Protein (view, download) , Domain (view, download)
TBK1_Hsap       MQ-------------------------------------------STSNHLWLLSDILGQ
IKKe_Hsap       MQ-------------------------------------------STANYLWHTDDLLGQ
IKKb_Hsap       MSWSP-------------------------------------SLTTQTCGAWEMKERLGT
IKKa_Hsap       MERPP-------------------------------------GLRPGAGGPWEMRERLGT
ird5_Dmel       MITVVFCFSDCHGGIQILGRMSSVN-K----------IKLNENNKMHSFGNWERCRNLGE
ik2_Dmel        MSF----------------------------------------LRGSVSYVWCTTSVLGK
IKKe_Mmus       MQ-------------------------------------------STTNYLWHTDDLLGQ
IKKb_Mmus       MSWSP-------------------------------------SLPTQTCGAWEMKERLGT
IKKa_Mmus       MERPP-------------------------------------GLRPGAGGPWEMRERLGT
TBK1_Mmus       MQ-------------------------------------------STSNHLWLLSDILGQ
TBK1_Spur       MAATQG-------------------------------------IRSTKTYIWYLKDVLGT
IKKe_Spur       MSDKDH-I------------QGWSRNFVEVMEQNGRARQPVPNIRSTPGYIIFLDTPLGQ
IKKa_Spur       MP-------------------------------------------SPSGDQWQFKKLLGS
AqueK157_Aque   MSIRK---------------------------------------------NWR-RAPIGR
AqueK158_Aque   MAYNYQQV------------RPAFIGGG------------DETEYYSLSYIWSSKDKLGQ
                *                                                        :*

TBK1_Hsap       GATANVFRGR--------------------------------------------------
IKKe_Hsap       GATASVYKAR--------------------------------------------------
IKKb_Hsap       GGFGNVIRWH--------------------------------------------------
IKKa_Hsap       GGFGNVCLYQ--------------------------------------------------
ird5_Dmel       GGFGLVIHWR--------------------------------------------------
ik2_Dmel        GATGSVFQGV--------------------------------------------------
IKKe_Mmus       GATASVYKAR--------------------------------------------------
IKKb_Mmus       GGFGNVIRWH--------------------------------------------------
IKKa_Mmus       GGFGNVSLYQ--------------------------------------------------
TBK1_Mmus       GATANVFRGR--------------------------------------------------
TBK1_Spur       GATSSVYLGR--------------------------------------------------
IKKe_Spur       GATSKVYGGR--------------------------------------------------
IKKa_Spur       GSFGEVLLYQLGVGRKVGRFEAESVDWSRCMWSRFGVGEESVRPCCGVWLASLWCLVGVV
AqueK157_Aque   GSFGDVSLFT--------------------------------------------------
AqueK158_Aque   GATGQVFAGY--------------------------------------------------
                *. . *

TBK1_Hsap       ------------------------------------------------------------
IKKe_Hsap       ------------------------------------------------------------
IKKb_Hsap       ------------------------------------------------------------
IKKa_Hsap       ------------------------------------------------------------
ird5_Dmel       ------------------------------------------------------------
ik2_Dmel        ------------------------------------------------------------
IKKe_Mmus       ------------------------------------------------------------
IKKb_Mmus       ------------------------------------------------------------
IKKa_Mmus       ------------------------------------------------------------
TBK1_Mmus       ------------------------------------------------------------
TBK1_Spur       ------------------------------------------------------------
IKKe_Spur       ------------------------------------------------------------
IKKa_Spur       VVSGWRRCGVGLVSMSSQFGVDANVGLASMWCHFGLVCGVDEESVCPRCGVGLVLMWSQF
AqueK157_Aque   ------------------------------------------------------------
AqueK158_Aque   ------------------------------------------------------------


