99.31 | SMART | 1-130 (130) | Show / Hide |
Range on Protein: 111-261 Range on HMM: 1-130/130 Sequence Identity: 18% (31 aa) TGPRGLHHLIYEVLDNAIDEVQAGF-----------ATQVDVVLHSDGSVSITDNGRGIPTDVHPATGKSTLETVLTVLHAGGKFGG-------DESGYT . |..|.... ..|||||.. ..|. ....| .| .....|||.||| . | |. | . ........... |.. . GDPDRLRQVLWNLLDNAIKHTPEGHADPDLHDGKPGGGRITVRVH---RITVEDNGPGIPPEMH-K---SI-EDIPRIFEPFYRTDDSPSRMCPDSRSRK VSGGLHGVGVSVVNALSKRLEATVWRNGQEYRQVFQRGKAVGSLTTRSLPRESSSRTGTCVKFLPDDEV ..|||.|.| |.......... |.| . |.. | .. |. YGGGLTGLGLSICKRIVEQHGGTIWVE-------------------------------TTFTFTLPLER |
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| Toprim | HisK_o.AA | Toprim | 534-609 | 15 | 6.6e-07 | 26.52 | Pfam | 1-119 (119) | Show / Hide |
Range on Protein: 534-609 Range on HMM: 1-119/119 Sequence Identity: 15% (19 aa) GKILNIERKDDAAIYKNQEI---------QDLIVALGLGTR-----------------------GEEFHKDTLRY--HK---IIILTDADVDGAHIRTLL ... | . ||. .. . |..| .|. . . | . |. .| .||.||.|..| .|.. | KVLIIVEGPMDAKTIHQYGGKPHREFECDYDYNVVATMGHIMDLPFPEYHGWWHCWCCIYKVIPLKKEHIKMLKKKAKKADEVIIATDPDREGEKIAWHL LTFFF------RYQRALFD .... .|. | YQYCKPYGPDKKIRRIFFP |
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