TBK1_Hsap       ----------HKKTGDLFAIKVFNNISFLRPVD---------VQMREFEVLKKL-NHKNI
IKKe_Hsap       ----------NKKSGELVAVKVFNTTSYLRPRE---------VQVREFEVLRKL-NHQNI
IKKb_Hsap       ----------NQETGEQIAIKQCRQELSPRNRE---------RWCLEIQIMRRL-THPNV
IKKa_Hsap       ----------HRELDLKIAIKSCRLELSTKNRE---------RWCHEIQIMKKL-NHANV
ird5_Dmel       ----------NRTTGREIATKHIKEMGALS-ADQQVK--LSERWNKELNWSRQFKNFPHI
ik2_Dmel        ----------NKITGESVAVKTFNPYSHMRPAD---------VQMREFEALKKV-NHENI
IKKe_Mmus       ----------NKKSGEVVAVKVFNSASYRRPPE---------VQVREFEVLRRL-NHQNI
IKKb_Mmus       ----------NQATGEQIAIKQCRQELSPKNRD---------RWCLEIQIMRRL-NHPNV
IKKa_Mmus       ----------HRELDLKIAIKSCRLELSSKNRE---------RWCHEIQIMKKL-DHANV
TBK1_Mmus       ----------HKKTGDLYAVKVFNNISFLRPVD---------VQMREFEVLKKL-NHKNI
TBK1_Spur       ----------HKKNGDVVAVKMFNHLSYMRPRD---------VQQREFEVLLKL-NHKNI
IKKe_Spur       ----------HKKLGKRVACKVPHTANLFRMGT---------DMERESQVLLRL-RNQNI
IKKa_Spur       GVDVVSVRRQCGETSEYIALKRCKSILQLE---------NLKRWRDEVEFMRNL-EHPNI
AqueK157_Aque   -----------SNDGEQIALKEMKLE-PLRNLDSHERDKMIVRLRNEIKIMWEH-NHPNL
AqueK158_Aque   ----------SKRSGDKVAIKMFTSPSEYKAMQ---------SEMQTIKALK---THPNI
                              .   * *                           :         ::

TBK1_Hsap       VKLFAIEEE---------TTTRHKVLIMEFCPCGSLYT-VLEEPSNAYGLPESEFLIVLR
IKKe_Hsap       VKLFAVEET---------GGSRQKVLVMEYCSSGSLLS-VLESPENAFGLPEDEFLVVLR
IKKb_Hsap       VAARDVPEG-----MQNLAPNDLPLLAMEYCQGGDLRK-YLNQFENCCGLREGAILTLLS
IKKa_Hsap       VKACDVPEE-----LNI-LIHDVPLLAMEYCSGGDLRK-LLNKPENCCGLKESQILSLLS
ird5_Dmel       VAGVDIEDPDFLEYLNGMFSAKLPVIVLEYCNGGDVRK-RLQSPENANGLTEFEVRQILG
ik2_Dmel        VKLLAIEED---------QEGRGKVIVMELCTGGSLFN-ILDDPENSYGLPEHEFLLVLE
IKKe_Mmus       VKLFAVEET---------GGSRQKVLIMEYCSSGSLLS-VLEDPENTFGLSEEEFLVVLR
IKKb_Mmus       VAARDVPEG-----MQNLAPNDLPLLAMEYCQGGDLRR-YLNQFENCCGLREGAVLTLLS
IKKa_Mmus       VKACDVPEE-----LNF-LINDVPLLAMEYCSGGDLRK-LLNKPENCCGLKESQILSLLS
TBK1_Mmus       VKLFAIEEE---------TTTRHKVLIMEFCPCGSLYT-VLEEPSNAYGLPESEFLIVLR
TBK1_Spur       IHLDQIEED---------QISKQPVIVMELCTGGSLYT-YLDTPENLYGLKEKEFLQVLN
IKKe_Spur       VCLEAIEKD---------QISKENILIMELCTGGSLYD-VLEKPENSCGLAEKAFLQVLA
IKKa_Spur       VQGRPVPPE-----L-EAKPNEPPCLAMEFCSRGDLRK-KLSELPNMCGLPEAEILLLSK
AqueK157_Aque   IKALGPPPD-----IPYHPPEDVMHVWMEFCNGGDLRNGVLKKIENCCGVEEKQFRKICG
AqueK158_Aque   VSFFELNEI-----E---KKHQYHIIAMELCNGGSLYE-VIDSPQNAYGLDEYQFKSVIF
                :                        : :* *  *.:    :.   *  *: *  .  :

TBK1_Hsap       DVVGGMNHLRE-NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGT
IKKe_Hsap       CVVAGMNHLRE-NGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGT
IKKb_Hsap       DIASALRYLHE-NRIIHRDLKPENIVLQQGE-QRLIHKIIDLGYAKELDQGSLCTSFVGT
IKKa_Hsap       DIGSGIRYLHE-NKIIHRDLKPENIVLQDVG-GKIIHKIIDLGYAKDVDQGSLCTSFVGT
ird5_Dmel       ALRKALHFLHSQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFGLARGTPDQTMVQSVVGT
ik2_Dmel        HLCAGMKHLRD-NKLVHRDLKPGNIMKFISEDGQTIYKLTDFGAARELEDNQPFASLYGT
IKKe_Mmus       CVVAGMNHLRE-NGIVHRDIKPGNIMRLVGEEGQSIYKLSDFGAARKLDDDEKFVSVYGT
IKKb_Mmus       DIASALRYLHE-NRIIHRDLKPENIVLQQGE-KRLIHKIIDLGYAKELDQGSLCTSFVGT
IKKa_Mmus       DIGSGIRYLHE-NKIIHRDLKPENIVLQDVG-GKTIHKIIDLGYAKDVDQGSLCTSFVGT
TBK1_Mmus       DVVGGMNHLRE-NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGT
TBK1_Spur       DVSAGMKHLRD-KGIVHRDIKPGNIMMVKGEDGVIVYKLADFGAARELEDDEAFKSLYGT
IKKe_Spur       DMTAGMKYLRD-NGVVHRDVKPGNIMCFKDDHGHTIYKLADFGAARQLTDDENFTSLHGT
IKKa_Spur       HIASAMEYLHK-SDIIHRDIKPENIMVQD-WKGQC----------------------HGT
AqueK157_Aque   DINNGIRFLHK-ISVIHRDLKPENILIKHTDANTVVYKLTDFGYAKTYALSSKAQSLVGT
AqueK158_Aque   DVASGMRHLRD-HGFVHRDIKPGNIMRCINPDGSFVFKLADFGTARQLDPNEHFTSLHGT
                 :  .:..*:.   . ***:** **:                                **

TBK1_Hsap       EEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFE-GPRRNKEVMY
IKKe_Hsap       EEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFG-GPRRNKEIMY
IKKb_Hsap       LQYLAPELLEQ--------QKYTVTVDYWSFGTLAFECITGFRPFLPNW-QPV---QWHS
IKKa_Hsap       LQYLAPELFEN--------KPYTATVDYWSFGTMVFECIAGYRPFLHHL-QPF---TWHE
ird5_Dmel       RHYYAPEVVEN--------GFYNSTVDLWSFGVIAYELVTGELPFIPHQ-TLK---NIIL
ik2_Dmel        EEYLHPDLYERAVLRKSIQRSFTANVDLWSIGVTLYHVATGNLPFRPFG-G-RKNRETMH
IKKe_Mmus       EEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFG-GPRRNKEIMY
IKKb_Mmus       LQYLAPELLEQ--------QKYTVTVDYWSFGTLAFECITGFRPFLPNW-QPV---QWHS
IKKa_Mmus       LQYLAPELFEN--------KPYTATVDYWSFGTMVFECIAGYRPFLHHL-QPF---TWHE
TBK1_Mmus       EEYLHPDMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFE-GPRRNKEVMY
TBK1_Spur       EEYLHPDLYERAVLGKRNRTEFTAQTDLWSLGVTFFHTATGSLPFRAHG-G-RNNRDVMH
IKKe_Spur       EEYLHPKVFERAVLRKPAALPFDARIDLWSIGATLYHLATGQLPFRPHG-G-RKNSRMMF
IKKa_Spur       TQ----------------------TVDLVI------------------------------
AqueK157_Aque   PQYVAPEIIDQ--------DSHGRPVDFWSFGVVAFELVTGIRPFLHKSRRPL---EWIG
AqueK158_Aque   EEYLYPAMYERALINYRSKEEFLDKVDLWSLGATFFHLATGRLPFRPYR-K-RQDRGTMF
                 .                        *

TBK1_Hsap       KIITGKPSGAISGVQK-AE--NGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQE--
IKKe_Hsap       RITTEKPAGAIAGAQR-RE--NGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQA--
IKKb_Hsap       KV-RQKSEVDIVVS-E-DL--NGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQR
IKKa_Hsap       KI-KKKDPKCIFAC-E-EM--SGEVRFSSHLPQPNSLCSLVVEPMENWLQLMLNWDPQQR
ird5_Dmel       NL-IKKPAKCIAIT-E-DPEDNTRFVNQFELPQTHHLSRPWAAQFTKWLASPLNSNYKER
ik2_Dmel        QITTKKASGVISGTQL-SE--NGPIEWSTTLPPHAHLSQGLKTLVTPLLAGLLEENRE--
IKKe_Mmus       RITTEKPAGAISGTQK-QE--NGPLEWSYSLPITCRLSMGLQNQLVPILANILEVEED--
IKKb_Mmus       KV-RQKSEVDIVVS-E-DL--NGAVKFSSSLPFPNNLNSVLAERLEKWLQLMLMWHPRQR
IKKa_Mmus       KI-KKKDPKCIFAC-E-EM--TGEVRFSSHLPQPNSLCSLIVEPMESWLQLMLNWDPQQR
TBK1_Mmus       KIITGKPSGAISGVQK-AE--NGPIDWSGDMPLSCSLSQGLQALLTPVLANILEADQE--
TBK1_Spur       RITTTKKSSMISGVQE-VP--NGPIIWSEDLPKTCHFSPDMRHQVKTLLSHTMECNIQ--
IKKe_Spur       HLTTKKAPGVISGVQTGPL--DHEITWSRELPETCRLSIGLKKLITPLLAGLLESNPS--
IKKa_Spur       ------------------------------------------------------------
AqueK157_Aque   PT-RNKRDNCIYIT---FN--NGQLEYYDSIPSPHQLSSAFAGELTKWLQVVLHQESEKR
AqueK158_Aque   KIINEKKTGIILGWQQ-EY--NAPIYYSDRLPPDIVISQGLRDIITPILAGVLDTF-D--


TBK1_Hsap       -----KCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKIYIHSY---NTATIFHELVYKQ
IKKe_Hsap       -----KCWGFDQFFAETSDILQRVVVHVFSLSQAVLHHIYIHAH---NTIAIFQEAVHKQ
IKKb_Hsap       G--TDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTED---ESLQSLKARIQQD
IKKa_Hsap       GGPVDLTLKQPRCFVLMDHILNLKIVHILNMTSAKIISFLLPPD---ESLHSLQSRIERE
ird5_Dmel       G--QLAANNVPVVFADLDKILNMNVLTIFAVNNCERLEYAVSAE---MTMKDLIALIVLD
ik2_Dmel        -----KTWSFDRFFHEVTLILRKRVIHVFFTNRTSSVEVFLEPD---EQIDNFRERIFLQ
IKKe_Mmus       -----KCWGFDQFFAETSDILQRTVIHVFSLPQAVLHHVYIHAH---NTIAIFLEAVYEQ
IKKb_Mmus       G--TDPQYGPNGCFRALDDILNLKLVHVLNMVTGTVHTYPVTED---ESLQSLKTRIQED
IKKa_Mmus       GGPIDLTLKQPRCFALMDHILNLKIVHILNMTSAKIISFLLPCD---ESLHSLQSRIERE
TBK1_Mmus       -----KCWGFDQFFAETSDVLHRMVIHVFSLQHMTAHKIYIHSY---NTAAVFHELVYKQ
TBK1_Spur       -----KMWTFDIFFDFVQRLTSMRPVDVFVAPTCECHIVYVEPQ---RKVADFQDKMAHL
IKKe_Spur       -----TVWSFQHFFQASQAITTKIAIDVFWVCEASYMKIYCSPT---DRFAEFQENIASQ
IKKa_Spur       ---------------------------------HSPVTYPLDHD---TS-----------
AqueK157_Aque   G--VAHNGDEAPCLLHIDRILRTKVLIIVSMSNGHVLSYSVRCD---SSYQSLSAWLE-E
AqueK158_Aque   -----SMWAFDRFFKAIDGIKKQNVVHIFCVSRCTCHMIYVDDAGEADIIPKFKELIARQ


TBK1_Hsap       TKIISSNQELIYEGRRLVLEPGRLAQH-FPKTTEENPI---------FVVSREPL--NTI
IKKe_Hsap       TSVAPRHQEYLFEGHLCVLEPSVSAQH-IAHTTASSPL---------TLFSTAI--PKGL
IKKb_Hsap       TGIPEEDQELLQEAGL-ALIPDKPATQCISDGKLNEGHTLDM--DLVFLFDNSKITYET-
IKKa_Hsap       TGINTGSQELLSETGI-SLDPRKPASQCVLDGVR----GCDS--YMVYLFDKSKTVYEG-
ird5_Dmel       TGMDEKELYFVLPTSH---------PHK-TITPKSTPLQL----YVEEWSDTSKDS--R-
ik2_Dmel        TEVPLEKQILLFNNEHLE--KKV-----TPR-TIDQPI---------FLYSNDDNNV-QL
IKKe_Mmus       TNVTPKHQEYLFEGHPCVLEPSLSAQH-IAHTAASSPL---------TLFSMSSDTPKGL
IKKb_Mmus       TGILETDQELLQEAGL-VLLPDKPATQCISDSKTNEGLTLDM--DLVFLFDNSKINYET-
IKKa_Mmus       TGINTGSQELLSETGI-SLDPRKPASQCVLDGVR----GCDS--YMVYLFDKSKTVYEG-
TBK1_Mmus       TKIVSSNQELIYEGRRLVLELGRLAQH-FPKTTEENPI---------FVTSREQL--NTV
TBK1_Spur       TGIQPETQSLLWDKEVFDLKKCLKCED-LPQTSPDNPL---------ILVRMGAEVF--P
IKKe_Spur       TKLSATKQSILYNGETFKPDGILPISS-YPITSVANPI---------TLSNKEQIHV-QH
IKKa_Spur       ------------------------------------------------------------
AqueK157_Aque   KGYPKSKQYLVTDRGE-LLSDSLLDLH-S-------SLRWDDCICTVYLFSQDVV-PSF-
AqueK158_Aque   TSLDPKHMEMYLENILFGTEPVR-ARD-LPLTTPDSPL---------TVFGGPPQKP--D


TBK1_Hsap       GLIYEK-ISLPKVHPRYDLDGDASMAKAITGVVCYACRIASTLLLY----QELMRKGIRW
IKKe_Hsap       AFRDPA-LDVPKFVPKVDLQADYNTAKGVLGAGYQALRLARALLDG----QELMFRGLHW
IKKb_Hsap       QISPRPQPESVSCILQE-----PKRNLAFF--------------------QLRKVWGQVW
IKKa_Hsap       PFASRSLSDCVNYIVQD-----SKIQLPII--------------------QLRKVWAEAV
ird5_Dmel       KWTKRSNPPVMLYIFQVKKECDYKIPEPILSILSRKF-IANKFKTKERWLQKRVVLDMLY
ik2_Dmel        PQQLDL-PKFPVFPPNVSVENDASLAKSACSVGHECKRRVDIFTSM----DILIKKGVEH
IKKe_Mmus       AFRDPA-LDVPKFVPKVDLQADYSTAKGVLGAGYQALWLARVLLDG----QALMLRGLHW
IKKb_Mmus       QITPRPQPESVSCILQE-----PKRNLSFF--------------------QLRKVWGQVW
IKKa_Mmus       PFASRSLSDCVNYIVQD-----SKIQLPII--------------------QLRKVWAEAV
TBK1_Mmus       GLRYEK-ISLPKIHPRYDLDGDASMAKAVTGVVCYACRTASTLLLY----QELMRKGVRW
TBK1_Spur       SVKVPSLPTQPKTATHFSVQQDSTLAKHIFTVVL--------------------------
IKKe_Spur       QLTPPFVATMPALRPRFSTQNDYPIAKGALATGCILQTRQKMIHEM----HGLFDQYVIT
IKKa_Spur       --------------------ND--------------------------------------
AqueK157_Aque   KLVVQVTP-SVTNLITN-----GDENLHRE--------------------DKYMHFAHAY
AqueK158_Aque   KLATPVVTQPPNMPPETTMVDDLRYAKDCTKAIWVMYRAAETMDRY----FRLMNQGALC


TBK1_Hsap       -LIELIKDDYNETVHKKTEVV---ITLD-----------------FCIR-----------
IKKe_Hsap       -VMEVLQATCRRTLEVARTSL---LYLS-----------------SSLG-----------
IKKb_Hsap       HSIQTLKEDCNRLQQGQRAAM---MNLL-------------RNN-SCLSKMKNSMASMSQ
IKKa_Hsap       HYVSGLKEDYSRLFQGQRAAM---LSLL-------------RYN-ANLTKMKNTLISASQ
ird5_Dmel       V-LTKEQARYEMLVSGINERA---LSLEDEMMENSFIDSIDKQR-IIISFAYDQLTSLLK
ik2_Dmel        -FIEMLVTTITLLLKKTESFD---NLLS-----------------TVID-----------
IKKe_Mmus       -VLEVLQDTCQQTLEVTRTAL---LYLS-----------------SSLG-----------
IKKb_Mmus       HSIQTLKEDCNRLQQGQRAAM---MSLL-------------RNN-SCLSKMKNAMASTAQ
IKKa_Mmus       HYVSGLKEDYSRLFQGQRAAM---LSLL-------------RYN-ANLTKMKNTLISASQ
TBK1_Mmus       -LVELVKDDYNETVHKKTEVV---ITLD-----------------FCIR-----------
TBK1_Spur       ------RMDYMKLRSEHSAVKSFCLQAD-----------------CRWR-----------
IKKe_Spur       -LRDRSKMDVLRLQDHHKLVKGKLSIMS-----------------THLG-----------
IKKa_Spur       ------------------------------------------------------------
AqueK157_Aque   SHIKDQERLFWRIHNGHRA-I---LQLI-------------RPVTEELKGHYDDHSTEVA
AqueK158_Aque   -LRETLDKDYRAWCRKYEEVQ---VRFN-----------------SL-------------


TBK1_Hsap       -----------NIEKTVKVYEKLM----------K---INLEAAE-L---GEISDIHT--
IKKe_Hsap       ----------------TERFSSVA--GTPEI---Q---ELKAAAE-L--RSRLRTLAE--
IKKb_Hsap       QLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVE--
IKKa_Hsap       QLKAKLEFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYAEVGVIGYLED--
ird5_Dmel       EAQAKIPSRQLISSAQWEKLNRNYNFIIQSAKSIRSFL------EACLREA--KDMVK--
ik2_Dmel        ------------YADVVHSMARVT----------K------G-------DQEIKTLLT--
IKKe_Mmus       ----------------TERFSSGA--GMPDV---Q---ERKEATE-L--RTRLQTLSE--
IKKb_Mmus       QLKAKLDFFKTSIQIDLEKYKEQTEFGITSDKLLLAWREMEQAVEQCGRENDVKHLVE--
IKKa_Mmus       QLKAKLEFFRKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYSEVGVIGYLED--
TBK1_Mmus       -----------NIEKTVKVYEKLM----------K---VNLEAAE-L---GEISDIHT--
TBK1_Spur       -----------ALERSLT------------------------------------------
IKKe_Spur       -----------DGK-------RIL--NL------------LRNTQ-E---GRISDITH--
IKKa_Spur       ---------------------------------------------TCIYK----------
AqueK157_Aque   KCLGVANFMKKMYSEDMEKLSDN--------SRINAWRSELS------------------
AqueK158_Aque   -----------------------I--DI------------SNSQI-V---GLQSDVEFLQ


TBK1_Hsap       K-----L-----LRLSSSQG---------------------TIETSLQDIDSRLSPGGS-
IKKe_Hsap       V-----L-----SRCSQNIT---------------------ETQESLSSLNREL------
IKKb_Hsap       R-----M-----MALQTDIVDLQRSPM---------------------------------
IKKa_Hsap       Q-----I-----MSLHAEIMELQKSPY---------------------------------
ird5_Dmel       TTNQLRK-----EVCEKDLFDCARFYK---------------------------------
ik2_Dmel        A-----L-----ENVKSDFD---------------------GAADVISQMHKHFVIDDE-
IKKe_Mmus       I-----L-----SKCSHNVT---------------------ETQRSLSCLGEEL------
IKKb_Mmus       R-----M-----MALQTDIVDLQRSPM---------------------------------
IKKa_Mmus       Q-----I-----MSLHTEIMELQKSPY---------------------------------
TBK1_Mmus       K-----L-----LRLSSSQG---------------------TIESSLQDISSRLSPGGL-
TBK1_Spur       -------------LVLTGVD-----------------------GASLDEIKLRII-----
IKKe_Spur       --------------------QLERKLEEGSHDLMQFEMQSNEIDEILNQLHTDVFINDI-
IKKa_Spur       ------------------------------------------------------------
AqueK157_Aque   ------------------------------------------------------------
AqueK158_Aque   A-----INPLCNNAFDHDIADLQRQLEDKNKHLVDVRDQSFALHEQTKDFHSTVN--SIT


TBK1_Hsap       LADAWA---HQEGTHPKD-RNVEKL---QVLLNCMTEIYYQFKKDKAERRLAYN--EEQI
IKKe_Hsap       ----VK---SRDQVHED--RSIQQI---QCCLDKMNFIYKQFKKSRMRPGLGYN--EEQI
IKKb_Hsap       ----------------GR-KQGGTL---DDLEEQARELYRRLREKPRDQRTEG-DSQEMV
IKKa_Hsap       ----------------GR-RQGDLM---ESLEQRAIDLYKQLKHRPSDHS-YS-DSTEMV
ird5_Dmel       ----------------KY-LCNGAIISPSELNNDAE----EFAKSRF-KL----YNEGEA
ik2_Dmel        LNDQWTSSMHGKKCPCKT-RASAQA---KYLVERLRDSWQHLLRDRATRTLTYN--DEQF
IKKe_Mmus       ----LK---NRDQIHEDN-KSIQKI---QCCLDKMHFIYKQFKKSRMRPGLSYN--EEQI
IKKb_Mmus       ----------------GR-KQGGTL---DDLEEQARELYRRLREKPRDQRTEG-DSQEMV
IKKa_Mmus       ----------------GR-RQGDLM---ESLEQRAIDLYKQLKHRPPDHL-YS-DSTEMV
TBK1_Mmus       LADTWA---HQEGTHPRD-RNVEKL---QVLLNCITEIYYQFKKDKAERRLAYN--EEQI
TBK1_Spur       -----K---CKERLYE--------V---QNVF---HSIFYV-------------------
IKKe_Spur       LQSIWKP---SQGCNVQDEKCSTEL---VHLTDEMEDIFKRFSRDKKTGKLSYN--EEQI
IKKa_Spur       ------------------------------L-----------------------------
AqueK157_Aque   ------------------------------------------------------------
AqueK158_Aque   SSSIWDT---NYLAKVFN-ESTKTM---MSYVDKVEEIFNAFQEQKKQRGAIHGDYDRRS


TBK1_Hsap       HKFDKQKLYY-----------------HATKAMTH--FTD---ECVKKY----EAFLN--
IKKe_Hsap       HKLDKVNFSH-----------------LAKRLLQV--FQE---ECVQKY----QASLV--
IKKb_Hsap       -RLLLQAIQS-----------------FEKKVRVIYTQLSKTVVCKQKA----LELLPKV
IKKa_Hsap       -KIIVHTVQS-----------------QDRVLKELFGHLSKLLGCKQKI----IDLLPKV
ird5_Dmel       -----------------------------RHLPKSIDHMHYLY-----------------
ik2_Dmel        HALEKIKVDH-----------------NGKRIKAL--LLD---NVNPTV----AQIAE--
IKKe_Mmus       HKLDKVNFSH-----------------LAKRLLQV--FQE---ECVQTY----QVSLV--
IKKb_Mmus       -RLLLQAIQS-----------------FEKKVRVIYTQLSKTVVCKQKA----LELLPKV
IKKa_Mmus       -KIIVHTVQS-----------------QDRVLKELFGHLSKLLGCKQKI----IDLLPKV
TBK1_Mmus       HKFDKQKLYY-----------------HATKAMSH--FSE---ECVRKY----EAFKD--
TBK1_Spur       ------------------------------------------------------------
IKKe_Spur       HKMEKLSLGD-----------------LMKRTMTC---SG---GCEERWRSQHKLLMV--
IKKa_Spur       ------------------------------------------------------------
AqueK157_Aque   ----------------------------------------------------------KL
AqueK158_Aque   HEYNKRTIKERLGMADKKLSEMIAGRNHVYGNLYH--FLE---KCTP----VRE------


TBK1_Hsap       -------KSEE-WIRK---MLHLRKQL-------LSL-------TNQCFD--IEEEVSKY
IKKe_Hsap       -------THGK-RMRV---VHETRNHL-------RLV-------GCSVAA--CNTEAQGV
IKKb_Hsap       EEVVSLMNEDEKTVVR-L-QEKRQKELW------NLL-------KIACSK--VRGPVSGS
IKKa_Hsap       EVALSNIKEADNTVMF-M-QGKRQKEIW------HLL-------KIACTQSSARSLVGSS
ird5_Dmel       --------------------FKTKESIP------VLL-------QQFCD---IKKEIFQI
ik2_Dmel        -------CLAD-WYKLAQ-TVYLKTQI---------L-------EKDVRD--CERKLNGI
IKKe_Mmus       -------THGK-RMRQ---VQRAQNHL-------HLI-------GHSVAT--CNSEARGA
IKKb_Mmus       EEVVSLMNEDERTVVR-L-QEKRQKELW------NLL-------KIACSK--VRGPVSGS
IKKa_Mmus       EVALSNIKEADNTVMF-M-QGKRQKEIW------HLL-------KIACTQSSARSLVGYS
TBK1_Mmus       -------KSEE-WMRK---MLHLRKQL-------LSL-------TNQCFD--IEEEVSKY
TBK1_Spur       -----------------------------------------------------EK-----
IKKe_Spur       -------CHNK-AYNQRQQLLKADRSLAPLVHHCNVLENTISDLHSQCWQ--IAESKTPP
IKKa_Spur       -----------------------------------------------AN---WEREILKF
AqueK157_Aque   D-----------------------------------------------------------
AqueK158_Aque   ------------------DLRNLMASLDHSAQCT---KEDTIRLQ---------KWLPHH


TBK1_Hsap       QEYT---NELQETLPQKMFTA-SSGIKHTMTP----------------------------
IKKe_Hsap       QESL---SKLLEELSHQLLQDRAKGAQASPPP----------------------------
IKKb_Hsap       PDSM---NASRLSQPGQLMSQ-PSTASNSL------------------------------
IKKa_Hsap       LEGAVTPQTSAWLPPTSAEHD-HSLSCVVT------------------------------
ird5_Dmel       NLQML--MSASSTPPPKLE-----------------------------------------
ik2_Dmel        RDEL---YHVKSELKLDVDTK-TINNNNQLAK----------------------------
IKKe_Mmus       QESL---NKIFDQLLLDR--ASEQGAEVSPQP----------------------------
IKKb_Mmus       PDSM---NVSRLSHPGQLMSQ-PSSACDSL------------------------------
IKKa_Mmus       LEGTVTPPVSAWLPPTLADRE-HPLTCVVT------------------------------
TBK1_Mmus       QDYT---NELQETLPQKMLAA-SGGVKHAMAP----------------------------
TBK1_Spur       ------------------------------------------------------------
IKKe_Spur       PDMK---RHHTYQAPKEILL-SASTQ-TSLPKEETPSHHTSLLLDHHYDQLTKGGKPLVM
IKKa_Spur       ------------------------------------------------------------
AqueK157_Aque   ------------------------QAIKVH------------------------------
AqueK158_Aque   QQRM---QNLLGKLPNSL-S-GGGG------------------------------GGGGM


TBK1_Hsap       -----------------------IYP-------------------------S-SNTLVE-
IKKe_Hsap       -----------------------IAP-------------------------YPSPTRKD-
IKKb_Hsap       -------------------------P-------------------------EPAKKSEE-
IKKa_Hsap       -------------------------P-------------------------QDGETSAQ-
ird5_Dmel       ------------------------------------------------------------
ik2_Dmel        ---------------------------------------------------------IE-
IKKe_Mmus       -----------------------MAP-------------------------HPGPDPKD-
IKKb_Mmus       -------------------------P-------------------------ESDKKSEE-
IKKa_Mmus       -------------------------P-------------------------QDGETLAQ-
TBK1_Mmus       -----------------------IYP-------------------------S-SNTLVE-
TBK1_Spur       ------------------------------------------------------------
IKKe_Spur       GKSTINSQRSPYSVDRSTGQYPELYQTASALSEPSCGTSQYRYDAPLTRARSSPPELVAR
IKKa_Spur       ------------------------------------------------------------
AqueK157_Aque   -------------------------P-------------------------HSSAIST--
AqueK158_Aque   GTLQLN------------------------------------------------------


TBK1_Hsap       -------------------------------------------MTLGMKKLKE-------
IKKe_Hsap       -------------------------------------------LLLHMQELCE-------
IKKb_Hsap       -------------------------------------------LVAEAHNLCT---LLEN
IKKa_Hsap       -------------------------------------------MIEENLNCLG---HLST
ird5_Dmel       -------------------------------------------LSAAMDRLAISSGSPSS
ik2_Dmel        -------------------------------------------ERNRLRVMQQ-------
IKKe_Mmus       -------------------------------------------LVFHMQELCN-------
IKKb_Mmus       -------------------------------------------LVAEAHALCS---RLES
IKKa_Mmus       -------------------------------------------MIEENLNCLG---HLST
TBK1_Mmus       -------------------------------------------MTLGMKKLKE-------
TBK1_Spur       ------------------------------------------------------------
IKKe_Spur       GISRRSPDAPSELYGVDPTPGAIGGLQDLRSPAGDYQQAEGPRMIKVSKEFKK-------
IKKa_Spur       ------------------------------------------------------------
AqueK157_Aque   -------------------------------------------HTHTHTHTCR---TFIH
AqueK158_Aque   ------------------------------------------------------------


TBK1_Hsap       EMEGVVKELAENNHI-------------------------------LERFGSLTMD----
IKKe_Hsap       GMKLLASDLLDNNRI-------------------------------IERLNRV-------
IKKb_Hsap       AIQDTVREQDQSFTA-------------------------------LDW-SWLQTEE---
IKKa_Hsap       IIHEANEEQGNSMMN-------------------------------LDW-----------
ird5_Dmel       DPFDS-----------------------------------------------LRTIN---
ik2_Dmel        QQQEVMAVMRTNSDI-------------------------------ISLLSKLGIT----
IKKe_Mmus       DMKLLAFDLQDNNRL-------------------------------IERLHRV-------
IKKb_Mmus       ALQDTVKEQDRSFTT-------------------------------LDW-SWLQMED---
IKKa_Mmus       IIREANEDQSSSLMS-------------------------------LDW-----------
TBK1_Mmus       EMEGVVKELAENNHI-------------------------------LERFGSLTMD----
TBK1_Spur       ------------------------------------------------KF--LKE-----
IKKe_Spur       RVADYRKESNTSYHIQRNLAELTQLELESMSLETPEMPRYTADSSLLDTLTGPGMDEGDE
IKKa_Spur       ------------------------------------------------------------
AqueK157_Aque   ----------------------------------------------------LLL-R---
AqueK158_Aque   -----------------SLRSLLQRAREST----GDLL------KLADKQ----------


TBK1_Hsap       ----------GGLRNVDCL
IKKe_Hsap       -------------PAPPDV
IKKb_Hsap       --------EEH-SCLEQAS
IKKa_Hsap       --------------SWLTE
ird5_Dmel       --------AIEEAERINNM
ik2_Dmel        ----------N--GSLESS
IKKe_Mmus       -------------PSAPDV
IKKb_Mmus       --------EERCSLEQACD
IKKa_Mmus       --------------SWLAE
TBK1_Mmus       ----------GGLRNVDCL
TBK1_Spur       ----------EG-SHMLLN
IKKe_Spur       SILEGLDIKRPPVSYQSGT
IKKa_Spur       ----------MGSMYNARL
AqueK157_Aque   --------CMHFPKRLERS
AqueK158_Aque   KTL-----IHPPSDKKEKS